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    Method of producing a processed kava product having an altered kavalactone distribution and processed kava products produced using the same
    1.
    发明授权
    Method of producing a processed kava product having an altered kavalactone distribution and processed kava products produced using the same 失效
    制备具有改变的卡维内酯分布的加工的卡瓦产品的方法和使用其制备的加工的卡瓦产品

    公开(公告)号：US07029707B2

    公开(公告)日：2006-04-18

    申请号：US10263579

    申请日：2002-10-03

    申请人： Robert Gow ,  John Pierce ,  Brian Pierce ,  William Birdsall

    发明人： Robert Gow ,  John Pierce ,  Brian Pierce ,  William Birdsall

    IPC分类号： A61K35/78

    CPC分类号： C07D407/06 ,  A61K31/365 ,  A61K31/366 ,  A61K36/28 ,  A61K36/48 ,  A61K36/67 ,  A61K45/06 ,  C07D309/32 ,  C07D309/38 ,  C07D309/40 ,  A61K2300/00

    摘要： A method of producing a processed kava product involves using an extraction solvent, such as liquid CO2, to preferentially extract different kavalactones from the source material at different rates. By controlling the extraction parameters and stopping the extraction before all of the kavalactones have been extracted or allowing the extracted kavalactones to be preferentially precipitated in one or more collection environments, a processed kava product can be produced that has a kavalactone distribution profile that can differ substantially from that of the source material. As a result, roots from a less desirable kava cultivar can be used to produce a processed kava product which has a kavalactone distribution profile that is similar to that of a highly desired cultivar. The kava paste can be further processed to produce a dry flowable powder suitable for use in, e.g., a tableting formula. A rapid dissolve tablet formulation for use in the delivery of kavalactones is also disclosed.

    摘要翻译： 一种生产加工过的卡瓦产品的方法包括使用萃取溶剂，例如液体CO 2，以不同的速率从源材料中优先提取不同的kavalactones。 通过控制提取参数并在所有的Kavalactone已被提取之前停止提取，或允许提取的kavalactones在一个或多个收集环境中优先沉淀，可以生产具有可以基本上不同的Kavalactone分布分布的加工的卡瓦尔产物 从源材料。 结果，来自较不理想的卡拉品种的根可以用于生产加工的卡瓦产品，其具有与高度期望的品种相似的考卡内酯分布轮廓。 可以进一步处理卡瓦酱以产生适用于例如压片配方的干燥可流动粉末。 还公开了一种用于投放kavalactones的快速溶解片剂制剂。

    Oral delivery of a botanical
    3.
    发明授权
    Oral delivery of a botanical 失效
    口服交付植物药

    公开(公告)号：US07037524B2

    公开(公告)日：2006-05-02

    申请号：US10273981

    申请日：2002-10-18

    申请人： Robert Gow ,  John Pierce ,  Brian Pierce ,  William Birdsall

    发明人： Robert Gow ,  John Pierce ,  Brian Pierce ,  William Birdsall

    IPC分类号： A61K9/20 ,  A61K9/26 ,  A61K35/78

    CPC分类号： A61K36/67 ,  A61K31/365 ,  A61K31/366 ,  A61K36/28 ,  A61K36/48 ,  A61K45/06 ,  C07D309/32 ,  C07D309/38 ,  C07D309/40 ,  C07D407/06 ,  A61K2300/00

    摘要： A method of producing a processed kava product involves using an extraction solvent, such as liquid CO2, to preferentially extract different kavalactones from the source material at different rates. By controlling the extraction parameters and stopping the extraction before all of the kavalactones have been extracted or allowing the extracted kavalactones to be preferentially precipitated in one or more collection environments, a processed kava product can be produced that has a kavalactone distribution profile that can differ substantially from that of the source material. As a result, roots from a less desirable kava cultivar can be used to produce a processed kava product which has a kavalactone distribution profile that is similar to that of a highly desired cultivar. The kava paste can be further processed to produce a dry flowable powder suitable for use in, e.g., a tableting formula. A rapid dissolve tablet formulation for use in the delivery of kavalactones and other botanicals is also disclosed.

    摘要翻译： 一种生产加工过的卡瓦产品的方法包括使用萃取溶剂，例如液体CO 2，以不同的速率从源材料中优先提取不同的kavalactones。 通过控制提取参数并在所有的Kavalactone已被提取之前停止提取，或允许提取的kavalactones在一个或多个收集环境中优先沉淀，可以生产具有可以基本上不同的Kavalactone分布分布的加工的卡瓦尔产物 从源材料。 结果，来自较不理想的卡拉品种的根可以用于生产加工的卡瓦产品，其具有与高度期望的品种相似的考卡内酯分布轮廓。 可以进一步处理卡瓦酱以产生适用于例如压片配方的干燥可流动粉末。 还公开了用于输送卡维内酯和其它植物药物的快速溶解片剂制剂。

    Kavalactone profile
    6.
    发明授权
    Kavalactone profile 失效
    Kavalactone简介

    公开(公告)号：US07105185B2

    公开(公告)日：2006-09-12

    申请号：US10273943

    申请日：2002-10-18

    申请人： Robert Gow ,  John Pierce ,  Brian Pierce ,  William Birdsall

    发明人： Robert Gow ,  John Pierce ,  Brian Pierce ,  William Birdsall

    IPC分类号： A61K32/78

    CPC分类号： C07D407/06 ,  A61K31/365 ,  A61K31/366 ,  A61K36/185 ,  A61K36/21 ,  A61K36/258 ,  A61K36/28 ,  A61K36/41 ,  A61K36/46 ,  A61K36/48 ,  A61K36/481 ,  A61K36/67 ,  A61K36/74 ,  A61K36/76 ,  A61K36/888 ,  A61K36/889 ,  A61K36/8988 ,  A61K36/9066 ,  A61K45/06 ,  C07D309/32 ,  C07D309/38 ,  C07D309/40 ,  A61K2300/00

    摘要： A method of producing a processed kava product involves using an extraction solvent, such as liquid CO2, to preferentially extract different kavalactones from the source material at different rates. By controlling the extraction parameters and stopping the extraction before all of the kavalactones have been extracted or allowing the extracted kavalactones to be preferentially precipitated in one or more collection environments, a processed kava product can be produced that has a kavalactone distribution profile that can differ substantially from that of the source material. As a result, roots from a less desirable kava cultivar can be used to produce a processed kava product which has a kavalactone distribution profile that is similar to that of a highly desired cultivar. A material having a preferred kavalactone distribution profile is also disclosed. The kava paste can be further processed to produce a dry flowable powder suitable for use in, e.g., a tableting formula. A rapid dissolve tablet formulation for use in the delivery of kavalactones is also disclosed.

    摘要翻译： 一种生产加工过的卡瓦产品的方法包括使用萃取溶剂，例如液体CO 2，以不同的速率从源材料中优先提取不同的kavalactones。 通过控制提取参数并在所有的Kavalactone已被提取之前停止提取，或允许提取的kavalactones在一个或多个收集环境中优先沉淀，可以生产具有可以显着差异的Kavalactone分布分布的加工的卡瓦产品 从源材料。 结果，来自较不理想的卡拉品种的根可以用于生产加工的卡瓦产品，其具有与高度期望的品种相似的考卡内酯分布轮廓。 还公开了具有优选的卡维内酯分布特性的材料。 可以进一步处理卡瓦酱以产生适用于例如压片配方的干燥可流动粉末。 还公开了一种用于投放kavalactones的快速溶解片剂制剂。

    Methods and compositions comprising Ilex
    7.
    发明申请
    Methods and compositions comprising Ilex 失效
    包含Ilex的方法和组合物

    公开(公告)号：US20050118293A1

    公开(公告)日：2005-06-02

    申请号：US10972986

    申请日：2004-10-25

    申请人： Robert Gow ,  George Sypert ,  John Pierce ,  Dan Li ,  Xun Yan ,  Rodger Marentis

    发明人： Robert Gow ,  George Sypert ,  John Pierce ,  Dan Li ,  Xun Yan ,  Rodger Marentis

    IPC分类号： A23F3/36 ,  A61K36/00 ,  A61K36/185 ,  A61K35/78

    CPC分类号： A61K36/185

    摘要： The present invention comprises methods for making compositions derived from Ilex species, particularly Ilex paraguariensis, having lowered caffeine and tannin concentrations, compositions made by such methods, oral delivery formulations, and methods of use of such compositions. In particular, the present invention comprises methods for making maté compositions that have a predetermined characeteristic, such as a lowered amount of caffeine, elevated amounts of caffeoyls, and/or lowered amounts of tannin compounds compared to the native maté plant materials. Further, the invention comprises methods of additional processing steps to produce compositions having a predetermined alkaloid ratio or profiles to meet particular considerations for final products. The compositions of the present invention may be processed for specific uses such as tablets or other oral delivery vehicles. These compositions may be used in methods for treatment of physiological and medical conditions.

    摘要翻译： 本发明包括用于制备衍生自具有降低的咖啡因和单宁浓度的Ilex种，特别是白僵菌的组合物的组合物的方法，通过这些方法制备的组合物，口服递送制剂和使用该组合物的方法。 特别地，本发明包括与天然植物材料相比制备具有预定特征的，例如降低量的咖啡因，升高的咖啡因量和/或降低量的单宁化合物的方法。 此外，本发明包括另外的加工步骤的方法，以生产具有预定生物碱比例或轮廓的组合物以满足最终产品的特定考虑。 本发明的组合物可以用于特定用途，例如片剂或其它口服递送载体。 这些组合物可用于治疗生理和医学状况的方法。

    Methods and compositions comprising kava and mate' or theobromine
    9.
    发明申请
    Methods and compositions comprising kava and mate' or theobromine 审中-公开
    包含卡瓦和伴侣或可可碱的方法和组合物

    公开(公告)号：US20050037025A1

    公开(公告)日：2005-02-17

    申请号：US10945108

    申请日：2004-09-20

    申请人： Robert Gow ,  John Pierce ,  George Sypert

    发明人： Robert Gow ,  John Pierce ,  George Sypert

    IPC分类号： A61K31/366 ,  A61K36/185 ,  A61K36/67 ,  A61K45/06 ,  A61K35/78

    CPC分类号： A61K45/06 ,  A61K31/366 ,  A61K36/185 ,  A61K36/67 ,  A61K2300/00

    摘要： The present invention comprises compositions comprising combinations of compositions of extracts of kava mate' extract compositions or theobromine. The invention further comprises methods for treating conditions related to mental and physical fatigue, anxiety, muscle tension, nervous depression, headache, obesity, and mild pain as well a enhancement of cognition and mental focus comprising administering effective amounts of the compositions of the present invention.

    摘要翻译： 本发明包括包含卡马姆提取物组合物或可可碱提取物的组合物的组合的组合物。 本发明还包括用于治疗与精神和身体疲劳，焦虑，肌肉紧张，神经抑郁，头痛，肥胖和轻度疼痛相关的病症的方法，以及增强认知和精神焦虑，包括施用有效量的本发明组合物 。

    Methods and compositions comprising Ilex
    10.
    发明申请
    Methods and compositions comprising Ilex 失效
    包含Ilex的方法和组合物

    公开(公告)号：US20050089591A1

    公开(公告)日：2005-04-28

    申请号：US10970017

    申请日：2004-10-21

    申请人： Robert Gow ,  George Sypert ,  John Pierce ,  Dan Li ,  Xun Yan ,  Rodger Marentis

    发明人： Robert Gow ,  George Sypert ,  John Pierce ,  Dan Li ,  Xun Yan ,  Rodger Marentis

    IPC分类号： A23F3/00 ,  A61K31/522 ,  A61K36/00 ,  A61K36/185 ,  A61K35/78

    CPC分类号： A61K36/185

    摘要： The present invention comprises methods for making compositions derived from Ilex species, particularly Ilex paraguariensis, having lowered caffeine and tannin concentrations, compositions made by such methods, oral delivery formulations, and methods of use of such compositions. In particular, the present invention comprises methods for making maté compositions that have a predetermined characeteristic, such as a lowered amount of caffeine, elevated amounts of caffeoyls, and/or lowered amounts of tannin compounds compared to the native maté plant materials. Further, the invention comprises methods of additional processing steps tp produce compositions having a predetermined alkaloid ratio or profiles to meet particular considerations for final products. The compositions of the present invention may be processed for specific uses such as tablets or other oral delivery vehicles. These compositions may be used in methods for treatment of physiological and medical conditions.

    摘要翻译： 本发明包括用于制备衍生自具有降低的咖啡因和单宁浓度的Ilex种，特别是白僵菌的组合物的组合物的方法，通过这些方法制备的组合物，口服递送制剂和使用该组合物的方法。 特别地，本发明包括与天然植物材料相比制备具有预定特征的，例如降低量的咖啡因，升高的咖啡因量和/或降低量的单宁化合物的方法。 此外，本发明包括附加处理步骤的方法，tp产生具有预定生物碱比例或分布的组合物以满足最终产品的特定考虑。 本发明的组合物可以用于特定用途，例如片剂或其它口服递送载体。 这些组合物可用于治疗生理和医学状况的方法。