-
1.发明申请ANTIMALARIAL AGENTS THAT ARE INHIBITORS OF DIHYDROOROTATE DEHYDROGENASE 有权作为DIHYDROOROTETE DEHYDROGENASE的抑制剂的抗菌药物公开(公告)号：US20120302586A1
公开(公告)日：2012-11-29
申请号：US13499031
申请日：2010-09-28
申请人： Pradipsinh K. Rathod , David Floyd , Jeremy Burrows , Alka Marwaha , Ramesh Gujjar , Jose Coteron-Lopez , Margaret Phillips , Susan A. Charman , David Matthews
发明人： Pradipsinh K. Rathod , David Floyd , Jeremy Burrows , Alka Marwaha , Ramesh Gujjar , Jose Coteron-Lopez , Margaret Phillips , Susan A. Charman , David Matthews
IPC分类号： A61K31/519 , C08B37/00 , A61P33/06 , C07D487/04 , A61P33/00
CPC分类号： C07D487/04
摘要： Inhibitors of parasitic dihydroorotate dehydrogenase enzyme (DHOD) are candidate therapeutics for treating malaria. Illustrative of such therapeutic agents include the compound: and a triazolopyrimidine class of compounds that conform to Formula IX: and their solvates, stereoisomers, tautomers and pharmaceutically acceptable salts.
摘要翻译： 寄生二氢乳清酸脱氢酶（DHOD）的抑制剂是治疗疟疾的候选治疗剂。 这样的治疗剂的实例包括化合物：和符合式IX的三唑并嘧啶类化合物及其溶剂合物，立体异构体，互变异构体和药学上可接受的盐。
-
公开(公告)号：US09238653B2
公开(公告)日：2016-01-19
申请号：US13499031
申请日：2010-09-28
申请人： Pradipsinh K. Rathod , David Floyd , Jeremy Burrows , Alka Marwaha , Ramesh Gujjar , Jose Coteron-Lopez , Margaret Phillips , Susan A. Charman , David Matthews
发明人： Pradipsinh K. Rathod , David Floyd , Jeremy Burrows , Alka Marwaha , Ramesh Gujjar , Jose Coteron-Lopez , Margaret Phillips , Susan A. Charman , David Matthews
IPC分类号： C07D487/04 , A61K31/519 , A61P33/06
CPC分类号： C07D487/04
摘要： Inhibitors of parasitic dihydroorotate dehydrogenase enzyme (DHOD) are candidate therapeutics for treating malaria. Illustrative of such therapeutic agents include the compound: and a triazolopyrimidine class of compounds that conform to Formula IX: and their solvates, stereoisomers, tautomers and pharmaceutically acceptable salts.
摘要翻译： 寄生二氢乳清酸脱氢酶（DHOD）的抑制剂是治疗疟疾的候选治疗剂。 这样的治疗剂的实例包括化合物：和符合式IX的三唑并嘧啶类化合物及其溶剂合物，立体异构体，互变异构体和药学上可接受的盐。
-
3.发明申请Novel 2-Amino-Imidazole-4-One Compounds and Their Use in the Manufacture of a Medicament to Be Used in the Treatment of Cognitive Impairment, Alzheimer's Disease, Neurodegeneration and Dementia 审中-公开新型2-氨基咪唑-4-酮化合物及其在制造用于治疗认知功能障碍，阿尔茨海默病，神经退行性和痴呆症药物中的应用公开(公告)号：US20090233930A9
公开(公告)日：2009-09-17
申请号：US12094276
申请日：2006-11-20
申请人： Stefan Berg , Jeremy Burrows , Gianni Chessari , Miles Stuart Congreve , Johan Hedstrom , Sven Hellberg , Katharina Hogdin , Jacob Kihlstrom , Karin Kolmodin , Johan Lindstrom , Christopher Murray , Sahil Patel
发明人： Stefan Berg , Jeremy Burrows , Gianni Chessari , Miles Stuart Congreve , Johan Hedstrom , Sven Hellberg , Katharina Hogdin , Jacob Kihlstrom , Karin Kolmodin , Johan Lindstrom , Christopher Murray , Sahil Patel
IPC分类号： A61K31/5377 , C07D401/10 , A61K31/4725 , C07D339/08 , A61P25/28 , C07F7/08 , C12N9/99 , C07D413/12
CPC分类号： C07D233/88 , C07C25/22 , C07C25/24 , C07C39/373 , C07C43/1747 , C07C43/23 , C07C47/575 , C07C49/792 , C07C49/813 , C07C49/83 , C07C49/84 , C07D209/08 , C07D217/06 , C07D233/86 , C07D265/36 , C07D307/79 , C07D339/08 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/10 , C07D409/06 , C07D409/10 , C07D413/06 , C07D413/10 , C07D417/04 , C07F7/1804
摘要： This invention relates to novel compounds having the structural formula I below: and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.
摘要翻译： 本发明涉及具有以下结构式I的新化合物及其药学上可接受的盐，组合物和使用方法。 这些新化合物提供了认知障碍，阿尔茨海默病，神经变性和痴呆症的治疗或预防。
-
4.发明申请Pyrimidine Derivatives and Their Use in Therapy as well as the Use of Pyrimidine Derivatives in the Manufacture of a Medicament for Prevention and/or Treatment of Alzheimer's Disease 审中-公开嘧啶衍生物及其在治疗中的应用以及嘧啶衍生物在制造预防和/或治疗阿尔茨海默病药物中的应用公开(公告)号：US20090105252A1
公开(公告)日：2009-04-23
申请号：US12089008
申请日：2006-10-02
申请人： Lars Andersson , Erwan Arzel , Stefan Berg , Jeremy Burrows , Sven Hellberg , Fernando Huerta , Torben Pedersen , Tobias Rein , Didier Rotticci , Karin Staaf , Dominika Turek
发明人： Lars Andersson , Erwan Arzel , Stefan Berg , Jeremy Burrows , Sven Hellberg , Fernando Huerta , Torben Pedersen , Tobias Rein , Didier Rotticci , Karin Staaf , Dominika Turek
IPC分类号： A61K31/5377 , C07D403/02 , A61K31/506 , C07D413/14 , A61P25/28 , C07D403/14 , A61K31/496
CPC分类号： C07D405/14 , A61K31/506 , C07D401/14 , C07D403/04 , C07D409/14
摘要： Compounds of formula I wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined in the specification as a base or a pharmaceutically acceptable salt, solvate or solvate of salt thereof, processes for their preparation, new intermediates used therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.
摘要翻译： 其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8和R 9如说明书中所定义的式I化合物或其盐，溶剂化物或其盐的溶剂合物，其制备方法，新的 其中使用的中间体，含有所述化合物的药物制剂和所述化合物在治疗中的用途。
-
![Novel Imidazo [4,5-b] Pyridine Derivatives as Inhibitors of Glycogen Synthase Kinase 3 for Use in the Treatment of Dementia and Neurodegenerative Disorders](/abs-image/US/2008/10/16/US20080255085A1/abs.jpg.150x150.jpg)
5.发明申请Novel Imidazo [4,5-b] Pyridine Derivatives as Inhibitors of Glycogen Synthase Kinase 3 for Use in the Treatment of Dementia and Neurodegenerative Disorders 审中-公开新型咪唑并[4,5-b]吡啶衍生物作为糖原合成酶激酶3抑制剂用于治疗痴呆和神经退行性疾病公开(公告)号：US20080255085A1
公开(公告)日：2008-10-16
申请号：US12089002
申请日：2006-10-02
申请人： Per I Arvidsson , Erwan Arzel , Jeremy Burrows , Martina Claesson , Colin Ray , Tobias Rein , Didier Rotticci , Peter Soderman
发明人： Per I Arvidsson , Erwan Arzel , Jeremy Burrows , Martina Claesson , Colin Ray , Tobias Rein , Didier Rotticci , Peter Soderman
IPC分类号： A61K31/5377 , C07D487/04 , A61K31/496 , A61P25/16 , A61P25/28 , A61K31/437 , A61K31/551
CPC分类号： C07D471/04
摘要： Compounds of formula I wherein X is or Y; and wherein A, Y, R1, R2, R3, R4 and R5 are as defined in the specification as a base or a pharmaceutically acceptable salt, solvate or solvate of salt thereof, processes for their preparation, new intermediates used therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.
摘要翻译： 其中X为或Y的式I化合物; 并且其中A，Y，R 1，R 2，R 3，R 4和R 4， 5的定义如本说明书中作为其盐或其药学上可接受的盐，溶剂化物或其盐的溶剂化物，其制备方法，其中使用的新中间体，含有所述化合物的药物制剂以及所述化合物的用途 治疗。
-
公开(公告)号：US20080188503A1
公开(公告)日：2008-08-07
申请号：US11769113
申请日：2007-06-27
申请人： Jeremy Burrows , Fernando Huerta , Tobias Rein , Didier Rotticci , Karin Staaf , Dominika Turek
发明人： Jeremy Burrows , Fernando Huerta , Tobias Rein , Didier Rotticci , Karin Staaf , Dominika Turek
IPC分类号： A61K31/506 , C07D401/04 , A61P25/28
CPC分类号： C07D403/14 , C07D403/04 , C07D405/14
摘要： The present invention relates to a compound of formula (I): as a free base or a pharmaceutically acceptable salt thereof. The present invention also relates to pharmaceutical formulations containing said compound and to the use of said compound in therapy. The present invention further relates to a process for the preparation of the compound of formula (I).
摘要翻译： 本发明涉及式（I）的化合物：作为游离碱或其药学上可接受的盐。 本发明还涉及含有所述化合物的药物制剂和所述化合物在治疗中的用途。 本发明还涉及制备式（I）化合物的方法。
-
公开(公告)号：US20080188502A1
公开(公告)日：2008-08-07
申请号：US11769102
申请日：2007-06-27
申请人： Jeremy Burrows , Fernando Huerta , Fredrik Lake , Torben Pedersen , Didier Rotticci , Tobias Rein , Karin Staaf , Ulrika Yngve
发明人： Jeremy Burrows , Fernando Huerta , Fredrik Lake , Torben Pedersen , Didier Rotticci , Tobias Rein , Karin Staaf , Ulrika Yngve
IPC分类号： A61K31/506 , C07D401/04 , A61P25/28
CPC分类号： C07D401/14 , C07D405/14
摘要： The present invention relates to a compound of formula (I): as a free base or a pharmaceutically acceptable salt thereof. The present invention also relates to pharmaceutical formulations containing said compound and to the use of said compound in therapy. The present invention further relates to a process for the preparation of compound of formula (I) and to new intermediates used therein.
摘要翻译： 本发明涉及式（I）的化合物：作为游离碱或其药学上可接受的盐。 本发明还涉及含有所述化合物的药物制剂和所述化合物在治疗中的用途。 本发明还涉及制备式（I）化合物及其中使用的新中间体的方法。
-
8.发明申请Sulphonylpiperidine derivatives containing an aryl or heteroaryl group for use as matrix metalloproteinase inhibitors 审中-公开含有用作基质金属蛋白酶抑制剂的芳基或杂芳基的磺酰基哌啶衍生物公开(公告)号：US20060173041A1
公开(公告)日：2006-08-03
申请号：US10520861
申请日：2003-07-09
IPC分类号： A61K31/445 , A61K31/454 , C07D401/02
CPC分类号： C07D401/12 , C07D211/96 , C07D401/14 , C07D409/12 , C07D413/12 , C07D495/04
摘要： A compound of formula (1), wherein B is an ortho substituted monocyclic aryl or heteroaryl group or a bicyclic aryl or heteroaryl group; useful in the inhibition of one or more metalloproteinases, and in particular TACE.
摘要翻译： 式（1）的化合物，其中B是邻位取代的单环芳基或杂芳基或双环芳基或杂芳基; 可用于抑制一种或多种金属蛋白酶，特别是TACE。
-
9.发明申请Novel 2-Amino-Imidazole-4-One Compounds and Their Use in the Manufacture of a Medicament to Be Used in the Treatment of Cognitive Impairment, Alzheimer's Disease, Neurodegeneration and Dementia 审中-公开新型2-氨基 - 咪唑-4-酮化合物及其在制造用于治疗认知功能障碍，阿尔茨海默病，神经退行性和痴呆症药物中的应用公开(公告)号：US20080293718A1
公开(公告)日：2008-11-27
申请号：US12094276
申请日：2006-11-20
申请人： Stefan Berg , Jeremy Burrows , Gianni Chessari , Miles Stuart Congreve , Johan Hedstrom , Sven Hellberg , Katharina Hogdin , Jacob Kihlstrom , Karin Kolmodin , Johan Lindstrom , Christopher Murray , Sahil Patel
发明人： Stefan Berg , Jeremy Burrows , Gianni Chessari , Miles Stuart Congreve , Johan Hedstrom , Sven Hellberg , Katharina Hogdin , Jacob Kihlstrom , Karin Kolmodin , Johan Lindstrom , Christopher Murray , Sahil Patel
IPC分类号： A61K31/5377 , C07D401/10 , A61K31/4725 , C07D339/08 , A61P25/28 , C07F7/08 , C12N9/99 , C07D413/12
CPC分类号： C07D233/88 , C07C25/22 , C07C25/24 , C07C39/373 , C07C43/1747 , C07C43/23 , C07C47/575 , C07C49/792 , C07C49/813 , C07C49/83 , C07C49/84 , C07D209/08 , C07D217/06 , C07D233/86 , C07D265/36 , C07D307/79 , C07D339/08 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/10 , C07D409/06 , C07D409/10 , C07D413/06 , C07D413/10 , C07D417/04 , C07F7/1804
摘要： This invention relates to novel compounds having the structural formula I below: and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.
摘要翻译： 本发明涉及具有以下结构式I的新化合物及其药学上可接受的盐，组合物和使用方法。 这些新化合物提供了认知障碍，阿尔茨海默病，神经变性和痴呆症的治疗或预防。
-
公开(公告)号：US20060142336A1
公开(公告)日：2006-06-29
申请号：US10521042
申请日：2003-07-09
申请人： Jeremy Burrows , Howard Tucker
发明人： Jeremy Burrows , Howard Tucker
IPC分类号： A61K31/4545 , A61K31/445 , C07D211/68 , C07D401/02
CPC分类号： C07D401/12 , C07D211/96 , C07D401/14
摘要： Compounds of formula (1), wherein Z is —CONR15OH or —N(OH)CHO and X is —(CR9R10)t-Q-(CR11R12)u- (where t and u are independently 0 or 1 with the proviso that t and u cannot both be 0);are inhibitors of metalloproteinases and in particular TACE.
摘要翻译： 式（1）的化合物，其中Z是-CONR 15 OH或-N（OH）CHO，X是 - （CR 9 R 10） u）（其中t和u独立地为0或1，条件是t和u不能都为0）;是 金属蛋白酶抑制剂，特别是TACE。
-
-
-
-
-
-
-
-
-
搜索结果
23 条记录 (耗时 0.046 秒)
