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    Heart valve suturing ring with surface coating to inhibit tissue ingrowth
    2.
    发明授权
    Heart valve suturing ring with surface coating to inhibit tissue ingrowth 失效
    心脏瓣膜缝合环与表面涂层，以抑制组织向内生长

    公开(公告)号：US5948019A

    公开(公告)日：1999-09-07

    申请号：US547854

    申请日：1995-10-25

    申请人： Mark C. Shu ,  Hong S. Shim

    发明人： Mark C. Shu ,  Hong S. Shim

    IPC分类号： A61F2/24 ,  A61F2/06

    CPC分类号： A61F2/2409

    摘要： An implantable prosthetic heart valve with a suturing ring having an impermeable or semi-impermeable coating over at least a portion of the surface thereof to prevent tissue ingrowth in the coated area or areas. The suturing ring is formed of a biocompatible fabric tube of a mesh weave having interstices permeable to tissue ingrowth and first and second axial ends fastened into a torus shaped, suturing ring body having an interior directed minor surface adapted to be fitted against the exterior annular wall of a valve body and an outward directed major surface. An upper ring shaped surface is formed adjacent the upper edge of the valve body and a lower ring shaped surface adjacent the lower edge of the valve body. The intermediate band is intended to be sutured into contact with the heart tissue orifice. First and second impermeable layer of biocompatible material fill the interstices of the mesh weave in the upper and lower ring shaped surface area. A smooth transition is formed at the junction of the suturing ring with the valve body by filling the gaps at the suturing ring/valve body juncture with the same or similar type of blood compatible material.

    摘要翻译： 一种具有缝合环的可植入假体心脏瓣膜，其在其表面的至少一部分上具有不可渗透或半不可渗透的涂层，以防止在涂覆区域或区域中的组织向内生长。 缝合环由具有可渗透组织向内生长的间隙的网状织物的生物相容性织物管形成，并且第一和第二轴向端部固定到环形缝合环体中，所述环形缝合环主体具有内部指向的小的表面，适于与外部环形壁 的阀体和向外的主表面。 邻近阀体的上边缘形成上环形表面和邻近阀体下边缘的下环形表面。 中间带旨在被缝合成与心脏组织孔口接触。 第一和第二不渗透层的生物相容性材料填充上下环形表面区域中网状织物的间隙。 通过用相同或相似类型的血液兼容材料填充缝合环/阀体接合处的间隙，在缝合环与阀体的接合处形成平滑过渡。

    Mechanical heart valve prosthesis
    3.
    发明授权
    Mechanical heart valve prosthesis 失效
    机械心脏瓣膜假体

    公开(公告)号：US5919226A

    公开(公告)日：1999-07-06

    申请号：US898144

    申请日：1997-07-22

    申请人： Mark C. Shu ,  Jeffrey M. Gross ,  Hong S. Shim

    发明人： Mark C. Shu ,  Jeffrey M. Gross ,  Hong S. Shim

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2403

    摘要： An improved artificial mechanical heart valve prosthesis having an improved leaflet hinge mechanism which improves washing of the hinge recess, reduces leaflet closing impact force and decreases noise and wear. A generally annular valve body having an annular interior surface extending between an inflow rim and an outflow rim thereof defines an annular orifice therethrough. A pair of leaflets are supported on said annular valve body for alternately blocking blood flow in an inflow direction when seated against the annular interior side wall in a closed position and then allowing the flow of blood through said annular orifice in a predetermined blood outflow direction when rotated into an open position. Each leaflet is supported for pivotal movement by a pair of hinge mechanisms comprising a pair of convexly extending leaflet ears that each fit within a hinge recess formed in parallel planar surfaces of the annular interior side wall. A relatively shallow inflow or entrance ramp is achieved in an inflow portion of the hinge recess employing an inwardly curved inflow transition surface from the planar surface at the arcuate inflow end edge into the inflow portion of the leaflet ear bearing surface. An open outflow or exit ramp is achieved employing a curved outflow transition surface of the leaflet ear bearing surface in the outflow portion of the hinge recess meeting the arcuate outflow end edge which itself joins a recessed outflow flat in the planar surface that the hinge recess is formed in. The hinge recess side walls are shaped to minimize blood cell damage. Inflow rim transition zones deflect blood flow centrally through the annular orifice. Planar inflow chamfers extending between the planar surfaces and the inflow rim deflect blood compomnents away from the hinge recesses.

    摘要翻译： 改进的人造机械心脏瓣膜假体具有改进的小叶铰链机构，其改善铰链凹部的洗涤，减少小叶闭合冲击力并降低噪音和磨损。 具有环形内表面的大致环形的阀体，其在流入边缘和流出边缘之间延伸，限定了通过其的环形孔。 一对传单被支撑在所述环形阀体上，用于在关闭位置时抵靠环形内侧壁交替阻挡流入方向的血液流动，然后允许血液以预定的血液流出方向流过所述环形孔口， 旋转到打开位置。 每个小叶被一对铰链机构支撑以枢转运动，该铰链机构包括一对凸形延伸的小叶耳，每个小叶耳均配合在形成于环形内侧壁的平行平面表面的铰链凹槽内。 在铰链凹槽的流入部分中实现相对较浅的流入或入口斜坡，其采用向内弯曲的流入过渡表面，该流入过渡表面从弧形流入端边缘处的平面表面进入传单支承表面的流入部分。 使用在铰链凹槽的流出部分中的小叶耳轴承表面的弯曲的流出过渡表面达到开口的流出或出口斜坡，该弯曲的流出过渡表面与弓形流出端边缘接合，该弯曲的流出端边缘本身连接在平面表面中的凹入的流出平面， 铰链凹槽侧壁成形为使血细胞损伤最小化。 流入边缘过渡区将血流中心偏转通过环形孔。 在平面表面和流入边缘之间延伸的平面流入倒角将血液元件偏离铰链凹槽。

    Hybrid mechanical heart valve prosthesis
    4.
    发明授权
    Hybrid mechanical heart valve prosthesis 失效
    混合机械心脏瓣膜假体

    公开(公告)号：US6139575A

    公开(公告)日：2000-10-31

    申请号：US286095

    申请日：1999-04-02

    申请人： Mark C. S. Shu ,  Hong S. Shim ,  Jeffrey M. Gross

    发明人： Mark C. S. Shu ,  Hong S. Shim ,  Jeffrey M. Gross

    IPC分类号： A61F2/24 ,  A61F2/06

    CPC分类号： A61F2/2403

    摘要： A prosthetic mechanical heart valve, and in particular, a bi-leaflet and/or a trileaflet mechanical valve formed with rigid frame and hinge elements for providing a stable reliable hinge mechanism with flexible leaflets formed of a thin elastomeric material adhering to and extending from the valve frame to form leaflet occluding sections bounded by outer peripheral edges for softening the opening and closing action of the valve leaflets. In one embodiment, the valve leaflet is formed of a rigid pyrolytic carbon frame supporting hinge elements and defining a leaflet pivot axis and a flexible leaflet body attached to the frame and defining a leaflet abutting section extending from one side of the valve frame and an occluding section extending from the other side of the valve frame to an arcuate leaflet seat. In the closing phase of operation, the abutting sections of the leaflet bodies contact one another in an abutting contact band, and the arcuate leaflet seats bear against arcuate seat regions of the valve body The seat regions of the valve body may also be coated with an elastomeric material.

    摘要翻译： 一种假体机械性心脏瓣膜，特别是形成有刚性框架和铰链元件的双叶片和/或三叶形机械阀门，用于提供稳定可靠的铰链机构，该铰链机构具有柔性小叶片，该柔性小叶片由粘附并延伸 阀框架形成由外围边缘限定的小叶闭塞部分，用于软化瓣膜单张的打开和关闭动作。 在一个实施例中，瓣叶由刚性热解碳框架构成，支撑铰链元件并且限定传单枢转轴线和附接到框架的柔性小叶体，并且限定从瓣膜框架的一侧延伸的小叶邻接部分和闭塞 从阀框架的另一侧延伸到弧形小叶座。 在关闭操作阶段，传动体的邻接部分在邻接的接触带处彼此接触，并且弧形小叶座部抵靠阀体的弓形座部区域。阀体的座部区域也可以涂覆有 弹性材料。

    Mechanical heart valve prosthesis
    5.
    发明授权
    Mechanical heart valve prosthesis 失效
    机械心脏瓣膜假体

    公开(公告)号：US06645244B2

    公开(公告)日：2003-11-11

    申请号：US09737112

    申请日：2000-12-14

    申请人： Mark C. Shu ,  Jeffrey M. Gross ,  Hong S. Shim

    发明人： Mark C. Shu ,  Jeffrey M. Gross ,  Hong S. Shim

    IPC分类号： A61F206

    CPC分类号： A61F2/2403

    摘要： An improved artificial mechanical heart valve prosthesis having an improved leaflet hinge mechanism which improves washing of the hinge recess, reduces leaflet closing impact force and decreases noise and wear. A generally annular valve body having an annular interior surface extending between an inflow rim and an outflow rim thereof defines an annular orifice therethrough. A pair of leaflets are supported on said annular valve body for alternately blocking blood flow in an inflow direction when seated against the annular interior side wall in a closed position and then allowing the flow of blood through said annular orifice in a predetermined blood outflow direction when rotated into an open position.

    摘要翻译： 改进的人造机械心脏瓣膜假体具有改进的小叶铰链机构，其改善铰链凹部的洗涤，减少小叶闭合冲击力并降低噪音和磨损。 具有环形内表面的大致环形的阀体，其在流入边缘和流出边缘之间延伸，限定了通过其的环形孔。 一对传单被支撑在所述环形阀体上，用于在关闭位置时抵靠环形内侧壁交替阻挡流入方向的血液流动，然后允许血液以预定的血液流出方向流过所述环形孔口， 旋转到打开位置。