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公开(公告)号：US11761034B2
公开(公告)日：2023-09-19
申请号：US17159028
申请日：2021-01-26
Applicant: STMICROELECTRONICS S.r.l.
Inventor： Lucio Renna , Clelia Carmen Galati , Natalia Maria Rita Spinella
IPC: C12Q1/686 , C12Q1/6816 , C12Q1/6844 , C12Q1/6851 , B01L7/00 , C12Q1/6825
CPC classification number: C12Q1/686 , B01L7/52 , C12Q1/6816 , C12Q1/6825 , C12Q1/6844 , C12Q1/6851 , B01L2200/10 , B01L2300/0663 , B01L2300/0829 , B01L2300/0887 , B01L2300/12 , B01L2300/18 , C12Q2561/113 , C12Q2563/107 , C12Q2563/143 , C12Q2563/107 , C12Q2561/113 , C12Q2563/143
Abstract: A method for real-time quantitative detection of single-type, target nucleic acid sequences amplified using a PCR in a microwell, comprising introducing in the microwell a sample comprising target nucleic acid sequences, magnetic primers, and labelling probes; performing an amplification cycle to form labelled amplicons; attracting the magnetic primers to a surface through a magnetic field to form a layer including labelled amplification products and free magnetic primers; and detecting the labelled amplification products in the layer with a surface-specific reading method.
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公开(公告)号：US20190071713A1
公开(公告)日：2019-03-07
申请号：US16181274
申请日：2018-11-05
Applicant: STMICROELECTRONICS S.R.L.
Inventor： Lucio Renna , Clelia Carmen Galati , Natalia Maria Rita Spinella
IPC: C12Q1/686 , C12Q1/6816 , C12Q1/6825 , C12Q1/6844 , C12Q1/6851 , B01L7/00
Abstract: A method for real-time quantitative detection of single-type, target nucleic acid sequences amplified using a PCR in a microwell, comprising introducing in the microwell a sample comprising target nucleic acid sequences, magnetic primers, and labelling probes; performing an amplification cycle to form labelled amplicons; attracting the magnetic primers to a surface through a magnetic field to form a layer including labelled amplification products and free magnetic primers; and detecting the labelled amplification products in the layer with a surface-specific reading method.
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Patent Agency Ranking
公开(公告)号：US20150267248A1
公开(公告)日：2015-09-24
申请号：US14732487
申请日：2015-06-05
Applicant: STMicroelectronics S.r.l.
Inventor： Lucio Renna , Clelia Carmen Galati , Natalia Maria Rita Spinella
CPC classification number: C12Q1/686 , B01L7/52 , B01L2200/10 , B01L2300/0663 , B01L2300/0829 , B01L2300/0887 , B01L2300/12 , B01L2300/18 , C12Q1/6816 , C12Q1/6825 , C12Q1/6844 , C12Q1/6851 , C12Q2561/113 , C12Q2563/107 , C12Q2563/143
Abstract: A method for real-time quantitative detection of single-type, target nucleic acid sequences amplified using a PCR in a microwell, comprising introducing in the microwell a sample comprising target nucleic acid sequences, magnetic primers, and labelling probes; performing an amplification cycle to form labelled amplicons; attracting the magnetic primers to a surface through a magnetic field to form a layer including labelled amplification products and free magnetic primers; and detecting the labelled amplification products in the layer with a surface-specific reading method.
Abstract translation: 一种用于在微孔中使用PCR扩增的单型靶核酸序列的实时定量检测方法，包括在微孔中引入包含靶核酸序列，磁性引物和标记探针的样品; 进行扩增循环以形成标记的扩增子; 通过磁场将磁性引物吸引到表面以形成包括标记的扩增产物和游离磁性引物的层; 并用表面特异性读取方法检测该层中标记的扩增产物。
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公开(公告)号：US10941440B2
公开(公告)日：2021-03-09
申请号：US16181274
申请日：2018-11-05
Applicant: STMICROELECTRONICS S.R.L.
Inventor： Lucio Renna , Clelia Carmen Galati , Natalia Maria Rita Spinella
IPC: C12Q1/686 , C12Q1/6816 , C12Q1/6844 , C12Q1/6851 , C12Q1/6825 , B01L7/00
Abstract: A method for real-time quantitative detection of single-type, target nucleic acid sequences amplified using a PCR in a microwell, comprising introducing in the microwell a sample comprising target nucleic acid sequences, magnetic primers, and labelling probes; performing an amplification cycle to form labelled amplicons; attracting the magnetic primers to a surface through a magnetic field to form a layer including labelled amplification products and free magnetic primers; and detecting the labelled amplification products in the layer with a surface-specific reading method.
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公开(公告)号：US10144959B2
公开(公告)日：2018-12-04
申请号：US14732487
申请日：2015-06-05
Applicant: STMicroelectronics S.r.l.
Inventor： Lucio Renna , Clelia Carmen Galati , Natalia Maria Rita Spinella
IPC: C12Q1/68 , C12P19/34 , C12Q1/686 , C12Q1/6816 , C12Q1/6844 , C12Q1/6851 , B01L7/00 , C12Q1/6825
Abstract: A method for real-time quantitative detection of single-type, target nucleic acid sequences amplified using a PCR in a microwell, comprising introducing in the microwell a sample comprising target nucleic acid sequences, magnetic primers, and labelling probes; performing an amplification cycle to form labelled amplicons; attracting the magnetic primers to a surface through a magnetic field to form a layer including labelled amplification products and free magnetic primers; and detecting the labelled amplification products in the layer with a surface-specific reading method.
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6.发明授权公开(公告)号：US09658158B2
公开(公告)日：2017-05-23
申请号：US13902468
申请日：2013-05-24
Applicant: STMICROELECTRONICS S.R.L.
IPC: G01N33/551 , G01N21/64
CPC classification number: G01N21/6428 , G01N21/6454 , G01N33/551
Abstract: A diagnostic device includes a photodiode formed by a body of semiconductor material having a first surface, an integrated optical structure on the first surface and having a second surface, and at least one detection region on the second surface. The at least one detection region includes at least one receptor that binds to a corresponding target molecule that can be mated with a corresponding marker, which, when excited by radiation having a first wavelength, emits radiation having a second wavelength that can be detected by the photodiode. The integrated optical structure includes at least a first layer of a first material having a first refractive index. The first layer has a thickness substantially equal to an integer and odd multiple of one fourth of the first wavelength divided by the first refractive index.
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公开(公告)号：US09062343B2
公开(公告)日：2015-06-23
申请号：US13856473
申请日：2013-04-04
Applicant: STMicroelectronics S.r.l
Inventor： Lucio Renna , Clelia Carmen Galati , Natalia Maria Rita Spinella
IPC: C12Q1/68
CPC classification number: C12Q1/686 , B01L7/52 , B01L2200/10 , B01L2300/0663 , B01L2300/0829 , B01L2300/0887 , B01L2300/12 , B01L2300/18 , C12Q1/6816 , C12Q1/6825 , C12Q1/6844 , C12Q1/6851 , C12Q2561/113 , C12Q2563/107 , C12Q2563/143
Abstract: A method for real-time quantitative detection of single-type, target nucleic acid sequences amplified using a PCR in a microwell, comprising introducing in the microwell a sample comprising target nucleic acid sequences, magnetic primers, and labelling probes; performing an amplification cycle to form labelled amplicons; attracting the magnetic primers to a surface through a magnetic field to form a layer including labelled amplification products and free magnetic primers; and detecting the labelled amplification products in the layer with a surface-specific reading method.
Abstract translation: 一种用于在微孔中使用PCR扩增的单型靶核酸序列的实时定量检测方法，包括在微孔中引入包含靶核酸序列，磁性引物和标记探针的样品; 进行扩增循环以形成标记的扩增子; 通过磁场将磁性引物吸引到表面以形成包括标记的扩增产物和游离磁性引物的层; 并用表面特异性读取方法检测该层中标记的扩增产物。
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