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公开(公告)号：US6120989A
公开(公告)日：2000-09-19
申请号：US506553
申请日：1995-07-25
IPC分类号： C07K14/045 , C07K16/00 , C07K19/00 , C12N15/09 , C12P21/02 , C12Q1/68 , C12R1/92 , G01N33/569 , C12Q1/70 , A61K39/245 , C07H21/04
CPC分类号： G01N33/56994 , C07K14/005 , C07K2319/00 , C12N2710/16122 , Y10S435/975
摘要： Diagnostically relevant polypeptides and fusion proteins comprising an amino acid sequence which originates from cytomegalovirus and corresponds to a region of the major DNA-binding protein or of the C-terminal region of the tegument protein pp150 fused with at least one further fragment from another antigenic protein of cytomegalovirus are disclosed. The major DNA-binding protein is encoded by the reading frame UL57. The poly-peptides and fusion proteins according to the invention can be used in an advantageous manner in diagnostic tests and methods for the detection of IgM antibodies against cytomegalovirus.
摘要翻译： 诊断相关的多肽和融合蛋白，其包含源自巨细胞病毒的氨基酸序列，并且对应于与来自另一种抗原蛋白质的至少一个另外的片段融合的主要DNA结合蛋白或片段蛋白质pp150的C-末端区域的区域 公开了巨细胞病毒。 主要的DNA结合蛋白由读框UL57编码。 根据本发明的多肽和融合蛋白可以以有利的方式用于诊断测试和用于检测针对巨细胞病毒的IgM抗体的方法。
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2.发明授权Viral particles which are released after the infection with the human cytomegalovirus, and the use of said particles as a vaccine 有权在用人巨细胞病毒感染后释放的病毒颗粒，以及所述颗粒作为疫苗的使用公开(公告)号：US06713070B1
公开(公告)日：2004-03-30
申请号：US09914948
申请日：2001-09-06
申请人： Bodo Plachter
发明人： Bodo Plachter
IPC分类号： A61K39245
CPC分类号： C12N15/86 , A61K2039/525 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N2710/16122 , C12N2710/16143 , C12N2710/16162
摘要： The invention relates to viral particles which are released by mammal cells after the infection with human cytomegalovirus (HCMV). The invention also relates to particles whose antigenicity has been optimized by changing the HCMV using genetic engineering. The invention further relates to the use of such particles as a vaccine and a method for multiplying the HCMV in mammal cells.
摘要翻译： 本发明涉及在人巨细胞病毒（HCMV）感染后由哺乳动物细胞释放的病毒颗粒。 本发明还涉及通过使用遗传工程改变HCMV来优化其抗原性的颗粒。 本发明还涉及这样的颗粒作为疫苗的使用以及在哺乳动物细胞中使HCMV倍增的方法。
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3.发明申请VIRAL PARTICLE RELEASED AFTER INFECTION OF MAMMALIAN CELLS BY HUMAN CYTOMEGALOVIRUS (HCMV) CONTAINING A FUSION PROTEIN AND USE THEREOF 有权包含融合蛋白的人类细胞病毒（HCMV）感染马氏体细胞后发现的病毒粒子及其用途公开(公告)号：US20130202708A1
公开(公告)日：2013-08-08
申请号：US13639636
申请日：2011-04-06
申请人： Sabine Becke , Sabine Reyda , Bodo Plachter
发明人： Sabine Becke , Sabine Reyda , Bodo Plachter
IPC分类号： A61K39/245
CPC分类号： A61K39/245 , C07K2319/40 , C12N7/00 , C12N15/86 , C12N2710/16143 , C12N2710/16162
摘要： The present invention is related to a viral particle released after infection of mammalian cells by human cytomegalovirus (HCMV), wherein a) the particle is surrounded by a lipid membrane in which viral glycoproteins are embedded, b) the particle contains neither viral DNA nor capsids; and c) the particle contains a fusion protein comprising one or more parts of the T-cell antigen pp65 and at least one heterologous peptide, and wherein the at least one heterologous peptide is inserted at amino acid position W175 or A534 of the amino acid sequence of the T-cell antigen pp65.
摘要翻译： 本发明涉及通过人巨细胞病毒（HCMV）感染哺乳动物细胞后释放的病毒颗粒，其中a）所述颗粒被其中包含病毒糖蛋白的脂质膜包围，b）所述颗粒不含病毒DNA和衣壳 ; 和c）所述颗粒含有包含T细胞抗原pp65的一个或多个部分和至少一个异源肽的融合蛋白，并且其中所述至少一个异源肽插入氨基酸序列的氨基酸位置W175或A534 的T细胞抗原pp65。
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公开(公告)号：US11591373B2
公开(公告)日：2023-02-28
申请号：US16972249
申请日：2019-06-28
申请人： Bodo Plachter
IPC分类号： C07K14/005 , A61K39/245 , C12N7/00 , A61K39/00
摘要： The present invention relates to nucleic acid molecules encoding a recombinant human cytomegalovirus (HCMV) strain, dense bodies produced by said HCMV strain and preparations of said dense bodies for use in medicine, particularly as a vaccine against HCMV.
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5.发明授权Viral particle released after infection of mammalian cells by human cytomegalovirus (HCMV) containing a fusion protein and use thereof 有权通过含有融合蛋白的人巨细胞病毒（HCMV）感染哺乳动物细胞后释放的病毒颗粒及其用途公开(公告)号：US09486517B2
公开(公告)日：2016-11-08
申请号：US13639636
申请日：2011-04-06
申请人： Sabine Becke , Sabine Reyda , Bodo Plachter
发明人： Sabine Becke , Sabine Reyda , Bodo Plachter
IPC分类号： A61K39/245 , C12N7/00 , C12N15/86
CPC分类号： A61K39/245 , C07K2319/40 , C12N7/00 , C12N15/86 , C12N2710/16143 , C12N2710/16162
摘要： The present invention is related to a viral particle released after infection of mammalian cells by human cytomegalovirus (HCMV), wherein a) the particle is surrounded by a lipid membrane in which viral glycoproteins are embedded, b) the particle contains neither viral DNA nor capsids; and c) the particle contains a fusion protein comprising one or more parts of the T-cell antigen pp65 and at least one heterologous peptide, and wherein the at least one heterologous peptide is inserted at amino acid position W175 or A534 of the amino acid sequence of the T-cell antigen pp65.
摘要翻译： 本发明涉及通过人巨细胞病毒（HCMV）感染哺乳动物细胞后释放的病毒颗粒，其中a）所述颗粒被其中包含病毒糖蛋白的脂质膜包围，b）所述颗粒不含病毒DNA和衣壳 ; 和c）所述颗粒含有包含T细胞抗原pp65的一个或多个部分和至少一个异源肽的融合蛋白，并且其中所述至少一个异源肽插入氨基酸序列的氨基酸位置W175或A534 的T细胞抗原pp65。
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