公开(公告)号：US20240319222A1

公开(公告)日：2024-09-26

申请号：US17284687

申请日：2019-08-26

Applicant: Hitachi High-Tech Corporation

Inventor： Daisuke EBIHARA ,  Shinya MATSUOKA ,  Makoto NOGAMI ,  Taku SAKAZUME

IPC: G01N35/10 ,  G01N35/00

CPC classification number: G01N35/1016 ,  G01N35/0098

Abstract: Provided is an automatic analysis device and an analysis method which are capable of reliably detecting an abnormality in a dispensing amount of a solution such as a specimen or a reagent to be dispensed and suppressing a decrease in analysis accuracy. Included are a specimen dispensing mechanism 113 that dispenses an analysis target specimen in a reaction vessel 116, a reagent dispensing mechanism 123 that dispenses another dispensing object different from the specimen in the reaction vessel 116, and a mass analyzing unit 133 that detects and analyzes a specific component in a reaction solution in which a specimen dispensed into the reaction vessel 116 and another dispensing object are mixed to each other, in which it is determined whether a dispensed liquid amount of the another dispensing object is abnormal or not, based on a detection result of a standard substance for dispensing inspection which has been added in advance to the another dispensing object, which is detected at the same time with the detection of the analysis target component of the specimen in the reaction solution in the mass analyzing unit 133.

公开(公告)号：US12030051B2

公开(公告)日：2024-07-09

申请号：US16419485

申请日：2019-05-22

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Kalyan Handique ,  Kyle Gleason ,  Austin Payne ,  Priyadarshini Gogoi ,  Christopher Siemer ,  Yi Zhou ,  Saedeh Javdani Sepehri

IPC: B01L3/00 ,  B01L7/00 ,  G01N35/00

CPC classification number: B01L3/502761 ,  B01L3/502715 ,  B01L3/527 ,  B01L3/5635 ,  B01L7/00 ,  G01N35/0098 ,  B01L2200/027 ,  B01L2200/0647 ,  B01L2200/0652 ,  B01L2200/0684 ,  B01L2300/06 ,  B01L2300/0816 ,  B01L2300/0832 ,  B01L2300/0864 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2300/185 ,  B01L2400/0487 ,  B01L2400/0683

Abstract: A system for isolating cells in at least one of single-cell format and single-cluster format, comprising a reservoir, including a reservoir inlet and a reservoir outlet, configured to receive a biological sample and to receive at least one fluid, a manifold configured to receive and deliver the biological sample and the at least one fluid from the reservoir into a biological sample substrate, the manifold comprising a broad surface comprising a central region configured to receive the biological sample substrate, a set of openings configured to enable fluid flow transmission across the biological sample substrate, a manifold inlet configured to transmit flow from the reservoir the first subset of openings, a manifold outlet configured at a downstream end of the broad surface and coupled to the second subset of openings, the manifold outlet configured to transmit waste fluid from the manifold.

公开(公告)号：US20240219413A1

公开(公告)日：2024-07-04

申请号：US18523938

申请日：2023-11-30

Applicant: Shenzhen New Industries Biomedical Engineering Co., Ltd.

Inventor： Yixian WANG ,  Xiaolin ZHENG ,  Guoyao HE ,  Zhenhua LIU ,  Yingchao XIONG ,  Tingting ZHANG ,  Muxiao CHEN ,  Juanjuan MA ,  Xueqing SHENG

IPC: G01N35/00

CPC classification number: G01N35/00663 ,  G01N35/0098 ,  G01N2035/00673

Abstract: The disclosure provides a reagent preparation apparatus and a nucleic acid testing integrated machine having the reagent preparation apparatus. The reagent preparation apparatus includes: a housing, the housing being provided with an extraction reagent filling position and an amplification reagent filling position; a reagent storage portion, arranged in the housing, the reagent storage portion including an extraction reagent storage portion and an amplification reagent storage portion; and a filling portion, movably arranged in the housing, the filling portion being able to suck an extraction reagent from the extraction reagent storage portion and move to above the extraction reagent filling position to fill the extraction reagent into a first vessel on the extraction reagent filling position, and the filling portion being able to suck an amplification reagent from the amplification reagent storage portion and move to above the amplification reagent filling position to fill the amplification reagent into a second vessel on the amplification reagent filling position.

公开(公告)号：US20240157366A1

公开(公告)日：2024-05-16

申请号：US18419606

申请日：2024-01-23

Applicant: MeMed Diagnostics Ltd.

Inventor： Noga SALOMON ,  Kfir OVED ,  Yana KHALFIN ,  Omer Nahum KATZENELSON ,  Amir GELMAN ,  Moran BROUK RUDICH ,  Roy NAVON ,  Assaf COHEN-DOTAN ,  Eran EDEN ,  Salit TZABAN ,  Arnon ZANGVIL ,  Ofer HALBREICH ,  Matthew FENWICK ,  Adrian Charles Ian SCOTT-MURPHY ,  Matthew Hou-Pou YEUNG ,  James William LUTHER ,  Barbara TORNAGHI ,  Andrea BESANA ,  Thomas Sanelli CRUGNALE

IPC: B01L3/00 ,  G01N35/00 ,  G01N35/10

CPC classification number: B01L3/50853 ,  G01N35/0098 ,  G01N35/0099 ,  G01N35/10 ,  A61B5/150022

Abstract: In a cartridge device for analyzing a body liquid, a first member of the cartridge has two or more wells for performing assays, and a second member of the cartridge has a compartment for holding one or more disposable pipette tips.

公开(公告)号：US11883820B2

公开(公告)日：2024-01-30

申请号：US15911184

申请日：2018-03-05

Applicant: Yuchen Zhou

Inventor： Yuchen Zhou

IPC: B01D21/02 ,  B03C1/033 ,  B03C1/28 ,  B03C1/30 ,  B01L3/00 ,  G01N1/40 ,  G01N33/49 ,  B01D21/28 ,  G01N33/543 ,  G01N35/00 ,  A61K38/27 ,  C12Q1/6806 ,  B03C1/005 ,  B01D35/06 ,  G01N27/74 ,  B03C1/23 ,  G01N15/00 ,  B01F31/86

CPC classification number: B01L3/502753 ,  A61K38/27 ,  B01D21/283 ,  B01D35/06 ,  B01F31/86 ,  B01L3/50273 ,  B01L3/502715 ,  B01L3/502761 ,  B03C1/005 ,  B03C1/0332 ,  B03C1/23 ,  B03C1/288 ,  B03C1/30 ,  C12Q1/6806 ,  G01N1/4077 ,  G01N15/00 ,  G01N27/745 ,  G01N33/491 ,  G01N33/54326 ,  G01N33/54333 ,  G01N35/0098 ,  B01L2200/027 ,  B01L2200/0647 ,  B01L2200/0652 ,  B01L2200/0668 ,  B01L2300/021 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2400/043 ,  B01L2400/0436 ,  B01L2400/0439 ,  B01L2400/0457 ,  B01L2400/0487 ,  B01L2400/0496 ,  B03C2201/18 ,  B03C2201/20 ,  B03C2201/26 ,  G01N2035/00554

Abstract: The current invention relates to the device and method to separate biological entities from a sample fluid by a microfluidic device. The claimed methods separate biological entities by differentiating the sizes of the biological entities with ultrasound modes. The claimed methods further utilize a multi-staged design that removes smaller size entities at earlier and wider sections and concentrates larger entities at later and narrower sections of a microfluidic channel.

公开(公告)号：US20230356224A1

公开(公告)日：2023-11-09

申请号：US18218454

申请日：2023-07-05

Applicant: NeuMoDx Molecular, Inc.

Inventor： Jeffrey WILLIAMS ,  Sundaresh BRAHMASANDRA ,  Michelle MASTRONARDI

IPC: B01L3/00 ,  B01L7/00 ,  G01N35/00 ,  C12Q1/686

CPC classification number: B01L3/502761 ,  B01L7/525 ,  B01L3/502738 ,  B01L3/50851 ,  G01N35/0098 ,  B01L7/52 ,  C12Q1/686 ,  B01L2400/0622 ,  B01L2400/0481 ,  B01L3/50855 ,  B01L2300/044 ,  B01L2300/0627 ,  B01L2300/168 ,  B01L2400/0633 ,  B01L2400/043 ,  B01L2200/0668 ,  B01L2300/0681 ,  B01L2300/1822 ,  B01L2400/0487 ,  B01L2400/0655 ,  B01L2200/10 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2300/1827 ,  B01L2400/0406 ,  B01L2400/0694

Abstract: A system and method for processing and detecting nucleic acids from a set of biological samples, comprising: a capture plate and a capture plate module configured to facilitate binding of nucleic acids within the set of biological samples to magnetic beads; a molecular diagnostic module configured to receive nucleic acids bound to magnetic beads, isolate nucleic acids, and analyze nucleic acids, comprising a cartridge receiving module, a heating/cooling subsystem and a magnet configured to facilitate isolation of nucleic acids, a valve actuation subsystem configured to control fluid flow through a microfluidic cartridge for processing nucleic acids, and an optical subsystem for analysis of nucleic acids; a fluid handling system configured to deliver samples and reagents to components of the system to facilitate molecular diagnostic protocols; and an assay strip configured to combine nucleic acid samples with molecular diagnostic reagents for analysis of nucleic acids.

公开(公告)号：US11774444B2

公开(公告)日：2023-10-03

申请号：US16349235

申请日：2017-11-10

Applicant: Beth Israel Deaconess Medical Center, Inc.

Inventor： Ionita C. Ghiran ,  Nathan Shapiro ,  Anish V. Sharda ,  Edward J. Felton

IPC: G01N33/543 ,  B03C1/01 ,  B03C1/033 ,  B03C1/30 ,  B03C1/32 ,  G01N9/36 ,  G01N33/50 ,  G01N35/00 ,  G01N33/569 ,  G01N33/537

CPC classification number: G01N33/54326 ,  B03C1/01 ,  B03C1/0332 ,  B03C1/30 ,  B03C1/32 ,  G01N9/36 ,  G01N33/5005 ,  G01N33/5044 ,  G01N33/537 ,  G01N33/56966 ,  G01N33/56972 ,  G01N35/0098 ,  B03C2201/26

Abstract: Methods and apparatus for detecting cell-bound and soluble antigens in a biological sample are described. The method comprises forming complexes of at least one antibody-coated bead and at least one antigen in a solution, placing the solution in a magnetic field such that the formed complexes levitate in the solution at a particular height, and determining at least one characteristic of the antigen in the complexes based, at least in part, on an image of the complexes showing the magnetic levitation height.

公开(公告)号：US20230257797A1

公开(公告)日：2023-08-17

申请号：US17922206

申请日：2020-12-01

Applicant: Chin Hung WANG

Inventor： Chin Hung WANG

IPC: C12Q1/6806 ,  G01N35/00 ,  G01N33/543 ,  C12N15/10 ,  B03C1/28 ,  B03C1/30 ,  B03C1/033

CPC classification number: C12Q1/6806 ,  G01N35/0098 ,  G01N33/543 ,  C12N15/1013 ,  B03C1/288 ,  B03C1/30 ,  B03C1/0332 ,  B03C2201/18

Abstract: A centrifugal reaction device includes: a centrifugal disk including a centrifugal shaft and at least one centrifugal holder, with the centrifugal holder disposed annularly about the centrifugal shaft; and at least one magnetic block disposed on at least one side of the centrifugal holder, wherein the centrifugal holder detachably holds a reaction tube, and the reaction tube contains magnetic beads, wherein the magnetic beads move within the reaction tube under a force of the sum of a magnetic force of the magnetic block and a centrifugal force. Therefore, a reaction mixture is blended quickly and sufficiently to facilitate a reaction. With the magnetic beads adsorbing a product, a valve of the reaction tube opens under the centrifugal force to discharge a waste liquid and reduce consumption of consumables of the reaction tube.

公开(公告)号：US11709175B2

公开(公告)日：2023-07-25

申请号：US16650125

申请日：2018-09-21

Applicant: AXXIN PTY LTD

Inventor： William R. Hopper

IPC: G01N35/10 ,  C12N1/06 ,  C12Q1/68 ,  G01N1/28 ,  G01N35/00 ,  C12Q1/686 ,  G01N21/76

CPC classification number: G01N35/1009 ,  C12N1/06 ,  C12Q1/686 ,  G01N1/28 ,  G01N21/763 ,  G01N35/0098 ,  G01N2035/00277 ,  G01N2035/00346 ,  Y02A90/10

Abstract: A diagnostic test system, including: a diagnostic test assembly and a diagnostic test apparatus to perform a test on a biological or environmental sample; the diagnostic test assembly includes: a sample preparation reservoir to receive the sample into a sample preparation fluid, such that a swab carrying the sample can be used to stir the preparation fluid and to wash the swab; a sample dispensing mechanism for insertion into the sample preparation reservoir; a closure to seal the sample preparation reservoir; at least one diagnostic test reservoir coupled to the sample preparation reservoir; and at least one seal between the sample preparation reservoir and the diagnostic test reservoir to prevent fluid movement between the respective reservoirs; wherein the sample dispensing mechanism is operable to disrupt the seal to allow sample fluid to enter the diagnostic test reservoir from the sample preparation reservoir, and to dispense a predetermined amount of fluid.

公开(公告)号：US20230176062A1

公开(公告)日：2023-06-08

申请号：US18083279

申请日：2022-12-16

Applicant: Miltenyi Biotec B.V. & Co. KG

Inventor： Stefan Miltenyi ,  Winfried Schimmelpfennig ,  Holger Lantow ,  Niklas Elmar Neuschaefer ,  Martin Biehl ,  Eiad Kabaha ,  Juergen Schulz

IPC: G01N33/58 ,  A61M1/36 ,  B03C1/28 ,  B04B5/04 ,  B04B13/00 ,  B03C1/032 ,  B03C1/00 ,  B03C1/027 ,  B03C1/033 ,  B03C1/034 ,  A61M1/02 ,  G01N35/00 ,  C12N5/00 ,  C12M1/26 ,  C12M1/00 ,  B01D21/26 ,  B04B5/00 ,  B04B5/10 ,  B04B1/12 ,  B04B7/08 ,  B01D15/38 ,  C12N5/0789 ,  C12N5/077 ,  C12N5/0783 ,  C12M1/36

CPC classification number: G01N33/58 ,  A61M1/0209 ,  A61M1/3618 ,  A61M1/3633 ,  A61M1/3679 ,  A61M1/3692 ,  A61M1/3693 ,  A61M1/3696 ,  B01D15/3809 ,  B01D15/3885 ,  B01D21/26 ,  B03C1/002 ,  B03C1/027 ,  B03C1/032 ,  B03C1/034 ,  B03C1/288 ,  B03C1/0332 ,  B03C1/0335 ,  B04B1/12 ,  B04B5/00 ,  B04B5/04 ,  B04B5/10 ,  B04B5/0442 ,  B04B7/08 ,  B04B13/00 ,  C12M23/28 ,  C12M33/10 ,  C12M41/48 ,  C12M47/04 ,  C12N5/0018 ,  C12N5/0636 ,  C12N5/0646 ,  C12N5/0647 ,  C12N5/0669 ,  G01N35/0098 ,  B01L3/5021 ,  B03C2201/18 ,  B03C2201/26

Abstract: The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.