公开(公告)号：US20070140915A1

公开(公告)日：2007-06-21

申请号：US11530300

申请日：2006-09-08

申请人： Robert Sakal ,  Hal Watts ,  Steven Scampini

发明人： Robert Sakal ,  Hal Watts ,  Steven Scampini

IPC分类号： B01L3/02

CPC分类号： B01L3/0272 ,  B01L3/50825 ,  B01L2300/047 ,  B01L2300/049 ,  B01L2300/0832 ,  B01L2400/0633 ,  G01N35/0099 ,  G01N2035/00524

摘要： An instrument for automated processing of sample vials are provided. The instrument causes an aliquot chamber within the vial to be filled with the fluid contained within the vial.

摘要翻译： 提供了一种用于样品瓶自动处理的仪器。 该仪器使小瓶内的等分试样室充满容纳在小瓶内的流体。

公开(公告)号：US20080081363A1

公开(公告)日：2008-04-03

申请号：US11839531

申请日：2007-08-15

申请人： Timothy Hutchins ,  Hal Watts ,  Steven Scampini ,  Eric Grimes ,  Andrew Fischer

发明人： Timothy Hutchins ,  Hal Watts ,  Steven Scampini ,  Eric Grimes ,  Andrew Fischer

IPC分类号： C12M3/04

CPC分类号： C12M47/00 ,  G01N1/36 ,  Y10T436/25 ,  Y10T436/2575

摘要： A system for making cell blocks includes a cell block cassette and processing station, the cassette including a main body having a having a collection aperture formed therein and a filter assembly removably attached to the main body, the filter assembly defining a collection well in communication with the collection aperture, and having a filter positioned across a bottom surface of the collection well, the filter configured to retain cellular matter carried in a fluid that is dispensed into the collection well and flows across the filter. The cell block processor has a cassette interface removably seating the cell block cassette, and a sensor positioned or positionable to detect and monitor a fluid level in the collection well. The processing station includes an automated fluid delivery system operable to dispense a fluid into the collection well, and a controller operatively coupled to the fluid delivery system, wherein the controller causes the fluid delivery system to selectively dispense fluids into the collection well based at least in part on a flow rate across the filter determined at least in part based on changes in the monitored fluid level in the collection well.

摘要翻译： 用于制造单元块的系统包括单元块盒和处理站，所述盒包括具有形成在其中的收集孔的主体和可移除地附接到主体的过滤器组件，所述过滤器组件限定与 收集孔，并且具有穿过收集阱的底表面定位的过滤器，所述过滤器被配置为保持携带在被分配到收集井中并流过过滤器的流体中的细胞物质。 细胞块处理器具有可移除地安置细胞块盒的盒式接口，以及定位或定位以便检测和监测收集阱中的液面的传感器。 处理站包括可操作以将流体分配到收集井中的自动化流体输送系统，以及可操作地耦合到流体输送系统的控制器，其中控制器使得流体输送系统选择性地将流体分配到收集井中， 至少部分地基于收集井中监测的液体水平的变化确定穿过过滤器的流速的部分。

公开(公告)号：US20080081351A1

公开(公告)日：2008-04-03

申请号：US11839528

申请日：2007-08-15

申请人： Timothy Hutchins ,  Hal Watts ,  Steven Scampini ,  Eric Grimes ,  Andrew Fischer

发明人： Timothy Hutchins ,  Hal Watts ,  Steven Scampini ,  Eric Grimes ,  Andrew Fischer

IPC分类号： C12Q1/24

CPC分类号： C12M47/00 ,  G01N1/36 ,  Y10T436/25 ,  Y10T436/2575

摘要： A system for making cell blocks includes a cell block cassette and processing station, the cassette including a main body having a having a collection aperture formed therein and a filter assembly removably attached to the main body, the filter assembly defining a collection well in communication with the collection aperture, and having a filter positioned across a bottom surface of the collection well, the filter configured to retain cellular matter carried in a fluid that is dispensed into the collection well and flows across the filter. The cell block processor has a cassette interface removably seating the cell block cassette, and a sensor positioned or positionable to detect and monitor a fluid level in the collection well. The processing station includes an automated fluid delivery system operable to dispense a fluid into the collection well, and a controller operatively coupled to the fluid delivery system, wherein the controller causes the fluid delivery system to selectively dispense fluids into the collection well based at least in part on a flow rate across the filter determined at least in part based on changes in the monitored fluid level in the collection well.

摘要翻译： 用于制造单元块的系统包括单元块盒和处理站，所述盒包括具有形成在其中的收集孔的主体和可移除地附接到主体的过滤器组件，所述过滤器组件限定与 收集孔，并且具有穿过收集阱的底表面定位的过滤器，所述过滤器被配置为保持携带在被分配到收集井中并流过过滤器的流体中的细胞物质。 细胞块处理器具有可移除地安置细胞块盒的盒式接口，以及定位或定位以便检测和监测收集阱中的液面的传感器。 处理站包括可操作以将流体分配到收集井中的自动化流体输送系统，以及可操作地耦合到流体输送系统的控制器，其中控制器使得流体输送系统选择性地将流体分配到收集井中， 至少部分地基于收集井中监测的液体水平的变化确定穿过过滤器的流速的部分。

公开(公告)号：US20080057573A1

公开(公告)日：2008-03-06

申请号：US11839533

申请日：2007-08-15

申请人： Timothy Hutchins ,  Hal Watts ,  Steven Scampini ,  Eric Grimes

发明人： Timothy Hutchins ,  Hal Watts ,  Steven Scampini ,  Eric Grimes

IPC分类号： C12M1/00

CPC分类号： C12M47/00 ,  G01N1/36 ,  Y10T436/25 ,  Y10T436/2575

摘要： A system for making cell blocks includes a cell block cassette and processing station, the cassette including a main body having a having a collection aperture formed therein and a filter assembly removably attached to the main body, the filter assembly defining a collection well in communication with the collection aperture, and having a filter positioned across a bottom surface of the collection well, the filter configured to retain cellular matter carried in a fluid that is dispensed into the collection well and flows across the filter. The cell block processor has a cassette interface removably seating the cell block cassette, and a sensor positioned or positionable to detect and monitor a fluid level in the collection well. The processing station includes an automated fluid delivery system operable to dispense a fluid into the collection well, and a controller operatively coupled to the fluid delivery system, wherein the controller causes the fluid delivery system to selectively dispense fluids into the collection well based at least in part on a flow rate across the filter determined at least in part based on changes in the monitored fluid level in the collection well.

摘要翻译： 用于制造单元块的系统包括单元块盒和处理站，所述盒包括具有形成在其中的收集孔的主体和可移除地附接到主体的过滤器组件，所述过滤器组件限定与 收集孔，并且具有穿过收集阱的底表面定位的过滤器，所述过滤器被配置为保持携带在被分配到收集井中并流过过滤器的流体中的细胞物质。 细胞块处理器具有可移除地安置细胞块盒的盒式接口，以及定位或定位以便检测和监测收集阱中的液面的传感器。 处理站包括可操作以将流体分配到收集井中的自动化流体输送系统，以及可操作地耦合到流体输送系统的控制器，其中控制器使得流体输送系统选择性地将流体分配到收集井中， 至少部分地基于收集井中监测的液体水平的变化确定穿过过滤器的流速的部分。

公开(公告)号：US07829021B2

公开(公告)日：2010-11-09

申请号：US11839531

申请日：2007-08-15

申请人： Timothy Hutchins ,  Hal Watts ,  Steven Scampini ,  Eric Grimes ,  Andrew H. Fischer

发明人： Timothy Hutchins ,  Hal Watts ,  Steven Scampini ,  Eric Grimes ,  Andrew H. Fischer

IPC分类号： G01N21/00

CPC分类号： C12M47/00 ,  G01N1/36 ,  Y10T436/25 ,  Y10T436/2575

摘要： A system for making cell blocks includes a cell block cassette and processing station, the cassette including a main body having a having a collection aperture formed therein and a filter assembly removably attached to the main body, the filter assembly defining a collection well in communication with the collection aperture, and having a filter positioned across a bottom surface of the collection well, the filter configured to retain cellular matter carried in a fluid that is dispensed into the collection well and flows across the filter. The cell block processor has a cassette interface removably seating the cell block cassette, and a sensor positioned or positionable to detect and monitor a fluid level in the collection well. The processing station includes an automated fluid delivery system operable to dispense a fluid into the collection well, and a controller operatively coupled to the fluid delivery system, wherein the controller causes the fluid delivery system to selectively dispense fluids into the collection well based at least in part on a flow rate across the filter determined at least in part based on changes in the monitored fluid level in the collection well.

摘要翻译： 用于制造单元块的系统包括单元块盒和处理站，所述盒包括具有形成在其中的收集孔的主体和可移除地附接到主体的过滤器组件，所述过滤器组件限定与 收集孔，并且具有穿过收集阱的底表面定位的过滤器，所述过滤器被配置为保持携带在被分配到收集井中并流过过滤器的流体中的细胞物质。 细胞块处理器具有可移除地安置细胞块盒的盒式接口，以及定位或定位以便检测和监测收集阱中的液面的传感器。 处理站包括可操作以将流体分配到收集井中的自动化流体输送系统，以及可操作地耦合到流体输送系统的控制器，其中控制器使得流体输送系统选择性地将流体分配到收集井中， 至少部分地基于收集井中监测的液体水平的变化确定穿过过滤器的流速的部分。

公开(公告)号：US07914462B2

公开(公告)日：2011-03-29

申请号：US11839528

申请日：2007-08-15

申请人： Timothy Hutchins ,  Hal Watts ,  Steven Scampini ,  Eric Grimes ,  Andrew H. Fischer

发明人： Timothy Hutchins ,  Hal Watts ,  Steven Scampini ,  Eric Grimes ,  Andrew H. Fischer

IPC分类号： A61B10/10 ,  B01L3/02 ,  C12M1/00 ,  G01N1/30

CPC分类号： C12M47/00 ,  G01N1/36 ,  Y10T436/25 ,  Y10T436/2575

摘要： A system for making cell blocks includes a cell block cassette and processing station, the cassette including a main body having a having a collection aperture formed therein and a filter assembly removably attached to the main body, the filter assembly defining a collection well in communication with the collection aperture, and having a filter positioned across a bottom surface of the collection well, the filter configured to retain cellular matter carried in a fluid that is dispensed into the collection well and flows across the filter. The cell block processor has a cassette interface removably seating the cell block cassette, and a sensor positioned or positionable to detect and monitor a fluid level in the collection well. The processing station includes an automated fluid delivery system operable to dispense a fluid into the collection well, and a controller operatively coupled to the fluid delivery system, wherein the controller causes the fluid delivery system to selectively dispense fluids into the collection well based at least in part on a flow rate across the filter determined at least in part based on changes in the monitored fluid level in the collection well.

摘要翻译： 用于制造单元块的系统包括单元块盒和处理站，所述盒包括具有形成在其中的收集孔的主体和可移除地附接到主体的过滤器组件，所述过滤器组件限定与 收集孔，并且具有穿过收集阱的底表面定位的过滤器，所述过滤器被配置为保持携带在被分配到收集井中并流过过滤器的流体中的细胞物质。 细胞块处理器具有可移除地安置细胞块盒的盒式接口，以及定位或定位以便检测和监测收集阱中的液面的传感器。 处理站包括可操作以将流体分配到收集井中的自动化流体输送系统，以及可操作地耦合到流体输送系统的控制器，其中控制器使得流体输送系统选择性地将流体分配到收集井中， 至少部分地基于收集井中监测的液体水平的变化确定穿过过滤器的流速的部分。

公开(公告)号：US08137289B2

公开(公告)日：2012-03-20

申请号：US12717566

申请日：2010-03-04

申请人： Hal Watts ,  Robert Sakal

发明人： Hal Watts ,  Robert Sakal

IPC分类号： A61B5/00 ,  G01N1/00 ,  G01N1/12

CPC分类号： B01L3/0272 ,  A61B10/0096 ,  B01L3/50825 ,  B01L2200/0605 ,  B01L2200/141 ,  B01L2300/042 ,  B01L2300/047 ,  B01L2300/049 ,  B01L2400/0633

摘要： Sample vials and methods of processing the sample vials are provided. The sample vial comprises a vial container, a sample collection chamber within the vial container, a vial cap configured to be mated with the vial container to enclose the collection chamber, an aliquot chamber, which may be carried by the vial cap or the vial container, and a valve mechanism for selectively sealing and unsealing the aliquot chamber from the collection chamber. The method may comprise flowing an aliquot of the sample from the collection chamber while the sample within the collection chamber is isolated from an environment exterior to the vial, sealing the aliquot chamber from the collection chamber to isolate the aliquot sample from the remaining sample portion, and transferring at least some of the remaining sample portion from the collection chamber to a microscope slide while the aliquot chamber is sealed from the collection chamber. The method further comprises reserving the slide for cytological screening of the sample, and reserving the aliquot sample for deoxynucleic acid (DNA) testing.

摘要翻译： 提供样品瓶和处理样品瓶的方法。 样品瓶包括小瓶容器，小瓶容器内的样品收集室，构造成与小瓶容器配合以封闭收集室的小瓶盖，等分试样室，其可以由小瓶盖或小瓶容器 以及用于从收集室选择性地密封和开封等分试样室的阀机构。 该方法可以包括使来自收集室的样品的等分试样流动，同时收集室内的样品与小瓶外部的环境隔离，将等分试样室从收集室密封以将等分试样与剩余样品部分隔离， 以及将所述剩余样品部分中的至少一部分从所述收集室转移到显微镜载玻片，同时所述等分试样室与所述收集室密封。 该方法还包括保留用于样品的细胞学筛选的载玻片，并保留等分试样以进行脱氧核酸（DNA）测试。

公开(公告)号：US20080121050A1

公开(公告)日：2008-05-29

申请号：US11563639

申请日：2006-11-27

申请人： Robert Sakal ,  Hal Watts ,  Steve Scampini

发明人： Robert Sakal ,  Hal Watts ,  Steve Scampini

IPC分类号： B01L3/00 ,  B01L11/00 ,  G01N1/28

CPC分类号： G01N35/10 ,  B01L3/50825 ,  B01L2300/047 ,  B01L2300/049 ,  B01L2300/0832 ,  B01L2400/0633 ,  G01N2035/1032

摘要： Vials used for obtaining an aliquot of a biological sample are provided. Also provided are method of using the vials and instruments to obtain an aliquot of a biological sample.

摘要翻译： 提供了用于获得生物样品等分试样的小瓶。 还提供了使用小瓶和器械获得生物样品等分试样的方法。

公开(公告)号：US07674434B2

公开(公告)日：2010-03-09

申请号：US11563639

申请日：2006-11-27

申请人： Robert Sakal ,  Hal Watts ,  Steve Scampini

发明人： Robert Sakal ,  Hal Watts ,  Steve Scampini

IPC分类号： B01L3/00

CPC分类号： G01N35/10 ,  B01L3/50825 ,  B01L2300/047 ,  B01L2300/049 ,  B01L2300/0832 ,  B01L2400/0633 ,  G01N2035/1032

摘要： Vials used for obtaining an aliquot of a biological sample are provided. Also provided are method of using the vials and instruments to obtain an aliquot of a biological sample.

摘要翻译： 提供了用于获得生物样品等分试样的小瓶。 还提供了使用小瓶和器械获得生物样品等分试样的方法。

公开(公告)号：US20070134134A1

公开(公告)日：2007-06-14

申请号：US11299394

申请日：2005-12-12

申请人： Hal Watts ,  Robert Sakal

发明人： Hal Watts ,  Robert Sakal

IPC分类号： B01L3/00 ,  C12Q1/68 ,  C12M1/00

CPC分类号： B01L3/0272 ,  A61B10/0096 ,  B01L3/50825 ,  B01L2200/0605 ,  B01L2200/141 ,  B01L2300/042 ,  B01L2300/047 ,  B01L2300/049 ,  B01L2400/0633

摘要： Sample vials and methods of processing the sample vials are provided. The sample vial comprises a vial container, a sample collection chamber within the vial container, a vial cap configured to be mated with the vial container to enclose the collection chamber, an aliquot chamber, which may be carried by the vial cap or the vial container, and a valve mechanism for selectively sealing and unsealing the aliquot chamber from the collection chamber. The method may comprise flowing an aliquot of the sample from the collection chamber while the sample within the collection chamber is isolated from an environment exterior to the vial, sealing the aliquot chamber from the collection chamber to isolate the aliquot sample from the remaining sample portion, and transferring at least some of the remaining sample portion from the collection chamber to a microscope slide while the aliquot chamber is sealed from the collection chamber. The method further comprises reserving the slide for cytological screening of the sample, and reserving the aliquot sample for deoxynucleic acid (DNA) testing.

摘要翻译： 提供样品瓶和处理样品瓶的方法。 样品瓶包括小瓶容器，小瓶容器内的样品收集室，构造成与小瓶容器配合以封闭收集室的小瓶盖，等分试样室，其可以由小瓶盖或小瓶容器 以及用于从收集室选择性地密封和开封等分试样室的阀机构。 该方法可以包括使来自收集室的样品的等分试样流动，同时收集室内的样品与小瓶外部的环境隔离，将等分试样室从收集室密封以将等分试样与剩余样品部分隔离， 以及将所述剩余样品部分中的至少一部分从所述收集室转移到显微镜载玻片，同时所述等分试样室与所述收集室密封。 该方法还包括保留用于样品的细胞学筛选的载玻片，并保留等分试样以进行脱氧核酸（DNA）测试。