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1.发明申请COMPOSITIONS THAT INCLUDE A HYDROPHOBIC COMPOUND AND A POLYAMINO ACID CONJUGATE 有权包含疏水化合物和聚氨基酸共混物的组合物公开(公告)号：US20120230917A1
公开(公告)日：2012-09-13
申请号：US13475672
申请日：2012-05-18
申请人： Sang Van , Yucheng Song , Xinghe Wang , Zheng Hou , Zhongling Feng , Gang Zhao , Lei Yu
发明人： Sang Van , Yucheng Song , Xinghe Wang , Zheng Hou , Zhongling Feng , Gang Zhao , Lei Yu
CPC分类号： B82Y5/00 , A61K47/645 , A61K47/6925 , A61K49/0056 , A61K49/085 , A61K49/146 , A61K49/1824
摘要： Various compositions that include a hydrophobic compound and a polyamino acid conjugate are prepared. The compositions described herein are useful for a variety of drug, biomolecule, and imaging agent delivery applications.
摘要翻译： 制备包括疏水化合物和聚氨基酸缀合物的各种组合物。 本文描述的组合物可用于各种药物，生物分子和成像剂递送应用。
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公开(公告)号：US08329199B2
公开(公告)日：2012-12-11
申请号：US13475672
申请日：2012-05-18
申请人： Sang Van , Yucheng Song , Xinghe Wang , Zheng Hou , Zhongling Feng , Gang Zhao , Lei Yu
发明人： Sang Van , Yucheng Song , Xinghe Wang , Zheng Hou , Zhongling Feng , Gang Zhao , Lei Yu
IPC分类号： A61K9/00
CPC分类号： B82Y5/00 , A61K47/645 , A61K47/6925 , A61K49/0056 , A61K49/085 , A61K49/146 , A61K49/1824
摘要： Various compositions that include a hydrophobic compound and a polyamino acid conjugate are prepared. The compositions described herein are useful for a variety of drug, biomolecule, and imaging agent delivery applications.
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3.发明授权Compositions that include a hydrophobic compound and a polyamino acid conjugate 有权包含疏水化合物和聚氨基酸缀合物的组合物公开(公告)号：US08197828B2
公开(公告)日：2012-06-12
申请号：US12117601
申请日：2008-05-08
申请人： Sang Van , Yucheng Song , Xinghe Wang , Zheng Hou , Zhongling Feng , Gang Zhao , Lei Yu
发明人： Sang Van , Yucheng Song , Xinghe Wang , Zheng Hou , Zhongling Feng , Gang Zhao , Lei Yu
IPC分类号： A61K9/00
CPC分类号： B82Y5/00 , A61K47/645 , A61K47/6925 , A61K49/0056 , A61K49/085 , A61K49/146 , A61K49/1824
摘要： Various compositions that include a hydrophobic compound and a polyamino acid conjugate are prepared. The compositions described herein are useful for a variety of drug, biomolecule, and imaging agent delivery applications.
摘要翻译： 制备包括疏水化合物和聚氨基酸缀合物的各种组合物。 本文描述的组合物可用于各种药物，生物分子和成像剂递送应用。
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4.发明申请COMPOSITIONS THAT INCLUDE A HYDROPHOBIC COMPOUND AND A POLYAMINO ACID CONJUGATE 有权包含疏水化合物和聚氨基酸共混物的组合物公开(公告)号：US20080279777A1
公开(公告)日：2008-11-13
申请号：US12117601
申请日：2008-05-08
申请人： Sang Van , Yucheng Song , Xinghe Wang , Zheng Hou , Zhongling Feng , Gang Zhao , Lei Yu
发明人： Sang Van , Yucheng Song , Xinghe Wang , Zheng Hou , Zhongling Feng , Gang Zhao , Lei Yu
CPC分类号： B82Y5/00 , A61K47/645 , A61K47/6925 , A61K49/0056 , A61K49/085 , A61K49/146 , A61K49/1824
摘要： Various compositions that include a hydrophobic compound and a polyamino acid conjugate are prepared. The compositions described herein are useful for a variety of drug, biomolecule, and imaging agent delivery applications.
摘要翻译： 制备包括疏水化合物和聚氨基酸缀合物的各种组合物。 本文描述的组合物可用于各种药物，生物分子和成像剂递送应用。
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公开(公告)号：US20070128118A1
公开(公告)日：2007-06-07
申请号：US11566141
申请日：2006-12-01
申请人： Lei Yu , Gang Zhao , Sang Van , Sanjib Das , Zhongling Feng , Xiaoli Fu , Xinghe Wang , Yi Jin , Fu Chen
发明人： Lei Yu , Gang Zhao , Sang Van , Sanjib Das , Zhongling Feng , Xiaoli Fu , Xinghe Wang , Yi Jin , Fu Chen
IPC分类号： A61K49/10 , A61K49/00 , A61K31/785
CPC分类号： A61K47/42 , A61K31/337 , A61K31/4745 , A61K31/704 , A61K47/56 , A61K47/62 , A61K47/64 , A61K47/645 , A61K49/0041 , A61K49/0056 , A61K49/146 , C08G69/10 , C08G69/48
摘要： Various biodegradable polyglutamate-amino acids comprising recurring units of the general formulae (I) and (II) are prepared. Such polymers are useful for variety of drug, biomolecule and imaging agent delivery applications.
摘要翻译： 制备包含通式（I）和（II）的重复单元的各种可生物降解的聚谷氨酸 - 氨基酸。 这些聚合物可用于各种药物，生物分子和成像剂递送应用。
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公开(公告)号：US20090226393A1
公开(公告)日：2009-09-10
申请号：US12397545
申请日：2009-03-04
申请人： Xinghe Wang , Gang Zhao , Sang Van , Lei Yu
发明人： Xinghe Wang , Gang Zhao , Sang Van , Lei Yu
IPC分类号： A61K47/48 , A61P35/00 , A61K31/337 , A61K31/74
CPC分类号： A61K47/645
摘要： Pharmaceutical compositions comprising a PGGA-PTX conjugate are prepared. The pharmaceutical compositions are used to treat a variety of cancers, such as lung cancer, skin cancer, kidney cancer, liver cancer and spleen cancer.
摘要翻译： 制备包含PGGA-PTX缀合物的药物组合物。 药物组合物用于治疗各种癌症，例如肺癌，皮肤癌，肾癌，肝癌和脾癌。
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公开(公告)号：US20130011336A1
公开(公告)日：2013-01-10
申请号：US13063193
申请日：2009-09-11
申请人： Yoshiro Niitsu , Lei Yu , Gang Zhao , Sang Van , Xinghe Wang , Jian Liu , Sanjib Kumar Das , Yasunobu Tanaka , Keiko Kajiwara , Hirokazu Takahashi , Miyono Miyazaki
发明人： Yoshiro Niitsu , Lei Yu , Gang Zhao , Sang Van , Xinghe Wang , Jian Liu , Sanjib Kumar Das , Yasunobu Tanaka , Keiko Kajiwara , Hirokazu Takahashi , Miyono Miyazaki
IPC分类号： A61K49/00 , A61K49/04 , A61K49/10 , G01N21/62 , A61K51/06 , A61K49/22 , A61P1/16 , C08G69/48 , C07C403/08 , A61K51/04
CPC分类号： A61K49/085 , A61K49/0002 , A61K49/0041 , A61K49/0052 , A61K49/0054 , A61K49/128 , A61K51/065 , C08G69/10 , C08G69/48
摘要： Agents and methods for imaging a cell and/or a portion of tissue characterized by fibrosis, as well as to agents and methods for determining and/or diagnosing fibrotic diseases are disclosed herein. Also disclosed herein are polymer conjugates that can include a detectable label, a retinoid and a polymer. The polymer conjugates can be used to image a portion of tissue, deliver a detectable label to a portion of tissue or a cell and/or diagnosis a condition or disease.
摘要翻译： 本文公开了用于成像细胞和/或特征在于纤维化的组织的一部分以及用于确定和/或诊断纤维化疾病的药剂和方法的药剂和方法。 本文还公开了可以包括可检测标记，类视色素和聚合物的聚合物缀合物。 聚合物缀合物可用于对组织的一部分进行成像，将可检测标记递送至组织或细胞的一部分和/或诊断病症或疾病。
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公开(公告)号：US07687603B2
公开(公告)日：2010-03-30
申请号：US11526224
申请日：2006-09-22
申请人： Gang Zhao , Lei Yu , Jian Liu , Chieko Kitaura , Xinghe Wang , Chris Castello
发明人： Gang Zhao , Lei Yu , Jian Liu , Chieko Kitaura , Xinghe Wang , Chris Castello
IPC分类号： A61K38/05
CPC分类号： C07K5/0215 , A61K31/555 , A61K47/641 , A61K47/645 , A61K49/085 , A61K49/146 , C07K7/02
摘要： Disclosed herein are transmembrane transporter compounds containing guanidinium groups. Also disclosed herein are methods for transporting a biologically active moiety across a biological membrane using the transmembrane transporter compounds. Particularly, this invention provides a method for the delivery of a biologically active moiety across the biological membranes of such membranes as endothelial tissues.
摘要翻译： 本文公开了含有胍基的跨膜转运体化合物。 本文还公开了使用跨膜转运体化合物在生物膜上输送生物活性部分的方法。 特别地，本发明提供了一种在诸如内皮组织之类的膜的生物膜上递送生物活性部分的方法。
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公开(公告)号：US20100160210A1
公开(公告)日：2010-06-24
申请号：US12710320
申请日：2010-02-22
申请人： Gang Zhao , Lei Yu , Jian Liu , Chieko Kitaura , Xinghe Wang , Chris Castello
发明人： Gang Zhao , Lei Yu , Jian Liu , Chieko Kitaura , Xinghe Wang , Chris Castello
CPC分类号： C07K5/0215 , A61K31/555 , A61K47/641 , A61K47/645 , A61K49/085 , A61K49/146 , C07K7/02
摘要： Disclosed herein are transmembrane transporter compounds containing guanidinium groups. Also disclosed herein are methods for transporting a biologically active moiety across a biological membrane using the transmembrane transporter compounds. Particularly, this invention provides a method for the delivery of a biologically active moiety across the biological membranes of such membranes as endothelial tissues.
摘要翻译： 本文公开了含有胍基的跨膜转运体化合物。 本文还公开了使用跨膜转运体化合物在生物膜上输送生物活性部分的方法。 特别地，本发明提供了一种在诸如内皮组织之类的膜的生物膜上递送生物活性部分的方法。
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公开(公告)号：US20070078094A1
公开(公告)日：2007-04-05
申请号：US11526224
申请日：2006-09-22
申请人： Gang Zhao , Lei Yu , Jian Liu , Chieko Kitaura , Xinghe Wang , Chris Castello
发明人： Gang Zhao , Lei Yu , Jian Liu , Chieko Kitaura , Xinghe Wang , Chris Castello
CPC分类号： C07K5/0215 , A61K31/555 , A61K47/641 , A61K47/645 , A61K49/085 , A61K49/146 , C07K7/02
摘要： Disclosed herein are transmembrane transporter compounds containing guanidinium groups. Also disclosed herein are methods for transporting a biologically active moiety across a biological membrane using the transmembrane transporter compounds. Particularly, this invention provides a method for the delivery of a biologically active moiety across the biological membranes of such membranes as endothelial tissues.
摘要翻译： 本文公开了含有胍基的跨膜转运体化合物。 本文还公开了使用跨膜转运体化合物在生物膜上输送生物活性部分的方法。 特别地，本发明提供了一种在诸如内皮组织之类的膜的生物膜上递送生物活性部分的方法。
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