-
公开(公告)号：US20060258888A1
公开(公告)日：2006-11-16
申请号：US11380956
申请日：2006-05-01
IPC分类号： C07C209/10
CPC分类号： C07C209/10 , C07C213/02 , C07C2601/02 , C07C211/51 , C07C211/52 , C07C211/58 , C07C217/84 , C07C211/56
摘要： Disclosed are methods for making 1,3- and 1,4-diamino-phenyl intermediates by utilizing bis-amination of ortho-substituted aryl halides.
摘要翻译： 公开了通过利用邻位取代的芳基卤化物的双 - 胺化制备1,3-和1,4-二氨基 - 苯基中间体的方法。
-
![Preparation of dihydrothieno [3,2-D] pyrimidines and intermediates used therein](/abs-image/US/2014/02/18/US08653282B2/abs.jpg.150x150.jpg)
2.发明授权Preparation of dihydrothieno [3,2-D] pyrimidines and intermediates used therein 有权制备二氢噻吩并[3,2-D]嘧啶及其中使用的中间体公开(公告)号：US08653282B2
公开(公告)日：2014-02-18
申请号：US12738152
申请日：2008-10-15
申请人： Rogelio Frutos , Dhileepkumar Krishnamurthy , Jason Alan Mulder , Sonia Rodriguez , Chris Hugh Senanayake , Thomas G. Tampone
发明人： Rogelio Frutos , Dhileepkumar Krishnamurthy , Jason Alan Mulder , Sonia Rodriguez , Chris Hugh Senanayake , Thomas G. Tampone
IPC分类号： C07D333/32 , C07D495/04
CPC分类号： C07D495/04
摘要： The invention relates to improved methods of preparing dihydrothienopyrimidines of formula 1, and intermediates thereof, (I) wherein X is SO or SO2, preferably SO, and wherein RA, R1, R2, R3, R4 and R5 have the meanings given in the description. The methods according to this invention are more suitable for large-scale synthesis of said compounds than prior methods because the new synthetic process avoids distillation and chromatographic purification between steps and results in a higher overall yield of the desired product.
摘要翻译： 本发明涉及制备式1的二氢噻吩并嘧啶的改进方法及其中间体，其中X是SO或SO 2，优选SO，其中RA，R 1，R 2，R 3，R 4和R 5具有在说明书中给出的含义 。 根据本发明的方法比现有方法更适合于大规模合成所述化合物，因为新的合成方法避免了步骤之间的蒸馏和色谱纯化并导致所需产物的更高的总产率。
-
![PREPARATION OF DIHYDROTHIENO [3, 2-D] PYRIMIDINES AND INTERMEDIATES USED THEREIN](/abs-image/US/2010/09/02/US20100222585A1/abs.jpg.150x150.jpg)
3.发明申请PREPARATION OF DIHYDROTHIENO [3, 2-D] PYRIMIDINES AND INTERMEDIATES USED THEREIN 有权二氢O O O O O IN IN IN IN IN IN IN IN IN IN IN IN IN IN IN IN IN IN IN IN IN公开(公告)号：US20100222585A1
公开(公告)日：2010-09-02
申请号：US12738152
申请日：2008-10-15
申请人： Rogelio Frutos , Dhileepkumar Krishnamurthy , Jason Alan Mulder , Sonia Rodriguez , Chris Hugh Senanayake , Thomas G. Tampone
发明人： Rogelio Frutos , Dhileepkumar Krishnamurthy , Jason Alan Mulder , Sonia Rodriguez , Chris Hugh Senanayake , Thomas G. Tampone
IPC分类号： C07D491/04
CPC分类号： C07D495/04
摘要： The invention relates to improved methods of preparing dihydrothienopyrimidines of formula 1, and intermediates thereof, (I) wherein X is SO or SO2, preferably SO, and wherein RA, R1, R2, R3, R4 and R5 have the meanings given in the description. The methods according to this invention are more suitable for large-scale synthesis of said pounds than prior methods because the new synthetic process avoids distillation and chromatographic purification between steps and results in a higher overall yield of the desired product.
摘要翻译： 本发明涉及制备式1的二氢噻吩并嘧啶的改进方法及其中间体，其中X是SO或SO 2，优选SO，其中RA，R 1，R 2，R 3，R 4和R 5具有在说明书中给出的含义 。 根据本发明的方法比现有方法更适合于大规模合成所述磅，因为新的合成方法避免了步骤之间的蒸馏和色谱纯化并导致所需产物的更高的总产率。
-
4.发明申请Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein 有权制备吡喃葡萄糖基取代的苄基苯衍生物及其中间体的方法公开(公告)号：US20060258749A1
公开(公告)日：2006-11-16
申请号：US11416683
申请日：2006-05-03
申请人： Matthias Eckhardt , Frank Himmelsbach , Xiao-jun Wang , Wenjun Tang , Xiufeng Sun , Li Zhang , Dhileepkumar Krishnamurthy , Christopher Senanayake , Zhengxu Han
发明人： Matthias Eckhardt , Frank Himmelsbach , Xiao-jun Wang , Wenjun Tang , Xiufeng Sun , Li Zhang , Dhileepkumar Krishnamurthy , Christopher Senanayake , Zhengxu Han
IPC分类号： A61K31/135
CPC分类号： C07D407/12 , C07D309/10 , C07F1/02 , C07F3/02 , C07H15/04 , C07H15/203 , C07H19/01
摘要： The present invention relates to processes for preparing the compounds of general formula I, wherein the groups R1 and R3 are defined according to claim 1. Furthermore this inventions relates to intermediates obtained in these processes.
摘要翻译： 本发明涉及制备通式I化合物的方法，其中R 1和R 3基团根据权利要求1定义。此外，本发明涉及中间体 在这些过程中获得。
-
5.发明授权Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivates and intermediates therein 有权制备吡喃葡萄糖基取代的苄基苯衍生物及其中间体的方法公开(公告)号：US09127034B2
公开(公告)日：2015-09-08
申请号：US12789859
申请日：2010-05-28
申请人： Matthias Eckhardt , Frank Himmelsbach , Xiao-jun Wang , Wenjun Tang , Xiufeng Sun , Li Zhang , Dhileepkumar Krishnamurthy , Christopher Hugh Senanayake , Zhengxu Han
发明人： Matthias Eckhardt , Frank Himmelsbach , Xiao-jun Wang , Wenjun Tang , Xiufeng Sun , Li Zhang , Dhileepkumar Krishnamurthy , Christopher Hugh Senanayake , Zhengxu Han
IPC分类号： C07D307/32 , C07C49/786 , C07C41/05 , C07C43/184 , C07C43/205 , C07C25/06 , C07H15/203
CPC分类号： C07D407/12 , C07D309/10 , C07F1/02 , C07F3/02 , C07H15/04 , C07H15/203 , C07H19/01
摘要： The present invention relates to processes for preparing the compounds of general formula I, wherein the groups R1 and R3 are defined according to claim 1. Furthermore this inventions relates to intermediates obtained in these processes.
摘要翻译： 本发明涉及制备通式I化合物的方法，其中基团R1和R3根据权利要求1定义。此外，本发明涉及在这些方法中获得的中间体。
-
6.发明授权Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein 有权制备吡喃葡萄糖基取代的苄基苯衍生物及其中间体的方法公开(公告)号：US07772191B2
公开(公告)日：2010-08-10
申请号：US11416683
申请日：2006-05-03
申请人： Matthias Eckhardt , Frank Himmelsbach , Xiao-jun Wang , Wenjun Tang , Xiufeng Sun , Li Zhang , Dhileepkumar Krishnamurthy , Chris Hugh Senanayake , Zhengxu Han
发明人： Matthias Eckhardt , Frank Himmelsbach , Xiao-jun Wang , Wenjun Tang , Xiufeng Sun , Li Zhang , Dhileepkumar Krishnamurthy , Chris Hugh Senanayake , Zhengxu Han
IPC分类号： A61K31/341 , A61K31/351 , A61K31/7034 , A61K31/7048 , C07H7/04 , C07D309/12 , C07D307/20
CPC分类号： C07D407/12 , C07D309/10 , C07F1/02 , C07F3/02 , C07H15/04 , C07H15/203 , C07H19/01
摘要： The present invention relates to processes for preparing the compounds of general formula I, wherein the groups R1 and R3 are defined according to claim 1. Furthermore this inventions relates to intermediates obtained in these processes.
摘要翻译： 本发明涉及制备通式I化合物的方法，其中基团R1和R3根据权利要求1定义。此外，本发明涉及在这些方法中获得的中间体。
-
公开(公告)号：US20070293682A1
公开(公告)日：2007-12-20
申请号：US11830166
申请日：2007-07-30
IPC分类号： C07D401/12 , C07D235/28 , C07D291/08
CPC分类号： C07D291/04 , C07B2200/07 , C07C303/36 , C07C313/04 , C07C315/00 , C07C317/04 , C07C2602/08 , C07D235/28 , C07D291/08 , C07D401/12 , C07C317/14 , C07C311/03
摘要： This invention encompasses novel methods of preparing sulfinamides and sulfoxides, particularly stereomerically pure sulfinamides and sulfoxides. The invention further encompasses novel compounds from which sulfinamides and sulfoxides can be prepared.
摘要翻译： 本发明包括制备亚磺酰胺和亚砜，特别是立体异构纯的亚磺酰胺和亚砜的新方法。 本发明还包括可以制备亚磺酰胺和亚砜的新化合物。
-
公开(公告)号：US06610887B2
公开(公告)日：2003-08-26
申请号：US10120503
申请日：2002-04-12
IPC分类号： C07C20962
CPC分类号： C07C209/60 , C07C313/06 , C07C2601/04 , C07C211/29
摘要： This invention encompasses novel methods of preparing sibutramine and sibutramine derivatives, and stereomerically pure sibutramine derivatives in particular. Examples of sibutramine derivatives include, but are not limited to, sibutramine metabolites such as desmethylsibutramine and didesmethylsibutramine. The invention further encompasses novel compounds useful in the synthesis of sibutramine derivatives.
-
![Synthesis of dihydrothieno[3,2-d]pyrimidine diols](/abs-image/US/2013/06/25/US08471010B2/abs.jpg.150x150.jpg)
公开(公告)号：US08471010B2
公开(公告)日：2013-06-25
申请号：US12989575
申请日：2009-05-07
申请人： Rogelio P. Frutos , Thomas G. Tampone , Jason Alan Mulder , Dhileepkumar Krishnamurthy , Chris H. Senanayake
发明人： Rogelio P. Frutos , Thomas G. Tampone , Jason Alan Mulder , Dhileepkumar Krishnamurthy , Chris H. Senanayake
IPC分类号： C07D495/04
CPC分类号： C07D495/04 , C07D239/70
摘要： The present invention relates to an improved process for the preparation of dihydrothieno[3,2-d]pyrimidine diols, and similar pyrimidine diols, that is efficient, high-yielding, and does not require expensive and potentially unstable intermediates. The diols are used as intermediates in the synthesis of pyrimidine compounds which inhibit PDE4, and are thus useful in the treatment of respiratory or gastrointestinal diseases and complaints, peripheral or central nervous system diseases and disorders, inflammatory conditions, and cancers.
摘要翻译： 本发明涉及制备二氢噻吩并[3,2-d]嘧啶二醇和类似的嘧啶二醇的改进方法，其是有效的，高产的，并且不需要昂贵和潜在的不稳定的中间体。 二醇用作合成抑制PDE4的嘧啶化合物的中间体，因此可用于治疗呼吸道或胃肠道疾病和投诉，外周或中枢神经系统疾病和病症，炎症状况和癌症。
-
![SYNTHESIS IF DIHYDROTHIENO[3,2-D]PYRIMIDINE DIOLS](/abs-image/US/2011/06/02/US20110130563A1/abs.jpg.150x150.jpg)
公开(公告)号：US20110130563A1
公开(公告)日：2011-06-02
申请号：US12989575
申请日：2009-05-07
申请人： Rogelio Perez Frutos , Thomas G. Tampone , Jason Alan Mulder , Dhileepkumar Krishnamurthy , Chris Hugh Senanayake
发明人： Rogelio Perez Frutos , Thomas G. Tampone , Jason Alan Mulder , Dhileepkumar Krishnamurthy , Chris Hugh Senanayake
IPC分类号： C07D239/00
CPC分类号： C07D495/04 , C07D239/70
摘要： The present invention relates to an improved process for the preparation of dihydrothieno[3,2-d]pyrimidine diols, and similar pyrimidine diols, that is efficient, high-yielding, and does not require expensive and potentially unstable intermediates. The diols are used as intermediates in the synthesis of pyrimidine compounds which inhibit PDE4, and are thus useful in the treatment of respiratory or gastrointestinal diseases and complaints, peripheral or central nervous system diseases and disorders, inflammatory conditions, and cancers.
摘要翻译： 本发明涉及制备二氢噻吩并[3,2-d]嘧啶二醇和类似的嘧啶二醇的改进方法，其是有效的，高产的，并且不需要昂贵和潜在的不稳定的中间体。 二醇用作合成抑制PDE4的嘧啶化合物的中间体，因此可用于治疗呼吸道或胃肠道疾病和投诉，外周或中枢神经系统疾病和病症，炎症状况和癌症。
-
-
-
-
-
-
-
-
-
搜索结果
28 条记录 (耗时 0.024 秒)
