公开(公告)号：US20180153609A1

公开(公告)日：2018-06-07

申请号：US15827875

申请日：2017-11-30

Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION

Inventor： Karl SCHOENBACH ,  Richard HELLER

IPC: A61B18/14 ,  A61B18/12 ,  A61B18/00

CPC classification number: A61B18/14 ,  A61B18/1206 ,  A61B2018/0016 ,  A61B2018/124 ,  A61B2018/143 ,  A61B2018/1467

Abstract: Systems and methods for treating or manipulating biological tissues are provided. In the systems and methods, a biological tissue is placed in contact with an array of electrodes. Electrical pulses are then applied between a bias voltage bus and a reference voltage bus of a distributor having switching elements associated with each of the electrodes. The switching elements provide a first contact position for coupling electrodes to bias voltage bus, a second contact position for coupling electrodes to the reference voltage bus, and a third contact position for isolating electrodes from the high and reference voltage buses. The switching elements are operated over various time intervals to provide the first contact position for first electrodes, a second contact position for second electrodes adjacent to the first electrodes, and a third contact position for a remainder of the electrodes adjacent to the first and second electrodes.

公开(公告)号：US20190038337A1

公开(公告)日：2019-02-07

申请号：US16057115

申请日：2018-08-07

Applicant: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION

Inventor： Karl H. SCHOENBACH ,  Richard HELLER ,  James CAMP ,  Stephen P. BEEBE ,  Shu XIAO ,  Amy DONATE

IPC: A61B18/12 ,  A61N5/06 ,  A61N1/32 ,  A61N1/40 ,  A61N5/00 ,  A61N5/02 ,  A61B18/00 ,  A61B18/24 ,  A61B18/20 ,  A61B18/18 ,  A61N5/067

CPC classification number: A61B18/1206 ,  A61B18/12 ,  A61B18/1815 ,  A61B18/20 ,  A61B18/24 ,  A61B2018/00613 ,  A61B2018/00761 ,  A61B2018/00767 ,  A61B2018/00791 ,  A61B2018/00994 ,  A61N1/327 ,  A61N1/403 ,  A61N5/00 ,  A61N5/025 ,  A61N5/0625 ,  A61N2005/0651 ,  A61N2005/0666 ,  A61N2005/067

Abstract: Systems and methods for treatment of a biological tissues including target tissues and other tissues. The method includes elevating a temperature of the target tissues above a physiological temperature of the biological tissues to treatment temperature, and generating an electric field extending through at least a portion of the target tissues using a pre-defined sequence of short voltage pulses applied between at least two electrodes. In the method, the treatment temperature is maintained during the generating. Further, the pre-defined sequence is selected such that a magnitude of the electric field generated is sufficient to induce electromanipulation in the portion of the target tissues without substantially elevating of the temperature of the portion of the target tissues above the treatment temperature.