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公开(公告)号：US07179918B2
公开(公告)日：2007-02-20
申请号：US10166979
申请日：2002-06-11
申请人： Stacie S. Canan Koch , Therese N. Alexander , Benjamin J. Burke , Tanya M. Jewell , David J. Kucera , Maria Angelica Linton , Lennert J. Mitchell, Jr. , Siegfried H. Reich , Donald J. Skalitzky , John H. Tatlock , Michael D. Varney , Scott C. Virgil , Stephen E. Webber , Stephen T. Worland , Mark Barvian , Gary Bolton , Frederick Earl Boyer, Jr. , Jeffrey J. Machak , Tod Holler , Sean T. Murphy , Michael Melnick , Vara Prasad Josyula
发明人： Stacie S. Canan Koch , Therese N. Alexander , Benjamin J. Burke , Tanya M. Jewell , David J. Kucera , Maria Angelica Linton , Lennert J. Mitchell, Jr. , Siegfried H. Reich , Donald J. Skalitzky , John H. Tatlock , Michael D. Varney , Scott C. Virgil , Stephen E. Webber , Stephen T. Worland , Mark Barvian , Gary Bolton , Frederick Earl Boyer, Jr. , Jeffrey J. Machak , Tod Holler , Sean T. Murphy , Michael Melnick , Vara Prasad Josyula
IPC分类号： C07D207/16 , C07D221/02
CPC分类号： C07D231/12 , A61K31/426 , A61K31/427 , C07D207/09 , C07D207/16 , C07D213/38 , C07D217/26 , C07D277/06 , C07D277/60 , C07D295/13 , C07D307/52 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/08
摘要： Compounds of the formula: where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.
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2.发明授权HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis 失效HIV蛋白酶抑制剂，含有它们的组合物，它们的药物用途和用于合成的材料公开(公告)号：US06953858B2
公开(公告)日：2005-10-11
申请号：US10166957
申请日：2002-06-11
申请人： Stacie S. Canan Koch , Therese N. Alexander , Mark Barvian , Gary Bolton , Frederick Earl Boyer, Jr. , Benjamin J. Burke , Tod Holler , Tanya M. Jewell , Vara Prasad Josyula , David J. Kucera , Maria Angelica Linton , Jeffrey J. Machak , Lennert J. Mitchell, Jr. , Sean T. Murphy , Siegfried H. Reich , Donald J. Skalitzky , John H. Tatlock , Michael D. Varney , Scott C. Virgil , Stephen E. Webber , Stephen T. Worland , Michael Melnick
发明人： Stacie S. Canan Koch , Therese N. Alexander , Mark Barvian , Gary Bolton , Frederick Earl Boyer, Jr. , Benjamin J. Burke , Tod Holler , Tanya M. Jewell , Vara Prasad Josyula , David J. Kucera , Maria Angelica Linton , Jeffrey J. Machak , Lennert J. Mitchell, Jr. , Sean T. Murphy , Siegfried H. Reich , Donald J. Skalitzky , John H. Tatlock , Michael D. Varney , Scott C. Virgil , Stephen E. Webber , Stephen T. Worland , Michael Melnick
IPC分类号： C07D277/04 , A61K31/40 , A61K31/401 , A61K31/4025 , A61K31/421 , A61K31/422 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/435 , A61K31/439 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/472 , A61K31/501 , A61K31/5377 , A61K31/541 , A61K38/04 , A61K45/00 , A61P31/00 , A61P31/12 , A61P31/18 , A61P37/02 , A61P43/00 , C07D207/09 , C07D207/16 , C07D207/24 , C07D209/52 , C07D213/38 , C07D217/26 , C07D231/12 , C07D263/04 , C07D263/06 , C07D277/00 , C07D277/06 , C07D277/20 , C07D277/28 , C07D277/32 , C07D277/38 , C07D277/60 , C07D295/13 , C07D307/52 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/08 , C07K5/04
CPC分类号： C07D231/12 , A61K31/426 , A61K31/427 , C07D207/09 , C07D207/16 , C07D213/38 , C07D217/26 , C07D277/06 , C07D277/60 , C07D295/13 , C07D307/52 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/08
摘要： Compounds of the formula: where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.
摘要翻译： 公开了下式的化合物：其中式变量如本文所定义，其有利地抑制或阻断HIV蛋白酶的生物活性。 这些化合物以及含有这些化合物的药物组合物可用于治疗感染HIV病毒的患者或宿主。 还描述了制备这些化合物的中间体和合成方法。
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3.发明申请公开(公告)号：US20050250707A1
公开(公告)日：2005-11-10
申请号：US11155568
申请日：2005-06-20
申请人： Stacie Canan Koch , Therese Alexander , Benjamin Burke , Tanya Jewell , David Kucera , Maria Linton , Lennert Mitchell , Siegfried Reich , Donald Skalitzky , John Tatlock , Michael Varney , Scott Virgil , Stephen Webber , Stephen Worland , Mark Barvian , Gary Bolton , Frederick Boyer , Jeffrey Machak , Tod Holler , Sean Murphy , Michael Melnick , Vara Josyula
发明人： Stacie Canan Koch , Therese Alexander , Benjamin Burke , Tanya Jewell , David Kucera , Maria Linton , Lennert Mitchell , Siegfried Reich , Donald Skalitzky , John Tatlock , Michael Varney , Scott Virgil , Stephen Webber , Stephen Worland , Mark Barvian , Gary Bolton , Frederick Boyer , Jeffrey Machak , Tod Holler , Sean Murphy , Michael Melnick , Vara Josyula
IPC分类号： C07D277/04 , A61K31/40 , A61K31/401 , A61K31/4025 , A61K31/421 , A61K31/422 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/435 , A61K31/439 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/472 , A61K31/501 , A61K31/5377 , A61K31/541 , A61K38/04 , A61K45/00 , A61P31/00 , A61P31/12 , A61P31/18 , A61P37/02 , A61P43/00 , C07D207/09 , C07D207/16 , C07D207/24 , C07D209/52 , C07D213/38 , C07D217/26 , C07D231/12 , C07D263/04 , C07D263/06 , C07D277/00 , C07D277/06 , C07D277/20 , C07D277/28 , C07D277/32 , C07D277/38 , C07D277/60 , C07D295/13 , C07D307/52 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/08 , C07K5/04
CPC分类号： C07D231/12 , A61K31/426 , A61K31/427 , C07D207/09 , C07D207/16 , C07D213/38 , C07D217/26 , C07D277/06 , C07D277/60 , C07D295/13 , C07D307/52 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/08
摘要： Compounds of the formula: where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.
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4.发明申请HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis 审中-公开HIV蛋白酶抑制剂，含有它们的组合物，它们的药物用途和用于合成的材料公开(公告)号：US20070021354A1
公开(公告)日：2007-01-25
申请号：US11450943
申请日：2006-06-09
申请人： Stacie Canan Koch , Therese Alexander , Benjamin Burke , Tanya Jewell , David Kucera , Maria Linton , Lennert Mitchell , Siegfried Reich , Donald Skalitzky , John Tatlock , Michael Varney , Scott Virgil , Stephen Webber , Stephen Worland , Mark Barvian , Gary Bolton , Frederick Boyer , Jeffrey Machak , Tod Holler , Sean Murphy , Michael Melnick , Vara Josyula
发明人： Stacie Canan Koch , Therese Alexander , Benjamin Burke , Tanya Jewell , David Kucera , Maria Linton , Lennert Mitchell , Siegfried Reich , Donald Skalitzky , John Tatlock , Michael Varney , Scott Virgil , Stephen Webber , Stephen Worland , Mark Barvian , Gary Bolton , Frederick Boyer , Jeffrey Machak , Tod Holler , Sean Murphy , Michael Melnick , Vara Josyula
IPC分类号： A61K38/04 , A61K31/4025 , A61K31/401 , C07K5/04 , C07D403/02
CPC分类号： C07D231/12 , A61K31/426 , A61K31/427 , C07D207/09 , C07D207/16 , C07D213/38 , C07D217/26 , C07D277/06 , C07D277/60 , C07D295/13 , C07D307/52 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/08
摘要： Compounds of the formula: where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.
摘要翻译： 公开了下式的化合物：其中式变量如本文所定义，其有利地抑制或阻断HIV蛋白酶的生物活性。 这些化合物以及含有这些化合物的药物组合物可用于治疗感染HIV病毒的患者或宿主。 还描述了制备这些化合物的中间体和合成方法。
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