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1.发明申请公开(公告)号：US20090012294A1
公开(公告)日：2009-01-08
申请号：US12079780
申请日：2008-03-28
申请人： Nicola Diulgheroff , Moran Pirkes , Alessandro Pontiroli , Marco Villa , Jonathan Busolli , Roberto Casalone
发明人： Nicola Diulgheroff , Moran Pirkes , Alessandro Pontiroli , Marco Villa , Jonathan Busolli , Roberto Casalone
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , C07B2200/13
摘要： Provided are highly pure pemetrexed diacid and pharmaceutically acceptable salts thereof, and processes for their preparation.
摘要翻译： 提供了高纯度培美曲塞二酸及其药学上可接受的盐，及其制备方法。
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公开(公告)号：US20070167480A1
公开(公告)日：2007-07-19
申请号：US11643013
申请日：2006-12-19
申请人： Roberta Volonte , Nicola Diulgheroff , Francesca Scarpitta , Alessandro Pontiroli , Roberto Casalone
发明人： Roberta Volonte , Nicola Diulgheroff , Francesca Scarpitta , Alessandro Pontiroli , Roberto Casalone
IPC分类号： A61K31/44
CPC分类号： C07D451/06 , C07D451/10
摘要： This invention relates to solvates of tiotropium bromide having a purity of at least 99%, process for preparing such pure solvates, and their use in pharmaceutical formulations. This invention also provides tiotropium bromide solvates containing less than about 0.15% area by HPLC of 2,2-dithienyl glycolic acid.
摘要翻译： 本发明涉及纯度至少为99％的噻托溴铵的溶剂合物，制备这种纯溶剂化物的方法及其在药物制剂中的用途。 本发明还提供通过HPLC的2,2-二噻烷基乙醇酸含量低于约0.15％的噻托溴铵溶剂化物。
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公开(公告)号：US20070032660A1
公开(公告)日：2007-02-08
申请号：US11476258
申请日：2006-06-27
IPC分类号： C07D249/08 , C07C253/34
CPC分类号： C07C253/34 , C07C255/33 , C07D249/08
摘要： The invention is directed to processes for purifying the Anastrozole intermediate, 3,5-bis(2-cyanoisopropyl)toluene, processes for producing Anastrozole, processes for preparing Anastrozole pharmaceutical compositions, and Anastrozole and Anastrozole pharmaceutical compositions prepared with the processes of the invention.
摘要翻译： 本发明涉及纯化阿那曲唑中间体，3,5-二（2-氰基异丙基）甲苯，制备阿那曲唑的方法，制备阿那曲唑药物组合物的方法，以及用本发明方法制备的阿那曲唑和阿那曲唑药物组合物的方法。
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公开(公告)号：US20090118517A1
公开(公告)日：2009-05-07
申请号：US12317392
申请日：2008-12-22
IPC分类号： C07D249/08
CPC分类号： C07C253/34 , C07C255/33 , C07D249/08
摘要： The invention is directed to processes for purifying the Anastrozole intermediate, 3,5-bis(2-cyanoisopropyl)toluene, processes for producing Anastrozole, processes for preparing Anastrozole pharmaceutical compositions, and Anastrozole and Anastrozole pharmaceutical compositions prepared with the processes of the invention.
摘要翻译： 本发明涉及纯化阿那曲唑中间体，3,5-二（2-氰基异丙基）甲苯，制备阿那曲唑的方法，制备阿那曲唑药物组合物的方法，以及用本发明方法制备的阿那曲唑和阿那曲唑药物组合物的方法。
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公开(公告)号：US20080145946A1
公开(公告)日：2008-06-19
申请号：US12012243
申请日：2008-01-31
IPC分类号： G01N33/00 , C07C255/01 , C07D249/04
CPC分类号： C07D249/08 , C07C255/33 , Y10T436/172307
摘要： Reference markers and reference standards for the determination of impurities in Anastrozole are provided.
摘要翻译： 提供了用于测定阿那曲唑中杂质的参考标记和参考标准。
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公开(公告)号：US20070087441A1
公开(公告)日：2007-04-19
申请号：US11476396
申请日：2006-06-27
IPC分类号： G01N33/00 , C07C255/63
CPC分类号： C07D249/08 , C07C255/33 , Y10T436/172307
摘要： Reference markers and reference standards for the determination of impurities in Anastrozole are provided.
摘要翻译： 提供了用于测定阿那曲唑中杂质的参考标记和参考标准。
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公开(公告)号：US5224770A
公开(公告)日：1993-07-06
申请号：US803179
申请日：1991-12-05
IPC分类号： F21S4/00 , F21S2/00 , F21S8/02 , F21S8/04 , F21V5/02 , F21V7/00 , F21V7/22 , F21V13/12 , G02B5/02 , G02F1/1335 , G02F1/13357 , G09F9/00 , G09F13/04 , G09F13/14
CPC分类号： F21V7/00 , G02F1/133605 , G09F13/0409 , G09F13/14 , G02F1/133604 , G09F2013/0422 , G09F2013/145
摘要： The light box is provided with a case having arranged therein a reflector directed to the front wall to be illuminated from the rear. The reflector surf ace has a concave curvature. An elongated light source is arranged in the center of the case. The reflector, in the central area thereof, is covered by an optical film having a structured surface directed to the light source. This structure consists of immediately adjacent V-shaped grooves, being parallel to each other and running transverse to the extension of the light source. By total reflection on the structured surface of the transparent optical film as well as by reflection on the reflector surface of the reflector, the light of the light source incident on the reflector is reflected in the direction of the back-lit front side of the light box. This arrangement provides for improved and more-uniform light distribution.
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