公开(公告)号：US5991668A

公开(公告)日：1999-11-23

申请号：US936991

申请日：1997-09-25

申请人： Robert Leinders ,  Nicolaas Lokhoff ,  Paulus Van Venrooij ,  Arnoldus Bakels

发明人： Robert Leinders ,  Nicolaas Lokhoff ,  Paulus Van Venrooij ,  Arnoldus Bakels

IPC分类号： A61N1/05 ,  A61N1/04

CPC分类号： A61N1/057 ,  A61N2001/0585

摘要： A transvenous lead specifically designed for coronary sinus implantation. In the preferred embodiment the lead features an electrode which is eccentricity placed along the lead body. Disposed on the opposite side of the lead body is a tine-like member to push or maintain the electrode into contact with the vessel wall. Because the electrode and tine-like member do not entirely block the cross sectional area of the vessel, blood flow through the vessel is not impeded. Through such a configuration electrical stimulation with the tissue comprising the left side of the heart may be accomplished. In alternative embodiments other mechanisms besides tine-like member are used to maintain the contact of the electrode with the vessel wall. In a still further alternative embodiment the eccentricity disposed electrode is positioned instead upon the tip of the tine.

摘要翻译： 专门设计用于冠状窦植入的静脉导管。 在优选实施例中，引线具有沿引线本体放置的偏心的电极。 设置在引线体的相反侧的是齿状部件，以推动或保持电极与血管壁接触。 因为电极和齿状构件不完全阻挡血管的横截面积，所以不会妨碍通过血管的血流。 通过这样的配置，可以实现包括心脏左侧的组织的电刺激。 在替代实施例中，使用除了类似元件之外的其它机构来保持电极与血管壁的接触。 在又一替代实施例中，偏心设置电极被替代地置于尖端。

公开(公告)号：US6006139A

公开(公告)日：1999-12-21

申请号：US794402

申请日：1997-02-03

申请人： Ib M. Kruse ,  Nicolaas Lokhoff ,  Paulus van Venrooij ,  Arnoldus Bakels

发明人： Ib M. Kruse ,  Nicolaas Lokhoff ,  Paulus van Venrooij ,  Arnoldus Bakels

IPC分类号： A61N1/05 ,  A61B5/04

CPC分类号： A61N1/057 ,  A61N1/056 ,  A61N1/0568

摘要： The present invention is directed to a single pass medical electrical lead. In one embodiment, the lead features a pair of bipolar electrodes positioned along the lead body so that they are positioned in the ventricle and atrium respectively when the lead is implanted. The lead body features a 90 degree bent reinforced section. The bend has a radius of curvature approximately 13 mm and begins approximately 90 mm from the distal end. This curved section is approximately 40 mm in length when straightened. The ventricular electrodes are positioned approximately 28 mm apart. The bend has at least one tine extending therefrom, an electrode is mounted on the tine.

摘要翻译： 本发明涉及单程医用电引线。 在一个实施例中，引线具有沿着引线体定位的一对双极电极，使得当引线被植入时它们分别位于心室和心室中。 引线体具有90度弯曲加强部分。 弯曲部具有大约13mm的曲率半径，并从远端开始大约90mm。 当弯曲时，该弯曲部分的长度约为40毫米。 心室电极间隔约28mm。 弯曲部具有从其延伸的至少一个齿，电极安装在齿上。

公开(公告)号：US6070104A

公开(公告)日：2000-05-30

申请号：US980438

申请日：1997-11-28

申请人： Douglas Hine ,  Nicolaas Lokhoff ,  Paulus Van Venrooij ,  Arnoldus Bakels

发明人： Douglas Hine ,  Nicolaas Lokhoff ,  Paulus Van Venrooij ,  Arnoldus Bakels

IPC分类号： A61N1/05

CPC分类号： A61N1/056

摘要： A transvenous lead specifically designed for multi-chamber electrical stimulation or sensing. In a first embodiment the lead features one or more electrodes for communication with the right atrium as well as one or more electrodes for communication with either or both of the left chambers of the heart. The lead further features structures to simultaneously bring the first electrode into contact with a first chamber, such as the right atrial wall and the second electrode into contact with a particular portion of the coronary sinus wall, to electrically access the left atrium or ventricle. In the preferred embodiment the lead body has varying flex or stiffness characteristics along its length between each of the electrodes. The relation of the varying flex or stiffness characteristics along the lead body length as well as the various linear placements of the electrodes along the lead body length function to simultaneously bring the first electrode into contact with a first desired portion of the heart, such as the right atrial wall, and the second electrode into contact with a second desired portion of the heart, such as a portion of the coronary sinus wall.

摘要翻译： 专为多室电刺激或感应设计的经静脉导管。 在第一实施例中，引线具有用于与右心房连通的一个或多个电极以及用于与心脏的左腔室中的一个或两者连通的一个或多个电极。 引线还具有结构，以同时使第一电极与诸如右心房壁和第二电极的第一腔室接触以与冠状静脉窦壁的特定部分接触以电接入左心房或心室。 在优选实施例中，引线主体沿其长度在每个电极之间具有变化的弯曲或刚度特性。 沿着引线主体长度的变化的弯曲或刚度特性以及电极沿引线体长度的各种线性放置的关系用于同时使第一电极与心脏的第一所需部分接触，例如 右心房壁和第二电极与心脏的第二期望部分接触，例如冠状窦壁的一部分。

公开(公告)号：US5995876A

公开(公告)日：1999-11-30

申请号：US794175

申请日：1997-02-03

申请人： Ib M. Kruse ,  Nicolaas Lokhoff ,  Paulus van Venrooij ,  Arnoldus Bakels

发明人： Ib M. Kruse ,  Nicolaas Lokhoff ,  Paulus van Venrooij ,  Arnoldus Bakels

IPC分类号： A61N1/05 ,  A61N1/04

CPC分类号： A61N1/057 ,  A61N1/056 ,  A61N1/0568

摘要： The present invention is directed to a single pass medical electrical lead. In one embodiment, the lead feature a pair of bipolar electrodes positioned along the lead body so that they are positioned in the ventricle and atrium respectively when the lead is implanted. The lead body features a 90 degree bent reinforced section. The bend has a radius of curvature approximately 13 mm and begins approximately 90 mm from the distal end. This curved section is approximately 40 mm in length when straightened. The ventricular electrodes are positioned approximately 28 mm apart. The ventricular cathode electrode is positioned at the distal end of the lead. The atrial electrodes are positioned approximately between 5-35 mm apart, with 28 mm preferred. The atrial anode is located at a position immediately adjacent and proximal the 90 degree bent reinforced section.

摘要翻译： 本发明涉及单程医用电引线。 在一个实施例中，引线具有一对沿引线体定位的双极电极，使得它们在引线被植入时分别定位在心室和心室中。 引线体具有90度弯曲加强部分。 弯曲部具有大约13mm的曲率半径，并从远端开始大约90mm。 当弯曲时，该弯曲部分的长度约为40mm。 心室电极间隔约28mm。 心室阴极位于引线的远端。 心房电极位于大约5-35mm之间，优选28mm。 心房阳极位于紧邻90度弯曲加强部分的位置。

公开(公告)号：US06301507B1

公开(公告)日：2001-10-09

申请号：US09487788

申请日：2000-01-20

申请人： Arnoldus Bakels ,  Nicolaas Lokhoff

发明人： Arnoldus Bakels ,  Nicolaas Lokhoff

IPC分类号： A61N105

CPC分类号： A61N1/056

摘要： A medical electrical lead having a pre-formed atrial portion assuming a distinctive U-shape is disclosed. The U-shaped atrial portion of the lead is configured and dimensioned to cause at least one atrial electrode disposed thereon to be pushed against the right atrial wall or right atrial sinus wall through pushing forces generated by the lead pressing against regions of the heart located near the superior vena cava or the tricuspid valve, and/or through the action of gravity. The lead provides superior coupling of the atrial electrodes thereof to the walls of the right atrium, and may be configured for single pass DDD stimulation of the right atrium and the right ventricle or other portions of the heart such as the coronary sinus or the great cardiac vein.

摘要翻译： 公开了具有呈现出独特的U形的预形成的心房部分的医用电线。 引线的U形心房部分的构造和尺寸被设计成使得设置在其上的至少一个心房电极被推压抵靠右心房壁或右心房窦壁。 上腔静脉或三尖瓣，和/或通过重力作用。 引线提供了其心房电极与右心房壁的优异耦合，并且可以被配置用于右心房和右心室或心脏的其它部分（例如冠状窦或大心脏）的单程DDD刺激 静脉。

公开(公告)号：US06754530B2

公开(公告)日：2004-06-22

申请号：US09946495

申请日：2001-09-06

申请人： Arnoldus Bakels ,  Robert Leinders ,  Cobus de Roos

发明人： Arnoldus Bakels ,  Robert Leinders ,  Cobus de Roos

IPC分类号： A61N1365

CPC分类号： A61N1/36521 ,  A61N1/3622 ,  A61N1/3627 ,  A61N1/368 ,  A61N1/3682

摘要： A pacing system and method for providing multiple chamber pacing of a patient's heart, and in particular, pacing programmed for treatment of various forms of heart failure. The system utilizes impedance sensing for determining optimum pacing parameters, e.g., for pacing the left ventricle so that left heart output is maximized. The impedance sensing also is used for determination of arrhythmias or progression of heart failure. Impedance sensing is provided for between selected pairs of the four chambers, to enable optimizing of information for control and diagnosis. In a preferred embodiment of the invention, impedance measurements are obtained for determining the timing of right heart valve closure or right ventricular contractions, and the timing of delivery of left ventricular pace pulses is adjusted so as to optimally synchronize left ventricular pacing with the right ventricular contractions. Impedance sensing in the left heart also provides timing of mechanical contraction, and the pacemaker controls pacing to maintain bi-ventricular mechanical synchronization adjusted for maximum cardiac output.

摘要翻译： 用于提供患者心脏的多个室起搏的起搏系统和方法，特别是针对治疗各种形式的心力衰竭的起搏。 系统利用阻抗感测来确定最佳起搏参数，例如用于起搏左心室，使得左心输出最大化。 阻抗检测也用于确定心律失常或心力衰竭进展。 在四个室的选定对之间提供阻抗感测，以实现用于控制和诊断的信息的优化。 在本发明的优选实施例中，获得用于确定右心瓣膜闭合或右心室收缩的时间的阻抗测量值，并且调节左心室起搏脉冲的传递时间，以便最佳地同步左心室起搏与右心室 收缩。 心脏中的阻抗传感还提供机械收缩的时机，并且起搏器控制起搏以维持双心室机械同步，以调节最大心输出量。

公开(公告)号：US06238420B1

公开(公告)日：2001-05-29

申请号：US09564036

申请日：2000-05-04

申请人： Arnoldus Bakels ,  Robert Leinders ,  Cobus de Roos

发明人： Arnoldus Bakels ,  Robert Leinders ,  Cobus de Roos

IPC分类号： A61N1368

CPC分类号： A61N1/36521 ,  A61N1/3622 ,  A61N1/3627 ,  A61N1/368 ,  A61N1/3682

摘要： A pacing system and method for providing multiple chamber pacing of a patient's heart, and in particular, pacing programmed for treatment of various forms of heart failure. The system utilizes impedance sensing for determining optimum pacing parameters, e.g., for pacing the left ventricle so that left heart output is maximized. The impedance sensing also is used for determination of arrhythmias or progression of heart failure. Impedance sensing is provided for between selected pairs of the four chambers, to enable optimizing of information for control and diagnosis. In a preferred embodiment of the invention, impedance measurements are obtained for determining the timing of right heart valve closure or right ventricular contractions, and the timing of delivery of left ventricular pace pulses is adjusted so as to optimally synchronize left ventricular pacing with the right ventricular contractions. Impedance sensing in the left heart also provides timing of mechanical contraction, and the pacemaker controls pacing to maintain bi-ventricular mechanical synchronization adjusted for maximum cardiac output.

摘要翻译： 用于提供患者心脏的多个室起搏的起搏系统和方法，特别是针对治疗各种形式的心力衰竭的起搏。 系统利用阻抗感测来确定最佳起搏参数，例如用于起搏左心室，使得左心输出最大化。 阻抗检测也用于确定心律失常或心力衰竭进展。 在四个室的选定对之间提供阻抗感测，以实现用于控制和诊断的信息的优化。 在本发明的优选实施例中，获得用于确定右心瓣膜闭合或右心室收缩的时间的阻抗测量值，并且调节左心室起搏脉冲的传递时间，以便最佳地同步左心室起搏与右心室 收缩。 心脏中的阻抗传感还提供机械收缩的时机，并且起搏器控制起搏以维持双心室机械同步，以调节最大心输出量。

公开(公告)号：US06219579B1

公开(公告)日：2001-04-17

申请号：US09493690

申请日：2000-01-28

申请人： Arnoldus Bakels ,  Robert Leinders ,  Cobus de Roos

发明人： Arnoldus Bakels ,  Robert Leinders ,  Cobus de Roos

IPC分类号： A61N1365

CPC分类号： A61N1/36521 ,  A61N1/3622 ,  A61N1/3627 ,  A61N1/368 ,  A61N1/3682

摘要： A pacing system and method for providing multiple chamber pacing of a patient's heart, and in particular, pacing programmed for treatment of various forms of heart failure. The system utilizes impedance sensing for determining optimum pacing parameters, e.g., for pacing the left ventricle so that left heart output is maximized. The impedance sensing also is used for determination of arrhythmias or progression of heart failure. Impedance sensing is provided for between selected pairs of the four chambers, to enable optimizing of information for control and diagnosis. In a preferred embodiment, impedance measurements are obtained for determining the timing of right heart valve closure or right ventricular contractions, and the timing of delivery of left ventricular pace pulses is adjusted so as to optimally synchronize left ventricular pacing with the right ventricular contractions. Impedance sensing in the left heart also provides timing of mechanical contraction, and the pacemaker controls pacing to maintain bi-ventricular mechanical synchronization adjusted for maximum cardiac output.

摘要翻译： 用于提供患者心脏的多个室起搏的起搏系统和方法，特别是针对治疗各种形式的心力衰竭的起搏。 系统利用阻抗感测来确定最佳起搏参数，例如用于起搏左心室，使得左心输出最大化。 阻抗检测也用于确定心律失常或心力衰竭进展。 在四个室的选定对之间提供阻抗感测，以实现用于控制和诊断的信息的优化。 在优选实施例中，获得用于确定右心瓣膜闭合或右心室收缩的时机的阻抗测量值，并且调节左心室起搏脉冲的传送时间，以便使左心室起搏与右心室收缩最佳地同步。 心脏中的阻抗传感还提供机械收缩的时机，并且起搏器控制起搏以维持双心室机械同步，以调节最大心输出量。

公开(公告)号：US06223082B1

公开(公告)日：2001-04-24

申请号：US09493689

申请日：2000-01-28

申请人： Arnoldus Bakels ,  Robert Leinders ,  Cobus de Roos

发明人： Arnoldus Bakels ,  Robert Leinders ,  Cobus de Roos

IPC分类号： A61N1365

CPC分类号： A61N1/36521 ,  A61N1/3622 ,  A61N1/3627 ,  A61N1/368 ,  A61N1/3682

摘要： A pacing system and method for providing multiple chamber pacing of a patient's heart, and in particular, pacing programmed for treatment of various forms of heart failure. The system utilizes impedance sensing for determining optimum pacing parameters, e.g., for pacing the left ventricle so that left heart output is maximized. The impedance sensing also is used for determination of arrhythmias or progression of heart failure. Impedance sensing is provided for between selected pairs of the four chambers, to enable optimizing of information for control and diagnosis. In a preferred embodiment impedance measurements are obtained for determining the timing of right heart valve closure or right ventricular contractions, and the timing of delivery of left ventricular pace pulses is adjusted so as to optimally synchronize left ventricular pacing with the right ventricular contractions. Impedance sensing in the left heart also provides timing of mechanical contraction, and the pacemaker controls pacing to maintain bi-ventricular mechanical synchronization adjusted for maximum cardiac output.

摘要翻译： 用于提供患者心脏的多个室起搏的起搏系统和方法，特别是针对治疗各种形式的心力衰竭的起搏。 系统利用阻抗感测来确定最佳起搏参数，例如用于起搏左心室，使得左心输出最大化。 阻抗检测也用于确定心律失常或心力衰竭进展。 在四个室的选定对之间提供阻抗感测，以实现用于控制和诊断的信息的优化。 在优选实施例中，获得用于确定右心瓣膜闭合或右心室收缩的时间的阻抗测量，并且调整左心室起搏脉冲的传递时间，以便使左心室起搏与右心室收缩最佳地同步。 心脏中的阻抗传感还提供机械收缩的时机，并且起搏器控制起搏以维持双心室机械同步，以调节最大心输出量。

公开(公告)号：US06223079B1

公开(公告)日：2001-04-24

申请号：US09493688

申请日：2000-01-28

申请人： Arnoldus Bakels ,  Robert Leinders ,  Cobus de Roos

发明人： Arnoldus Bakels ,  Robert Leinders ,  Cobus de Roos

IPC分类号： A61N1362

CPC分类号： A61N1/36521 ,  A61N1/3622 ,  A61N1/3627 ,  A61N1/368 ,  A61N1/3682

摘要： A pacing system and method for providing multiple chamber pacing of a patient's heart, and in particular, pacing programmed for treatment of various forms of heart failure. The system utilizes impedance sensing for determining optimum pacing parameters, e.g., for pacing the left ventricle so that left heart output is maximized. The impedance sensing also is used for determination of arrhythmias or progression of heart failure. Impedance sensing is provided for between selected pairs of the four chambers, to enable optimizing of information for control and diagnosis. In a preferred embodiment, impedance measurements are obtained for determining the timing of right heart valve closure or right ventricular contractions, and the timing of delivery of left ventricular pace pulses is adjusted so as to optimally synchronize left ventricular pacing with the right ventricular contractions. Impedance sensing in the left heart also provides timing of mechanical contraction, and the pacemaker controls pacing to maintain bi-ventricular mechanical synchronization adjusted for maximum cardiac output.

摘要翻译： 用于提供患者心脏的多个室起搏的起搏系统和方法，特别是针对治疗各种形式的心力衰竭的起搏。 系统利用阻抗感测来确定最佳起搏参数，例如用于起搏左心室，使得左心输出最大化。 阻抗检测也用于确定心律失常或心力衰竭进展。 在四个室的选定对之间提供阻抗感测，以实现用于控制和诊断的信息的优化。 在优选实施例中，获得用于确定右心瓣膜闭合或右心室收缩的时机的阻抗测量值，并且调节左心室起搏脉冲的传送时间，以便使左心室起搏与右心室收缩最佳地同步。 心脏中的阻抗传感还提供机械收缩的时机，并且起搏器控制起搏以维持双心室机械同步，以调节最大心输出量。