公开(公告)号：US20180315880A1

公开(公告)日：2018-11-01

申请号：US15735662

申请日：2016-06-14

申请人： UNIVERSITY OF MARYLAND, COLLEGE PARK

发明人： MOHAMMAD M. JADIDI ,  ANDREI B. SUSHKOV ,  DAVID KURT GASKILL ,  MICHAEL FUHRER ,  HOWARD DENNIS DREW ,  THOMAS E. MURPHY

IPC分类号： H01L31/09 ,  G01N21/3581

CPC分类号： H01L31/09 ,  G01N21/3581 ,  G01N2021/258 ,  H01G9/2045 ,  Y02E10/542

摘要： A new approach to graphene-enabled plasmonic resonant structures in the THz is demonstrated in a hybrid graphene-metal design in which the graphene acts as a gate-tunable inductor, and metal acts as a capacitive reservoir for charge accumulation. A large resonant absorption in graphene can be achieved using the metal-graphene plasmonic scheme, and the peak can approach 100% in an optimized device, ideal for graphene-based THz detectors. Using high mobility graphene (μ>50000 cm2V−1s−1) will allow anomalously high resonant THz transmission (near 100%) through ultra-subwavelength graphene-filled metallic apertures at a resonance frequency that is gate tunable. This metal-graphene plasmonic scheme enables near perfect tunable THz filter or modulator.

公开(公告)号：US09677936B2

公开(公告)日：2017-06-13

申请号：US14707537

申请日：2015-05-08

申请人： SAMSUNG ELECTRONICS CO., LTD.

发明人： Seunghoon Han ,  Hongkyu Park ,  Moonsook Lee ,  Seongho Cho

IPC分类号： G01J3/00 ,  G01J3/28 ,  G01J3/44 ,  B82Y15/00 ,  G01N21/552 ,  G01N21/64 ,  G01N21/65 ,  G01J3/36 ,  B82Y20/00 ,  B82Y30/00 ,  G01N21/25

CPC分类号： G01J3/28 ,  B82Y15/00 ,  B82Y20/00 ,  B82Y30/00 ,  G01J3/36 ,  G01J3/44 ,  G01J3/4412 ,  G01N21/554 ,  G01N21/648 ,  G01N21/658 ,  G01N2021/258 ,  Y10S977/953

摘要： Provided is a spectro-sensor which includes a nano antenna array. The nano antenna array includes a plurality of nano antennas which have different resonance wavelength bands and an optical detector array which includes a plurality of optical detectors that respectively detect light from the plurality of nano antennas.

公开(公告)号：US09322830B2

公开(公告)日：2016-04-26

申请号：US14258932

申请日：2014-04-22

申请人： Bio-Rad Laboratories, Inc.

发明人： Fredrik Hook ,  Magnus Branden ,  Seyed Tabaei

IPC分类号： G01N21/41 ,  G01N21/552 ,  G01N33/68 ,  G01N33/543 ,  G01N33/50 ,  G01N21/21 ,  G01N21/25

CPC分类号： G01N33/68 ,  G01N21/211 ,  G01N21/41 ,  G01N21/553 ,  G01N33/50 ,  G01N33/5432 ,  G01N33/54353 ,  G01N33/54373 ,  G01N33/6872 ,  G01N33/92 ,  G01N2021/258 ,  G01N2333/43565 ,  G01N2500/00

摘要： The present invention provides a method for studying transport of an agent across a membrane comprising the steps a) providing at least one surface with a bilayer structure tethered to the surface, said bilayer structure comprising a detection volume, b) contacting the bilayer with at least one agent to be analyzed, and c) detecting a change in refractive index in the detection volume resulting from transportation of the agent across the membrane. Further there is provided a device comprising a) at least one surface, b) at least one bilayer structure tethered to the surface, and c) at least one sensor capable of detecting a change in refractive index in a detection volume, wherein the bilayer structure encloses a first volume of the detection volume and wherein the volume not enclosed by the bilayer structure but within the detection volume is a second volume and wherein the ratio between the first volume and second volume is above about 0.001.

摘要翻译： 本发明提供一种用于研究试剂穿过膜的输送的方法，包括以下步骤：a）提供至少一个表面，其具有与表面结合的双层结构，所述双层结构包含检测体积，b）使所述双层与至少 一种要分析的试剂，以及c）检测由所述试剂穿过所述膜的运输导致的检测体积中的折射率的变化。 此外，提供了一种装置，其包括：a）至少一个表面，b）与该表面连接的至少一个双层结构，以及c）至少一个能够检测检测体积中的折射率变化的传感器，其中双层结构 包围检测体积的第一体积，并且其中未被双层结构包围但在检测体积内的体积是第二体积，并且其中第一体积和第二体积之间的比率高于约0.001。

公开(公告)号：US20130168543A1

公开(公告)日：2013-07-04

申请号：US13701769

申请日：2011-06-02

申请人： Andrew R. Barron ,  Samuel J. Maguire-Boyle ,  Alvin W. Orbaek

发明人： Andrew R. Barron ,  Samuel J. Maguire-Boyle ,  Alvin W. Orbaek

IPC分类号： G01V8/02

CPC分类号： G01V8/02 ,  G01N30/74 ,  G01N33/24 ,  G01N2015/0693 ,  G01N2021/258

摘要： A transport of plasmonic particles through a mineral formation is analyzed by flowing a plasmonic particles solution through an immobile phase (e.g., a mineral formation), determining an absorbance of the plasmonic particles solution subsequent to flowing the plasmonic particles solution through the immobile phase, comparing the determined absorbance of the plasmonic particles solution with an absorbance of the plasmonic particles solution determined previous to flowing the plasmonic particles solution through the immobile phase, and determining an absorbance of the plasmonic particles to the immobile phase as a function of the comparison. The plasmonic particles solution may be produced by dissolving or suspending plasmonic particles in a mobile phase. Flowing the plasmonic particles solution through the immobile phase may include injecting the plasmonic particles solution into the immobile phase, and then flushing the plasmonic particles solution through the immobile phase.

摘要翻译： 通过使等离子体颗粒溶液流过固定相（例如矿物形成）来分析通过矿物形成的等离子体激元粒子的运输，确定等离子体激元粒子溶液在使等离子体激元粒子溶液流过固定相后的吸光度，比较 所述等离子体激元粒子溶液的吸光度与先前将等离子体激元粒子溶液流过固定相所确定的等离子体激元粒子溶液的吸光度，以及根据比较确定等离子体激元粒子与固定相的吸光度。 等离子体颗粒溶液可以通过将等离子体激元粒子溶解或悬浮在流动相中来制备。 将等离子体激元颗粒溶液流过固定相可包括将等离子体激元颗粒溶液注入固定相，然后通过固定相冲洗等离子体颗粒溶液。

公开(公告)号：US08164755B2

公开(公告)日：2012-04-24

申请号：US13232794

申请日：2011-09-14

申请人： Iwijn De Vlaminck ,  Pol Van Dorpe ,  Liesbet Lagae

发明人： Iwijn De Vlaminck ,  Pol Van Dorpe ,  Liesbet Lagae

IPC分类号： G01N21/55

CPC分类号： G01N21/554 ,  B82Y15/00 ,  G01N2021/258

摘要： In one aspect of the invention, a method or apparatus is described for determining concentration(s) of one or more analytes in a sample using plasmonic excitations. In another aspect, a method relates to designing systems for such concentration determination, wherein metallic nanostructures are used in combination with local electrical detection of such plasmon resonances via a semiconducting photodetector. In certain aspects, the method exploits the coupling of said metallic nanostructure(s) to a semiconducting photodetector, said detector being placed in the “metallic structure's” near field. Surface plasmon excitation can be transduced efficiently into an electrical signal through absorption of light that is evanescently coupled or scattered in a semiconductor volume. This local detection technique allows the construction of sensitive nanoscale bioprobes and arrays thereof.

摘要翻译： 在本发明的一个方面，描述了一种用于使用等离子体激发来测定样品中一种或多种分析物的浓度的方法或装置。 在另一方面，一种方法涉及设计用于这种浓度测定的系统，其中金属纳米结构经由半导体光电检测器与这种等离子体共振的局部电检测结合使用。 在某些方面，该方法利用所述金属纳米结构与半导体光电检测器的耦合，所述检测器被放置在“金属结构”的近场中。 表面等离子体激发可以通过吸收在半导体体积中瞬时耦合或散射的光而有效地转换成电信号。 这种局部检测技术允许构建敏感的纳米级生物探针及其阵列。

公开(公告)号：US08043868B2

公开(公告)日：2011-10-25

申请号：US11555544

申请日：2006-11-01

申请人： Filip Frederix ,  Kristien Bonroy

发明人： Filip Frederix ,  Kristien Bonroy

IPC分类号： G01N33/543

CPC分类号： G01N33/54346 ,  B82Y15/00 ,  B82Y30/00 ,  B82Y40/00 ,  G01N21/554 ,  G01N21/648 ,  G01N2021/258

摘要： A method for determining a concentration of an analyte is provided. The method includes providing a substrate including a conductive region and a recognition layer where the conductive region has a first surface operatively coupled with the recognition layer; The method also includes contacting the substrate with the sample to bind at least some of the analyte that may present in the sample with the recognition layer; The method further includes directing radiation through the conductive region and the recognition layer, where the conductive region comprises at least one particle and a combination of the at least one particle effect when the radiation is directed through the conductive region and the recognition layer; The method still further includes measuring at least a part of a spectrum of the radiation that is absorbed or transmitted by or through the substrate, the at least part of the spectrum being related to one or more of the at least one particle effects; The method further includes determining a change of the at least part of the spectrum as compared with a reference spectrum and determining the concentration of the analyte from the change.

摘要翻译： 提供了一种用于确定分析物浓度的方法。 该方法包括提供包括导电区域和识别层的衬底，其中导电区域具有可操作地与识别层耦合的第一表面; 该方法还包括使基底与样品接触以将可能存在于样品中的至少一些分析物与识别层结合; 该方法还包括引导辐射穿过导电区域和识别层，其中当辐射被引导通过导电区域和识别层时，导电区域包括至少一个颗粒和至少一个颗粒效应的组合; 该方法还包括测量被衬底或通过衬底吸收或透过的辐射光谱的至少一部分，该光谱的至少部分与至少一种或多种颗粒效应有关; 该方法还包括与参考光谱相比确定光谱的至少部分的变化，并确定来自变化的分析物的浓度。

公开(公告)号：US07659987B2

公开(公告)日：2010-02-09

申请号：US11659717

申请日：2005-09-14

申请人： Norihiko Utsunomiya ,  Mitsuro Sugita ,  Satoru Nishiuma ,  Takao Yonehara

发明人： Norihiko Utsunomiya ,  Mitsuro Sugita ,  Satoru Nishiuma ,  Takao Yonehara

IPC分类号： G01N21/00

CPC分类号： G01N21/554 ,  G01N21/648 ,  G01N2021/258 ,  G01N2201/0635 ,  G01N2201/0636

摘要： An information-acquiring device for acquiring information on an objective substance to be detected, which is provided with a sensing element that has a surface capable of fixing the objective substance to be detected thereon, and makes applied light change its wavelength characteristics in response to the fixed state of the objective substance to be detected onto the surface, a light source, and light-receiving means for receiving light emitted from the light source through the sensing element, has the light-receiving means and the light source arranged on the same substrate so that the light which has been emitted from the light source and has been transmitted through the sensing element can be led to the light-receiving means, and has means for varying the wavelength regions of each light incident on each of a plurality of the light-receiving means installed in an optical path from the light source to the light-receiving means.

摘要翻译： 一种信息获取装置，用于获取关于待检测的物质的信息，该信息获取装置设置有具有能够固定待检测的物体的表面的感测元件，并且使得施加的光响应于该检测元件的波长特性而改变其 要检测的目标物质的固定状态，光源和用于接收通过感测元件从光源发射的光的光接收装置，其中光接收装置和光源布置在同一基板上 使得已经从光源发射并已经透射通过感测元件的光可以被引导到光接收装置，并且具有用于改变入射到多个光中的每一个的每个光的波长区域的装置 - 接收装置安装在从光源到光接收装置的光路中。

公开(公告)号：US20070206194A1

公开(公告)日：2007-09-06

申请号：US11677890

申请日：2007-02-22

申请人： Tomohiro Yamada ,  Yoichiro Handa

发明人： Tomohiro Yamada ,  Yoichiro Handa

IPC分类号： G01N21/55 ,  B32B27/04

CPC分类号： G01N21/554 ,  G01N2021/258

摘要： Even when only a few antigens exist in a specimen, a change in a dielectric constant and a change in an optical spectrum accompanied thereto in the periphery of a conductive member are made larger, so that sensing at high sensitivity can be performed. A structure including a protrusion including a dielectric material protruded on a substrate and a conductive member provided on a first surface of the protrusion, in which the maximum value of the cross-sectional area in the cross-section in parallel with a first surface of the conductive member is larger than the area of the first surface.

摘要翻译： 即使在试样中只存在少量抗原，导电性部件的周围的介电常数的变化和伴随其的光谱的变化也变大，可以进行高灵敏度的感测。 一种结构，其特征在于，具有包括突出在基板上的介电材料的突起和设置在所述突起的第一面上的导电性部件，所述突起的横截面积的最大值与所述突起的第一面平行的截面积的最大值 导电构件比第一表面的面积大。

公开(公告)号：US20060269966A1

公开(公告)日：2006-11-30

申请号：US11441076

申请日：2006-05-26

申请人： Tetsuro Miyamoto ,  Mami Hakari ,  Shigenori Togashi

发明人： Tetsuro Miyamoto ,  Mami Hakari ,  Shigenori Togashi

IPC分类号： G01N33/53 ,  C12M1/34

CPC分类号： G01N21/554 ,  G01N21/274 ,  G01N21/314 ,  G01N2021/258 ,  G01N2021/3148

摘要： Biomolecular and other interactions are analyzed with a simpler construction. A biotic sample is fixed to noble metal nanoparticles, and light is irradiated from a light source to the noble metal nanoparticles through an optical fiber. Light obtained after reflection of the irradiated light by the noble metal nanoparticles is introduced to one or more optical detecting units through another optical fiber. The optical detecting unit(s) separately measure the intensity of the input light in a second band including a maximum absorption wavelength, a first band covering a longer wavelength range than the range covered by the second band, and a third band covering a shorter wavelength range than the range covered by the second band.

摘要翻译： 用更简单的结构分析生物分子和其他相互作用。 将生物样品固定在贵金属纳米粒子上，通过光纤将光从光源照射到贵金属纳米粒子上。 通过贵金属纳米颗粒反射照射光后获得的光通过另一光纤被引入一个或多个光学检测单元。 光学检测单元分别测量包括最大吸收波长的第二波段中的输入光的强度，覆盖比由第二波段覆盖的范围更长的波长范围的第一波段和覆盖较短波长的第三波段 范围超过第二频带覆盖的范围。

公开(公告)号：US20050168745A1

公开(公告)日：2005-08-04

申请号：US11029023

申请日：2005-01-05

申请人： Masayuki Naya

发明人： Masayuki Naya

IPC分类号： G01N21/27 ,  B82Y15/00 ,  G01N21/41 ,  G01N33/543 ,  G01N33/553 ,  G01N21/55

CPC分类号： G01N21/554 ,  G01N33/54346 ,  G01N33/54373 ,  G01N2021/258

摘要： A fine structure body comprising first fine metal particles, which have head regions projected upwardly from a surface of a base body, is utilized. A substance capable of undergoing specific binding with a test body is fixed to the head regions of the first fine metal particles. Second fine metal particles, to which a substance capable of undergoing specific binding with the test body has been fixed, are dispersed in a sample liquid. The test body is detected from variation of a resonance wavelength of localized plasmon resonance, which variation occurs when the test body is adsorbed to the surface of the fine structure body by being sandwiched between the substance fixed to the first fine metal particle and the substance fixed to the second fine metal particle.

摘要翻译： 利用具有从基体的表面向上突出的头部区域的第一细小金属颗粒的精细结构体。 能够与试验体进行特异性结合的物质固定在第一金属微粒的头部区域。 将能够与试验体进行特异性结合的物质固定在其上的第二金属微粒分散在样品液中。 通过局部等离子体共振的共振波长的变化来检测测试体，当通过夹在固定到第一金属微粒的物质和固定的物质之间而将测试体吸附到微细结构体的表面时发生变化 到第二细金属颗粒。