公开(公告)号：US3644382A

公开(公告)日：1972-02-22

申请号：US3644382D

申请日：1969-03-18

Applicant: ROUSSEL UCLAF

Inventor： CLEMENCE FRANCOIS ,  MARTRET ODILE LE

IPC: C07D213/82 ,  C07D235/06 ,  C07D235/08 ,  C07D235/18 ,  C07D307/68 ,  C07D333/38 ,  C07D49/38

CPC classification number: C07D213/82 ,  C07D235/06 ,  C07D235/08 ,  C07D235/18 ,  C07D307/68 ,  C07D333/38

Abstract: BENZIMIDAZOLES OF THE FORMULA

1-(2-R-PHENYL),2-R1,5-X'',6-X-BENZMIDAZOLE

WHERIN X AND X'' MAY BE DIFFERENT AND ARE SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, HALOGEN, ALKYL, ALKOXY, TRIHALOMETHYL AND NITRO, R IS SELECTED FROM THE GROUP CONSISTING OF -COOH, -COOR'', AND

-CO-N(-A)-B

R'' IS SELECTED FROM THE GROUP CONSISTING OF ALIPHATIC AND HHDROXYLATED RESIDUE OF A GLYCOL, A AND B ARE SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND OPTIONALLY SUBSTITUTED ALIPHATIC AND R1 IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, LOWER ALIPHATIC HDROCARBON, UNSUBSTITUTED AND POLYSUBSTITUTED ARYL, ARYLALIPHATIC, A THIENYL, A B-PYRIDYL AND A FURYL WITH THE PROVISO THAT WHEN R1 IS PHENYL, X'' AND X ARE OTHER THAN HALOGEN, ALKOXY AND TRIFLUROMETHYL WHICH COMPOUNDS POSSESS ANTI-INFLAMMATORY AND ANTIVIRAL ACTIVITY AND A NOVEL PROCESS FOR THEIR PREPARATION.

公开(公告)号：US3700677A

公开(公告)日：1972-10-24

申请号：US3700677D

申请日：1969-07-15

Applicant: ROUSSEL UCLAF

Inventor： CLEMENCE FRANCOIS ,  MARTRET ODILE LE

IPC: C07D277/32 ,  C07D277/56 ,  C07D491/04 ,  C07D91/32

CPC classification number: C07D491/04 ,  C07D277/56

Abstract: 5-THIAZOL CARBOXYLATES OF THE FORMULA WHEREIN R is an alkali-metal atom, the residue of an organic base or the alkyl radical of an aliphatic, arylaliphatic or alkylheterocyclic alcohol having hypolipemiant activity and their preparation.

Abstract translation: 其中R为碱金属原子的有机碱的残基或具有低活性活性的脂族，芳基脂族或烷基杂环醇的烷基的制备方法及其制备方法制备的5-噻唑羧酸酯。

公开(公告)号：US3668238A

公开(公告)日：1972-06-06

申请号：US3668238D

申请日：1968-09-25

Applicant: ROUSSEL UCLAF

Inventor： CLEMENCE FRANCOIS ,  MARTRET ODILE LE

IPC: C07D295/192 ,  C07C69/02

CPC classification number: C07D295/192

Abstract: WHEREIN R is selected from the group consisting of hydrogen, alkyl of one to seven carbon atoms and acyl of an organic carboxylic acid of one to 18 carbon atoms, R1 and R2 are selected from the group consisting of hydrogen, substituted and unsubstituted alkyl of one to seven carbon atoms, aryl and cycloalkyl and when taken together with the nitrogen atom form a heterocyclic which may contain another heteroatom, which products possess outstanding choleretic properties far superior to dehydrocholic acid. The invention also relates to a novel process and novel intermediate for the preparation of the said benzamides of Formula I.

An amide of 2-hydroxy-3-methoxy-5-allyl-benzoic acid of the formula

Abstract translation: 式WHEREIN R的2-羟基-3-甲氧基-5-烯丙基 - 苯甲酸的酰胺选自氢，1至7个碳原子的烷基和1至18个碳原子的有机羧酸的酰基 原子，R 1和R 2选自氢，取代和未取代的1至7个碳原子的烷基，芳基和环烷基，并且当与氮原子一起形成可含有另外杂原子的杂环时，该产物具有优异的胆固醇 性质远优于脱氢胆酸。 本发明还涉及用于制备所述式I的苯甲酰胺的新方法和新型中间体。