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1.发明授权Imaging platform for nanoparticle detection applied to SPR biomolecular interaction analysis 失效用于纳米颗粒检测的成像平台应用于SPR生物分子相互作用分析公开(公告)号：US07057732B2
公开(公告)日：2006-06-06
申请号：US10788971
申请日：2004-02-27
IPC分类号： G01N21/55
CPC分类号： G01N21/658 , B82Y15/00 , B82Y20/00 , G01J3/2803 , G01J3/2823 , G01N15/1434 , G01N15/147 , G01N21/554 , G01N21/6428 , G01N21/648 , G01N21/85 , G01N33/54346 , G01N2015/0294 , G01N2015/1006 , G01N2015/1472 , G01N2015/1486 , G01N2021/052 , G01N2021/058 , G01N2021/258 , G02B7/28 , G02B27/1013
摘要： A flow imaging system is used to implement surface plasmon resonance (SPR) detection to study bio-molecular interactions. The flow imaging system is used to capture SPR absorption spectra of large numbers of objects, where each object includes both a metal film capable of exhibiting SPR, and detecting molecules. Analyte molecules are added to a solution of such objects, and the result is introduced into the flow imaging system which collects full SPR spectral data from individual objects. The objects can be nanoparticles or larger particles that support metal island films. The SPR spectral data can be used to determine specificity, kinetics, affinity, and concentration with respect to the interactions between the detecting molecules and the analyte molecules.
摘要翻译： 流动成像系统用于实现表面等离子体共振（SPR）检测，以研究生物分子相互作用。 流动成像系统用于捕获大量物体的SPR吸收光谱，其中每个物体都包含能够显示SPR的金属膜和检测分子。 将分析物分子加入到这些物体的溶液中，并将结果引入到从各个物体收集完整的SPR光谱数据的流动成像系统中。 物体可以是支撑金属岛膜的纳米颗粒或更大的颗粒。 SPR光谱数据可用于确定相对于检测分子和分析物分子之间的相互作用的特异性，动力学，亲和力和浓度。
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2.发明授权Imaging platform for nanoparticle detection applied to SPR biomolecular interaction analysis 失效用于纳米颗粒检测的成像平台应用于SPR生物分子相互作用分析公开(公告)号：US07221457B2
公开(公告)日：2007-05-22
申请号：US11379972
申请日：2006-04-24
IPC分类号： G01N21/55
CPC分类号： G01N21/658 , B82Y15/00 , B82Y20/00 , G01J3/2803 , G01J3/2823 , G01N15/1434 , G01N15/147 , G01N21/554 , G01N21/6428 , G01N21/648 , G01N21/85 , G01N33/54346 , G01N2015/0294 , G01N2015/1006 , G01N2015/1472 , G01N2015/1486 , G01N2021/052 , G01N2021/058 , G01N2021/258 , G02B7/28 , G02B27/1013
摘要： A flow imaging system is used to implement surface plasmon resonance (SPR) detection to study bio-molecular interactions. The flow imaging system is used to capture SPR absorption spectra of large numbers of objects, where each object includes both a metal film capable of exhibiting SPR, and detecting molecules. Analyte molecules are added to a solution of such objects, and the result is introduced into the flow imaging system which collects full SPR spectral data from individual objects. The objects can be nanoparticles or larger particles that support metal island films. The SPR spectral data can be used to determine specificity, kinetics, affinity, and concentration with respect to the interactions between the detecting molecules and the analyte molecules.
摘要翻译： 流动成像系统用于实现表面等离子体共振（SPR）检测，以研究生物分子相互作用。 流动成像系统用于捕获大量物体的SPR吸收光谱，其中每个物体都包含能够显示SPR的金属膜和检测分子。 将分析物分子加入到这些物体的溶液中，并将结果引入到从各个物体收集完整的SPR光谱数据的流动成像系统中。 物体可以是支撑金属岛膜的纳米颗粒或更大的颗粒。 SPR光谱数据可用于确定相对于检测分子和分析物分子之间的相互作用的特异性，动力学，亲和力和浓度。
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公开(公告)号：US5647030A
公开(公告)日：1997-07-08
申请号：US584960
申请日：1996-01-11
CPC分类号： G01N21/7703 , G01N21/553 , G01N2021/433
摘要： There is disclosed fiber optic sensor which detects a sample in contact with the sensor by surface plasmon resonance (SPR) measurements, as well as methods and apparatus relating thereto. The fiber optic SPR sensor of this invention employs a limited range of incident angles and uses incident light having multiple wavelengths. In preferred embodiments, both an in-line transmission-based fiber optic SPR sensor and a terminated reflection-based fiber optic SPR sensor are disclosed. The fiber optic SPR sensor includes a surface plasmon supporting metal layer in contact with an exposed portion of the optical fiber core, and may optionally contain one or more additional layers deposited on the surface plasmon supporting metal layer. In further embodiments, methods are disclosed for detecting a sample by contacting the sample with the fiber optic SPR sensor of this invention, as well as sensing apparatus which contain the fiber optic SPR sensor in combination with a source of electromagnetic radiation of multiple wavelengths and a detection device.
摘要翻译： 公开了通过表面等离子共振（SPR）测量来检测与传感器接触的样品的光纤传感器以及与其相关的方法和装置。 本发明的光纤SPR传感器采用有限范围的入射角并使用具有多个波长的入射光。 在优选实施例中，公开了基于在线传输的光纤SPR传感器和端接的基于反射的光纤SPR传感器。 光纤SPR传感器包括与光纤芯的暴露部分接触的表面等离子体支撑金属层，并且可任选地包含沉积在表面等离子体支撑金属层上的一个或多个附加层。 在另外的实施例中，公开了用于通过使样品与本发明的光纤SPR传感器接触来检测样品的方法，以及包含与多个波长的电磁辐射源组合的光纤SPR传感器的感测装置，以及 检测装置
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公开(公告)号：US5359681A
公开(公告)日：1994-10-25
申请号：US3224
申请日：1993-01-11
CPC分类号： G01N21/7703 , G01N21/553 , G01N2021/433
摘要： There is disclosed fiber optic sensor which detects a sample in contact with the sensor by surface plasmon resonance (SPR) measurements, as well as methods and apparatus relating thereto. The fiber optic SPR sensor of this invention employs a limited range of incident angles and uses incident light having multiple wavelengths. In preferred embodiments, both an in-line transmission-based fiber optic SPR sensor and a terminated reflection-based fiber optic SPR sensor are disclosed. The fiber optic SPR sensor includes a surface plasmon supporting metal layer in contact with an exposed portion of the optical fiber core, and may optionally contain one or more additional layers deposited on the surface plasmon supporting metal layer. In further embodiments, methods are disclosed for detecting a sample by contacting the sample with the fiber optic SPR sensor of this invention, as well as sensing apparatus which contain the fiber optic SPR sensor in combination with a source of electromagnetic radiation of multiple wavelengths and a detection device.
摘要翻译： 公开了通过表面等离子体共振（SPR）测量来检测与传感器接触的样品的光纤传感器以及与其相关的方法和装置。 本发明的光纤SPR传感器采用有限范围的入射角并使用具有多个波长的入射光。 在优选实施例中，公开了基于在线传输的光纤SPR传感器和端接的基于反射的光纤SPR传感器。 光纤SPR传感器包括与光纤芯的暴露部分接触的表面等离子体支撑金属层，并且可任选地包含沉积在表面等离子体支撑金属层上的一个或多个附加层。 在另外的实施例中，公开了用于通过使样品与本发明的光纤SPR传感器接触来检测样品的方法，以及包含与多个波长的电磁辐射源组合的光纤SPR传感器的感测装置，以及 检测装置
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公开(公告)号：US5835645A
公开(公告)日：1998-11-10
申请号：US806268
申请日：1997-02-25
CPC分类号： G01N21/7703 , G01N21/553 , G01N2021/433
摘要： There is disclosed fiber optic sensor which detects a sample in contact with the sensor by surface plasmon resonance (SPR) measurements, as well as methods and apparatus relating thereto. The fiber optic SPR sensor of this invention employs a limited range of incident angles and uses incident light having multiple wavelengths. In preferred embodiments, both an in-line transmission-based fiber optic SPR sensor and a terminated reflection-based fiber optic SPR sensor are disclosed. The fiber optic SPR sensor includes a surface plasmon supporting metal layer in contact with an exposed portion of the optical fiber core, and may optionally contain one or more additional layers deposited on the surface plasmon supporting metal layer. In further embodiments, methods are disclosed for detecting a sample by contacting the sample with the fiber optic SPR sensor of this invention, as well as sensing apparatus which contain the fiber optic SPR sensor in combination with a source of electromagnetic radiation of multiple wavelengths and a detection device.
摘要翻译： 公开了通过表面等离子体共振（SPR）测量来检测与传感器接触的样品的光纤传感器以及与其相关的方法和装置。 本发明的光纤SPR传感器采用有限范围的入射角并使用具有多个波长的入射光。 在优选实施例中，公开了基于在线传输的光纤SPR传感器和端接的基于反射的光纤SPR传感器。 光纤SPR传感器包括与光纤芯的暴露部分接触的表面等离子体支撑金属层，并且可任选地包含沉积在表面等离子体支撑金属层上的一个或多个附加层。 在另外的实施例中，公开了用于通过使样品与本发明的光纤SPR传感器接触来检测样品的方法，以及包含与多个波长的电磁辐射源组合的光纤SPR传感器的感测装置，以及 检测装置
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