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公开(公告)号：US12275795B2
公开(公告)日：2025-04-15
申请号：US17934064
申请日：2022-09-21
Applicant: NOVARTIS AG
Inventor： Aida Abujoub , John Blankenship , Tony Fleming , Brian Holmberg , Connie Hong , Lu Huang , Haihui Lu
IPC: C07K16/28 , A61K39/395 , A61K47/68 , A61P35/00 , C07K14/715 , C07K14/725 , C07K14/735 , C07K16/30 , C07K16/46 , C12N5/10 , C12N15/63 , A61K39/00
Abstract: The present disclosure provides BCMA binding molecules that specifically bind to human BCMA, conjugates comprising the BCMA binding molecules, and pharmaceutical compositions comprising the BCMA binding molecules and the conjugates. The disclosure further provides methods of using the BCMA binding molecules to treat cancers that express cell surface BCMA. The disclosure yet further provides recombinant host cells engineered to express the BCMA binding molecules and methods of producing the BCMA binding molecules by culturing the host cells under conditions in which the BCMA binding molecules are expressed.
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公开(公告)号：US11952428B2
公开(公告)日：2024-04-09
申请号：US18170941
申请日：2023-02-17
Applicant: Novartis AG
Inventor： Aida Abujoub , John Blankenship , Dexiu Bu , Tony Fleming , Brian Holmberg , Connie Hong , Lu Huang , Chonghui Zhang
IPC: C07K16/28 , A61K35/17 , A61P35/00 , C07K14/705 , C07K14/725 , C12N5/0783 , A61K38/00
CPC classification number: C07K16/2878 , A61K35/17 , A61P35/00 , C07K14/7051 , C07K14/70578 , C12N5/0636 , A61K38/00 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2317/76 , C07K2319/02 , C07K2319/03 , C07K2319/30 , C07K2319/33
Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA, vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.
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公开(公告)号：US20230416390A1
公开(公告)日：2023-12-28
申请号：US18184860
申请日：2023-03-16
Applicant: Novartis AG
Inventor： Aida Abujoub , John Blankenship , Dexiu Bu , Tony Fleming , Brian Holmberg , Connie Hong , Lu Huang , Chonghui Zhang
IPC: C07K16/28 , A61P35/00 , A61K35/17 , C07K14/725 , C07K14/705 , C12N5/0783
CPC classification number: C07K16/2878 , A61P35/00 , A61K35/17 , C07K14/7051 , C07K14/70578 , C12N5/0636 , A61K38/00
Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA, vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.
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公开(公告)号：US11939389B2
公开(公告)日：2024-03-26
申请号：US18170969
申请日：2023-02-17
Applicant: Novartis AG
Inventor： Aida Abujoub , John Blankenship , Dexiu Bu , Tony Fleming , Brian Holmberg , Connie Hong , Lu Huang , Chonghui Zhang
IPC: C07K16/28 , A61K35/17 , A61P35/00 , C07K14/705 , C07K14/725 , C12N5/0783 , A61K38/00
CPC classification number: C07K16/2878 , A61K35/17 , A61P35/00 , C07K14/7051 , C07K14/70578 , C12N5/0636 , A61K38/00 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2317/76 , C07K2319/02 , C07K2319/03 , C07K2319/30 , C07K2319/33
Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA, vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.
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公开(公告)号：US20230183368A1
公开(公告)日：2023-06-15
申请号：US18170969
申请日：2023-02-17
Applicant: Novartis AG
Inventor： Aida Abujoub , John Blankenship , Dexiu Bu , Tony Fleming , Brian Holmberg , Connie Hong , Lu Huang , Chonghui Zhang
IPC: C07K16/28 , A61P35/00 , A61K35/17 , C07K14/725 , C07K14/705 , C12N5/0783
CPC classification number: C07K16/2878 , A61P35/00 , A61K35/17 , C07K14/7051 , C07K14/70578 , C12N5/0636 , A61K38/00
Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA, vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.
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Patent Agency Ranking
公开(公告)号：US11608382B2
公开(公告)日：2023-03-21
申请号：US16439495
申请日：2019-06-12
Applicant: Novartis AG
Inventor： Aida Abujoub , John Blankenship , Dexiu Bu , Tony Fleming , Brian Holmberg , Connie Hong , Lu Huang , Chonghui Zhang
IPC: C07K16/28 , A61P35/00 , A61K35/17 , C07K14/725 , C07K14/705 , C12N5/0783 , A61K38/00
Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA, vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.
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公开(公告)号：US20220396631A1
公开(公告)日：2022-12-15
申请号：US17595637
申请日：2020-05-19
Applicant: Lu HUANG , Brian GRANDA , John BLANKENSHIP , Aida ABUJOUB , Tony FLEMING , Haihui LU , Connie HONG , Brian HOLMBERG , Novartis AG
Inventor： Brian Walter Granda , John Blankenship , Aida Abujoub , Tony Fleming , Lu Huang , Connie Hong , Brian Holmberg , Haihui Lu
IPC: C07K16/28
Abstract: The present disclosure provides multispecific binding molecules that specifically bind to BCMA, a component of a human T-cell receptor complex and either CD2 or a tumor associated antigen, conjugates comprising the multispecific binding molecules, and pharmaceutical compositions comprising the multispecific binding molecules and the conjugates The disclosure further provides methods of using the multispecific binding molecules to treat disease and disorders associated with expression of BCMA. The disclosure yet further provides recombinant host cells engineered to express the multispecific binding molecules and methods of producing the multispecific binding molecules by culturing the host cells under conditions in which the multispecific binding molecules are expressed.
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公开(公告)号：US20220364055A1
公开(公告)日：2022-11-17
申请号：US17271430
申请日：2019-08-30
Applicant: Novartis AG
Inventor： Louise Treanor , Michael R. Greene , Jennifer Brogdon , Boris Engels , Glenn Dranoff , Olja Kodrasi , Hyungwook Lim , Akash Sohoni , Elizabeth Dorothy Pratico , Anniesha Hack , Aida Abujoub , Tony Fleming , Lu Huang , Connie Hong , John Blankenship , Brian Holmberg , Chonghui Zhang , Dexiu Bu , Andrew Price , Xu Zhu , Andrew Stein , Attilio Bondanza
IPC: C12N5/0783 , A61K35/17 , A61K31/519 , A61K38/20 , C07K16/28 , C07K14/705
Abstract: The invention provides methods of making immune effector cells (for example, T cells, NK cells) that express a chimeric antigen receptor (CAR), and compositions generated by such methods.
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公开(公告)号：US20210220404A1
公开(公告)日：2021-07-22
申请号：US17104983
申请日：2020-11-25
Applicant: Michael R. Greene , Novartis AG
Inventor： Aida Abujoub , John Blankenship , Attilio Bondanza , Jennifer Brogdon , Dexiu Bu , Serena De Vita , Glenn Dranoff , Boris Engels , Tony Fleming , Brian Walter Granda , Michael R. Greene , Carla Patricia Guimaraes , Anniesha Hack , Brian Holmberg , Connie Hong , Lu Huang , Olja Kodrasi , Joni Waiee Lam , Hyungwook Lim , Elizabeth Dorothy Pratico , Andrew Price , Akash Sohoni , Andrew Marc Stein , Louise Treanor , Chonghui Zhang , Xu Zhu
IPC: A61K35/17 , C07K16/28 , A61P35/00 , A61K45/06 , A61K39/395 , C07K14/705 , A61K38/17 , C12N5/0783 , C07K14/725
Abstract: The invention provides immune effector cells (for example, T cells, NK cells) that express a chimeric antigen receptor (CAR), and compositions and methods thereof.
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公开(公告)号：US20230250179A1
公开(公告)日：2023-08-10
申请号：US18170941
申请日：2023-02-17
Applicant: Novartis AG
Inventor： Aida Abujoub , John Blankenship , Dexiu Bu , Tony Fleming , Brian Holmberg , Connie Hong , Lu Huang , Chonghui Zhang
IPC: C07K16/28 , A61P35/00 , A61K35/17 , C07K14/725 , C07K14/705 , C12N5/0783
CPC classification number: C07K16/2878 , A61P35/00 , A61K35/17 , C07K14/7051 , C07K14/70578 , C12N5/0636 , A61K38/00
Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA, vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.
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