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公开(公告)号：US11112415B2
公开(公告)日：2021-09-07
申请号：US15921429
申请日：2018-03-14
发明人： David Fournier , Todd Campbell , Cheuk Kan , John Lawson , Andrew Rivnak , Michael Kagan , David C. Duffy
摘要： Described are systems, devices, and methods which related to various aspects of assays for detecting and/or determining a measure of the concentration of analyte molecules or particles in a sample fluid. In some cases, the systems employ an assay consumable comprising a plurality of assay sites. The systems, devices, and/or methods, in some cases, are automated. In some cases, the systems, devices, and/or methods relate to inserting a plurality of beads into assay sites, sealing assay sites, imaging assay sites, or the like.
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公开(公告)号：US10725032B2
公开(公告)日：2020-07-28
申请号：US15487889
申请日：2017-04-14
发明人： David C. Duffy , David M. Rissin , David R. Walt , David Fournier , Cheuk Kan
IPC分类号： G01N33/543
摘要： The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles with respect to a plurality of capture objects. At least a portion of the plurality of capture objects may be spatially separated into a plurality of locations. A measure of the concentration of analyte molecules in a fluid sample may be determined, at least in part, on the number of reaction vessels comprising an analyte molecule immobilized with respect to a capture object. In some cases, the assay may additionally comprise steps including binding ligands, precursor labeling agents, and/or enzymatic components.
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公开(公告)号：US11619631B2
公开(公告)日：2023-04-04
申请号：US16381614
申请日：2019-04-11
发明人： David C. Duffy , David M. Rissin , David R. Walt , David Fournier , Cheuk Kan
IPC分类号： G01N33/543
摘要： The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles with respect to a plurality of capture objects. At least a portion of the plurality of capture objects may be spatially separated into a plurality of locations. A measure of the concentration of analyte molecules in a fluid sample may be determined, at least in part, on the number of reaction vessels comprising an analyte molecule immobilized with respect to a capture object. In some cases, the assay may additionally comprise steps including binding ligands, precursor labeling agents, and/or enzymatic components.
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公开(公告)号：US20180306830A1
公开(公告)日：2018-10-25
申请号：US15921429
申请日：2018-03-14
发明人： David Fournier , Todd Campbell , Cheuk Kan , John Lawson , Andrew Rivnak , Michael Kagan , David C. Duffy
CPC分类号： G01N35/00029 , B01L3/502761 , B01L3/5085 , B01L2200/0668 , B01L2200/0689 , B01L2300/0803 , B01L2400/043 , B01L2400/086 , G01N35/0098 , G01N35/1065 , G01N2035/00287
摘要： Described are systems, devices, and methods which related to various aspects of assays for detecting and/or determining a measure of the concentration of analyte molecules or particles in a sample fluid. In some cases, the systems employ an assay consumable comprising a plurality of assay sites. The systems, devices, and/or methods, in some cases, are automated. In some cases, the systems, devices, and/or methods relate to inserting a plurality of beads into assay sites, sealing assay sites, imaging assay sites, or the like.
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5.发明申请公开(公告)号：US20180017552A1
公开(公告)日：2018-01-18
申请号：US15487889
申请日：2017-04-14
发明人： David C. Duffy , David M. Rissin , David R. Walt , David Fournier , Cheuk Kan
IPC分类号： G01N33/543
摘要： The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles with respect to a plurality of capture objects. At least a portion of the plurality of capture objects may be spatially separated into a plurality of locations. A measure of the concentration of analyte molecules in a fluid sample may be determined, at least in part, on the number of reaction vessels comprising an analyte molecule immobilized with respect to a capture object. In some cases, the assay may additionally comprise steps including binding ligands, precursor labeling agents, and/or enzymatic components.
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6.发明公开公开(公告)号：US20240295552A1
公开(公告)日：2024-09-05
申请号：US18642104
申请日：2024-04-22
发明人： David C. Duffy , David M. Rissin , David R. Walt , David Fournier , Cheuk Kan
IPC分类号： G01N33/543
CPC分类号： G01N33/54393 , G01N33/54306 , G01N33/54313
摘要： The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles with respect to a plurality of capture objects. At least a portion of the plurality of capture objects may be spatially separated into a plurality of locations. A measure of the concentration of analyte molecules in a fluid sample may be determined, at least in part, on the number of reaction vessels comprising an analyte molecule immobilized with respect to a capture object. In some cases, the assay may additionally comprise steps including binding ligands, precursor labeling agents, and/or enzymatic components.
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7.发明申请公开(公告)号：US20190302109A1
公开(公告)日：2019-10-03
申请号：US16381614
申请日：2019-04-11
发明人： David C. Duffy , David M. Rissin , David R. Walt , David Fournier , Cheuk Kan
IPC分类号： G01N33/543
摘要： The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles with respect to a plurality of capture objects. At least a portion of the plurality of capture objects may be spatially separated into a plurality of locations. A measure of the concentration of analyte molecules in a fluid sample may be determined, at least in part, on the number of reaction vessels comprising an analyte molecule immobilized with respect to a capture object. In some cases, the assay may additionally comprise steps including binding ligands, precursor labeling agents, and/or enzymatic components.
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