公开(公告)号：US20200268780A1

公开(公告)日：2020-08-27

申请号：US16643732

申请日：2018-09-04

Applicant: SHOWA DENKO K.K.

Inventor： Ichiro FUJITA ,  Shinji YAMAKI ,  Yuko NAKAGAMI

IPC: A61K31/7034 ,  A61K31/716 ,  A61K8/60 ,  A61K8/73 ,  A61Q19/00

Abstract: A mixture of inositol derivatives in which a sugar is bonded to inositol includes an inositol derivative (A10) in which total sugars bonded to one inositol molecule is 10 or more in terms of monosaccharide units. In addition, a mixture of inositol derivatives in which a sugar is bonded to inositol includes 5% by mass or more of an inositol derivative (A7), in which total sugars bonded to one inositol molecule is 7 or more in terms of monosaccharide units, with respect to a total amount of inositol derivatives (100% by mass).

公开(公告)号：US20180360719A1

公开(公告)日：2018-12-20

申请号：US16061008

申请日：2016-10-28

Applicant: SHOWA DENKO K.K.

Inventor： Yuko NAKAGAMI ,  Shinji YAMAKI ,  Ichiro FUJITA ,  Tadashi YONEDA

IPC: A61K8/60 ,  A61K8/73 ,  A61K31/7016 ,  A61K31/702 ,  A61Q19/08

Abstract: Provided is an anti-aging agent for skin which contains, as an active component, an inositol derivative in which a monosaccharide or an oligosaccharide is bonded to inositol, in which a total amount of the monosaccharide or the oligosaccharide bonded to one inositol molecule is 2 or greater in terms of monosaccharide unit.

公开(公告)号：US20190224199A1

公开(公告)日：2019-07-25

申请号：US16314960

申请日：2017-06-08

Applicant: SHOWA DENKO K.K.

Inventor： Daisuke YAGYU ,  Yuko NAKAGAMI ,  Ryota NIIBAYASHI ,  Eiko KATO

IPC: A61K31/513 ,  A61K8/49 ,  A61P17/16 ,  A61Q19/08 ,  A61Q19/02

Abstract: The present invention provides an agent containing an orotic acid derivative that has high solubility in solvent and has superior physiological activity. The agent of the present invention is a melanin production inhibitor, whitening agent, fibroblast activator, collagen and/or elastin production promoter or wrinkle ameliorant containing as an active ingredient thereof an orotic acid derivative represented by the following general formula (1) or a salt thereof. In formula (1), R preferably represents a side chain of glutamic acid, glycine, histidine or aspartic acid. [In formula (1), R represents a side chain of a naturally-occurring amino acid and R may form, together with a nitrogen atom adjacent thereto through a single carbon atom, a hetero ring.]

公开(公告)号：US20220257621A1

公开(公告)日：2022-08-18

申请号：US17610190

申请日：2020-05-08

Applicant: SHOWA DENKO K.K.

Inventor： Yuko NAKAGAMI ,  Go FUKADA ,  Eiko KATO

IPC: A61K31/702 ,  A61K31/355 ,  A61K31/7016 ,  A61P35/00 ,  A61P39/06

Abstract: A cancer cell proliferation suppression agent containing, as an active ingredient, an inositol derivative in which a sugar is bound to inositol is provided. Furthermore, a composition for suppressing proliferation of cancer cells containing the above-mentioned cancer cell proliferation suppression agent and a pharmaceutically acceptable carrier is provided.

公开(公告)号：US20200215069A1

公开(公告)日：2020-07-09

申请号：US16820773

申请日：2020-03-17

Applicant: SHOWA DENKO K.K.

Inventor： Daisuke YAGYU ,  Yuko NAKAGAMI ,  Ryota NIIBAYASHI ,  Eiko KATO

IPC: A61K31/513 ,  A61Q19/02 ,  A61Q19/08 ,  A61P17/16 ,  A61K8/49

Abstract: The present invention provides an agent containing an orotic acid derivative that has high solubility in solvent and has superior physiological activity. The agent of the present invention is a melanin production inhibitor, whitening agent, fibroblast activator, collagen and/or elastin production promoter or wrinkle ameliorant containing as an active ingredient thereof an orotic acid derivative represented by the following general formula (1) or a salt thereof. In formula (1), R preferably represents a side chain of glutamic acid, glycine, histidine or aspartic acid. [In formula (1), R represents a side chain of a naturally-occurring amino acid and R may form, together with a nitrogen atom adjacent thereto through a single carbon atom, a hetero ring.]

公开(公告)号：US20220226358A1

公开(公告)日：2022-07-21

申请号：US17714240

申请日：2022-04-06

Applicant: Showa Denko K.K.

Inventor： Ichiro FUJITA ,  Shinji YAMAKI ,  Yuko NAKAGAMI

IPC: A61K31/7034 ,  A61K8/60 ,  A61K8/73 ,  A61K31/716 ,  A61Q19/00

Abstract: A mixture of inositol derivatives in which a sugar is bonded to inositol includes an inositol derivative (A10) in which total sugars bonded to one inositol molecule is 10 or more in terms of monosaccharide units. In addition, a mixture of inositol derivatives in which a sugar is bonded to inositol includes 5% by mass or more of an inositol derivative (A7), in which total sugars bonded to one inositol molecule is 7 or more in terms of monosaccharide units, with respect to a total amount of inositol derivatives (100% by mass).

公开(公告)号：US20220211605A1

公开(公告)日：2022-07-07

申请号：US17610284

申请日：2020-05-08

Applicant: SHOWA DENKO K.K.

Inventor： Yuko NAKAGAMI ,  Go FUKADA ,  Eiko KATO

IPC: A61K8/67 ,  A61K8/04 ,  A61Q17/00

Abstract: An agent for protection against atmospheric pollutants containing a tocopherol phosphate ester or a salt thereof as an active ingredient is provided. A composition for protection against atmospheric pollutants containing the above-mentioned agent for protection against atmospheric pollutants and a pharmaceutically acceptable carrier is further provided.