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    INHIBITORS OF SERINE PALMITOYLTRANSFERASE
    5.
    发明申请
    INHIBITORS OF SERINE PALMITOYLTRANSFERASE 审中-公开
    丝氨酸蛋白酶抑制剂的抑制剂

    公开(公告)号：US20080287479A1

    公开(公告)日：2008-11-20

    申请号：US11945452

    申请日：2007-11-27

    申请人： Richard Hutchings ,  William Park ,  Gary Bolton ,  Chad Van Huis ,  Jeff Kohrt

    发明人： Richard Hutchings ,  William Park ,  Gary Bolton ,  Chad Van Huis ,  Jeff Kohrt

    IPC分类号： A61K31/438 ,  C07D401/14 ,  A61K31/454 ,  A61K31/439

    CPC分类号： C07D401/04 ,  C07D401/14

    摘要： This invention provides compounds of the formula: useful in the inhibition or modulation of serine palmitoyl transferase and their use in methods of treatment or amelioration of type 2 diabetes, type 1 diabetes, insulin resistance, the effects of obesity, metabolic syndrome (sometimes referred to as Syndrome X), impaired glucose tolerance, Cushing's disease, cardiovascular disease, prothrombotic conditions, myocardial infarction, hypertension, congestive heart failure, cardiomyopathy, atherosclerosis, dyslipidemia, sepsis, liver damage, retinal degenerative disorders, cachexia, emphysema, hepatitis C infections, HIV infections and inflammatory disorders and useful in methods for raising HDL plasma levels in a mammal. The compounds of this invention can also be used to prevent damage or loss of pancreatic islet beta cells (such as in the case of pancreatic beta cell apoptosis, including those related to insulin-dependent diabetes mellitus).

    摘要翻译： 本发明提供下式的化合物：可用于抑制或调节丝氨酸棕榈酰转移酶及其在治疗或改善2型糖尿病，1型糖尿病，胰岛素抵抗，肥胖症，代谢综合征（有时称为 作为综合征X），葡萄糖耐量减低，库欣氏病，心血管疾病，血栓形成状况，心肌梗死，高血压，充血性心力衰竭，心肌病，动脉粥样硬化，血脂异常，败血症，肝损伤，视网膜退行性疾病，恶病质，肺气肿，丙型肝炎感染， HIV感染和炎症性疾病，并且可用于在哺乳动物中提高HDL血浆水平的方法。 本发明的化合物也可用于防止胰岛β细胞的损伤或损失（例如在胰腺β细胞凋亡的情况下，包括与胰岛素依赖性糖尿病相关的细胞凋亡）。

    Locking wheel rim cover
    6.
    发明授权
    Locking wheel rim cover 有权
    锁边轮盖

    公开(公告)号：US09227678B2

    公开(公告)日：2016-01-05

    申请号：US13851263

    申请日：2013-03-27

    申请人： Gary Bolton

    发明人： Gary Bolton

    IPC分类号： B62D43/00

    CPC分类号： B62D43/007

    摘要： A locking wheel rim cover is described for attachment to the outer face of a spare wheel rim having a given diameter, an outer face and log openings. The cover includes a circular rim plate having a diameter substantial the same as the diameter of the wheel rim, an inner face and an outer face; a locking member extending inwardly from the inner face of the rim plate; a first attachment member extending inwardly from the inner face of the rim plate; and an attachment bracket mountable on the outer face of the wheel rim, the bracket including a locking member opening to receive the locking member, a second attachment member connectable with the first attachment member and inwardly extending adapters sized for insertion into the wheel lug openings.

    摘要翻译： 描述了锁定轮缘盖，用于附接到具有给定直径，外表面和对数开口的备用轮缘的外表面。 该盖包括圆形边框板，其直径与轮缘的直径基本相同，内表面和外表面; 从所述边缘板的内表面向内延伸的锁定件; 从所述边缘板的内表面向内延伸的第一附接构件; 以及可安装在所述轮缘的外表面上的附接支架，所述支架包括用于接收所述锁定构件的锁定构件开口，与所述第一附接构件连接的第二附接构件和尺寸适于插入到所述轮突起开口中的向内延伸的适配器。

    LOCKING WHEEL RIM COVER
    7.
    发明申请
    LOCKING WHEEL RIM COVER 有权
    锁定轮RIM盖

    公开(公告)号：US20140077583A1

    公开(公告)日：2014-03-20

    申请号：US13851263

    申请日：2013-03-27

    申请人： Gary Bolton

    发明人： Gary Bolton

    IPC分类号： B62D43/00

    CPC分类号： B62D43/007

    摘要： A locking wheel rim cover is described for attachment to the outer face of a spare wheel rim having a given diameter, an outer face and log openings. The cover includes a circular rim plate having a diameter substantial the same as the diameter of the wheel rim, an inner face and an outer face; a locking member extending inwardly from the inner face of the rim plate; a first attachment member extending inwardly from the inner face of the rim plate; and an attachment bracket mountable on the outer face of the wheel rim, the bracket including a locking member opening to receive the locking member, a second attachment member connectable with the first attachment member and inwardly extending adapters sized for insertion into the wheel lug openings.

    摘要翻译： 描述了锁定轮缘盖，用于附接到具有给定直径，外表面和对数开口的备用轮缘的外表面。 该盖包括圆形边框板，其直径与轮缘的直径基本相同，内表面和外表面; 从所述边缘板的内表面向内延伸的锁定件; 从所述边缘板的内表面向内延伸的第一附接构件; 以及可安装在所述轮缘的外表面上的附接支架，所述支架包括用于接收所述锁定构件的锁定构件开口，与所述第一附接构件连接的第二附接构件和尺寸适于插入到所述轮突起开口中的向内延伸的适配器。