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公开(公告)号：US20190224199A1
公开(公告)日：2019-07-25
申请号：US16314960
申请日：2017-06-08
Applicant: SHOWA DENKO K.K.
Inventor： Daisuke YAGYU , Yuko NAKAGAMI , Ryota NIIBAYASHI , Eiko KATO
IPC: A61K31/513 , A61K8/49 , A61P17/16 , A61Q19/08 , A61Q19/02
Abstract: The present invention provides an agent containing an orotic acid derivative that has high solubility in solvent and has superior physiological activity. The agent of the present invention is a melanin production inhibitor, whitening agent, fibroblast activator, collagen and/or elastin production promoter or wrinkle ameliorant containing as an active ingredient thereof an orotic acid derivative represented by the following general formula (1) or a salt thereof. In formula (1), R preferably represents a side chain of glutamic acid, glycine, histidine or aspartic acid. [In formula (1), R represents a side chain of a naturally-occurring amino acid and R may form, together with a nitrogen atom adjacent thereto through a single carbon atom, a hetero ring.]
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公开(公告)号：US20170312207A1
公开(公告)日：2017-11-02
申请号：US15520254
申请日：2015-11-10
Applicant: SHOWA DENKO K.K.
Inventor： Yuko SAEKI , Eiko KATO
CPC classification number: A61K8/60 , A61K8/06 , A61K8/602 , A61K8/73 , A61K9/0014 , A61K9/107 , A61K31/7034 , A61K47/44 , A61K2800/78 , A61Q19/00 , A61Q19/08
Abstract: The present invention provides a moisturizing agent including an inositol derivative as an active ingredient in which saccharide of three or more monosaccharide unit is bonded to per molecule of inositol.
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公开(公告)号：US20220211605A1
公开(公告)日：2022-07-07
申请号：US17610284
申请日：2020-05-08
Applicant: SHOWA DENKO K.K.
Inventor： Yuko NAKAGAMI , Go FUKADA , Eiko KATO
Abstract: An agent for protection against atmospheric pollutants containing a tocopherol phosphate ester or a salt thereof as an active ingredient is provided. A composition for protection against atmospheric pollutants containing the above-mentioned agent for protection against atmospheric pollutants and a pharmaceutically acceptable carrier is further provided.
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Patent Agency Ranking
4.发明申请公开(公告)号：US20180086779A1
公开(公告)日：2018-03-29
申请号：US15573715
申请日：2016-05-20
Applicant: SHOWA DENKO K.K.
Inventor： Eiko KATO , Hiroshi ISHII , Akira SHIBUYA
IPC: C07F9/655
CPC classification number: C07F9/65522 , A61K8/67 , A61K31/665 , A61Q19/00 , C07F9/655
Abstract: A tocopherol phosphoric acid ester salt in which the tocopherol phosphoric acid ester salt is represented by Formula (1), and in the Formula (1), “R1”, “R2”, and “R3” each independently represents a hydrogen atom or a methyl group, “M” represents an alkali metal, and “a” is 1.10 or more and 2.00 or less.
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5.发明申请公开(公告)号：US20170312301A1
公开(公告)日：2017-11-02
申请号：US15521427
申请日：2015-07-23
Applicant: SHOWA DENKO K.K.
Inventor： Yuko SAEKI , Eiko KATO
IPC: A61K31/7034 , A61Q17/00 , A61K8/60
CPC classification number: A61K31/7034 , A61K8/602 , A61K8/73 , A61K31/7032 , A61K2800/78 , A61Q17/00 , A61Q19/00 , A61Q19/08
Abstract: The present invention provides a skin barrier function-improving agent including an inositol derivative as an active ingredient in which inositol and saccharide are bonded, and a composition for improving a skin barrier function including the above skin barrier function-improving agent and a pharmacologically acceptable carrier.
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公开(公告)号：US20220280396A1
公开(公告)日：2022-09-08
申请号：US17632725
申请日：2020-08-04
Applicant: SHOWA DENKO K.K.
Abstract: A water-in-oil emulsion composition includes (a) at least one ascorbic acid phosphate ester compound selected from the group consisting of ascorbic acid phosphate esters and salts thereof, (b) an organically modified clay mineral, (c) an oil-based agent, and (d) water, in which a content of the component (b) is 0.2% by mass to 4.5% by mass.
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公开(公告)号：US20220257621A1
公开(公告)日：2022-08-18
申请号：US17610190
申请日：2020-05-08
Applicant: SHOWA DENKO K.K.
Inventor： Yuko NAKAGAMI , Go FUKADA , Eiko KATO
IPC: A61K31/702 , A61K31/355 , A61K31/7016 , A61P35/00 , A61P39/06
Abstract: A cancer cell proliferation suppression agent containing, as an active ingredient, an inositol derivative in which a sugar is bound to inositol is provided. Furthermore, a composition for suppressing proliferation of cancer cells containing the above-mentioned cancer cell proliferation suppression agent and a pharmaceutically acceptable carrier is provided.
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公开(公告)号：US20200215069A1
公开(公告)日：2020-07-09
申请号：US16820773
申请日：2020-03-17
Applicant: SHOWA DENKO K.K.
Inventor： Daisuke YAGYU , Yuko NAKAGAMI , Ryota NIIBAYASHI , Eiko KATO
IPC: A61K31/513 , A61Q19/02 , A61Q19/08 , A61P17/16 , A61K8/49
Abstract: The present invention provides an agent containing an orotic acid derivative that has high solubility in solvent and has superior physiological activity. The agent of the present invention is a melanin production inhibitor, whitening agent, fibroblast activator, collagen and/or elastin production promoter or wrinkle ameliorant containing as an active ingredient thereof an orotic acid derivative represented by the following general formula (1) or a salt thereof. In formula (1), R preferably represents a side chain of glutamic acid, glycine, histidine or aspartic acid. [In formula (1), R represents a side chain of a naturally-occurring amino acid and R may form, together with a nitrogen atom adjacent thereto through a single carbon atom, a hetero ring.]
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