Microscope system and image data transfer method therefor

    公开(公告)号:US10802257B2

    公开(公告)日:2020-10-13

    申请号:US16399774

    申请日:2019-04-30

    申请人: Sony Corporation

    IPC分类号: G02B21/00 H04N5/232 G02B21/16

    摘要: A microscope system includes a microscope apparatus including a stage on which a sample is placed and an objective lens that collects laser light to the sample on the stage, a light source unit including a light source that emits the laser light, a scanning mechanism configured to guide the laser light from the light source unit and change a direction of the guided laser light to scan the sample on the stage, a photodetector configured to guide returned light from the objective lens of the microscope apparatus and convert the guided light into an electrical signal, a controller configured to control at least the scanning mechanism and generate image data from the electrical signal output from the photodetector, and a computer connected to the controller through a bus interface and configured to process the image data transferred from the controller through the bus interface.

    Information processing device, image acquisition system, information processing method, and image information acquisition method

    公开(公告)号:US10753871B2

    公开(公告)日:2020-08-25

    申请号:US16218764

    申请日:2018-12-13

    申请人: SONY CORPORATION

    发明人: Koichiro Kishima

    摘要: [Object] To propose an information processing device, an image acquisition system, an information processing method, an image information acquisition method, and a program which enable a position of a surface of a measurement subject to be more simply specified.[Solution] An information processing device according to the present invention includes: a representative luminance value specifying unit configured to, when luminance values constituting a plurality of fluorescence images of a measurement subject captured while a position of the measurement subject in a thickness direction is changed are sequentially rearranged from a highest luminance value on the basis of the fluorescence images for each of the fluorescence images corresponding to respective thickness positions, extract a luminance value ranked at a predetermined position from the highest luminance value and set the extracted luminance value as a representative luminance value of the fluorescence image at the thickness position to be noted; and a surface position specifying unit configured to use the representative luminance value for each of the fluorescence images and set the thickness position corresponding to the fluorescence image that gives the maximum representative luminance value as a position corresponding to a surface of the measurement subject.

    Fine particle detection device
    3.
    发明授权

    公开(公告)号:US10215684B2

    公开(公告)日:2019-02-26

    申请号:US15767767

    申请日:2016-08-18

    申请人: SONY CORPORATION

    发明人: Koichiro Kishima

    IPC分类号: G01N15/00 G01N15/14 G01N21/64

    摘要: A fine particle detection device according to the present disclosure includes: a first irradiation portion configured to radiate excitation light to a flow passage in which a fine particle flows to excite fluorescent light from the fine particle; a first separation portion configured to separate the excitation light and the fluorescent light from light that has been radiated to the flow passage by the first irradiation portion; a first detection portion configured to detect the fluorescent light separated by the first separation portion; a second irradiation portion configured to radiate the excitation light separated by the first separation portion to the flow passage to excite the fluorescent light from the fine particle; a second separation portion configured to separate the excitation light and the fluorescent light from light that has been radiated to the flow passage by the second irradiation portion; and a second detection portion configured to detect the fluorescent light separated by the second separation portion.

    Image obtaining apparatus, image obtaining method, and image obtaining program
    5.
    发明授权
    Image obtaining apparatus, image obtaining method, and image obtaining program 有权
    图像获取装置,图像获取方法和图像获取程序

    公开(公告)号:US09438848B2

    公开(公告)日:2016-09-06

    申请号:US13672763

    申请日:2012-11-09

    申请人: Sony Corporation

    发明人: Koichiro Kishima

    摘要: An image obtaining apparatus includes: a light source configured to irradiate a biological sample having a fluorescent label with an excitation light, the excitation light exciting the fluorescent label; a focus moving unit configured to move a focus position of an optical system in the thickness direction of the biological sample; and a data processing unit configured to expose an image sensor to light while moving the focus position of the optical system in each of a plurality of preset scanning ranges to thereby obtain fluorescent images of the biological sample, each of the plurality of scanning ranges having a predetermined scanning length, the predetermined scanning length being smaller than the length of a bright-point detection range of the biological sample in the thickness direction, the center positions of the scanning ranges being different from each other in the thickness direction.

    摘要翻译: 一种图像获取装置包括:光源,被配置为用激发光照射具有荧光标签的生物样品,所述激发光激发荧光标记; 焦点移动单元,被配置为沿生物样本的厚度方向移动光学系统的聚焦位置; 以及数据处理单元,被配置为在多个预设扫描范围中的每一个移动光学系统的聚焦位置的同时曝光图像传感器,从而获得生物样品的荧光图像,所述多个扫描范围中的每一个具有 预定扫描长度,所述预定扫描长度小于所述生物样本在厚度方向上的亮点检测范围的长度,所述扫描范围的中心位置在厚度方向上彼此不同。

    INFORMATION PROCESSING APPARATUS, INFORMATION PROCESSING METHOD, AND INFORMATION PROCESSING PROGRAM
    7.
    发明申请
    INFORMATION PROCESSING APPARATUS, INFORMATION PROCESSING METHOD, AND INFORMATION PROCESSING PROGRAM 审中-公开
    信息处理设备,信息处理方法和信息处理程序

    公开(公告)号:US20140016005A1

    公开(公告)日:2014-01-16

    申请号:US13910533

    申请日:2013-06-05

    申请人: Sony Corporation

    发明人: Koichiro Kishima

    IPC分类号: H04N5/367

    摘要: There is provided an information processing apparatus, including: an image obtaining section configured to obtain a RAW image, the RAW image being taken by an imaging unit, the imaging unit including an image sensor; and a controller configured to cause the imaging unit to preliminarily photograph a preliminary photographing object, and to obtain the RAW image as a first RAW image, to specify a defective pixel of the first RAW image based on the amount of difference between a value of a target pixel and a value of a neighboring pixel around the target pixel, and to create defective position data, to cause the imaging unit to actually photograph an actual photographing object, and to obtain the RAW image as a second RAW image, and to correct a luminance value of the second RAW image based on the defective position data.

    摘要翻译: 提供了一种信息处理设备,包括:图像获取部分,被配置为获得RAW图像,RAW图像由成像单元拍摄,所述成像单元包括图像传感器; 以及控制器,被配置为使所述成像单元预先拍摄初步拍摄对象,并且获得作为第一RAW图像的RAW图像,以基于所述第一RAW图像的值之间的差异量来指定所述第一RAW图像的缺陷像素 目标像素和目标像素周围的相邻像素的值,并且创建缺陷位置数据,以使成像单元实际拍摄实际拍摄对象,并获得作为第二RAW图像的RAW图像,并且校正 基于缺陷位置数据的第二RAW图像的亮度值。

    Information processing device, image acquisition system, information processing method, image information acquisition method, and program

    公开(公告)号:US10190982B2

    公开(公告)日:2019-01-29

    申请号:US15529790

    申请日:2015-09-30

    申请人: SONY CORPORATION

    发明人: Koichiro Kishima

    摘要: [Object] To propose an information processing device, an image acquisition system, an information processing method, an image information acquisition method, and a program which enable a position of a surface of a measurement subject to be more simply specified.[Solution] An information processing device according to the present invention includes: a representative luminance value specifying unit configured to, when luminance values constituting a plurality of fluorescence images of a measurement subject captured while a position of the measurement subject in a thickness direction is changed are sequentially rearranged from a highest luminance value on the basis of the fluorescence images for each of the fluorescence images corresponding to respective thickness positions, extract a luminance value ranked at a predetermined position from the highest luminance value and set the extracted luminance value as a representative luminance value of the fluorescence image at the thickness position to be noted; and a surface position specifying unit configured to use the representative luminance value for each of the fluorescence images and set the thickness position corresponding to the fluorescence image that gives the maximum representative luminance value as a position corresponding to a surface of the measurement subject.

    LASER SCANNING MICROSCOPE APPARATUS AND CONTROL METHOD
    9.
    发明申请
    LASER SCANNING MICROSCOPE APPARATUS AND CONTROL METHOD 有权
    激光扫描显微镜设备和控制方法

    公开(公告)号:US20150226949A1

    公开(公告)日:2015-08-13

    申请号:US14612629

    申请日:2015-02-03

    申请人: Sony Corporation

    摘要: There is provided a laser scanning microscope apparatus including a first moving part equipped with an objective lens and configured to move the objective lens in a first direction, and a second moving part configured to be movable in a second direction orthogonal to the first moving part and equipped with the first moving part and a reflecting mirror that guides laser light radiated to an observation object and returning light of the observation object in a predetermined direction.

    摘要翻译: 提供了一种激光扫描显微镜装置,包括:第一移动部件,其配备有物镜并被构造成沿第一方向移动物镜;以及第二移动部件,其构造成能够在与第一移动部件正交的第二方向上移动, 配备有第一移动部分和反射镜,其将照射到观察对象的激光引导并且沿预定方向返回观察对象的光。

    MICROSCOPE SYSTEM AND IMAGE DATA TRANSFER METHOD THEREFOR
    10.
    发明申请
    MICROSCOPE SYSTEM AND IMAGE DATA TRANSFER METHOD THEREFOR 审中-公开
    MICROSCOPE系统及其图像数据传输方法

    公开(公告)号:US20150177501A1

    公开(公告)日:2015-06-25

    申请号:US14574840

    申请日:2014-12-18

    申请人: Sony Corporation

    IPC分类号: G02B21/00 H04N5/232

    摘要: A microscope system includes a microscope apparatus including a stage on which a sample is placed and an objective lens that collects laser light to the sample on the stage, a light source unit including a light source that emits the laser light, a scanning mechanism configured to guide the laser light from the light source unit and change a direction of the guided laser light to scan the sample on the stage, a photodetector configured to guide returned light from the objective lens of the microscope apparatus and convert the guided light into an electrical signal, a controller configured to control at least the scanning mechanism and generate image data from the electrical signal output from the photodetector, and a computer connected to the controller through a bus interface and configured to process the image data transferred from the controller through the bus interface.

    摘要翻译: 显微镜系统包括显微镜装置,其包括放置样品的台和将台灯上的样品收集激光的物镜,包括发射激光的光源的光源单元,配置为 引导来自光源单元的激光,并且改变被引导的激光的方向以扫描载物台上的样品;光电检测器,被配置为引导来自显微镜装置的物镜的返回光,并将被引导的光转换成电信号 控制器,被配置为至少控制所述扫描机构,并且从所述光电检测器输出的电信号中生成图像数据,以及通过总线接口连接到所述控制器的计算机,并且被配置为处理通过所述总线接口从所述控制器传送的图像数据 。