公开(公告)号：US10112890B2

公开(公告)日：2018-10-30

申请号：US15543261

申请日：2016-01-15

Applicant: SHOWA DENKO K.K.

Inventor： Toru Tachibana ,  Ryota Niibayashi ,  Daisuke Yagyu

IPC: C07C235/12 ,  A23L33/15 ,  A61K8/67 ,  A61Q19/00

Abstract: Provided is a compound represented by Formula (1) or a salt thereof (in the formula, R1 and R2 each independently represent a hydrogen atom or a linear or branched acyl group having 11 to 30 carbon atoms, a hydrocarbon group bonded to a carbonyl carbon of the acyl group is a saturated or unsaturated hydrocarbon group, and at least one of R1 and R2 represents the acyl group).

公开(公告)号：US10646487B2

公开(公告)日：2020-05-12

申请号：US16314960

申请日：2017-06-08

Applicant: SHOWA DENKO K.K.

Inventor： Daisuke Yagyu ,  Yuko Nakagami ,  Ryota Niibayashi ,  Eiko Kato

IPC: A61K31/513 ,  A61Q19/02 ,  A61Q19/08 ,  A61P17/16 ,  A61K8/49

Abstract: The present invention provides an agent containing an orotic acid derivative that has high solubility in solvent and has superior physiological activity. The agent of the present invention is a melanin production inhibitor, whitening agent, fibroblast activator, collagen and/or elastin production promoter or wrinkle ameliorant containing as an active ingredient thereof an orotic acid derivative represented by the following general formula (1) or a salt thereof. In formula (1), R preferably represents a side chain of glutamic acid, glycine, histidine or aspartic acid. [In formula (1), R represents a side chain of a naturally-occurring amino acid and R may form, together with a nitrogen atom adjacent thereto through a single carbon atom, a hetero ring].

公开(公告)号：US12146009B2

公开(公告)日：2024-11-19

申请号：US15734114

申请日：2019-04-11

Applicant: SHOWA DENKO K.K.

Inventor： Ryota Niibayashi

IPC: C08F2/44 ,  C08F290/06 ,  C08K5/00 ,  C08K5/11 ,  C08K5/12 ,  C08K5/14 ,  C08K5/17 ,  C08K5/521 ,  C09K3/10

Abstract: The present invention relates to a radical polymerizable putty-like resin composition containing a resin component containing a radical reactive resin (A) and a radical polymerizable unsaturated monomer (B) having a (meth)acryloyl group in a molecule thereof, an aromatic tertiary amine (C) represented by the following general formula (I), an organic peroxide (D), and a filler (E): wherein, R1 is a hydrogen atom, a methyl group, or a methoxy group; and R2 and R3 are each independently an alkyl group having 1 to 20 carbon atoms or a hydroxyalkyl group having 1 to 20 carbon atoms.

公开(公告)号：US11045471B2

公开(公告)日：2021-06-29

申请号：US16820773

申请日：2020-03-17

Applicant: SHOWA DENKO K.K.

Inventor： Daisuke Yagyu ,  Yuko Nakagami ,  Ryota Niibayashi ,  Eiko Kato

IPC: A61K31/513 ,  A61Q19/02 ,  A61Q19/08 ,  A61P17/16 ,  A61K8/49

Abstract: The present invention provides an agent containing an orotic acid derivative that has high solubility in solvent and has superior physiological activity. The agent of the present invention is a melanin production inhibitor, whitening agent, fibroblast activator, collagen and/or elastin production promoter or wrinkle ameliorant containing as an active ingredient thereof an orotic acid derivative represented by the following general formula (1) or a salt thereof. In formula (1), R preferably represents a side chain of glutamic acid, glycine, histidine or aspartic acid. [In formula (1), R represents a side chain of a naturally-occurring amino acid and R may form, together with a nitrogen atom adjacent thereto through a single carbon atom, a hetero ring.]