公开(公告)号：US20090105221A1

公开(公告)日：2009-04-23

申请号：US11576096

申请日：2005-09-28

申请人： Mohammad Salman ,  Pakala Kumara Savithru Sarma ,  Arani Pal ,  Anita Chugh ,  Suman Gupta ,  Venkata P. Palle ,  Naresh Kumar ,  Kirandeep Kaur

发明人： Mohammad Salman ,  Pakala Kumara Savithru Sarma ,  Arani Pal ,  Anita Chugh ,  Suman Gupta ,  Venkata P. Palle ,  Naresh Kumar ,  Kirandeep Kaur

IPC分类号： A61K31/55 ,  C07D223/14 ,  C07D405/12 ,  A61P11/00 ,  A61P1/00

CPC分类号： C07D401/12 ,  C07D221/24 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12

摘要： This present invention generally relates to muscarinic receptor antagonists of Formula (I), which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to the process for the prepration of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors.

摘要翻译： 本发明一般涉及式（I）的毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病。 本发明还涉及所述化合物的制备方法，包含所公开的化合物的药物组合物，以及通过毒蕈碱受体介导的疾病的治疗方法。

公开(公告)号：US20080319043A1

公开(公告)日：2008-12-25

申请号：US11913599

申请日：2006-05-01

申请人： Mohammad Salman ,  Naresh Kumar ,  Kirandeep Kaur ,  Shelly Aeron ,  Pakala Kumara Savithru Sarma ,  Sankaranarayanan Dharmarajan ,  Anita Mehta ,  Anita Chugh

发明人： Mohammad Salman ,  Naresh Kumar ,  Kirandeep Kaur ,  Shelly Aeron ,  Pakala Kumara Savithru Sarma ,  Sankaranarayanan Dharmarajan ,  Anita Mehta ,  Anita Chugh

IPC分类号： A61K31/4035 ,  C07D209/44

CPC分类号： C07D209/52

摘要： The present invention generally relates to muscarinic receptor antagonists, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to the process for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors.

摘要翻译： 本发明一般涉及毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病，以及其它用途。 本发明还涉及制备所公开的化合物的方法，含有所公开的化合物的药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。

公开(公告)号：US07446123B2

公开(公告)日：2008-11-04

申请号：US10552455

申请日：2004-01-07

申请人： Mohammad Salman ,  Anita Mehta ,  Pakala Kumara Savithru Sarma ,  Naresh Kumar ,  Sankaranarayanan Dharmarajan ,  Kirandeep Kaur ,  Anita Chugh

发明人： Mohammad Salman ,  Anita Mehta ,  Pakala Kumara Savithru Sarma ,  Naresh Kumar ,  Sankaranarayanan Dharmarajan ,  Kirandeep Kaur ,  Anita Chugh

IPC分类号： A61K31/40 ,  A61K31/4035 ,  C07D209/52

CPC分类号： C07D209/52 ,  C07D403/06

摘要： This invention generally relates to muscarinic receptor antagonists of formula (I) which are useful, among other uses for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to pharmaceutical compositions containing the compounds of the present invention and the methods of treating the diseases mediated through muscarinic receptors.

摘要翻译： 本发明一般涉及式（I）的毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病的其它用途。 本发明还涉及含有本发明化合物的药物组合物和通过毒蕈碱受体介导的疾病的治疗方法。

公开(公告)号：US20090137623A1

公开(公告)日：2009-05-28

申请号：US12158435

申请日：2007-01-02

申请人： Naresh Kumar ,  Ian Anthony Cliffe ,  Mohammad Salman ,  Venkata P. Palle ,  Kirandeep Kaur ,  Yogesh D. Shejul ,  Anita Chugh ,  Suman Gupta ,  Abhijit Ray ,  Shivani Malhotra ,  Raj Kumar Shirumalla

发明人： Naresh Kumar ,  Ian Anthony Cliffe ,  Mohammad Salman ,  Venkata P. Palle ,  Kirandeep Kaur ,  Yogesh D. Shejul ,  Anita Chugh ,  Suman Gupta ,  Abhijit Ray ,  Shivani Malhotra ,  Raj Kumar Shirumalla

IPC分类号： A61K31/439 ,  C07D487/08 ,  A61P1/00 ,  A61P3/10 ,  A61P3/04 ,  A61P11/06

CPC分类号： C07D209/52

摘要： The present invention relates to muscarinic receptor modulators, specifically, 7-oxo-2-azabicyclo[2.2.1]heptanes of formula (I) which are useful for the treatment of various diseases and conditions, for example, Alzheimer's disease, glaucoma, psychosis, particularly schizophrenia or schizophreniform conditions, mania, pain, bipolar disorder, depression, sleeping disorders, epilepsy, gastrointestinal motility disorders, urinary incontinence, and cognition enhancement.

摘要翻译： 本发明涉及可用于治疗各种疾病和病症（例如阿尔茨海默病，青光眼，精神病）的式（I）的毒蕈碱受体调节剂，具体地，7-氧代-2-氮杂双环[2.2.1]庚烷 特别是精神分裂症或精神分裂症状，躁狂症，疼痛，双相情感障碍，抑郁症，睡眠障碍，癫痫，胃肠动力障碍，尿失禁和认知增强。

公开(公告)号：US07544708B2

公开(公告)日：2009-06-09

申请号：US10520572

申请日：2003-04-11

申请人： Mohammad Salman ,  Anita Mehta ,  Pakala Kumara Savithru Sarma ,  Shankar Jayram Shetty ,  Sankaranarayanan Dharmarajan ,  Naresh Kumar ,  Arundutt Vishwanatham Silamkoti ,  Anita Chugh

发明人： Mohammad Salman ,  Anita Mehta ,  Pakala Kumara Savithru Sarma ,  Shankar Jayram Shetty ,  Sankaranarayanan Dharmarajan ,  Naresh Kumar ,  Arundutt Vishwanatham Silamkoti ,  Anita Chugh

IPC分类号： A61K31/40 ,  C07D209/44

CPC分类号： C07D401/12 ,  C07D209/52 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

摘要： This invention generally relates to muscarinic receptor antagonists which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. Specifically, the invention relates to derivatives of azabicyclo compounds, including, for example, 6-substituted azabicyclo[3.1.0] hexanes, and 2,4,6-trisubstituted derivatives. The invention also relates to pharmaceutical compositions containing the compounds and the methods of treating the diseases mediated through muscarinic receptors.

摘要翻译： 本发明一般涉及毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病，以及其它用途。 具体地，本发明涉及氮杂双环化合物的衍生物，包括例如6-取代的氮杂双环[3.1.0]己烷和2,4,6-三取代的衍生物。 本发明还涉及含有化合物的药物组合物和通过毒蕈碱受体介导的疾病的治疗方法。

公开(公告)号：US20090012116A1

公开(公告)日：2009-01-08

申请号：US11995376

申请日：2006-07-11

申请人： Naresh Kumar ,  Kirandeep Kaur ,  Sandeep Sinha ,  Suman Gupta ,  Venkata P. Palle ,  Anita Chugh

发明人： Naresh Kumar ,  Kirandeep Kaur ,  Sandeep Sinha ,  Suman Gupta ,  Venkata P. Palle ,  Anita Chugh

IPC分类号： A61K31/44 ,  C07D453/02 ,  A61K31/40 ,  C07D487/08

CPC分类号： C07D209/52 ,  C07D405/12 ,  C07D409/12 ,  C07D471/08

摘要： Provided are muscarinic receptor antagonists, which can be useful in treating various diseases of the respiratory, urinary or gastrointestinal system mediated through muscarinic receptors. Also provided are processes for preparing compounds described herein, pharmaceutical compositions comprising compounds described herein, and methods for treating diseases mediated through muscarinic receptors.

摘要翻译： 提供毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿或胃肠系统的各种疾病。 还提供了用于制备本文所述化合物的方法，包含本文所述化合物的药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。

公开(公告)号：US20090131410A1

公开(公告)日：2009-05-21

申请号：US12089150

申请日：2006-10-05

申请人： Naresh Kumar ,  Kirandeep Kaur ,  Suman Gupta ,  Anita Chugh ,  Mohammad Salman ,  Raj Kumar Shirumalla ,  Shivani Malhotra

发明人： Naresh Kumar ,  Kirandeep Kaur ,  Suman Gupta ,  Anita Chugh ,  Mohammad Salman ,  Raj Kumar Shirumalla ,  Shivani Malhotra

IPC分类号： A61K31/55 ,  C07D223/14 ,  A61P3/10

CPC分类号： C07D221/24 ,  C07D405/12 ,  C07D409/12

摘要： Provided are muscarinic receptor antagonists, which can be useful in treating various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. Also provided are processes for preparing compounds described herein, pharmaceutical compositions thereof, and methods for treating diseases mediated through muscarinic receptors.

摘要翻译： 提供毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，尿和胃肠道系统的各种疾病。 还提供了用于制备本文所述的化合物的方法，其药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。

公开(公告)号：US20060287380A1

公开(公告)日：2006-12-21

申请号：US10552455

申请日：2004-01-07

申请人： Mohammad Salman ,  Anita Mehta ,  Pakata Sarma ,  Naresh Kumar ,  Sankaranarayanan Dharmarajan ,  Kirandeep Kaur ,  Anita Chugh

发明人： Mohammad Salman ,  Anita Mehta ,  Pakata Sarma ,  Naresh Kumar ,  Sankaranarayanan Dharmarajan ,  Kirandeep Kaur ,  Anita Chugh

IPC分类号： A61K31/4035 ,  C07D403/02

CPC分类号： C07D209/52 ,  C07D403/06

摘要： This invention generally relates to muscarinic receptor antagonists of formula (I) which are useful, among other uses for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to pharmaceutical compositions containing the compounds of the present invention and the methods of treating the diseases mediated through muscarinic receptors.

摘要翻译： 本发明一般涉及式（I）的毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病的其它用途。 本发明还涉及含有本发明化合物的药物组合物和通过毒蕈碱受体介导的疾病的治疗方法。

公开(公告)号：US20100016400A1

公开(公告)日：2010-01-21

申请号：US11719687

申请日：2005-11-18

申请人： Naresh Kumar ,  Mohammad Salman ,  Kirandeep Kaur ,  Anita Mehta ,  Sudershan K. Arora ,  Anita Chugh

发明人： Naresh Kumar ,  Mohammad Salman ,  Kirandeep Kaur ,  Anita Mehta ,  Sudershan K. Arora ,  Anita Chugh

IPC分类号： A61K31/403 ,  C07D209/52 ,  C07D409/06 ,  A61P11/00

CPC分类号： C07D209/52 ,  C07D409/06

摘要： The present invention generally relates to muscarinic receptor antagonists, which are useful for treating various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to processes for preparing compounds described herein, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors.

摘要翻译： 本发明一般涉及毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病。 本发明还涉及制备本文所述化合物的方法，含有所公开化合物的药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。

公开(公告)号：US20080255188A1

公开(公告)日：2008-10-16

申请号：US11995433

申请日：2006-07-11

申请人： Naresh Kumar ,  Mohammad Salman ,  Kirandeep Kaur ,  Anita Chugh ,  Sandeep Sinha

发明人： Naresh Kumar ,  Mohammad Salman ,  Kirandeep Kaur ,  Anita Chugh ,  Sandeep Sinha

IPC分类号： A61K31/472 ,  C07D217/26

CPC分类号： C07D471/08

摘要： This present invention generally relates to muscarinic receptor antagonists of Formula (I), which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to the process for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors.

摘要翻译： 本发明一般涉及式（I）的毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病。 本发明还涉及制备所公开的化合物的方法，含有所公开的化合物的药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。