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公开(公告)号：US20210269416A1
公开(公告)日：2021-09-02
申请号：US17260393
申请日：2019-07-15
Applicant: NOVARTIS AG
Inventor： Peng FU , Yu GAI , Feng GAO , Weiyong KONG , Yadong LU , Zhongcheng MIN , Shaofeng RONG , Chutian SHU , Can WANG , Ruidong WANG , Jibin ZHAO , Xianglin ZHAO , Yi ZHAO , Jianguang ZHOU , Benjamin MARTIN
IPC: C07D401/06 , C07D211/74 , C07D209/04
Abstract: The present invention relates to a method of synthesizing a compound of formula (I) also referred to as 4-((2S,4S)-(4-ethoxy-1-((5-methoxy-7-methyl-1/-/-indol-4-yl)methyl)piperidin-2-yl))benzoic acid, or a pharmaceutically acceptable salt thereof, and/or intermediates thereof, their use as pharmaceuticals and pharmaceutical compositions and the use of intermediates for preparing a compound of formula (I), or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20220169630A1
公开(公告)日：2022-06-02
申请号：US17546284
申请日：2021-12-09
Applicant: NOVARTIS AG
Inventor： Peng FU , Yu GAI , Feng GAO , Weiyong KONG , Yadong LU , Zhongcheng MIN , Shaofeng RONG , Chutian SHU , Can WANG , Ruidong WANG , Jibin ZHAO , Xianglin ZHAO , Yi ZHAO , Jianguang ZHOU , Benjamin MARTIN
IPC: C07D401/06 , C07D209/04 , C07D211/74
Abstract: The present invention relates to a method of synthesizing a compound of formula (I) also referred to as 4-(((2S,4S)-(4-ethoxy-1-(((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl))benzoic acid, or a pharmaceutically acceptable salt thereof, and/or intermediates thereof, their use as pharmaceuticals and pharmaceutical compositions and the use of intermediates for preparing a compound of formula (I), or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20190247392A1
公开(公告)日：2019-08-15
申请号：US16210968
申请日：2018-12-05
Applicant: Novartis AG
Inventor： Jeffrey T. BAGDANOFF , Yu DING , Wooseok HAN , Zilin HUANG , Qun JIANG , Xianming JIN , Xiang KOU , Patrick LEE , Mika LINDVALL , Zhongcheng MIN , Yue PAN , Sabina PECCHI , Keith Bruce PFISTER , Daniel POON , Vivek RAUNIYAR , Xiaojing Michael WANG , Qiong ZHANG , Jianguang ZHOU , Shejin ZHU
IPC: A61K31/497 , A61K31/5355 , A61K31/4436 , A61K31/4433 , A61K31/44 , C07D403/06 , C07D401/12 , C07D401/06 , C07D213/73 , C07D413/14 , C07D241/20 , C07D401/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D498/04 , A61K31/4439 , A61K31/4545 , A61K31/4965 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/553 , A61K45/06
Abstract: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.
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公开(公告)号：US20180028532A1
公开(公告)日：2018-02-01
申请号：US15672568
申请日：2017-08-09
Applicant: Novartis AG
Inventor： Jeffrey T. BAGDANOFF , Yu DING , Wooseok HAN , Zilin HUANG , Qun JIANG , Xianming JIN , Xiang KOU , Patrick LEE , Mika LINDVALL , Zhongcheng MIN , Yue PAN , Sabina PECCHI , Keith Bruce PFISTER , Daniel POON , Vivek RAUNIYAR , Xiaojing Michael WANG , Qiong ZHANG , Jianguang ZHOU , Shejin ZHU
IPC: A61K31/497 , A61K31/4433 , A61K31/5355 , A61K31/44 , A61K31/4436
CPC classification number: A61K31/497 , A61K31/44 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/4545 , A61K31/4965 , A61K31/506 , A61K31/5355 , A61K31/5377 , A61K31/5383 , A61K31/553 , A61K45/06 , A61K2121/00 , C07D213/73 , C07D241/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/14 , C07D498/04
Abstract: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.
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