公开(公告)号：US20130157892A1

公开(公告)日：2013-06-20

申请号：US13766130

申请日：2013-02-13

Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.

Inventor： Veit Peter Grunert ,  Ursula Klause ,  Pavel Kubalec ,  Matthias Rothfuss ,  Barbara Upmeier

IPC: G01N33/68

CPC classification number: G01N33/6854 ,  C40B30/04 ,  G01N2800/52

Abstract: Methods and system for determination of an anti- antibody (anti- AB) in vitro in a sample from a patient treated with a therapeutic monoclonal antibody (TmAB). Also, methods and systems for the determination of antigen specific antibodies of a particular immunoglobulin class and for the identification of a patient who is at risk of developing an adverse drug reaction (ADR) during treatment with a TmAB.

Abstract translation: 在用治疗性单克隆抗体（TmAB）治疗的患者的样品中体外测定抗<治疗性单克隆抗体>抗体（抗-TABAB> AB）的方法和系统。 而且，用于确定特定免疫球蛋白类别的抗原特异性抗体的方法和系统以及用于在用TmAB治疗期间鉴定患有不良药物反应（ADR）的风险的患者的方法和系统。

公开(公告)号：US09081016B2

公开(公告)日：2015-07-14

申请号：US13766130

申请日：2013-02-13

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Veit Peter Grunert ,  Ursula Klause ,  Pavel Kubalec ,  Matthias Rothfuss ,  Barbara Upmeier

IPC: C40B30/04 ,  G01N33/68

CPC classification number: G01N33/6854 ,  C40B30/04 ,  G01N2800/52

Abstract: Methods and system for determination of an anti- antibody (anti- AB) in vitro in a sample from a patient treated with a therapeutic monoclonal antibody (TmAB). Also, methods and systems for the determination of antigen specific antibodies of a particular immunoglobulin class and for the identification of a patient who is at risk of developing an adverse drug reaction (ADR) during treatment with a TmAB.

Abstract translation: 在用治疗性单克隆抗体（TmAB）治疗的患者的样品中体外测定抗<治疗性单克隆抗体>抗体（抗-TABAB> AB）的方法和系统。 而且，用于确定特定免疫球蛋白类别的抗原特异性抗体的方法和系统以及用于在用TmAB治疗期间鉴定患有不良药物反应（ADR）的风险的患者的方法和系统。

公开(公告)号：US20210017272A1

公开(公告)日：2021-01-21

申请号：US16825181

申请日：2020-03-20

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Tobias Oelschlaegel ,  Pavel Kubalec

IPC: C07K16/26 ,  G01N33/76 ,  C07K16/18 ,  C07K16/10 ,  G01N33/569 ,  G01N33/68

Abstract: The present disclosure relates to novel analyte-specific multivalent recombinant antibodies that are particularly useful in immunoassays. Specifically, hexavalent, octavalent and decavalent antibodies are disclosed, including their construction, production, characterization and use in target antigen detection assays.

公开(公告)号：US20210009660A1

公开(公告)日：2021-01-14

申请号：US15934055

申请日：2018-03-23

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Alfred Engel ,  Pavel Kubalec ,  Alfons Nichtl ,  Tobias Oelschlaegel ,  Rainer Schlecht

IPC: C07K16/00

Abstract: The disclosure describes a recombinant immunoglobulin heavy chain comprising a sortase conjugation loop, methods for conjugating and/or labeling such recombinant immunoglobulin heavy chains by use of the enzyme sortase and to the conjugates/labeled products obtained via the method.

公开(公告)号：US11136376B2

公开(公告)日：2021-10-05

申请号：US15934055

申请日：2018-03-23

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Alfred Engel ,  Pavel Kubalec ,  Alfons Nichtl ,  Tobias Oelschlaegel ,  Rainer Schlecht

IPC: C07K16/00

Abstract: The disclosure describes a recombinant immunoglobulin heavy chain comprising a sortase conjugation loop, methods for conjugating and/or labeling such recombinant immunoglobulin heavy chains by use of the enzyme sortase and to the conjugates/labeled products obtained via the method.