摘要:
Inhibitors of parasitic dihydroorotate dehydrogenase enzyme (DHOD) are candidate therapeutics for treating malaria. Illustrative of such therapeutic agents include the compound: and a triazolopyrimidine class of compounds that conform to Formula IX: and their solvates, stereoisomers, tautomers and pharmaceutically acceptable salts.
摘要:
Inhibitors of parasitic dihydroorotate dehydrogenase enzyme (DHOD) are candidate therapeutics for treating malaria. Illustrative of such therapeutic agents include the compound: and a triazolopyrimidine class of compounds that conform to Formula IX: and their solvates, stereoisomers, tautomers and pharmaceutically acceptable salts.
摘要:
In one aspect, the invention relates to novel substituted 2-alkyl-1-oxo-N-phenyl-3-heteroaryl -1,2,3,4-tetrahydroisoquinoline-4-carboxamides; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating and/or preventing malaria. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要:
Calcium channel blocking activity is exhibited by compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein the stereochemistry at the chiral centers in the 3 and 4-positions of the benzothiazepine nucleus is cis, and whereinR.sub.1 is alkyl, aryl, arylalkyl, alkenyl or alkynyl;R.sub.2 and R.sub.5 are each independently hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, halogen or trifluoromethyl; andR.sub.3 and R.sub.4 are each independently alkyl or cycloalkyl or R.sub.3 and R.sub.4 together with the nitrogen atom to which they are attached are pyrrolidinyl, piperidinyl or morpholinyl.
摘要:
Vasodilating activity is exhibited by compounds having the formula ##STR1## n is 2 or 3; X is oxygen or sulfur;R.sub.1 and R.sub.2 are each independently hydrogen alkyl, cycloalkyl, or allyl, or R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached are pyrrolidinyl, piperidinyl, or morpholinyl;R.sub.3 is alkyl, alkoxy, halogen, trifluoromethyl, or nitro;R.sub.4 is hydrogen, halogen, trifluoromethyl, or nitro; andR.sub.5 and R.sub.6 are each independently alkyl or cycloalkyl or R.sub.5 and R.sub.6 together with the nitrogen atom to which they are attached are pyrrolidinyl, piperidinyl, or morpholinyl.
摘要翻译:具有下式的化合物表现出血管扩张活性:n = 2或3; X是氧或硫; R 1和R 2各自独立地为烷基,环烷基或烯丙基,或者R 1和R 2与它们所连接的氮原子一起为吡咯烷基,哌啶基或吗啉基; R3是烷基,烷氧基,卤素,三氟甲基或硝基; R4是氢,卤素,三氟甲基或硝基; R 5和R 6各自独立地为烷基或环烷基或R 5和R 6与它们所连接的氮原子一起为吡咯烷基,哌啶基或吗啉基。
摘要:
An arrangement (20) for locating at least one device (22) utilizes an assisted global positioning system technique based upon Internet communications. In a disclosed example, a network server (26) detects the presence of a device (22) on the Internet (24). The network server (26) makes an initial estimate of a location of the device based upon Internet information regarding the device (22). The initial estimate is used by a location server to generate an assisted global positioning system communication that is provided to the device (22). An assisted global positioning system receiver (72) associated with the device (22) uses the received communication for interacting with a global positioning system (32). An indication of that interaction can then be used by the network server (26) or the location server (28) for making an actual device location determination.
摘要:
A wireless communication network (20) including mobile applications (56-62) includes a security approach that uses a combination of at least two techniques (42, 50, 54, 72). One disclosed example includes a combination of all four techniques. The combined, layered approach greatly reduces the probability that an unauthorized individual will be able to masquerade as a valid application within the network so that network security is improved. Disclosed techniques include obfuscating software code of a mobile application, providing a mobile application with a plurality of code signatures for generating a corresponding plurality of unique control values, limiting the useful lifetime of a mobile application and determining that a control value of a mobile application corresponds to the control value of another application before the two applications are allowed to interact in a manner that could compromise either application or the network.
摘要:
7-Oxabicycloheptane substituted prostaglandin analogs useful in treating thrombotic and vasospastic disease have the structural formula ##STR1## wherein m is 1, 2 or 3; n is 1, 2, 3 or 4; Z is --(CH.sub.2).sub.2 --, --CH.dbd.CH-- or ##STR2## wherein Y is O, a single bond or vinyl, with the proviso that when n is O, if Z is ##STR3## then Y cannot be O, and when Z is --CH.dbd.CH--, n is 1, 2, 3 or 4; and when Y=vinyl, n=0; R is CO.sub.2 H, CO.sub.2 lower alkyl, CH.sub.2 OH, CO.sub.2 alkali metal, CONHSOR.sup.3, CONHR.sup.3a or --CH.sub.2 -5-tetrazolyl, X is O, S or NH; and where R.sup.1, R.sup.2, R.sup.3 and R.sup.3a are as defined herein.