公开(公告)号：US20250152560A1

公开(公告)日：2025-05-15

申请号：US18838130

申请日：2023-02-13

Applicant: OnKure, Inc. ,  Array BioPharma Inc.

Inventor： Anthony D. Piscopio ,  Patrice Anne Lee ,  James Winkler ,  Richard D. Woessner

IPC: A61K31/429 ,  A61K31/4184 ,  A61K31/506 ,  A61P35/00

Abstract: A method of treating cancer in a subject in need thereof, wherein the method comprises administration of therapeutically effective amounts of OKI-179 and binimetinib or a pharmaceutically acceptable salt thereof, or administration of therapeutically effective amounts of OKI-179, binimetinib or a pharmaceutically acceptable salt thereof, and encorafenib or a pharmaceutically acceptable salt thereof according to the dosing schedules described herein.

公开(公告)号：US11339150B2

公开(公告)日：2022-05-24

申请号：US17421658

申请日：2020-12-23

Applicant: OnKure, Inc.

Inventor： Anthony D. Piscopio ,  Gan Zhang ,  Kevin Hunt

IPC: C07D413/14 ,  A61K45/06 ,  C07D417/14

Abstract: Novel compounds of Formula I are described, where the compounds are selective HDAC6 inhibitors suitable for treatment of diseases associated with HDAC6, where X, Y, Z, A1, A2, Q1 and Q2 are as described.

公开(公告)号：US11739123B2

公开(公告)日：2023-08-29

申请号：US17340731

申请日：2021-06-07

Applicant: OnKure, Inc.

Inventor： Anthony D. Piscopio ,  Xiaoyong Fu ,  Feng Shi ,  Huayan Liu ,  Zhifeng Li

IPC: C07K1/113 ,  C07K11/02 ,  C07K5/097 ,  C07D498/06 ,  C07D513/06 ,  C07D513/14 ,  C07K11/00 ,  A61K38/15 ,  C07K1/107

CPC classification number: C07K11/02 ,  A61K38/15 ,  C07D498/06 ,  C07D513/06 ,  C07D513/14 ,  C07K1/1077 ,  C07K1/113 ,  C07K5/0821 ,  C07K11/00

Abstract: Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R1-R7, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.

公开(公告)号：US11203602B2

公开(公告)日：2021-12-21

申请号：US16303217

申请日：2017-05-18

Applicant: OnKure, Inc.

Inventor： Anthony D. Piscopio

IPC: C07D513/08 ,  A61K45/06 ,  A61K38/15 ,  C07K11/02

Abstract: The present invention provides a novel macrocyclic prodrug compound of general Formula (I), a pharmaceutical composition comprising a compound of Formula (I), and a method for treating diseases mediated by HDAC enzymes by administering a compound of Formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, A and Z are defined herein.

公开(公告)号：US20240116989A1

公开(公告)日：2024-04-11

申请号：US18222170

申请日：2023-07-14

Applicant: OnKure, Inc.

Inventor： Anthony D. Piscopio ,  Xiaoyong Fu ,  Feng Shi ,  Huayan Liu ,  Zhifeng Li

IPC: C07K11/02 ,  A61K38/15 ,  C07D498/06 ,  C07D513/06 ,  C07D513/14 ,  C07K1/107 ,  C07K1/113 ,  C07K5/097 ,  C07K11/00

CPC classification number: C07K11/02 ,  A61K38/15 ,  C07D498/06 ,  C07D513/06 ,  C07D513/14 ,  C07K1/1077 ,  C07K1/113 ,  C07K5/0821 ,  C07K11/00

Abstract: Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R1-R7, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.

公开(公告)号：US20190177372A1

公开(公告)日：2019-06-13

申请号：US16127399

申请日：2018-09-11

Applicant: ONKURE, INC.

Inventor： Anthony D. Piscopio ,  Xiaoyong Fu ,  Feng Shi ,  Huayan Liu ,  Zhifeng Li

IPC: C07K11/02 ,  C07D513/14 ,  C07D513/06 ,  C07K5/097 ,  C07K1/113 ,  C07D498/06

Abstract: Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R1-R7, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.

公开(公告)号：US20220017538A1

公开(公告)日：2022-01-20

申请号：US17358656

申请日：2021-06-25

Applicant: OnKure, Inc.

Inventor： Anthony D. Piscopio

IPC: C07D513/08 ,  A61K38/15 ,  C07K11/02

Abstract: The present invention provides a novel macrocyclic prodrug compound of general Formula (I), a pharmaceutical composition comprising a compound of Formula (I), and a method for treating diseases mediated by HDAC enzymes by administering a compound of Formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, A and Z are defined herein.

公开(公告)号：US11053284B2

公开(公告)日：2021-07-06

申请号：US16781233

申请日：2020-02-04

Applicant: ONKURE, INC.

Inventor： Anthony D. Piscopio ,  Xiaoyong Fu ,  Feng Shi ,  Huayan Liu ,  Zhifeng Li

IPC: A61K38/15 ,  C07K11/00 ,  C07K11/02 ,  C07K5/097 ,  C07D498/06 ,  C07D513/06 ,  C07D513/14 ,  C07K1/113

Abstract: Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R1-R7, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.

公开(公告)号：US20200347097A1

公开(公告)日：2020-11-05

申请号：US16781233

申请日：2020-02-04

Applicant: ONKURE, INC.

Inventor： Anthony D. Piscopio ,  Xiaoyong Fu ,  Feng Shi ,  Huayan Liu ,  Zhifeng Li

IPC: C07K11/02 ,  C07K5/097 ,  C07D498/06 ,  C07D513/06 ,  C07D513/14 ,  C07K11/00 ,  A61K38/15 ,  C07K1/113

Abstract: Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R1-R7, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.

公开(公告)号：US12252511B2

公开(公告)日：2025-03-18

申请号：US18222170

申请日：2023-07-14

Applicant: OnKure, Inc.

Inventor： Anthony D. Piscopio ,  Xiaoyong Fu ,  Feng Shi ,  Huayan Liu ,  Zhifeng Li

IPC: C07K1/113 ,  A61K38/15 ,  C07D498/06 ,  C07D513/06 ,  C07D513/14 ,  C07K1/107 ,  C07K5/097 ,  C07K11/00 ,  C07K11/02

Abstract: Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R1-R7, L and n are defined herein. Intermediates useful in the preparation of the compounds of Formula (1) and Formula (2) are also described.