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公开(公告)号：US6159240A
公开(公告)日：2000-12-12
申请号：US144374
申请日：1998-08-31
申请人： Randall V. Sparer , Darrel F. Untereker , Elizabeth A. Ebner , Thomas P. Grailer , Brett R. Vegoe , Hong S. Shim , Carlos M. G. Duran
发明人： Randall V. Sparer , Darrel F. Untereker , Elizabeth A. Ebner , Thomas P. Grailer , Brett R. Vegoe , Hong S. Shim , Carlos M. G. Duran
CPC分类号： A61F2/2445 , A61F2/2448 , A61L31/048 , A61L31/06 , A61L31/12 , A61L31/14
摘要： A band-shaped annuloplasty device (e.g., C- or D-shaped ring) that is relatively rigid during handling and implantation and becomes relatively complaint after implantation. Preferably, the device includes a core material that softens after implantation.
摘要翻译： 在处理和植入期间相对刚性并且在植入后变得相对抱怨的带状瓣环成形术装置（例如，C形或D形环）。 优选地，该装置包括在植入后软化的芯材料。
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2.发明授权公开(公告)号：US06491511B1
公开(公告)日：2002-12-10
申请号：US09418675
申请日：1999-10-14
申请人： Carlos M. G. Duran , Joon Hock Yeo
发明人： Carlos M. G. Duran , Joon Hock Yeo
IPC分类号： A61F224
CPC分类号： A61F2/2496 , A61F2/2412 , A61F2/2415 , A61F2240/002
摘要： A pair of templates form a mold for substantially flat biological membranes to shape the membrane into a configuration that, after trimming of excess tissue, is adapted for forming a replacement aortic, pulmonary, tricuspid or mitral heart valve. Each template has three members joined to another laterally, with each member configured to form, together with its mating member, the mold for one leaflet or cusp of the replacement heart valve. The negative template has concave surfaces for each member and the positive template has convex surfaces which mate with the concave surfaces of the first template. Each of the templates is made of thin, shell like material and has beveled edges. The biological membrane is placed between the mating convex and concave surfaces of the two templates assembled to one another to form the membrane into the configuration of the three leaflets of the replacement heart valve.
摘要翻译： 一对模板形成用于基本平坦的生物膜的模具，以将膜成形为在修剪多余组织之后适于形成替代主动脉，肺，三尖瓣或二尖瓣心脏瓣膜的构型。 每个模板具有三个连接到另一侧的构件，每个构件被配置成与其配合构件一起形成用于替换心脏瓣膜的一个叶片或尖瓣的模具。 负模板对于每个构件具有凹面，并且正模板具有与第一模板的凹面配合的凸面。 每个模板由薄的壳状材料制成，并具有斜边。 将生物膜放置在彼此组装的两个模板的配合凸和凹表面之间，以将膜形成为置换心脏瓣膜的三个小叶的构型。
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公开(公告)号：US5489297A
公开(公告)日：1996-02-06
申请号：US333553
申请日：1994-11-02
申请人： Carlos M. G. Duran
发明人： Carlos M. G. Duran
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2/06 , A61F2210/0004 , A61F2220/0075 , Y10S623/90
摘要： The invention relates to a bioprosthetic heart valve having leaflets affixed to a substantially absorpable stent. The leaflets can be derived from a biological membrane which is affixed to the absorbable stent. The leaflets can also be derived from a sigmoid valve of human or animal origin, the sigmoid valve being placed inside the absorbable stent and affixed thereto. Methods of treatment using the bioprosthetic heart valve and methods of making the valve are also provided.
摘要翻译： 本发明涉及一种生物假体心脏瓣膜，其具有固定到基本上可吸收的支架上的小叶。 小叶可以来自固定在可吸收支架上的生物膜。 小叶也可以从人或动物来源的乙状结肠瓣获得，乙状结肠瓣置于可吸收支架内并固定在其上。 还提供了使用生物假体心脏瓣膜的治疗方法和制造瓣膜的方法。
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4.发明授权公开(公告)号：US06630001B2
公开(公告)日：2003-10-07
申请号：US09103874
申请日：1998-06-24
IPC分类号： A61F202
CPC分类号： A61L27/3691 , A61L27/3604 , A61L27/3687 , Y10S623/915 , Y10S623/917
摘要： A process for preparing pliable soft tissue specimen which are resistant to cracking and devoid of viable cells includes the steps of treating native soft tissue obtained from a donor by a gradually increasing gradient of aliphatic alcohol or other suitable water miscible polar organic solvent until the last alcohol (or other solvent) solution has at least 25% by volume of the organic liquid. Thereafter, the tissue specimen is treated with a solution containing glycerol or low molecular weight (
摘要翻译： 用于制备耐破裂和没有活细胞的柔韧软组织标本的方法包括以下步骤：通过逐渐增加的脂族醇或其它合适的水混溶性极性有机溶剂的梯度处理从供体获得的天然软组织，直到最后的醇 （或其它溶剂）溶液具有至少25体积％的有机液体。 此后，用含有甘油或低分子量（<1000D）聚乙二醇的溶液和分子量约6,000至15,000D的聚乙二醇和肝素处理组织标本。 此后，将组织标本短暂地浸入肝素水溶液中，冷冻并冻干。 组织标本适合作为同种移植物或异种移植物植入，有或没有补液。
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公开(公告)号：US06358277B1
公开(公告)日：2002-03-19
申请号：US09598630
申请日：2000-06-21
申请人： Carlos M. G. Duran
发明人： Carlos M. G. Duran
IPC分类号： A61F224
CPC分类号： A61F2/2496 , A61F2/2412 , A61F2/2457
摘要： An anatomically designed atrioventricular valve is made of biologically compatible synthetic membrane or biological membrane of autologous, homologous or heterologous origin. A single piece of the selected membrane material is trimmed so as to form two unequal sheaths similar to the normal anterior and posterior mammalian mitral valve leaflets with a wide upper base to be sutured to the host's mitral annulus. These two leaflets are prolonged and tapered into two thin bands to be connected to the papillary muscles serving as replacements for the natural marginal chordae tendinae of the normal mitral valve. The two lateral sides of the membrane are joined to form a truncated cone with a wider upper circular base and a narrow extremity formed by the thin chordal bands. A set of sutures are placed between selected points at the base of the cone and the two thin prolongations serving as replacements for the strut or stay basal chords of the natural mitral valve. Thus, the mitral valve prosthesis is anatomical because it is stentless, bicuspid and supported by marginal and basal chordae. Obturators and sizers in the configuration of rods of varying diameter, to measure the host's valve annulus diameter and select the appropriate size of the prosthesis are used during implantation of the prosthesis. A rod shaped holder maintains the prosthesis during implantation, and a curved bodied measuring instrument is used to determine the precise location where the chordae tendinae of the prosthesis are to be sutured to the papillary muscles of a recipient mammal.
摘要翻译： 解剖学设计的房室瓣由生物相容的合成膜或自体，同源或异源的生物膜制成。 所选择的膜材料的单件被修剪，以便形成两个不同的护套，类似于正常的前和后哺乳动物二尖瓣小叶，具有宽的上部基部以被缝合到宿主的二尖瓣环。 这两个小叶被延长并渐缩成两条薄带，以连接到乳头肌，作为正常二尖瓣的天然边缘腱索倾斜的替代物。 膜的两个侧面被连接以形成具有较宽的上圆形基部和由薄的弦带形成的窄末端的截头圆锥体。 一组缝合线放置在锥体底部的选定点之间，两个细延长部分用作自然二尖瓣的支柱或支撑基底和弦的替代物。 因此，二尖瓣假体是解剖学的，因为它是无支架的，双尖瓣的，并且由边缘和基底腱索支撑。 在假体植入期间使用在不同直径的杆的构造中的闭塞器和筛分器来测量主体的瓣膜环直径并选择适当的假体尺寸。 棒状保持器在植入期间保持假体，并且使用弯曲的身体测量仪器来确定假体的腱索被缝合到受体哺乳动物的乳头肌的精确位置。
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6.发明授权公开(公告)号：US06352708B1
公开(公告)日：2002-03-05
申请号：US09418674
申请日：1999-10-14
IPC分类号： A61F202
CPC分类号： A61L27/3687 , A61F2/2415 , A61L27/3604 , A61L2430/40
摘要： An aqueous solution containing a water miscible organic solvent, polyethylene glycol and heparine, is used to modify the tissue reactivity of an autologous tissue freshly obtained from a host mammal and to render the tissue temporarily more rigid than in its native state, and better suited for shaping, molding, handling and cutting prior to implantation into the host patient. The implant is highly resistant or immune to thickening, contraction and reduced fibrin deposition after it is implanted and exposed to the bloodstream of the host.
摘要翻译： 使用含有水混溶性有机溶剂，聚乙二醇和肝素的水溶液来改变从宿主哺乳动物新鲜获得的自体组织的组织反应性，并使组织临时比其天然状态更刚性，并且更适合于 成形，成型，处理和切割，然后植入宿主患者。 植入物在植入和暴露于宿主的血流之后具有高度抗性或免疫增厚，收缩和减少的纤维蛋白沉积。
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7.发明授权公开(公告)号：US06277555B1
公开(公告)日：2001-08-21
申请号：US09535490
申请日：2000-03-24
IPC分类号： A01N100
CPC分类号： A61L27/3691 , A61L27/3604 , A61L27/3687 , Y10S623/915 , Y10S623/917
摘要： A process for preparing pliable soft tissue specimen which are resistant to cracking and devoid of viable cells includes the steps of treating native soft tissue obtained from a donor by a gradually increasing gradient of aliphatic alcohol or other suitable water miscible polar organic solvent until the last alcohol (or other solvent) solution has at least 25% by volume of the organic liquid. Thereafter, the tissue specimen is treated with a solution containing glycerol or low molecular weight (
摘要翻译： 用于制备耐破裂和没有活细胞的柔韧软组织标本的方法包括以下步骤：通过逐渐增加的脂族醇或其它合适的水混溶性极性有机溶剂的梯度处理从供体获得的天然软组织，直到最后的醇 （或其它溶剂）溶液具有至少25体积％的有机液体。 此后，用含有甘油或低分子量（<1000D）聚乙二醇的溶液和分子量约6,000至15,000D的聚乙二醇和肝素处理组织标本。 此后，将组织标本短暂地浸入肝素水溶液中，冷冻并冻干。 组织标本适合作为同种移植物或异种移植物植入，有或没有补液。
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公开(公告)号：US5669919A
公开(公告)日：1997-09-23
申请号：US700620
申请日：1996-08-16
CPC分类号： A61F2/2448 , A61F2/2466 , Y10S623/90
摘要： In annuloplastic surgery, the holder which supports the annuloplasty ring during the suturing of the ring to a heart valve annulus is released from its handle, and reattached for subsequent removal, without rotary or axially compressive stress on the holder. This is accomplished by inserting laterally movable locking tabs from the handle into the holder. The locking tabs are the ends of a Y-shaped clip which translates the axial movement of a locking button on the handle into a transverse holder-engaging movement.
摘要翻译： 在环形外科手术中，将环缝合到心脏瓣膜环的支撑瓣环成形术环的支架从其手柄释放，并且重新附接以用于随后的移除，而在支架上没有旋转或轴向压缩应力。 这是通过将可移动的锁定突片从手柄插入保持器来实现的。 锁定突片是Y形夹子的端部，其将把手上的锁定按钮的轴向移动转换成横向保持器接合运动。
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