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公开(公告)号：US08361971B2
公开(公告)日：2013-01-29
申请号：US13246732
申请日：2011-09-27
CPC分类号： C07K5/0215 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K31/165 , A61K31/216
摘要： Disclosed herein are tablets comprising ezatiostat hydrochloride wherein the ezatiostat hydrochloride comprises from about 75 to about 82 percent by weight of the tablet.
摘要翻译： 本文公开了包含盐酸西替伐他汀的片剂，其中盐酸替扎他昔坦包含片剂的约75-约82重量％。
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公开(公告)号：US20120021054A1
公开(公告)日：2012-01-26
申请号：US13246732
申请日：2011-09-27
CPC分类号： C07K5/0215 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K31/165 , A61K31/216
摘要： Disclosed herein are tablets comprising ezatiostat hydrochloride wherein the ezatiostat hydrochloride comprises from about 75 to about 82 percent by weight of the tablet.
摘要翻译： 本文公开了包含盐酸西替伐他汀的片剂，其中盐酸替扎他昔坦包含片剂的约75-约82重量％。
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公开(公告)号：US20110300215A1
公开(公告)日：2011-12-08
申请号：US13075116
申请日：2011-03-29
CPC分类号： C07K5/0215 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K31/165 , A61K31/216
摘要： Disclosed herein are tablets comprising ezatiostat hydrochloride wherein the ezatiostat hydrochloride comprises from about 75 to about 82 percent by weight of the tablet.
摘要翻译： 本文公开了包含盐酸西替伐他汀的片剂，其中盐酸替扎他昔坦包含片剂的约75-约82重量％。
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公开(公告)号：US20110301088A1
公开(公告)日：2011-12-08
申请号：US13041136
申请日：2011-03-04
申请人： Stephan D. Parent , Steven R. Schow
发明人： Stephan D. Parent , Steven R. Schow
CPC分类号： C07K5/0215 , A61K38/00
摘要： Crystalline ezatiostat hydrochloride ansolvate form D is more stable and/or more soluble that various solvated crystalline polymorphic forms of ezatiostat hydrochloride.
摘要翻译： 盐酸盐酸稳氮酸盐的各种溶剂化结晶多晶型形式的盐酸盐稳定剂形式D更稳定和/或更易溶解。
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公开(公告)号：US06458998B1
公开(公告)日：2002-10-01
申请号：US09579279
申请日：2000-05-25
申请人： Wayne R. Spevak , Songyuan Shi , Prasad V. V. S. V. Manchem , Michael R. Kozlowski , Steven R. Schow , Robert T. Lum
发明人： Wayne R. Spevak , Songyuan Shi , Prasad V. V. S. V. Manchem , Michael R. Kozlowski , Steven R. Schow , Robert T. Lum
IPC分类号： C07C27300
CPC分类号： C07D257/04 , C07C309/51 , C07C311/47 , C07C335/16 , C07C335/18 , C07C335/32 , C07D211/96 , C07D213/76 , C07D233/36 , C07D239/42 , C07D241/20 , C07F9/4021
摘要： Compounds of formula I are useful for treating conditions associated with hyperglycemia, especially Type II diabetes. These compounds are useful in stimulating the kinase activity of the insulin receptor, activating the insulin receptor, and stimulating the uptake of glucose. Pharmaceutical compositions comprising the antidiabetic compounds are also disclosed.
摘要翻译： 式I化合物可用于治疗与高血糖相关的病症，特别是II型糖尿病。 这些化合物可用于刺激胰岛素受体的激酶活性，激活胰岛素受体，并刺激葡萄糖摄取。 还公开了包含抗糖尿病化合物的药物组合物。
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公开(公告)号：US06337338B1
公开(公告)日：2002-01-08
申请号：US09464360
申请日：1999-12-15
IPC分类号： A61K3147
CPC分类号： A61K31/4706 , A61K31/425 , A61K31/47 , A61K2300/00
摘要： Methods for treating diseases associated with the activity of the insulin growth factor-1 receptor (IGF-1R), such as cancer, are provided. Methods for inhibiting cell growth and proliferation, especially of tumor cells, and promoting apoptosis are also provided. Each of these methods employs the use of a heteroaryl-aryl urea compound as an antagonist for IGF-1R.
摘要翻译： 提供了治疗与胰岛素生长因子-1受体（IGF-1R）的活性相关的疾病如癌症的方法。 还提供了抑制细胞生长和增殖，特别是肿瘤细胞增殖和促进细胞凋亡的方法。 这些方法中的每一种都使用杂芳基 - 芳基脲化合物作为IGF-1R的拮抗剂。
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公开(公告)号：US07071231B2
公开(公告)日：2006-07-04
申请号：US10237583
申请日：2002-09-06
申请人： Wayne R. Spevak , Songyuan Shi , Prasad V. V. S. V. Manchem , Michael R. Kozlowski , Steven R. Schow , Robert T. Lum
发明人： Wayne R. Spevak , Songyuan Shi , Prasad V. V. S. V. Manchem , Michael R. Kozlowski , Steven R. Schow , Robert T. Lum
IPC分类号： A61K31/18 , C12N5/06 , C07C309/01
CPC分类号： C07D257/04 , C07C309/51 , C07C311/47 , C07C335/16 , C07C335/18 , C07C335/32 , C07D211/96 , C07D213/76 , C07D233/36 , C07D239/42 , C07D241/20 , C07F9/4021
摘要： Compounds of formula I are useful for treating conditions associated with hyperglycemia, especially Type II diabetes. These compounds are useful in stimulating the kinase activity of the insulin receptor, activating the insulin receptor, and stimulating the uptake of glucose. Pharmaceutical compositions comprising the antidiabetic compounds are also disclosed.
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8.发明授权Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents 有权作为抗肿瘤剂的二 - （N，N'-双 - （2-卤代乙基）氨基）氨基磷酸酯公开(公告)号：US06506739B1
公开(公告)日：2003-01-14
申请号：US09847533
申请日：2001-05-01
申请人： R. Jason Herr , Robert T. Lum , Steven R. Schow , Fanying Meng , Michael R. Kozlowski , Pavel Zhichkin
发明人： R. Jason Herr , Robert T. Lum , Steven R. Schow , Fanying Meng , Michael R. Kozlowski , Pavel Zhichkin
IPC分类号： A61K31664
CPC分类号： A61K45/06 , A61K31/664 , C07F9/2458 , A61K2300/00
摘要： Bis-(N,N′-bis-(2-haloethyl)amino)phosphoramidates, pharmaceutical compositions containing them, methods of treatment using them, and processes for their preparation. The compounds possess anti-tumor activities or are capable of being modified to have anti-tumor activities; and this invention relates to the use of the compounds in methods for the treatment of tumors and, especially, for the treatment of cancer.
摘要翻译： 双（（N，N'-双 - （2-卤代乙基）氨基）氨基磷酸酯，含有它们的药物组合物，使用它们的治疗方法及其制备方法。 该化合物具有抗肿瘤活性或能够被修饰以具有抗肿瘤活性; 本发明涉及化合物在治疗肿瘤，特别是用于治疗癌症的方法中的用途。
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公开(公告)号：US5834487A
公开(公告)日：1998-11-10
申请号：US719042
申请日：1996-09-24
申请人： Robert T. Lum , Steven R. Schow , Alison Joly , Suresh Kerwar , Marek G. Nelson , Michael M. Wick
发明人： Robert T. Lum , Steven R. Schow , Alison Joly , Suresh Kerwar , Marek G. Nelson , Michael M. Wick
IPC分类号： A61K38/00 , A61K31/00 , A61K31/12 , A61K31/122 , A61K31/165 , A61K31/40 , A61K31/445 , A61K31/505 , A61K38/04 , A61K38/05 , A61K38/06 , A61P9/00 , A61P29/00 , A61P31/00 , A61P37/00 , C07C49/115 , C07C49/537 , C07C49/67 , C07C233/22 , C07C235/78 , C07D295/185 , C07K5/06 , C07K5/062 , A61K31/195
CPC分类号： C07D295/185 , A61K31/165 , A61K31/40 , A61K31/445 , A61K31/505 , A61K38/05 , A61K38/06 , C07C233/22 , C07C235/78 , C07C2101/04 , C07C2102/08
摘要： This invention is a method for inhibiting cell proliferation using indanones.
摘要翻译： 本发明是使用茚满酮抑制细胞增殖的方法。
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公开(公告)号：US06790958B2
公开(公告)日：2004-09-14
申请号：US09929772
申请日：2001-08-14
申请人： Robert T. Lum , Cheri Lynn Blum , Richard Mackman , Michael M. Wick , Steven R. Schow , Jeffery A. Zablocki , Prabbha Ibrahim
发明人： Robert T. Lum , Cheri Lynn Blum , Richard Mackman , Michael M. Wick , Steven R. Schow , Jeffery A. Zablocki , Prabbha Ibrahim
IPC分类号： C07D47304
CPC分类号： B60R1/00 , C07D473/16 , C07D473/40 , G08G1/163
摘要： Compounds of the following formula are provided: wherein: R1 is —X—R1′; in which R1′ is alkyl, cycloalkyl, aryl, aralkyl, hetaryl, or heterocyclyl, all of which are optionally substituted; X is —NH; R2 is optionally substituted lower alkyl; and R3 is —NR4R5; in which R4 and R5 independently are hydrogen or lower alkyl optionally substituted by hydroxy or amino; or acid addition salts or cationic salts thereof. The compounds inhibit CDK-2 activity and are useful for treating disorders characterized by undesirable cell proliferation.
摘要翻译： 提供下式的化合物：其中：R1是-X-R1'; 其中R 1'是烷基，环烷基，芳基，芳烷基，杂芳基或杂环基，其全部是任选取代的; X是-NH; R 2是任选取代的低级烷基; 和R 3是-NR 4 R 5; 其中R4和R5独立地是氢或任选被羟基或氨基取代的低级烷基; 或其酸加成盐或阳离子盐。 该化合物抑制CDK-2活性，并且可用于治疗以不期望的细胞增殖为特征的疾病。
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