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公开(公告)号：US11535630B2
公开(公告)日：2022-12-27
申请号：US17082650
申请日：2020-10-28
Applicant: Research Triangle Institute
Inventor： Scott P. Runyon , Rangan Maitra , Sanju Narayanan , James Barnwell Thomas , Kenneth S. Rehder , Srinivas Olepu
IPC: C07D491/107 , C07D403/12 , C07D231/14 , C07D403/06 , C07D407/12 , C07D413/12 , A61K31/415 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/439 , A61K31/4439 , A61K31/454 , A61K31/497 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/04 , C07D413/04 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/08 , C07D487/08 , C07D403/04 , C07D403/14
Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
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公开(公告)号：US20160207889A1
公开(公告)日：2016-07-21
申请号：US15023510
申请日：2015-06-05
Applicant: Scott P. RUNYON , Rangan MAITRA , Sanju NARAYANAN , James Barnwell THOMAS , RESEARCH TRIANGLE INSTITUTE
Inventor： Scott P. Runyon , Rangan Maitra , Sanju Narayanan , James Barnwell Thomas
IPC: C07D231/14 , A61K45/06 , A61K31/415 , C07D405/12 , A61K31/422 , A61K31/454 , A61K31/4155 , A61K31/496 , C07D413/12
CPC classification number: C07D231/14 , A61K31/415 , A61K31/4155 , A61K31/422 , A61K31/454 , A61K31/496 , A61K45/06 , C07D403/06 , C07D403/12 , C07D405/12 , C07D407/12 , C07D413/12
Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
Abstract translation: 本公开涉及apelin受体（APJ）的激动剂和这种激动剂的用途。
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公开(公告)号：US11926612B2
公开(公告)日：2024-03-12
申请号：US16341597
申请日：2017-10-11
Applicant: Research Triangle Institute
Inventor： Scott P. Runyon , Rangan Maitra , Sanju Narayanan , Kenneth S. Rehder
IPC: C07D233/90 , C07D249/10 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D417/14
CPC classification number: C07D401/12 , C07D233/90 , C07D249/10 , C07D401/04 , C07D401/14 , C07D403/12 , C07D417/14
Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) with heterocyclic cores and uses of such agonists.
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公开(公告)号：USRE49594E1
公开(公告)日：2023-08-01
申请号：US16974363
申请日：2020-05-04
Applicant: Research Triangle Institute
Inventor： Scott P. Runyon , Rangan Maitra , Sanju Narayanan , James Barnwell Thomas , Kenneth S. Rehder , Srinivas Olepu
IPC: C07D491/107 , C07D403/12 , C07D231/14 , C07D403/06 , C07D407/12 , C07D413/12 , A61K31/415 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/439 , A61K31/4439 , A61K31/454 , A61K31/497 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/12 , C07D409/04 , C07D413/04 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/08 , C07D487/08
CPC classification number: C07D491/107 , A61K31/415 , A61K31/4196 , A61K31/422 , A61K31/427 , A61K31/4245 , A61K31/439 , A61K31/4439 , A61K31/454 , A61K31/497 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D231/14 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D407/12 , C07D409/04 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/08 , C07D487/08
Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
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公开(公告)号：US11267789B2
公开(公告)日：2022-03-08
申请号：US16448976
申请日：2019-06-21
Applicant: Research Triangle Institute
Inventor： Scott P. Runyon , Rangan Maitra , Sanju Narayanan , James Barnwell Thomas
IPC: C07D231/14 , C07D405/12 , A61K45/06 , A61K31/415 , A61K31/4155 , A61K31/422 , C07D403/12 , A61K31/496 , C07D413/12 , C07D407/12 , C07D403/06 , A61K31/454
Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
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Patent Agency Ranking
公开(公告)号：US09750738B2
公开(公告)日：2017-09-05
申请号：US14968258
申请日：2015-12-14
Applicant: RESEARCH TRIANGLE INSTITUTE
Inventor： Frank Ivy Carroll , Juan P. Cueva , James B. Thomas , S. Wayne Mascarella , Scott P. Runyon
IPC: A61K31/495 , A61K31/496 , C07D241/04 , C07D401/12 , C07D295/096
CPC classification number: A61K31/495 , A61K31/496 , C07D241/04 , C07D295/096 , C07D401/12
Abstract: Provided are opioid receptor antagonists represented by the formula (I): where R, Y3, R1, R2, R3, R4 and R5 are as defined herein.
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公开(公告)号：US10954247B2
公开(公告)日：2021-03-23
申请号：US15983519
申请日：2018-05-18
Applicant: Research Triangle Institute
Inventor： Scott P. Runyon , Rangan Maitra , Sanju Narayanan , James Barnwell Thomas , Kenneth S. Rehder , Srinivas Olepu
IPC: C07D491/107 , C07D403/04 , A61K31/5377 , C07D401/12 , C07D403/14 , C07D405/12 , C07D417/04 , C07D409/04 , C07D403/12 , C07D417/12 , C07D403/06 , C07D231/14 , C07D471/08 , C07D413/12 , C07D401/14 , C07D417/14 , A61K45/06 , C07D487/08 , C07D407/12 , A61K31/55 , A61K31/427 , A61K31/422 , A61K31/415 , A61K31/4245 , A61K31/4196 , A61K31/454 , A61K31/497 , A61K31/4439 , A61K31/439 , C07D413/04
Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
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公开(公告)号：US20190263781A1
公开(公告)日：2019-08-29
申请号：US16333849
申请日：2017-09-15
Applicant: Research Triangle Institute
Inventor： Frank Ivy Carroll , Chad M. Kormos , Pauline W. Ondachi , Scott P. Runyon , Hernan A. Navarro , James B. Thomas , S. Wayne Mascarella
IPC: C07D401/12 , C07D413/12 , A61P25/18 , A61P25/24 , A61P25/32 , A61P25/34 , A61P25/36 , C07D217/26 , C07D211/18
Abstract: Potent opioid receptor antagonists of formula (I) and their use as pharmacotherapies for treating depression, anxiety, schizophrenia, eating disorders, and addiction to cocaine, methamphetamine, nicotine, alcohol, and opiates are disclosed. More specifically, the disclosure provides potent and selective kappa opioid receptor antagonist compounds, pharmaceutical compositions of those compounds and uses of those compounds to ameliorate or treat addictions, eating disorders, etc.
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9.发明授权公开(公告)号：US09512105B2
公开(公告)日：2016-12-06
申请号：US14364003
申请日：2012-12-10
Applicant: RESEARCH TRIANGLE INSTITUTE
Inventor： Frank I. Carroll , James B. Thomas , Hernan A. Navarro , S. Wayne Mascarella , Scott P. Runyon , Chunyang Jin , Chad M. Kormos
IPC: C07D241/04 , C07D401/12 , C07D295/13
CPC classification number: C07D401/12 , C07D241/04 , C07D295/13
Abstract: Provided are compounds represented by the formula: where R, Y3, R1, R2, R3, R4, R6, G, R7, E1, E2, A, B, W, X, Y and Z are as defined herein.
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公开(公告)号：US10100059B2
公开(公告)日：2018-10-16
申请号：US15374386
申请日：2016-12-09
Applicant: Research Triangle Institute
Inventor： Scott P. Runyon , Rangan Maitra , Sanju Narayanan , James Barnwell Thomas , Kenneth S. Rehder , Srinivas Olepu
IPC: C07D491/107 , C07D231/14 , C07D401/12 , C07D401/14 , C07D487/08 , C07D405/12 , C07D417/12 , C07D413/12 , C07D409/04 , C07D403/04 , C07D413/04 , C07D417/04 , C07D403/14 , C07D403/12 , C07D471/08 , A61K45/06 , A61K31/454 , A61K31/415 , A61K31/5377 , A61K31/497 , A61K31/4439 , A61K31/55 , A61K31/427 , A61K31/422 , C07D417/14 , A61K31/4196 , A61K31/4245 , A61K31/439
Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
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