-
公开(公告)号：US20100197742A1
公开(公告)日：2010-08-05
申请号：US12709953
申请日：2010-02-22
申请人： Fredrik Nicklasson , Kristina Thyresson , Nils-Olof Lindberg , Alice C. Martino , Katarina Lindell
发明人： Fredrik Nicklasson , Kristina Thyresson , Nils-Olof Lindberg , Alice C. Martino , Katarina Lindell
IPC分类号： A61K31/44 , A61K31/135 , A61K31/138 , A61P43/00
CPC分类号： A61K31/00 , A61K9/0056 , A61K9/006 , A61K9/2013 , A61K9/2068 , A61K36/185 , A61K36/22 , A61K36/28 , A61K36/31 , A61K36/35 , A61K36/38 , A61K36/48 , A61K36/63 , A61K36/889 , A61K36/899 , A61K2300/00
摘要： A pharmaceutical formulation comprising one or more active pharmaceutical ingredients (APIs) suitable for intraoral uptake, that comprises cocoa powder, a process for manufacturing the formulation and use of the formulation for medical treatment.
摘要翻译： 一种药物制剂，其包含一种或多种适用于口腔内摄取的活性药物成分（API），其包含可可粉，用于制备制剂的方法和用于医疗的制剂的用途。
-
公开(公告)号：US20080249143A1
公开(公告)日：2008-10-09
申请号：US12143001
申请日：2008-06-20
申请人： Fredrik Nicklasson , Kristina Thyresson , Nils-Olof Lindberg , Alice C. Martino , Katarina Lindell
发明人： Fredrik Nicklasson , Kristina Thyresson , Nils-Olof Lindberg , Alice C. Martino , Katarina Lindell
IPC分类号： A61K31/4402
CPC分类号： A61K31/00 , A61K9/0056 , A61K9/006 , A61K9/2013 , A61K9/2068 , A61K36/185 , A61K36/22 , A61K36/28 , A61K36/31 , A61K36/35 , A61K36/38 , A61K36/48 , A61K36/63 , A61K36/889 , A61K36/899 , A61K2300/00
摘要： A pharmaceutical formulation comprising one or more active pharmaceutical ingredients (APIs) suitable for intraoral uptake, that comprises cocoa powder, a process for manufacturing the formulation and use of the formulation for medical treatment.
摘要翻译： 一种药物制剂，其包含一种或多种适用于口腔内摄取的活性药物成分（API），其包含可可粉，用于制备制剂的方法和用于医疗的制剂的用途。
-
公开(公告)号：US20070269386A1
公开(公告)日：2007-11-22
申请号：US11444787
申请日：2006-06-01
申请人： Per Steen , Darek Dymitrowicz , Andreas Hugerth , Asa Waltermo , Magnus Palsson , Roland Olsson , Fredrik Nicklasson , Anette Schluter , Kristina Thyresson , Seema K. Mody , Bengt Bosson , Katarina Lindell , Gregory Koll
发明人： Per Steen , Darek Dymitrowicz , Andreas Hugerth , Asa Waltermo , Magnus Palsson , Roland Olsson , Fredrik Nicklasson , Anette Schluter , Kristina Thyresson , Seema K. Mody , Bengt Bosson , Katarina Lindell , Gregory Koll
IPC分类号： A61K31/4439 , A61K9/68
CPC分类号： A61K9/0056 , A61K9/0058 , A61K9/006 , A61K9/12 , A61K9/2013 , A61K9/2018 , A61K9/4858 , A61K9/7007 , A61K31/465
摘要： A pharmaceutical oral formulation for delivering nicotine in any form to a subject by transmucosal uptake in the oral cavity comprising nicotine in any form, wherein said oral formulation is buffered with at least trometamol. Also contemplated is a method for the oral delivery of nicotine in any form, a method for the reduction of the urge to smoke or use tobacco as well as methods for manufacturing the oral formulation, the use of the oral formulation for obtaining transmucosal uptake of nicotine in the oral cavity of a subject, and use of nicotine for the production of an oral formulation for the treatment of a disease selected from the group consisting of tobacco or nicotine dependence, Alzheimer's disease, Crohn's disease, Parkinson's disease, Tourette's syndrome, ulcerous colitis and post-smoking-cessation weight control.
摘要翻译： 一种药物口服制剂，其用于通过口腔内经粘膜摄取将任何形式的尼古丁递送至受试者，其包含任何形式的尼古丁，其中所述口服制剂至少使用氨丁三醇缓冲。 还考虑了以任何形式口服输送尼古丁的方法，用于减少吸烟或使用烟草的欲望的方法以及制备口服制剂的方法，口服制剂用于获得尼古丁的经粘膜摄取的方法 在对象的口腔中，以及使用尼古丁来制备用于治疗选自烟草或尼古丁依赖性疾病，阿尔茨海默氏病，克罗恩病，帕金森病，图雷特综合征，溃疡性结肠炎的口服制剂 和戒烟后重量控制。
-
4.发明申请Solid Nicotine-Comprising Dosage Form with Reduced Organoleptic Disturbance 审中-公开具有减轻感觉障碍的固体尼古丁包含剂型公开(公告)号：US20130177646A1
公开(公告)日：2013-07-11
申请号：US13355768
申请日：2012-01-23
IPC分类号： A61K9/28 , A61K9/00 , A61P25/34 , A61P1/04 , A61P1/00 , A61P25/16 , A61P25/00 , A61K31/465 , A61P25/28
CPC分类号： A61K9/284 , A61K9/0056 , A61K9/2009 , A61K9/2018 , A61K9/205 , A61K9/2826 , A61K9/2866 , A61K31/465
摘要： Solid pharmaceutical dosage form for the release of nicotine in the oral cavity comprising a core encapsulated by at least one film coating, wherein the core comprises nicotine and wherein the film coating comprises at least one film-forming polymer and at least one component for reduction of one or more organoleptically disturbing sensations, and where the at least one film coating is devoid of nicotine and devoid of buffer.
摘要翻译： 用于在口腔中释放尼古丁的固体药物剂型，其包含通过至少一种膜包衣包封的核心，其中所述核心包含尼古丁，并且其中所述膜包衣包含至少一种成膜聚合物和至少一种用于还原 一种或多种感觉不舒适的感觉，并且其中至少一种薄膜包衣没有尼古丁并且没有缓冲液。
-
公开(公告)号：US20100124560A1
公开(公告)日：2010-05-20
申请号：US12271094
申请日：2008-11-14
申请人： Andreas Hugerth , Katarina Lindell , Fredrik Nicklasson , Kristina Thyresson , Frank Bunick , Joseph Luber
发明人： Andreas Hugerth , Katarina Lindell , Fredrik Nicklasson , Kristina Thyresson , Frank Bunick , Joseph Luber
IPC分类号： A61K8/02 , A61K9/00 , A61K31/4439 , A61P25/34 , A61Q11/00
CPC分类号： A61K31/4439 , A23G3/364 , A61K9/0058 , A61K9/209 , A61K9/2095 , A61K9/4825 , A61K9/4833 , A61K9/4858 , A61K35/747
摘要： The present invention relates to a multi portion intra-oral dosage form where at least one portion is rapidly disintegrating and at least one portion is slowly disintegrating, whereby the disintegration time for the slowest disintegrating portion is at least two times longer than for the most rapidly disintegrating portion. Of certain interest is use of sensory markers/signals as conceptual aids for the subject.Also contemplated are a method and a system for delivering active agents, such as nicotine and/or metabolites thereof, such as cotinine, nicotine N′-oxide, nornicotine, (S)-nicotine-N-β-glucuronide and mixtures, isomers, salts and complexes thereof as well as use and production of said formulations.
摘要翻译： 本发明涉及多部分口腔内剂型，其中至少一部分快速崩解并且至少一部分缓慢崩解，因此最慢崩解部分的崩解时间比最快速度的至少两倍 崩解部分 感兴趣的是使用感官标记/信号作为主题的概念辅助。 还考虑了用于递送活性剂的方法和系统，例如尼古丁和/或其代谢物，例如可替宁，尼古丁N'-氧化物，降烟碱，（S） - 烟碱-N-葡萄糖苷 - 葡萄糖苷和其混合物 ，其盐和络合物以及所述制剂的使用和生产。
-
公开(公告)号：US20090130189A1
公开(公告)日：2009-05-21
申请号：US10591388
申请日：2005-03-10
IPC分类号： A61K9/70 , A61K31/465
CPC分类号： A61N1/0432 , A61K9/0009 , A61K9/703 , A61N1/325
摘要： Devices for transdermal administration of nicotine, which provide for basic as well as additional user activatable administration of nicotine, as well as use of such devices.
摘要翻译： 用于经皮给药尼古丁的装置，其提供碱性以及额外的用户可激活的尼古丁给药以及使用这些装置。
-
公开(公告)号：US20100247586A1
公开(公告)日：2010-09-30
申请号：US12430238
申请日：2009-04-27
CPC分类号： A61K8/02 , A23G1/32 , A23G3/36 , A23G4/06 , A61K8/0216 , A61K9/0056 , A61K9/0058 , A61K9/209 , A61K9/2095 , A61K9/4808 , A61K31/05 , A61K31/135 , A61K31/19 , A61K31/198 , A61K31/4545 , A61K31/465 , A61K31/519 , A61K31/55 , A61K45/06 , A61Q11/00 , A61K2300/00
摘要： A multi portion intra-oral dosage form has at least one pharmaceutically active agent or health promoting agent with at least one portion comprises a component for creating a noticeable organoleptic sensation. The sensory markers or signals are conceptual aids for a subject using the dosage form where the organoleptic sensation is such that it facilitates the subject to identify a portion and differentiate between different portions. Also contemplated are a dosage form, a method and a system for delivering active agents, such as nicotine and/or metabolites thereof, such as cotinine, nicotine N′-oxide, nomicotine, (S)-nicotine-N-β-glucuronide and mixtures, isomers, salts and complexes thereof as well as use and production of said dosage forms.
摘要翻译： 多部分口服内剂型具有至少一种药学活性剂或健康促进剂，其至少一部分包含用于产生明显感官感觉的组分。 感官标记或信号是使用剂型的受试者的概念性帮助，其中感觉感觉使得其有助于受试者识别部分并在不同部分之间进行区分。 还考虑了用于递送活性剂的剂型，方法和系统，例如尼古丁和/或其代谢物，例如可替宁，尼古丁N'氧化物，依诺汀，（S） - 烟碱-N-葡萄糖苷 - 葡萄糖苷酸 及其混合物，异构体，盐和复合物，以及所述剂型的使用和生产。
-
8.发明申请PROCESS FOR THE MANUFACTURE OF NICOTINE-COMPRISING CHEWING GUM AND NICOTINE-COMPRISING CHEWING GUM MANUFACTURED ACCORDING TO SAID PROCESS 审中-公开用于制造包含CHEWING GUM和NICOTINE包含根据SAI过程制造的CHEWING GUM的制造方法公开(公告)号：US20110070286A1
公开(公告)日：2011-03-24
申请号：US12887593
申请日：2010-09-22
申请人： Andreas Hugerth , Katarina Lindell , Fredrik Nicklasson , John Hedenstrom , Gregory E. Koll , Harry S. Sowden , Joseph R. Luber , Leo B. Kriksunov , Frank J. Bunick , Jen-Chi Chen , Roland Olsson , Christopher E. Szymczak
发明人： Andreas Hugerth , Katarina Lindell , Fredrik Nicklasson , John Hedenstrom , Gregory E. Koll , Harry S. Sowden , Joseph R. Luber , Leo B. Kriksunov , Frank J. Bunick , Jen-Chi Chen , Roland Olsson , Christopher E. Szymczak
CPC分类号： A61K9/0058 , A23G4/04 , A23G4/06 , A23G4/12 , A23P10/20
摘要： A process for making a nicotine-comprising chewing gum by (i) dispensing a powder portion from a gum-base-comprising powder, (ii) optionally shaping said powder portion into a powder aggregate, and (iii) applying sufficient electromagnetic energy (EM energy) to said powder portion or said powder aggregate to transform said powder portion or said powder aggregate into said chewing gum, whereby said EM energy is Radio Frequency (RF) energy, MicroWave (MW) energy, InfraRed (IR) energy or UltraViolet (UV) energy or combinations thereof. The invention also features a chewing gum made by such process. The chewing gum may comprise one or more deposits.
摘要翻译： 一种通过以下步骤制备含尼古丁的口香糖的方法：（i）从含胶基的粉末中分配粉末部分，（ii）任选将所述粉末部分成型为粉末聚集体，和（iii）施加足够的电磁能 能量）到所述粉末部分或所述粉末聚集体以将所述粉末部分或所述粉末聚集体转化成所述口香糖，由此所述EM能量是射频（RF）能量，微波（MW）能量，红外（IR）能量或紫外线 UV）能量或其组合。 本发明还具有通过这种方法制成的口香糖。 口香糖可以包含一种或多种沉积物。
-
公开(公告)号：US20080286341A1
公开(公告)日：2008-11-20
申请号：US11803865
申请日：2007-05-16
申请人： Sven-Borje Andersson , Gunnar Bergengren , Bengt Bosson , Andreas Hugerth , Fredrik Nicklasson , Roland Olsson
发明人： Sven-Borje Andersson , Gunnar Bergengren , Bengt Bosson , Andreas Hugerth , Fredrik Nicklasson , Roland Olsson
CPC分类号： A61K9/0058 , A23G3/343 , A23G4/062 , A23G2200/00 , A23G2200/10 , A23L33/175 , A24B15/16 , A61K9/0056 , A61K9/2826 , A61K9/2853 , A61K9/2866 , A61K9/2873 , A61K9/288 , A61K31/465
摘要： Coated oral dosage forms for the delivery of nicotine in any form to a subject by rapid intraoral delivery of nicotine comprising at least one core, nicotine in any form and/or a nicotine mimicking agent, at least one coating layer and optionally at least one or more other additives, wherein said at last one coating layer is buffered, whereby is used at least one amino acid as buffering agent. Also contemplated are a method for the delivery of nicotine in any form, a method for the reduction of the urge to smoke or use tobacco as well as a method for producing said coated product and use of the same for obtaining a rapid intraoral uptake of nicotine.
摘要翻译： 用于将任何形式的尼古丁以任何形式递送至受试者的涂覆的口服剂型包括至少一种核心，任何形式的尼古丁和/或尼古丁模拟剂，至少一种包衣层和任选的至少一种或多种 更多其它添加剂，其中所述最后一个涂层被缓冲，由此使用至少一个氨基酸作为缓冲剂。 还考虑了以任何形式递送尼古丁的方法，用于减少吸烟或使用烟草的欲望的方法以及用于生产所述包衣产品的方法及其用于获得尼古丁快速口内摄取的方法 。
-
公开(公告)号：US20080286340A1
公开(公告)日：2008-11-20
申请号：US11803747
申请日：2007-05-16
申请人： Sven-Borje Andersson , Gunnar Bergengren , Bengt Bosson , Andreas Hugerth , Fredrik Nicklasson , Roland Olsson
发明人： Sven-Borje Andersson , Gunnar Bergengren , Bengt Bosson , Andreas Hugerth , Fredrik Nicklasson , Roland Olsson
CPC分类号： A61K9/006 , A23G3/44 , A23G4/14 , A23L33/175 , A24B15/16 , A61K9/0056 , A61K9/0058 , A61K31/465
摘要： A pharmaceutical oral formulation for delivering nicotine in any form to a subject by transmucosal uptake in the oral cavity comprising nicotine in any form, wherein said oral formulation is buffered with at least one amino acid, preferably at least one endogenous amino acid. Also contemplated is a method for the oral delivery of nicotine in any form, a method for the reduction of the urge to smoke or use tobacco as well as methods for manufacturing the oral formulation, the use of said oral formulation for obtaining transmucosal uptake of nicotine in the oral cavity of a subject, and use of nicotine for the production of an oral formulation as per above for the treatment of a disease selected from the group consisting of tobacco or nicotine dependence, Alzheimer's disease, Crohn's disease, Parkinson's disease, Tourette's syndrome, ulcerous colitis and post-smoking-cessation weight control.
摘要翻译： 一种药物口服制剂，其用于通过口腔内经粘膜摄取将任何形式的尼古丁以任何形式递送至任何形式的尼古丁，其中所述口服制剂用至少一种氨基酸，优选至少一种内源性氨基酸缓冲。 还考虑了以任何形式口服输送尼古丁的方法，减少吸烟或使用烟草的欲望的方法以及制备口服制剂的方法，所述口服制剂用于获得尼古丁的经粘膜摄取 在受试者的口腔中，以及使用尼古丁制备如上所述的口服制剂用于治疗选自烟草或尼古丁依赖性疾病，阿尔茨海默氏病，克罗恩病，帕金森氏病，图雷特综合征 ，溃疡性结肠炎和戒烟后重量控制。
-
-
-
-
-
-
-
-
-
搜索结果
11 条记录 (耗时 0.026 秒)
