公开(公告)号：US20100179116A1

公开(公告)日：2010-07-15

申请号：US12601867

申请日：2008-05-30

申请人： Song Li ,  Jing Su ,  Yao Liu ,  Junhai Xiao ,  Lili Wang ,  Wu Zhong ,  Zhibing Zheng ,  Yunde Kie ,  Xingzhou Li ,  Guoming Zhao ,  Xiaokui Wang ,  Xinbo Zhou ,  Hongying Liu

发明人： Song Li ,  Jing Su ,  Yao Liu ,  Junhai Xiao ,  Lili Wang ,  Wu Zhong ,  Zhibing Zheng ,  Yunde Kie ,  Xingzhou Li ,  Guoming Zhao ,  Xiaokui Wang ,  Xinbo Zhou ,  Hongying Liu

IPC分类号： A61K31/395 ,  C07D257/02 ,  C07D403/10 ,  A61P31/18

CPC分类号： C07D471/08 ,  C07D255/04 ,  C07D257/02 ,  C07D401/10

摘要： The present invention relates to arene connected polyamine macrocyclic derivatives represented by general formula I, pharmaceutically acceptable salts or hydrates thereof which have anti-HIV activities, in which the definitions of substituents are as defined in the description; to preparation methods of the compounds of formula I; to pharmaceutical compositions containing the compounds of formula I or their pharmaceutically acceptable salts or hydrates; to the use of the compounds of formula I or their pharmaceutically acceptable salts or hydrates for the preparation of a medicament for the treatment and prevention of HIV-associated diseases.

摘要翻译： 本发明涉及具有抗HIV活性的由通式I表示的芳族连接的多胺大环衍生物，其药学上可接受的盐或水合物，其中取代基的定义如说明书中所定义; 制备式I化合物的方法; 包含式I化合物或其药学上可接受的盐或水合物的药物组合物; 涉及使用式I化合物或其药学上可接受的盐或水合物来制备用于治疗和预防HIV相关疾病的药物。

公开(公告)号：US08420626B2

公开(公告)日：2013-04-16

申请号：US12601867

申请日：2008-05-30

申请人： Song Li ,  Jing Su ,  Yao Liu ,  Junhai Xiao ,  Lili Wang ,  Wu Zhong ,  Zhibing Zheng ,  Yunde Xie ,  Xingzhou Li ,  Guoming Zhao ,  Xiaokui Wang ,  Xinbo Zhou ,  Hongying Liu

发明人： Song Li ,  Jing Su ,  Yao Liu ,  Junhai Xiao ,  Lili Wang ,  Wu Zhong ,  Zhibing Zheng ,  Yunde Xie ,  Xingzhou Li ,  Guoming Zhao ,  Xiaokui Wang ,  Xinbo Zhou ,  Hongying Liu

IPC分类号： A61K31/33 ,  C07D245/00 ,  C07D245/02 ,  C07D245/04 ,  C07D245/06 ,  C07D487/02

CPC分类号： C07D471/08 ,  C07D255/04 ,  C07D257/02 ,  C07D401/10

摘要： The present invention relates to arene connected polyamine macrocyclic derivatives represented by general formula I, pharmaceutically acceptable salts or hydrates thereof which have anti-HIV activities, in which the definitions of substituents are as defined in the description; to preparation methods of the compounds of formula I; to pharmaceutical compositions containing the compounds of formula I or their pharmaceutically acceptable salts or hydrates; to the use of the compounds of formula I or their pharmaceutically acceptable salts or hydrates for the preparation of a medicament for the treatment and prevention of HIV-associated diseases.

摘要翻译： 本发明涉及具有抗HIV活性的由通式I表示的芳族连接的多胺大环衍生物，其药学上可接受的盐或水合物，其中取代基的定义如说明书中所定义; 制备式I化合物的方法; 包含式I化合物或其药学上可接受的盐或水合物的药物组合物; 涉及使用式I化合物或其药学上可接受的盐或水合物来制备用于治疗和预防HIV相关疾病的药物。

公开(公告)号：US08802669B2

公开(公告)日：2014-08-12

申请号：US13380270

申请日：2010-05-27

申请人： Song Li ,  Xiaoqian Xu ,  Guoming Zhao ,  Lili Wang ,  Hua Guan ,  Junhai Xiao ,  Wu Zhong ,  Zhibing Zheng ,  Yunde Xie ,  Xingzhou Li ,  Xiaokui Wang ,  Xinbo Zhou ,  Hongying Liu

发明人： Song Li ,  Xiaoqian Xu ,  Guoming Zhao ,  Lili Wang ,  Hua Guan ,  Junhai Xiao ,  Wu Zhong ,  Zhibing Zheng ,  Yunde Xie ,  Xingzhou Li ,  Xiaokui Wang ,  Xinbo Zhou ,  Hongying Liu

IPC分类号： C07D239/20 ,  C07D401/06 ,  C07D401/14 ,  A61K31/505 ,  A61K31/506 ,  C07D211/14 ,  A61K31/4025 ,  A61K31/4453

CPC分类号： C07D239/20 ,  A61K31/4025 ,  A61K31/4453 ,  A61K31/505 ,  A61K31/506 ,  A61K45/06 ,  C07D211/14 ,  C07D239/28 ,  C07D239/557 ,  C07D401/06 ,  C07D403/06 ,  A61K2300/00

摘要： Disclosed are dihydropyrimidine compounds and preparation methods, pharmaceutical compositions and uses thereof. Specifically, the compounds described herein in general formula (I), or their isomers, pharmaceutically acceptable salts or hydrates are provided, wherein each variable has the meaning as defined in the description. Also provided are a process for preparing the compounds of the general formula (I), the use of the compounds, an isomer thereof, a pharmaceutically acceptable salt thereof or a hydrate thereof as a medicament, in particular as a medicament for the treatment and/or prevention of Hepatitis B.

摘要翻译： 公开了二氢嘧啶化合物及其制备方法，药物组合物及其用途。 具体地，提供通式（I）中所述的化合物或其异构体，药学上可接受的盐或水合物，其中每个变量具有如说明书中所定义的含义。 还提供了制备通式（I）的化合物，其化合物，其异构体，其药学上可接受的盐或其水合物作为药物的用途的方法，特别是作为治疗和/ 或预防乙型肝炎。

公开(公告)号：US20110065795A1

公开(公告)日：2011-03-17

申请号：US12673355

申请日：2008-08-13

申请人： Song Li ,  Wu Zhong ,  Zhibing Zheng ,  Xinbo Zhou ,  Junhai Xiao ,  Yunde Xie ,  Lili Wang ,  Xingzhou Li ,  Guoming Zhao ,  Xiaokui Wang ,  Hongying Liu

发明人： Song Li ,  Wu Zhong ,  Zhibing Zheng ,  Xinbo Zhou ,  Junhai Xiao ,  Yunde Xie ,  Lili Wang ,  Xingzhou Li ,  Guoming Zhao ,  Xiaokui Wang ,  Hongying Liu

IPC分类号： A61K31/196 ,  C07C279/16 ,  C07C277/08 ,  A61P31/16

CPC分类号： C07C279/16 ,  C07B2200/07 ,  C07C277/06 ,  C07C277/08 ,  C07C2601/08

摘要： The present invention relates to (1S,2S,3S,4R)-3-[(1S)-1-acetylamino-2-ethyl-butyl]-4-guanidino-2-hydroxy-cyclopentyl-1-carboxylic acid hydrates compounds, preparing methods thereof, pharmaceutical compositions containing said compounds and preparing methods thereof, and the clinical uses of said compounds as neuramidinase inhibitors for anti-influenza.

摘要翻译： 本发明涉及（1S，2S，3S，4R）-3 - [（1S）-1-乙酰氨基-2-乙基 - 丁基] -4-胍基-2-羟基 - 环戊基-1-羧酸水合物， 其制备方法，含有所述化合物的药物组合物及其制备方法，以及所述化合物作为抗流感病毒的神经脒酶抑制剂的临床应用。

公开(公告)号：US20120149695A1

公开(公告)日：2012-06-14

申请号：US13380270

申请日：2010-05-27

申请人： Song Li ,  Xiaoqian Xu ,  Guoming Zhao ,  Lili Wang ,  Hua Guan ,  Junhai Xiao ,  Wu Zhong ,  Zhibing Zheng ,  Yunde Xie ,  Xingzhou Li ,  Xiaokui Wang ,  Xinbo Zhou ,  Hongying Liu

发明人： Song Li ,  Xiaoqian Xu ,  Guoming Zhao ,  Lili Wang ,  Hua Guan ,  Junhai Xiao ,  Wu Zhong ,  Zhibing Zheng ,  Yunde Xie ,  Xingzhou Li ,  Xiaokui Wang ,  Xinbo Zhou ,  Hongying Liu

IPC分类号： A61K31/505 ,  C07D403/06 ,  C07D401/06 ,  C07D413/06 ,  A61K31/5377 ,  A61P31/20 ,  A61K31/541 ,  C07D401/14 ,  C07D413/14 ,  C07D403/14 ,  A61P31/12 ,  A61K31/506 ,  C07D239/20 ,  C07D417/06

CPC分类号： C07D239/20 ,  A61K31/4025 ,  A61K31/4453 ,  A61K31/505 ,  A61K31/506 ,  A61K45/06 ,  C07D211/14 ,  C07D239/28 ,  C07D239/557 ,  C07D401/06 ,  C07D403/06 ,  A61K2300/00

摘要： Disclosed are dihydropyrimidine compounds and preparation methods, pharmaceutical compositions and uses thereof. Specifically, the compounds described herein in general formula (I), or their isomers, pharmaceutically acceptable salts or hydrates are provided, wherein each variable has the meaning as defined in the description. Also provided are a process for preparing the compounds of the general formula (I), the use of the compounds, an isomer thereof, a pharmaceutically acceptable salt thereof or a hydrate thereof as a medicament, in particular as a medicament for the treatment and/or prevention of Hepatitis B.

摘要翻译： 公开了二氢嘧啶化合物及其制备方法，药物组合物及其用途。 具体地，提供通式（I）中所述的化合物或其异构体，药学上可接受的盐或水合物，其中每个变量具有如说明书中所定义的含义。 还提供了制备通式（I）的化合物，其化合物，其异构体，其药学上可接受的盐或其水合物作为药物的用途的方法，特别是作为治疗和/ 或预防乙型肝炎。

公开(公告)号：US20140080840A1

公开(公告)日：2014-03-20

申请号：US13991534

申请日：2011-12-06

申请人： Song Li ,  Hongliang Wang ,  Junhai Xiao ,  Xian Zhang ,  Lili Wang ,  Zhibing Zheng ,  Wu Zhong ,  Yunde Xie ,  Xingzhou Li ,  Xinbo Zhou ,  Guoming Zhao ,  Xiaokui Wang

发明人： Song Li ,  Hongliang Wang ,  Junhai Xiao ,  Xian Zhang ,  Lili Wang ,  Zhibing Zheng ,  Wu Zhong ,  Yunde Xie ,  Xingzhou Li ,  Xinbo Zhou ,  Guoming Zhao ,  Xiaokui Wang

IPC分类号： C07D417/04

CPC分类号： C07D417/04 ,  A61K31/496 ,  C07D277/42 ,  Y02A50/465

摘要： Disclosed is as a substituted thiazolamine derivative represented by Formula I or a pharmaceutically acceptable salt thereof or a hydrate thereof (the definitions of each group in the formula are as presented in the description), and the application thereof in the prevention and/or treatment of viral diseases induced by picornavirus. Also disclosed is a pharmaceutical composition containing the compound.

摘要翻译： 公开了作为由式I表示的取代的噻唑胺衍生物或其药学上可接受的盐或其水合物（式中各组的定义如说明书中所述）及其在预防和/或治疗 由小核糖核酸病毒引起的病毒性疾病。 还公开了含有该化合物的药物组合物。

公开(公告)号：US20130190319A1

公开(公告)日：2013-07-25

申请号：US13813806

申请日：2011-08-02

申请人： Song Li ,  Hongliang Wang ,  Junhai Xiao ,  Xian Zhang ,  Lili Wang ,  Zhibing Zheng ,  Wu Zhong ,  Yunde Xie ,  Xingzhou Li ,  Xinbo Zhou ,  Guoming Zhao ,  Xiaokui Wang

发明人： Song Li ,  Hongliang Wang ,  Junhai Xiao ,  Xian Zhang ,  Lili Wang ,  Zhibing Zheng ,  Wu Zhong ,  Yunde Xie ,  Xingzhou Li ,  Xinbo Zhou ,  Guoming Zhao ,  Xiaokui Wang

IPC分类号： C07D237/20

CPC分类号： C07D237/20

摘要： Disclosed are pyridazine derivatives represented by Formula I or pharmaceutically acceptable salts or hydrates thereof, pharmaceutical compositions comprising the compounds, methods of treating and/or preventing diseases or disorders associated with viral infections in patients using the compounds, and the use of the compounds in preparing the medicaments for treating and/or preventing diseases or disorders associated with viral infections. The compounds represented by Formula I have antiviral activity, especially anti-microRNA viral activity. Symbols in the compounds represented are described in the specification.

公开(公告)号：US09428496B2

公开(公告)日：2016-08-30

申请号：US13991534

申请日：2011-12-06

申请人： Song Li ,  Hongliang Wang ,  Junhai Xiao ,  Xian Zhang ,  Lili Wang ,  Zhibing Zheng ,  Wu Zhong ,  Yunde Xie ,  Xingzhou Li ,  Xinbo Zhou ,  Guoming Zhao ,  Xiaokui Wang

发明人： Song Li ,  Hongliang Wang ,  Junhai Xiao ,  Xian Zhang ,  Lili Wang ,  Zhibing Zheng ,  Wu Zhong ,  Yunde Xie ,  Xingzhou Li ,  Xinbo Zhou ,  Guoming Zhao ,  Xiaokui Wang

IPC分类号： C07D417/04 ,  A61K31/496 ,  C07D277/42

CPC分类号： C07D417/04 ,  A61K31/496 ,  C07D277/42 ,  Y02A50/465

摘要： Disclosed is as a substituted thiazolamine derivative represented by Formula I or a pharmaceutically acceptable salt thereof or a hydrate thereof (the definitions of each group in the formula are as presented in the description), and the application thereof in the prevention and/or treatment of viral diseases induced by picornavirus. Also disclosed is a pharmaceutical composition containing the compound.

摘要翻译： 公开了作为由式I表示的取代的噻唑胺衍生物或其药学上可接受的盐或其水合物（式中各组的定义如说明书中所述）及其在预防和/或治疗 由小核糖核酸病毒引起的病毒性疾病。 还公开了含有该化合物的药物组合物。

公开(公告)号：US20130085183A1

公开(公告)日：2013-04-04

申请号：US13698465

申请日：2011-05-16

申请人： Song Li ,  Wu Zhong ,  Ping Liu ,  Junhai Xiao ,  Zhibing Zheng ,  Yunde Xie ,  Guoming Zhao ,  Xiaokui Wang ,  Lili Wang ,  Xingzhou Li ,  Xinbo Zhou

发明人： Song Li ,  Wu Zhong ,  Ping Liu ,  Junhai Xiao ,  Zhibing Zheng ,  Yunde Xie ,  Guoming Zhao ,  Xiaokui Wang ,  Lili Wang ,  Xingzhou Li ,  Xinbo Zhou

IPC分类号： C07C217/72 ,  C07C213/00

CPC分类号： C07C217/72 ,  A61K31/137 ,  C07C213/00 ,  C07C215/62

摘要： Aromatic butan-2-ol compounds, preparation methods for making the compounds, and uses of the compounds are provided. Specifically, the compound of Formula I, or an optical isomer, racemate, diastereomer, pharmaceutically acceptable salt, or solvate thereof, is provided, where each of the substituents is defined. In addition, a pharmaceutical composition containing the compound, and the use of the compound in manufacture of a medicament for the treatment and/or prophylaxis of a disease or disorder caused by tubercle bacillus infection, is provided.

摘要翻译： 提供芳族丁-2-醇化合物，制备化合物的方法和化合物的用途。 具体地，提供式I化合物或其旋光异构体，外消旋物，非对映体，药学上可接受的盐或溶剂合物，其中每个取代基被定义。 此外，提供了含有该化合物的药物组合物，以及该化合物在制造用于治疗和/或预防由结核杆菌感染引起的疾病或病症的药物中的用途。

公开(公告)号：US08846678B2

公开(公告)日：2014-09-30

申请号：US13813806

申请日：2011-08-02

申请人： Song Li ,  Hongliang Wang ,  Junhai Xiao ,  Xian Zhang ,  Lili Wang ,  Zhibing Zheng ,  Wu Zhong ,  Yunde Xie ,  Xingzhou Li ,  Xinbo Zhou ,  Guoming Zhao ,  Xiaokui Wang

发明人： Song Li ,  Hongliang Wang ,  Junhai Xiao ,  Xian Zhang ,  Lili Wang ,  Zhibing Zheng ,  Wu Zhong ,  Yunde Xie ,  Xingzhou Li ,  Xinbo Zhou ,  Guoming Zhao ,  Xiaokui Wang

IPC分类号： A61K31/501 ,  C07D237/20

CPC分类号： C07D237/20

摘要： Disclosed are pyridazine derivatives represented by Formula I or pharmaceutically acceptable salts or hydrates thereof, pharmaceutical compositions comprising the compounds, methods of treating and/or preventing diseases or disorders associated with viral infections in patients using the compounds, and the use of the compounds in preparing the medicaments for treating and/or preventing diseases or disorders associated with viral infections. The compounds represented by Formula I have antiviral activity, especially anti-microRNA viral activity. Symbols in the compounds represented are described in the specification.

摘要翻译： 公开了由式I表示的哒嗪衍生物或其药学上可接受的盐或水合物，包含该化合物的药物组合物，使用该化合物治疗和/或预防与病毒感染相关的疾病或病症的方法，以及该化合物在制备中的用途 用于治疗和/或预防与病毒感染相关的疾病或病症的药物。 由式I表示的化合物具有抗病毒活性，特别是抗微小RNA病毒活性。 所示化合物中的符号在说明书中描述。