公开(公告)号：US20220127284A1

公开(公告)日：2022-04-28

申请号：US17291938

申请日：2019-11-07

Applicant: Nathanael S. Gray ,  Tinghu Zhang ,  Yao Liu Brookline ,  Mingfeng Flao ,  David Weinstock ,  Loretta Sze-Mun

Inventor： Nathanael S. Gray ,  Tinghu Zhang ,  Yao Liu Brookline ,  Mingfeng Flao ,  David Weinstock ,  Loretta Sze-Mun

IPC: C07D513/04 ,  A61K45/06 ,  A61K31/4353 ,  A61K31/496

Abstract: The present disclosure provides compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. The provided compounds may be kinase (e.g., Janus kinase (JAK), e.g., Janus kinase 2 (JAK2)) inhibitors. Also provided are pharmaceutical compositions and kits including the provided compounds. Further provided are methods of using the provided compounds, pharmaceutical compositions, and kits (e.g., for treating a disease (e.g., proliferative disease) in a subject in need thereof).

公开(公告)号：US09304057B2

公开(公告)日：2016-04-05

申请号：US14237336

申请日：2011-10-27

Applicant: Yumei Huang ,  Yao Liu ,  Ye Hui ,  Guangpeng Zhang ,  Chuang Gao

Inventor： Yumei Huang ,  Yao Liu ,  Ye Hui ,  Guangpeng Zhang ,  Chuang Gao

IPC: G01M5/00

CPC classification number: G01M5/0075

Abstract: A device and a method for testing the rigidity and non-linear relationship of the coupling interface for cylindrical fitting including an axial loading assembly which is provided along a horizontal central line within a side wall of a frame test bench and contacting with the test-piece shaft via a steel ball, a radial loading assembly downward provided along a vertical central line of top board of the frame test bench, a tip of a perpendicular loading part of the radial loading assembly extending into the outer housing of the test-piece housing fixed on an upper plane of a bottom wall of the frame test bench, with the test-piece shaft and the test-piece housing fitted and connected to each other via a coupling interface for cylindrical fitting; a plurality of displacement sensors fixed on the test-piece housing, and test heads of respective displacement sensor assembly aiming at the test-piece shaft.

Abstract translation: 一种用于测试用于圆柱形接头的联接接口的刚度和非线性关系的装置和方法，包括沿着框架试验台的侧壁内的水平中心线设置的轴向加载组件，并与试验片 轴，其沿着框架测试台的顶板的垂直中心线向下设置的径向加载组件，所述径向加载组件的垂直装载部分的尖端延伸到所述试件壳体固定的外壳体中 在框架试验台的底壁的上平面上，试件轴和试件壳体通过用于圆柱形配合的联接接口彼此配合和连接; 固定在试件壳体上的多个位移传感器和针对试验轴的各个位移传感器组件的测试头。

公开(公告)号：US20140067898A1

公开(公告)日：2014-03-06

申请号：US13604756

申请日：2012-09-06

Applicant: Moritz M. Steiner ,  Yao Liu

Inventor： Moritz M. Steiner ,  Yao Liu

IPC: G06F15/16

CPC classification number: H04N21/23439 ,  H04N21/222 ,  H04N21/231 ,  H04N21/23103

Abstract: A capability is provided for determining a fraction of content item versions to cache for use in responding to requests for content items. The fraction of content item versions to cache is determined based on a popularity distribution of the content item versions and cost model information associated with the content item versions. The cost model information may include information indicative of a cost of storing one of the content item versions and at least one of a cost of transcoding one of the content item versions or a cost of transferring one of the content item versions. The fraction of content item versions to cache may be determined based a skewness factor of the popularity distribution of the content item versions.

Abstract translation: 提供了一种功能，用于确定要缓存的内容项目版本的一小部分，以用于响应内容项目的请求。 基于与内容项目版本相关联的内容项目版本和成本模型信息的流行度分布来确定要缓存的内容项目版本的一部分。 成本模型信息可以包括指示存储内容项目版本之一的成本的信息以及代码转换内容项目版本之一的成本中的至少一个或转移内容项目版本之一的成本中的至少一个。 要缓存的内容项目版本的一部分可以基于内容项目版本的流行度分布的偏度因子来确定。

公开(公告)号：US08420626B2

公开(公告)日：2013-04-16

申请号：US12601867

申请日：2008-05-30

Applicant: Song Li ,  Jing Su ,  Yao Liu ,  Junhai Xiao ,  Lili Wang ,  Wu Zhong ,  Zhibing Zheng ,  Yunde Xie ,  Xingzhou Li ,  Guoming Zhao ,  Xiaokui Wang ,  Xinbo Zhou ,  Hongying Liu

Inventor： Song Li ,  Jing Su ,  Yao Liu ,  Junhai Xiao ,  Lili Wang ,  Wu Zhong ,  Zhibing Zheng ,  Yunde Xie ,  Xingzhou Li ,  Guoming Zhao ,  Xiaokui Wang ,  Xinbo Zhou ,  Hongying Liu

IPC: A61K31/33 ,  C07D245/00 ,  C07D245/02 ,  C07D245/04 ,  C07D245/06 ,  C07D487/02

CPC classification number: C07D471/08 ,  C07D255/04 ,  C07D257/02 ,  C07D401/10

Abstract: The present invention relates to arene connected polyamine macrocyclic derivatives represented by general formula I, pharmaceutically acceptable salts or hydrates thereof which have anti-HIV activities, in which the definitions of substituents are as defined in the description; to preparation methods of the compounds of formula I; to pharmaceutical compositions containing the compounds of formula I or their pharmaceutically acceptable salts or hydrates; to the use of the compounds of formula I or their pharmaceutically acceptable salts or hydrates for the preparation of a medicament for the treatment and prevention of HIV-associated diseases.

Abstract translation: 本发明涉及具有抗HIV活性的由通式I表示的芳族连接的多胺大环衍生物，其药学上可接受的盐或水合物，其中取代基的定义如说明书中所定义; 制备式I化合物的方法; 包含式I化合物或其药学上可接受的盐或水合物的药物组合物; 涉及使用式I化合物或其药学上可接受的盐或水合物来制备用于治疗和预防HIV相关疾病的药物。

公开(公告)号：US20120168391A1

公开(公告)日：2012-07-05

申请号：US13293143

申请日：2011-11-10

Applicant: Kuang-Yao Liu

Inventor： Kuang-Yao Liu

IPC: G03B21/54

CPC classification number: F16M13/02 ,  F16M11/105 ,  F16M11/18 ,  F16M11/2064 ,  F16M2200/022 ,  G03B21/54

Abstract: An adjustment module adapted to a projector includes first and second racks, a screw, a rotary knob, a pin, and an elastic member. The first rack fixed to the projector has a first opening. The second rack is pivotally connected to the first rack and has a second opening. The screw is configured between the first rack and the second rack. The rotary knob has a threaded hole. One end of the screw passes through the first opening and is screwed into the threaded hole. The other end of the screw passes through the second opening and is fixed to the pin. The first rack and the second rack are located between the rotary knob and the pin. The elastic member is configured between the first rack and the second rack. The elastic member pushes the first rack against the rotary knob and pushes the second rack against the pin.

Abstract translation: 适于投影机的调节模块包括第一和第二机架，螺钉，旋钮，销和弹性构件。 固定在投影机上的第一个机架具有第一个开口。 第二齿条枢转地连接到第一齿条并且具有第二开口。 螺钉配置在第一机架和第二机架之间。 旋钮有一个螺纹孔。 螺钉的一端通过第一开口并拧入螺纹孔中。 螺钉的另一端穿过第二开口并固定在销上。 第一个机架和第二个机架位于旋钮和销之间。 弹性构件配置在第一齿条与第二齿条之间。 弹性构件将第一机架推靠在旋钮上并将第二机架推向销。

公开(公告)号：US08151310B2

公开(公告)日：2012-04-03

申请号：US11580564

申请日：2006-10-13

Applicant: Pascal Hochart ,  Zhuyun Dai ,  Yao Liu ,  Min He

Inventor： Pascal Hochart ,  Zhuyun Dai ,  Yao Liu ,  Min He

IPC: H04N7/173 ,  H04N7/16 ,  G06G7/58 ,  G06F3/00

CPC classification number: H04L65/602 ,  H04L65/607 ,  H04L67/12 ,  H04N7/17318 ,  H04N21/234336 ,  H04N21/4402 ,  H04N21/6581 ,  H04N21/8455 ,  H04N21/854

Abstract: A data delivering system comprises a video server receiving and processing oilfield data into a video delivery, and a network delivering the video delivery from the video server to at least one client device, where the video delivery including a plurality of sections.

Abstract translation: 数据传送系统包括视频服务器，其将油田数据接收并处理成视频传送，以及将视频传送从视频服务器传送到至少一个客户端设备的网络，其中包括多个部分的视频传送。

公开(公告)号：US08006684B2

公开(公告)日：2011-08-30

申请号：US12000115

申请日：2007-12-10

Applicant: Kuo-Liang Lee ,  Lu-Shan Chang ,  Shih-Yao Liu ,  Shih-Wei Tung

Inventor： Kuo-Liang Lee ,  Lu-Shan Chang ,  Shih-Yao Liu ,  Shih-Wei Tung

IPC: A21B1/08

CPC classification number: A47J37/0611 ,  A47J27/04

Abstract: A superheated stream grill includes a heating tray to serve as a heat source for heating and cooking the food materials. In addition, it also provides a function of heating food materials by using a superheated stream. The grill has a heating system for generating the superheated stream. The heating system atomizes the water molecules to form mist by means of the supersonic vibration, and then the mist is heated and converted into the superheated stream. The superheated stream is injected and sprayed onto the food materials. In this way, the mouth feeling of the food materials after cooking is much better and the time for cooking is also reduced.

Abstract translation: 过热流格栅包括用作加热和烹饪食物材料的热源的加热盘。 此外，它还提供通过使用过热流加热食物材料的功能。 格栅具有用于产生过热流的加热系统。 加热系统通过超音速振动雾化水分子形成雾，然后将雾加热转化成过热流。 将过热流注入并喷洒到食物材料上。 这样，烹调后的食物的口感就好多了，烹调时间也减少了。

公开(公告)号：US20100179116A1

公开(公告)日：2010-07-15

申请号：US12601867

申请日：2008-05-30

Applicant: Song Li ,  Jing Su ,  Yao Liu ,  Junhai Xiao ,  Lili Wang ,  Wu Zhong ,  Zhibing Zheng ,  Yunde Kie ,  Xingzhou Li ,  Guoming Zhao ,  Xiaokui Wang ,  Xinbo Zhou ,  Hongying Liu

Inventor： Song Li ,  Jing Su ,  Yao Liu ,  Junhai Xiao ,  Lili Wang ,  Wu Zhong ,  Zhibing Zheng ,  Yunde Kie ,  Xingzhou Li ,  Guoming Zhao ,  Xiaokui Wang ,  Xinbo Zhou ,  Hongying Liu

IPC: A61K31/395 ,  C07D257/02 ,  C07D403/10 ,  A61P31/18

CPC classification number: C07D471/08 ,  C07D255/04 ,  C07D257/02 ,  C07D401/10

Abstract: The present invention relates to arene connected polyamine macrocyclic derivatives represented by general formula I, pharmaceutically acceptable salts or hydrates thereof which have anti-HIV activities, in which the definitions of substituents are as defined in the description; to preparation methods of the compounds of formula I; to pharmaceutical compositions containing the compounds of formula I or their pharmaceutically acceptable salts or hydrates; to the use of the compounds of formula I or their pharmaceutically acceptable salts or hydrates for the preparation of a medicament for the treatment and prevention of HIV-associated diseases.

Abstract translation: 本发明涉及具有抗HIV活性的由通式I表示的芳族连接的多胺大环衍生物，其药学上可接受的盐或水合物，其中取代基的定义如说明书中所定义; 制备式I化合物的方法; 包含式I化合物或其药学上可接受的盐或水合物的药物组合物; 涉及使用式I化合物或其药学上可接受的盐或水合物来制备用于治疗和预防HIV相关疾病的药物。

公开(公告)号：US20090145418A1

公开(公告)日：2009-06-11

申请号：US12000115

申请日：2007-12-10

Applicant: Kuo-Liang Lee ,  Lu Shan Chang ,  Shih Yao Liu ,  Shih Wei Tung

Inventor： Kuo-Liang Lee ,  Lu Shan Chang ,  Shih Yao Liu ,  Shih Wei Tung

IPC: A21B1/36

CPC classification number: A47J37/0611 ,  A47J27/04

Abstract: A superheated stream grill includes a heating tray to serve as a heat source for heating and cooking the food materials. In addition, it also provides a function of heating food materials by using a superheated stream. The grill has a heating system for generating the superheated stream. The heating system atomizes the water molecules to form mist by means of the supersonic vibration, and then the mist is heated and converted into the superheated stream. The superheated stream is injected and sprayed onto the food materials. In this way, the mouth feeling of the food materials after cooking is much better and the time for cooking is also reduced.

Abstract translation: 过热流格栅包括用作加热和烹饪食物材料的热源的加热盘。 此外，它还提供通过使用过热流加热食物材料的功能。 格栅具有用于产生过热流的加热系统。 加热系统通过超音速振动雾化水分子形成雾，然后将雾加热转化成过热流。 将过热流注入并喷洒到食物材料上。 这样，烹调后的食物的口感就好多了，烹调时间也减少了。

公开(公告)号：US07475290B2

公开(公告)日：2009-01-06

申请号：US11308919

申请日：2006-05-25

Applicant: He-Yao Liu ,  Hung-Chih Huang

Inventor： He-Yao Liu ,  Hung-Chih Huang

IPC: G06F11/00

CPC classification number: G06F11/263

Abstract: A debugging apparatus is provided for debugging an information storage apparatus. The debugging apparatus includes a debugging control unit, an information converting circuit, and a computer device. The debugging control unit captures raw data and then generates a coded data sequence representing the raw data. The information converting circuit receives the coded data sequence and transforms the coded data sequence into a predetermined format. The computer device is connected to the information converting circuit, and for receiving the coded data sequence in the predetermined format and decoding the coded data sequence to the raw data.

Abstract translation: 提供一种用于调试信息存储装置的调试装置。 调试装置包括调试控制单元，信息转换电路和计算机设备。 调试控制单元捕获原始数据，然后生成表示原始数据的编码数据序列。 信息转换电路接收编码数据序列并将编码数据序列变换为预定格式。 计算机设备连接到信息转换电路，并用于以预定格式接收编码数据序列，并将编码数据序列解码为原始数据。