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公开(公告)号：US10464969B2
公开(公告)日：2019-11-05
申请号：US16098289
申请日：2017-05-03
Applicant: NOVARTIS AG
Inventor： Matthew T. Burger , Yunho Jin , Tetsuo Uno
Abstract: The invention disclosed herein relates to cytotoxic cyclic peptides of Formula (A), methods of inhibiting RNA polymerase with such cyclic peptides, immunoconjugates comprising such cyclic peptides (i.e Antibody Drug Conjugates), pharmaceutical compositions comprising such cyclic peptides immunoconjugates, compositions comprising such cyclic peptides immunoconjugates with a therapeutic co-agent and methods of treatment using such cyclic peptides immunoconjugates:
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公开(公告)号：US20190144504A1
公开(公告)日：2019-05-16
申请号：US16098289
申请日：2017-05-03
Applicant: NOVARTIS AG
Inventor： Matthew T. Burger , Yunho Jin , Tetsuo Uno
CPC classification number: C07K7/64 , A61K47/6831 , A61K47/6849 , A61K47/6851 , A61K47/6863 , A61P35/00 , C07K16/32 , C07K2318/10
Abstract: The invention disclosed herein relates to cytotoxic cyclic peptides of Formula (A), methods of inhibiting RNA polymerase with such cyclic peptides, immunoconjugates comprising such cyclic peptides (i.e Antibody Drug Conjugates), pharmaceutical compositions comprising such cyclic peptides immunoconjugates, compositions comprising such cyclic peptides immunoconjugates with a therapeutic co-agent and methods of treatment using such cyclic peptides immunoconjugates:
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公开(公告)号：US12171839B2
公开(公告)日：2024-12-24
申请号：US17833077
申请日：2022-06-06
Applicant: Novartis AG
Inventor： Anthony Edward Boitano , Matthew Burger , Susan E. Cellitti , Michael P. Cooke , Catrin Finner , Bernhard Hubert Geierstanger , Yunho Jin , Si Tuen Lee-Hoeflich , HongNgoc Thi Pham , Siew Ho Schleyer , Kathrin Tissot , Tetsuo Uno , Ben Wen
Abstract: The present invention provides antibody drug conjugates, wherein an antibody or antibody fragment that specifically binds to human cKIT is linked to a drug moiety, optionally through a linker. The present invention further provides pharmaceutical compositions comprising the antibody drug conjugates; and methods of making and using such pharmaceutical compositions for ablating hematopoietic stem cells in a patient in need thereof.
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公开(公告)号：US10392421B2
公开(公告)日：2019-08-27
申请号：US15961531
申请日：2018-04-24
Applicant: NOVARTIS AG
Inventor： Bernhard Hubert Geierstanger , Jan Grunewald , Yunho Jin , Weijia Ou , Tetsuo Uno , Yongqin Wan , Xing Wang
Abstract: Disclosed herein are novel cytotoxic peptides of formula (I) as described herein: and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel cytotoxic peptide linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.
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公开(公告)号：US09938323B2
公开(公告)日：2018-04-10
申请号：US15524197
申请日：2015-11-05
Applicant: NOVARTIS AG
Inventor： Jan Grunewald , Yunho Jin , Weijia Ou , Tetsuo Uno
CPC classification number: C07K7/64 , C07K16/22 , C07K16/30 , C07K2319/30
Abstract: The invention disclosed herein relates to cytotoxic cyclic peptides of Formula (I), methods of inhibiting RNA polymerase with such cyclic peptides, immunoconjugates comprising such cyclic peptides (i.e Antibody Drug Conjugates), pharmaceutical compositions comprising such cyclic peptides immunoconjugates, compositions comprising such cyclic peptides immunoconjugates with a therapeutic co-agent and methods of treatment using such cyclic peptides immunoconjugates:
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Patent Agency Ranking
公开(公告)号：US10787480B2
公开(公告)日：2020-09-29
申请号：US16439204
申请日：2019-06-12
Applicant: NOVARTIS AG
Inventor： Bernhard Hubert Geierstanger , Jan Grunewald , Yunho Jin , Weijia Ou , Tetsuo Uno , Yongqin Wan , Xing Wang
Abstract: Disclosed herein are novel cytotoxic peptides of formula (I) as described herein: and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel cytotoxic peptide linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.
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公开(公告)号：US10604547B2
公开(公告)日：2020-03-31
申请号：US16574500
申请日：2019-09-18
Applicant: NOVARTIS AG
Inventor： Matthew T. Burger , Yunho Jin , Tetsuo Uno
Abstract: The invention disclosed herein relates to cytotoxic cyclic peptides of Formula (A), methods of inhibiting RNA polymerase with such cyclic peptides, immunoconjugates comprising such cyclic peptides (i.e Antibody Drug Conjugates), pharmaceutical compositions comprising such cyclic peptides immunoconjugates, compositions comprising such cyclic peptides immunoconjugates with a therapeutic co-agent and methods of treatment using such cyclic peptides immunoconjugates:
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公开(公告)号：US20250064964A1
公开(公告)日：2025-02-27
申请号：US18937914
申请日：2024-11-05
Applicant: Novartis AG
Inventor： Anthony Edward Boitano , Matthew Burger , Susan E. Cellitti , Michael P. Cooke , Catrin Finner , Bernhard Hubert Geierstanger , Yunho Jin , Si Tuen Lee-Hoeflich , HongNgoc Thi Pham , Siew Ho Schleyer , Kathrin Tissot , Tetsuo Uno , Ben Wen
Abstract: The present invention provides antibody drug conjugates, wherein an antibody or antibody fragment that specifically binds to human cKIT is linked to a drug moiety, optionally through a linker. The present invention further provides pharmaceutical compositions comprising the antibody drug conjugates; and methods of making and using such pharmaceutical compositions for ablating hematopoetic stem cells in a patient in need thereof.
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公开(公告)号：US11357864B2
公开(公告)日：2022-06-14
申请号：US16470897
申请日：2017-12-19
Applicant: NOVARTIS AG
Inventor： Ben Wen , Anthony E. Boitano , Matthew Burger , Susan E. Cellitti , Michael P. Cooke , Catrin Finner , Bernhard Hubert Geierstanger , Yunho Jin , Si Tuen Lee-Hoeflich , HongNgoc Thi Pham , Siew Ho Schleyer , Kathrin Tissot , Tetsuo Uno
Abstract: The present invention provides antibody drug conjugates, wherein an antibody or antibody fragment that specifically binds to human cKIT is linked to a drug moiety, optionally through a linker. The present invention further provides pharmaceutical compositions comprising the antibody drug conjugates; and methods of making and using such pharmaceutical compositions for ablating hematopoietic stem cells in a patient in need thereof.
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公开(公告)号：US20200024311A1
公开(公告)日：2020-01-23
申请号：US16574500
申请日：2019-09-18
Applicant: NOVARTIS AG
Inventor： Matthew T. Burger , Yunho Jin , Tetsuo Uno
Abstract: The invention disclosed herein relates to cytotoxic cyclic peptides of Formula (A), methods of inhibiting RNA polymerase with such cyclic peptides, immunoconjugates comprising such cyclic peptides (i.e. Antibody Drug Conjugates), pharmaceutical compositions comprising such cyclic peptides immunoconjugates, compositions comprising such cyclic peptides immunoconjugates with a therapeutic co-agent and methods of treatment using such cyclic peptides immunoconjugates:
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