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公开(公告)号：US20240382600A1
公开(公告)日：2024-11-21
申请号：US18687615
申请日：2022-08-30
Applicant: Novartis AG
Inventor： Emilie CHAPEAU , Patrick CHENE , Pascal FURET , Laurence KIEFFER , Rainer MACHAUER , Anne PICARD , Tobias SCHMELZLE , Holger SELLNER , Nicolas SOLDERMANN , Markus VOEGTLE , Markus WARTMANN
IPC: A61K47/54 , A61K47/55 , C07D405/14 , C07D417/12
Abstract: The present disclosure relates to a conjugate comprising a YAP/TAZ-TEAD Protein Protein Interaction Inhibitor (PPII) linked to a Ligase Binder via a linker, or a pharmaceutically acceptable salt thereof, as well as methods of using such conjugates.
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公开(公告)号：US20210299100A1
公开(公告)日：2021-09-30
申请号：US17201268
申请日：2021-03-15
Applicant: Novartis AG
Inventor： Vincent BORDAS , Cara BROCKLEHURST , Patrick CHENE , Zhongbo FEI , Pascal FURET , Vito GUAGNANO , Patricia IMBACH-WEESE , Joerg KALLEN , Mickael LE DOUGET , Jialiang LI , Wei LI , Edwige Liliane Jeanne LORTHIOIS , Joseph McKENNA , Bahaa SALEM , Tobias SCHMELZLE , Holger SELLNER , Nicolas SOLDERMANN , Markus VOEGTLE , Markus WARTMANN
IPC: A61K31/4155 , C07D307/81 , C07D405/12 , A61K31/343 , A61K31/443 , A61K31/426 , C07D417/04 , C07D407/04 , A61K31/357 , C07D405/04 , A61K31/403 , A61K31/4525 , A61K31/351 , C07D407/12 , A61K31/506 , A61K31/41 , A61K31/4025 , A61K31/4439 , C07D405/14 , A61P35/00
Abstract: The present invention provides a compound of formula (1) or a pharmaceutically acceptable salt thereof; a method for manufacturing said compound, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.
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公开(公告)号：US20250090699A1
公开(公告)日：2025-03-20
申请号：US18802972
申请日：2024-08-13
Applicant: Novartis AG
Inventor： Salvatore BONGARZONE , Davide CAMPORESE , Gonçalo dos Santos CLEMENTE , Takeru EHARA , Matteo FISCHER , Andrei Alexandrovich GOLOSOV , Philipp GROSCHE , Philipp HOLZER , Alexei KARPOV , Marion LACAUD-BAUMLIN , Lukas LEDER , Rafael Bermeo MALO , Andreas MARZINZIK , Yoshihide MIZUKOSHI , Charlie MUNSCH , Markus Oliver RESCHKE , Holger SELLNER , Therese-Marie STACHYRA
Abstract: Described herein are cyclic peptides targeting fibroblast activation protein (FAP), and their incorporation into compounds for radioligand imaging and therapies, as well as methods and/or uses of such compounds for the imaging, treatment and/or prevention of FAP-implicated diseases and disorders.
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公开(公告)号：US20240382457A1
公开(公告)日：2024-11-21
申请号：US18776928
申请日：2024-07-18
Applicant: Novartis AG
Inventor： Vincent BORDAS , Cara BROCKLEHURST , Patrick CHENE , Pascal FURET , Vito GUAGNANO , Patricia IMBACH-WEESE , Joerg KALLEN , Mickael LE DOUGET , Edwige Liliane Jeanne LORTHIOIS , Joseph MCKENNA , Bahaa SALEM , Tobias SCHMELZLE , Holger SELLNER , Nicolas SOLDERMANN , Markus VOEGTLE , Markus WARTMANN
IPC: A61K31/4155 , A61K31/343 , A61K31/351 , A61K31/357 , A61K31/4025 , A61K31/403 , A61K31/41 , A61K31/426 , A61K31/443 , A61K31/4439 , A61K31/4525 , A61K31/506 , A61P35/00 , C07D307/81 , C07D405/04 , C07D405/12 , C07D405/14 , C07D407/04 , C07D407/12 , C07D417/04
Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing said compound, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.
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