公开(公告)号：US20210080420A1

公开(公告)日：2021-03-18

申请号：US17106620

申请日：2020-11-30

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Klaus Andreas Bauer-Espindola ,  Michael Marquant ,  Christine Nortmeyer ,  Reiner Stein

IPC: G01N27/327 ,  C12Q1/00

Abstract: A test element for electrochemically detecting at least one analyte in a bodily fluid is disclosed. The test element comprises at least one first electrode and at least one second electrode. The first electrode is designed as a working electrode and the second electrode is designed as a counter electrode. The test element comprises at least one capillary capable of receiving a sample of the body fluid. The first electrode and the second electrode are arranged on opposing sides of the capillary. The first electrode and the second electrode are arranged such that during a capillary filling the first electrode and the second electrode are wetted simultaneously and at an equal rate.

公开(公告)号：US20190079045A1

公开(公告)日：2019-03-14

申请号：US16185210

申请日：2018-11-09

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Uwe Goebbert ,  Eloisa Lopez-Calle ,  Michael Marquant ,  Christine Nortmeyer ,  Katja Reiter ,  Reiner Stein

IPC: G01N27/327 ,  G01N21/78 ,  B01L3/00

Abstract: A test system for analyzing a sample of a bodily fluid is provided and comprises: at least one test strip comprising at least one capillary channel comprising an inlet opening configured to receive the sample; a vent opening configured to provide an air vent to the capillary channel; and at least one zone consisting of a detection zone and a reagent zone; at least one measuring device configured for interacting with the test strip, the measuring device comprising at least one sealing element for hermetically sealing the vent opening from an ambient atmosphere; and at least one suction device adapted to provide an underpressure to the vent opening; wherein the measuring device further comprises at least one valve or is connectable to the valve, wherein the valve is configured to vent the vent opening of the test strip when the measuring device interacts with the test strip.

公开(公告)号：US20170226068A1

公开(公告)日：2017-08-10

申请号：US15290440

申请日：2016-10-11

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Dieter Heindl ,  Christine Nortmeyer ,  Peter Gebauer ,  Stacy H. Duvall ,  Klaus Andreas Bauer-Espindola

IPC: C07D241/46 ,  C12Q1/26

CPC classification number: C07D241/46 ,  C12Q1/26

Abstract: The present invention relates to a chemical compound or a salt or solvate thereof being an 1-amino-phenazine derivative and to uses thereof. The present invention further relates to a chemistry matrix and to a test element comprising the aforesaid chemical compound. Moreover, the present invention relates to a method for determining the amount of an analyte in a sample, comprising contacting said sample with a chemistry matrix according to the present invention, estimating the amount of electrons liberated or consumed by the chemistry matrix in the presence of said liquid sample, and thereby determining the amount of an analyte in a liquid sample.

公开(公告)号：US11774395B2

公开(公告)日：2023-10-03

申请号：US17106620

申请日：2020-11-30

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Klaus Andreas Bauer-Espindola ,  Michael Marquant ,  Christine Nortmeyer ,  Reiner Stein

IPC: G01N27/327 ,  C12Q1/00

CPC classification number: G01N27/3272 ,  C12Q1/006 ,  G01N27/3274

Abstract: A test element for electrochemically detecting at least one analyte in a bodily fluid is disclosed. The test element comprises at least one first electrode and at least one second electrode. The first electrode is designed as a working electrode and the second electrode is designed as a counter electrode. The test element comprises at least one capillary capable of receiving a sample of the body fluid. The first electrode and the second electrode are arranged on opposing sides of the capillary. The first electrode and the second electrode are arranged such that during a capillary filling the first electrode and the second electrode are wetted simultaneously and at an equal rate.

公开(公告)号：US09988358B2

公开(公告)日：2018-06-05

申请号：US15290440

申请日：2016-10-11

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Dieter Heindl ,  Christine Nortmeyer ,  Peter Gebauer ,  Stacy H. Duvall ,  Klaus Andreas Bauer-Espindola

IPC: C07D241/46 ,  C12Q1/26

CPC classification number: C07D241/46 ,  C12Q1/26

Abstract: The present invention relates to a chemical compound or a salt or solvate thereof being an 1-amino-phenazine derivative and to uses thereof. The present invention further relates to a chemistry matrix and to a test element comprising the aforesaid chemical compound. Moreover, the present invention relates to a method for determining the amount of an analyte in a sample, comprising contacting said sample with a chemistry matrix according to the present invention, estimating the amount of electrons liberated or consumed by the chemistry matrix in the presence of said liquid sample, and thereby determining the amount of an analyte in a liquid sample.

公开(公告)号：US20160091482A1

公开(公告)日：2016-03-31

申请号：US14963576

申请日：2015-12-09

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Klaus Andreas Bauer-Espindola ,  Carina Horn ,  Michael Marquant ,  Christine Nortmeyer ,  Volker Unkrig

IPC: G01N33/49 ,  G01N21/78 ,  G01N27/12 ,  G01N21/64

CPC classification number: G01N33/492 ,  G01N21/6428 ,  G01N21/78 ,  G01N21/8483 ,  G01N27/02 ,  G01N27/12 ,  G01N27/3274 ,  G01N2021/7786

Abstract: A method for detecting at least one analyte in a body fluid is disclosed comprising performing an optical measurement, wherein at least one test chemical is contacts the body fluid. The test chemical is an optical test chemical adapted to perform at least one detection reaction, wherein at least one optically detectable property is changed due to the detection reaction to provide at least one optical measurement value. At least one impedance measurement is generated wherein at least one alternating electrical signal is applied to the body fluid via the impedance measurement electrodes and at least one answer signal is recorded, and at least one impedance measurement value is generated. At least one evaluation step is performed wherein at least one evaluation algorithm is used, and the optical measurement value and the impedance measurement value are used for determining a concentration of the analyte in the body fluid.

Abstract translation: 公开了一种用于检测体液中的至少一种分析物的方法，包括执行光学测量，其中至少一种测试化学品接触体液。 测试化学品是适于执行至少一个检测反应的光学测试化学品，其中由于检测反应而改变至少一种可光学检测的性质以提供至少一种光学测量值。 产生至少一个阻抗测量，其中经由阻抗测量电极将至少一个交流电信号施加到体液，并记录至少一个应答信号，并且产生至少一个阻抗测量值。 执行至少一个评估步骤，其中使用至少一个评估算法，并且使用光学测量值和阻抗测量值来确定体液中分析物的浓度。

公开(公告)号：US20160089867A1

公开(公告)日：2016-03-31

申请号：US14962519

申请日：2015-12-08

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Kurt Klonig ,  Marc Moldt ,  Christine Nortmeyer

IPC: B32B37/12 ,  B32B38/00 ,  G01N21/64

CPC classification number: B32B37/12 ,  B32B38/0008 ,  G01N21/6428 ,  G01N27/3272

Abstract: A method and a production device for producing a test element are disclosed. The method comprises providing in a transport step a continuous substrate tape, wherein the tape is transported in a transport direction parallel to a direction of extension of the continuous substrate tape; applying in an adhesive application step at least one continuous adhesive strip, wherein the strip is applied to the continuous substrate tape with a liquid adhesive and a slot coating process, and wherein the continuous adhesive strip is oriented parallel to the transport direction; applying in a cover element application step at least one cover element, wherein the at least one cover element is applied to the continuous adhesive strip, thereby securing the cover element to the continuous substrate tape; and individualizing in an individualization step the continuous substrate tape, wherein the tape is individualized into single test elements.

Abstract translation: 公开了一种用于制造测试元件的方法和生产装置。 该方法包括在输送步骤中提供连续的基底带，其中所述带沿平行于所述连续基底带的延伸方向的输送方向输送; 在粘合剂施加步骤中施加至少一个连续的粘合剂条，其中所述条带用液体粘合剂和狭缝涂布工艺施加到连续的基材带上，并且其中连续的粘合带平行于输送方向取向; 在覆盖元件施加步骤中施加至少一个覆盖元件，其中所述至少一个覆盖元件施加到所述连续的粘合剂条上，从而将所述覆盖元件固定到所述连续的基底带上; 并且在个体化步骤中个性化连续基材带，其中胶带被个体化成单个测试元件。

公开(公告)号：US11099149B2

公开(公告)日：2021-08-24

申请号：US15604017

申请日：2017-05-24

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Klaus Andreas Bauer-Espindola ,  Michael Marquant ,  Christine Nortmeyer ,  Reiner Stein

IPC: G01N27/327 ,  C12Q1/00

Abstract: A test element for electrochemically detecting at least one analyte in a bodily fluid is disclosed. The test element comprises at least one first electrode and at least one second electrode. The first electrode is designed as a working electrode and the second electrode is designed as a counter electrode. The test element comprises at least one capillary capable of receiving a sample of the body fluid. The first electrode and the second electrode are arranged on opposing sides of the capillary. The first electrode and the second electrode are arranged such that during a capillary filling the first electrode and the second electrode are wetted simultaneously and at an equal rate.

公开(公告)号：US11697279B2

公开(公告)日：2023-07-11

申请号：US14962519

申请日：2015-12-08

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Kurt Klonig ,  Marc Moldt ,  Christine Nortmeyer

IPC: B32B37/12 ,  G01N27/327 ,  B32B38/00 ,  G01N21/64

CPC classification number: B32B37/12 ,  B32B38/0008 ,  G01N21/6428 ,  G01N27/3272

Abstract: A method and a production device for producing a test element are disclosed. The method comprises providing in a transport step a continuous substrate tape, wherein the tape is transported in a transport direction parallel to a direction of extension of the continuous substrate tape; applying in an adhesive application step at least one continuous adhesive strip, wherein the strip is applied to the continuous substrate tape with a liquid adhesive and a slot coating process, and wherein the continuous adhesive strip is oriented parallel to the transport direction; applying in a cover element application step at least one cover element, wherein the at least one cover element is applied to the continuous adhesive strip, thereby securing the cover element to the continuous substrate tape; and individualizing in an individualization step the continuous substrate tape, wherein the tape is individualized into single test elements.

公开(公告)号：US11215577B2

公开(公告)日：2022-01-04

申请号：US16185210

申请日：2018-11-09

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Uwe Goebbert ,  Eloísa Lopez-Calle ,  Michael Marquant ,  Christine Nortmeyer ,  Katja Reiter ,  Reiner Stein

IPC: G01N27/327 ,  B01L3/00 ,  G01N21/78

Abstract: A test system for analyzing a sample of a bodily fluid is provided and comprises: at least one test strip comprising at least one capillary channel comprising an inlet opening configured to receive the sample; a vent opening configured to provide an air vent to the capillary channel; and at least one zone consisting of a detection zone and a reagent zone; at least one measuring device configured for interacting with the test strip, the measuring device comprising at least one sealing element for hermetically sealing the vent opening from an ambient atmosphere; and at least one suction device adapted to provide an underpressure to the vent opening; wherein the measuring device further comprises at least one valve or is connectable to the valve, wherein the valve is configured to vent the vent opening of the test strip when the measuring device interacts with the test strip.