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    Eubacterial RNA-Polymerase Mutants with Altered Product Production
    1.
    发明申请
    Eubacterial RNA-Polymerase Mutants with Altered Product Production 审中-公开
    具有改变产品生产的细菌RNA聚合酶突变体

    公开(公告)号：US20150147783A1

    公开(公告)日：2015-05-28

    申请号：US14616950

    申请日：2015-02-09

    Applicant: Novozymes A/S

    Inventor： Steen Troels Joergensen ,  Jens Toenne Andersen ,  Niels Banke ,  Preben Nielsen

    IPC: C12N9/12 ,  C12N9/54 ,  C12N9/28

    CPC classification number: C12N9/1247 ,  C12N9/2408 ,  C12N9/2417 ,  C12N9/54

    Abstract: The present invention relates to an isolated mutant eubacterium comprising at least one mutation resulting in a substitution of at least one amino acid in the beta-subunit of the RNA-polymerase encoded for by the rpoB-gene providing an altered production of a product of interest when said production of a product of interest is compared to the production of the same product in an isogenic wild type strain grown at identical conditions, wherein the substitution of at least one amino acid occurs at any of positions 469, 478, 482, 485, or 487 of SEQ ID NO:2, or at the equivalent positions in any eubacterial RNA-polymerase beta-subunit family member. Another aspect of the invention relates to a process for producing at least one product of interest in a mutant eubacterium and to a use of the mutant eubacterium according to the invention for producing at least one product of interest.

    Abstract translation: 本发明涉及分离的突变体真细胞，其包含至少一个导致由rpoB基因编码的RNA聚合酶的β-亚基中的至少一个氨基酸取代的突变体，提供改变产生感兴趣的产物 当所述感兴趣的产物的生产与在相同条件下生长的等基因野生型菌株中相同产物的产生进行比较时，其中至少一个氨基酸的取代发生在位置469,478,482,485， 或487，或在任何真细菌RNA聚合酶β-亚基家族成员中的等同位置。 本发明的另一方面涉及用于产生至少一种在突变体杆菌中感兴趣的产物的方法和本发明的突变型杆菌的用途，用于生产至少一种目标产物。

    Eubacterial RNA-Polymerase Mutants With Altered Product Production
    2.
    发明申请
    Eubacterial RNA-Polymerase Mutants With Altered Product Production 审中-公开

    公开(公告)号：US20130122548A1

    公开(公告)日：2013-05-16

    申请号：US13747032

    申请日：2013-01-22

    Applicant: Novozymes A/S

    Inventor： Steen Troels Joergensen ,  Jens Toenne Andersen ,  Niels Banke ,  Preben Nielsen

    IPC: C12N9/54 ,  C12N9/26

    CPC classification number: C12N9/1247 ,  C12N9/2408 ,  C12N9/2417 ,  C12N9/54

    Abstract: The present invention relates to an isolated mutant eubacterium comprising at least one mutation resulting in a substitution of at least one amino acid in the beta-subunit of the RNA-polymerase encoded for by the rpoB-gene providing an altered production of a product of interest when said production of a product of interest is compared to the production of the same product in an isogenic wild type strain grown at identical conditions, wherein the substitution of at least one amino acid occurs at any of positions 469, 478, 482, 485, or 487 of SEQ ID NO:2, or at the equivalent positions in any eubacterial RNA-polymererase beta-subunit family member. Another aspect of the invention relates to a process for producing at least one product of interest in a mutant eubacterium and to a use of the mutant eubacterium according to the invention for producing at least one product of interest.

    Bacterial Mutants with Improved Transformation Efficiency
    6.
    发明申请
    Bacterial Mutants with Improved Transformation Efficiency 有权
    具有改善转化效率的细菌突变体

    公开(公告)号：US20150125959A1

    公开(公告)日：2015-05-07

    申请号：US14397512

    申请日：2013-05-17

    Applicant: Novozymes A/S

    Inventor： Steen Troels Joergensen ,  Torsten Bak Regueira ,  Brian Kobmann ,  Peter Bjarke Olsen ,  Bjarke Christensen

    IPC: C12N15/74

    CPC classification number: C12N15/746 ,  C12N9/1007 ,  C12N9/22

    Abstract: Provided herein are Lactobacillus mutants having improved transformation efficiency, comprising a disruption to an endogenous gene encoding a restriction modification system protein. Also described are methods for producing the mutants, methods for generating transformants using the mutants, and methods for producing a polypeptide or fermentation product using the mutants.

    Abstract translation: 本文提供了具有改善的转化效率的乳杆菌突变体，其包含对编码限制性修饰系统蛋白质的内源基因的破坏。 还描述了用于产生突变体的方法，使用突变体产生转化体的方法，以及使用突变体产生多肽或发酵产物的方法。

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