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公开(公告)号：US20070092554A1
公开(公告)日：2007-04-26
申请号：US11561650
申请日：2006-11-20
IPC分类号： A61K31/519 , A61K9/68
CPC分类号： A61K31/505 , A61K9/0056 , A61K9/006 , A61K9/2068 , A61K31/435 , A61K31/437 , A61K31/4745
摘要： The present invention provides for a sexual dysfunction compound comprising a rapid-onset pharmaceutical composition that further comprises cocoa powder. The invention also provides for a process for manufacturing the composition, and use of the composition in sexual dysfunction therapy.
摘要翻译： 本发明提供了一种性功能障碍化合物，其包含进一步包含可可粉的快速起效药物组合物。 本发明还提供了制备组合物的方法，以及组合物在性功能障碍治疗中的用途。
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公开(公告)号：US20100069397A1
公开(公告)日：2010-03-18
申请号：US12623723
申请日：2009-11-23
IPC分类号： A61K31/496 , A61K47/00 , A61P15/10
CPC分类号： A61K31/505 , A61K9/0056 , A61K9/006 , A61K9/2068 , A61K31/435 , A61K31/437 , A61K31/4745
摘要： The present invention provides for a sexual dysfunction compound comprising a rapid-onset pharmaceutical composition that further comprises cocoa powder. The invention also provides for a process for manufacturing the composition, and use of the composition in sexual dysfunction therapy.
摘要翻译： 本发明提供了一种性功能障碍化合物，其包含进一步包含可可粉的快速起效药物组合物。 本发明还提供了制备组合物的方法，以及组合物在性功能障碍治疗中的用途。
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公开(公告)号：US20100197742A1
公开(公告)日：2010-08-05
申请号：US12709953
申请日：2010-02-22
申请人： Fredrik Nicklasson , Kristina Thyresson , Nils-Olof Lindberg , Alice C. Martino , Katarina Lindell
发明人： Fredrik Nicklasson , Kristina Thyresson , Nils-Olof Lindberg , Alice C. Martino , Katarina Lindell
IPC分类号： A61K31/44 , A61K31/135 , A61K31/138 , A61P43/00
CPC分类号： A61K31/00 , A61K9/0056 , A61K9/006 , A61K9/2013 , A61K9/2068 , A61K36/185 , A61K36/22 , A61K36/28 , A61K36/31 , A61K36/35 , A61K36/38 , A61K36/48 , A61K36/63 , A61K36/889 , A61K36/899 , A61K2300/00
摘要： A pharmaceutical formulation comprising one or more active pharmaceutical ingredients (APIs) suitable for intraoral uptake, that comprises cocoa powder, a process for manufacturing the formulation and use of the formulation for medical treatment.
摘要翻译： 一种药物制剂，其包含一种或多种适用于口腔内摄取的活性药物成分（API），其包含可可粉，用于制备制剂的方法和用于医疗的制剂的用途。
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公开(公告)号：US20080249143A1
公开(公告)日：2008-10-09
申请号：US12143001
申请日：2008-06-20
申请人： Fredrik Nicklasson , Kristina Thyresson , Nils-Olof Lindberg , Alice C. Martino , Katarina Lindell
发明人： Fredrik Nicklasson , Kristina Thyresson , Nils-Olof Lindberg , Alice C. Martino , Katarina Lindell
IPC分类号： A61K31/4402
CPC分类号： A61K31/00 , A61K9/0056 , A61K9/006 , A61K9/2013 , A61K9/2068 , A61K36/185 , A61K36/22 , A61K36/28 , A61K36/31 , A61K36/35 , A61K36/38 , A61K36/48 , A61K36/63 , A61K36/889 , A61K36/899 , A61K2300/00
摘要： A pharmaceutical formulation comprising one or more active pharmaceutical ingredients (APIs) suitable for intraoral uptake, that comprises cocoa powder, a process for manufacturing the formulation and use of the formulation for medical treatment.
摘要翻译： 一种药物制剂，其包含一种或多种适用于口腔内摄取的活性药物成分（API），其包含可可粉，用于制备制剂的方法和用于医疗的制剂的用途。
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5.发明申请Solid Nicotine-Comprising Dosage Form with Reduced Organoleptic Disturbance 审中-公开具有减轻感觉障碍的固体尼古丁包含剂型公开(公告)号：US20130177646A1
公开(公告)日：2013-07-11
申请号：US13355768
申请日：2012-01-23
IPC分类号： A61K9/28 , A61K9/00 , A61P25/34 , A61P1/04 , A61P1/00 , A61P25/16 , A61P25/00 , A61K31/465 , A61P25/28
CPC分类号： A61K9/284 , A61K9/0056 , A61K9/2009 , A61K9/2018 , A61K9/205 , A61K9/2826 , A61K9/2866 , A61K31/465
摘要： Solid pharmaceutical dosage form for the release of nicotine in the oral cavity comprising a core encapsulated by at least one film coating, wherein the core comprises nicotine and wherein the film coating comprises at least one film-forming polymer and at least one component for reduction of one or more organoleptically disturbing sensations, and where the at least one film coating is devoid of nicotine and devoid of buffer.
摘要翻译： 用于在口腔中释放尼古丁的固体药物剂型，其包含通过至少一种膜包衣包封的核心，其中所述核心包含尼古丁，并且其中所述膜包衣包含至少一种成膜聚合物和至少一种用于还原 一种或多种感觉不舒适的感觉，并且其中至少一种薄膜包衣没有尼古丁并且没有缓冲液。
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公开(公告)号：US20070269386A1
公开(公告)日：2007-11-22
申请号：US11444787
申请日：2006-06-01
申请人： Per Steen , Darek Dymitrowicz , Andreas Hugerth , Asa Waltermo , Magnus Palsson , Roland Olsson , Fredrik Nicklasson , Anette Schluter , Kristina Thyresson , Seema K. Mody , Bengt Bosson , Katarina Lindell , Gregory Koll
发明人： Per Steen , Darek Dymitrowicz , Andreas Hugerth , Asa Waltermo , Magnus Palsson , Roland Olsson , Fredrik Nicklasson , Anette Schluter , Kristina Thyresson , Seema K. Mody , Bengt Bosson , Katarina Lindell , Gregory Koll
IPC分类号： A61K31/4439 , A61K9/68
CPC分类号： A61K9/0056 , A61K9/0058 , A61K9/006 , A61K9/12 , A61K9/2013 , A61K9/2018 , A61K9/4858 , A61K9/7007 , A61K31/465
摘要： A pharmaceutical oral formulation for delivering nicotine in any form to a subject by transmucosal uptake in the oral cavity comprising nicotine in any form, wherein said oral formulation is buffered with at least trometamol. Also contemplated is a method for the oral delivery of nicotine in any form, a method for the reduction of the urge to smoke or use tobacco as well as methods for manufacturing the oral formulation, the use of the oral formulation for obtaining transmucosal uptake of nicotine in the oral cavity of a subject, and use of nicotine for the production of an oral formulation for the treatment of a disease selected from the group consisting of tobacco or nicotine dependence, Alzheimer's disease, Crohn's disease, Parkinson's disease, Tourette's syndrome, ulcerous colitis and post-smoking-cessation weight control.
摘要翻译： 一种药物口服制剂，其用于通过口腔内经粘膜摄取将任何形式的尼古丁递送至受试者，其包含任何形式的尼古丁，其中所述口服制剂至少使用氨丁三醇缓冲。 还考虑了以任何形式口服输送尼古丁的方法，用于减少吸烟或使用烟草的欲望的方法以及制备口服制剂的方法，口服制剂用于获得尼古丁的经粘膜摄取的方法 在对象的口腔中，以及使用尼古丁来制备用于治疗选自烟草或尼古丁依赖性疾病，阿尔茨海默氏病，克罗恩病，帕金森病，图雷特综合征，溃疡性结肠炎的口服制剂 和戒烟后重量控制。
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公开(公告)号：US20100124560A1
公开(公告)日：2010-05-20
申请号：US12271094
申请日：2008-11-14
申请人： Andreas Hugerth , Katarina Lindell , Fredrik Nicklasson , Kristina Thyresson , Frank Bunick , Joseph Luber
发明人： Andreas Hugerth , Katarina Lindell , Fredrik Nicklasson , Kristina Thyresson , Frank Bunick , Joseph Luber
IPC分类号： A61K8/02 , A61K9/00 , A61K31/4439 , A61P25/34 , A61Q11/00
CPC分类号： A61K31/4439 , A23G3/364 , A61K9/0058 , A61K9/209 , A61K9/2095 , A61K9/4825 , A61K9/4833 , A61K9/4858 , A61K35/747
摘要： The present invention relates to a multi portion intra-oral dosage form where at least one portion is rapidly disintegrating and at least one portion is slowly disintegrating, whereby the disintegration time for the slowest disintegrating portion is at least two times longer than for the most rapidly disintegrating portion. Of certain interest is use of sensory markers/signals as conceptual aids for the subject.Also contemplated are a method and a system for delivering active agents, such as nicotine and/or metabolites thereof, such as cotinine, nicotine N′-oxide, nornicotine, (S)-nicotine-N-β-glucuronide and mixtures, isomers, salts and complexes thereof as well as use and production of said formulations.
摘要翻译： 本发明涉及多部分口腔内剂型，其中至少一部分快速崩解并且至少一部分缓慢崩解，因此最慢崩解部分的崩解时间比最快速度的至少两倍 崩解部分 感兴趣的是使用感官标记/信号作为主题的概念辅助。 还考虑了用于递送活性剂的方法和系统，例如尼古丁和/或其代谢物，例如可替宁，尼古丁N'-氧化物，降烟碱，（S） - 烟碱-N-葡萄糖苷 - 葡萄糖苷和其混合物 ，其盐和络合物以及所述制剂的使用和生产。
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公开(公告)号：US20090130189A1
公开(公告)日：2009-05-21
申请号：US10591388
申请日：2005-03-10
IPC分类号： A61K9/70 , A61K31/465
CPC分类号： A61N1/0432 , A61K9/0009 , A61K9/703 , A61N1/325
摘要： Devices for transdermal administration of nicotine, which provide for basic as well as additional user activatable administration of nicotine, as well as use of such devices.
摘要翻译： 用于经皮给药尼古丁的装置，其提供碱性以及额外的用户可激活的尼古丁给药以及使用这些装置。
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公开(公告)号：US20100247586A1
公开(公告)日：2010-09-30
申请号：US12430238
申请日：2009-04-27
CPC分类号： A61K8/02 , A23G1/32 , A23G3/36 , A23G4/06 , A61K8/0216 , A61K9/0056 , A61K9/0058 , A61K9/209 , A61K9/2095 , A61K9/4808 , A61K31/05 , A61K31/135 , A61K31/19 , A61K31/198 , A61K31/4545 , A61K31/465 , A61K31/519 , A61K31/55 , A61K45/06 , A61Q11/00 , A61K2300/00
摘要： A multi portion intra-oral dosage form has at least one pharmaceutically active agent or health promoting agent with at least one portion comprises a component for creating a noticeable organoleptic sensation. The sensory markers or signals are conceptual aids for a subject using the dosage form where the organoleptic sensation is such that it facilitates the subject to identify a portion and differentiate between different portions. Also contemplated are a dosage form, a method and a system for delivering active agents, such as nicotine and/or metabolites thereof, such as cotinine, nicotine N′-oxide, nomicotine, (S)-nicotine-N-β-glucuronide and mixtures, isomers, salts and complexes thereof as well as use and production of said dosage forms.
摘要翻译： 多部分口服内剂型具有至少一种药学活性剂或健康促进剂，其至少一部分包含用于产生明显感官感觉的组分。 感官标记或信号是使用剂型的受试者的概念性帮助，其中感觉感觉使得其有助于受试者识别部分并在不同部分之间进行区分。 还考虑了用于递送活性剂的剂型，方法和系统，例如尼古丁和/或其代谢物，例如可替宁，尼古丁N'氧化物，依诺汀，（S） - 烟碱-N-葡萄糖苷 - 葡萄糖苷酸 及其混合物，异构体，盐和复合物，以及所述剂型的使用和生产。
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公开(公告)号：US07767698B2
公开(公告)日：2010-08-03
申请号：US10453808
申请日：2003-06-02
IPC分类号： A61K31/44
CPC分类号： A61K9/0078 , A61K31/4439 , A61K31/465 , A61K47/02 , A61K47/10 , A61K47/12
摘要： A liquid pharmaceutical formulation comprising nicotine in any form for administration essentially to the lungs being acidified and/or alkalized by buffering and/or pH regulation providing for a tmax of nicotine in arterial blood of a subject within a short period of time after administration.The administration is preferably by spraying an aerosol into the oral cavity for further distribution essentially into the lungs. A method for manufacturing said formulation. Use of said formulation in therapy, such as therapy for treating addiction to tobacco.
摘要翻译： 一种液体药物制剂，其包含任何形式的烟碱，用于主要用于通过缓冲和/或pH调节酸化和/或碱化，其在施用后短时间内提供受试者的动脉血中的尼古丁的最大值。 给药优选通过将气溶胶喷雾到口腔中用于基本上进入肺部进一步分布。 一种制造所述制剂的方法。 在治疗中使用所述制剂，例如治疗对烟草成瘾的治疗。
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