专利检索 ap:"Maria Linton" 第 1 页

1.

发明申请
INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME 失效
标题翻译： HEPATITIS C病毒RNA依赖RNA聚合酶的抑制剂及其组合物和治疗

公开(公告)号：US20060189681A1

公开(公告)日：2006-08-24

申请号：US11382154

申请日：2006-05-08

申请人： Allen Borchardt , Javier Gonzalez , Hui Li , Maria Linton , John Tatlock

发明人： Allen Borchardt , Javier Gonzalez , Hui Li , Maria Linton , John Tatlock

IPC分类号： A61K31/366 , C07D309/30

CPC分类号： C07D285/06 , C07D263/58 , C07D309/32 , C07D405/06 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/06 , C07D407/10 , C07D407/12 , C07D409/06 , C07D409/10 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/10 , C07D417/12 , C07D471/04 , C07D473/30 , C07D473/36 , C07D487/04 , C07D495/04 , C07D513/04

摘要： The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, solvates, prodrugs and metabolites thereof, wherein W, Z, R1 and R2, are as defined herein. The invention also relates to methods of treating Hepatitis C virus in mammals by administering the compounds of formula 1, and to pharmaceutical compositions for treating such disorders, which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.

摘要翻译： 本发明涉及式1的化合物及其药学上可接受的盐，溶剂合物，前药和代谢物，其中W，Z，R 1和R 2定义同上这里。本发明还涉及通过给予式1化合物治疗哺乳动物中的丙型肝炎病毒的方法以及含有式1化合物的用于治疗这种病症的药物组合物。本发明还涉及制备式 1。

2.

发明申请
HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis 审中-公开
标题翻译： HIV蛋白酶抑制剂，含有它们的组合物，它们的药物用途和用于合成的材料

公开(公告)号：US20070021354A1

公开(公告)日：2007-01-25

申请号：US11450943

申请日：2006-06-09

申请人： Stacie Canan Koch , Therese Alexander , Benjamin Burke , Tanya Jewell , David Kucera , Maria Linton , Lennert Mitchell , Siegfried Reich , Donald Skalitzky , John Tatlock , Michael Varney , Scott Virgil , Stephen Webber , Stephen Worland , Mark Barvian , Gary Bolton , Frederick Boyer , Jeffrey Machak , Tod Holler , Sean Murphy , Michael Melnick , Vara Josyula

发明人： Stacie Canan Koch , Therese Alexander , Benjamin Burke , Tanya Jewell , David Kucera , Maria Linton , Lennert Mitchell , Siegfried Reich , Donald Skalitzky , John Tatlock , Michael Varney , Scott Virgil , Stephen Webber , Stephen Worland , Mark Barvian , Gary Bolton , Frederick Boyer , Jeffrey Machak , Tod Holler , Sean Murphy , Michael Melnick , Vara Josyula

IPC分类号： A61K38/04 , A61K31/4025 , A61K31/401 , C07K5/04 , C07D403/02

CPC分类号： C07D231/12 , A61K31/426 , A61K31/427 , C07D207/09 , C07D207/16 , C07D213/38 , C07D217/26 , C07D277/06 , C07D277/60 , C07D295/13 , C07D307/52 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/08

摘要： Compounds of the formula: where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.

摘要翻译： 公开了下式的化合物：其中式变量如本文所定义，其有利地抑制或阻断HIV蛋白酶的生物活性。这些化合物以及含有这些化合物的药物组合物可用于治疗感染HIV病毒的患者或宿主。还描述了制备这些化合物的中间体和合成方法。

3.

发明申请
Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same 失效
标题翻译：丙型肝炎病毒RNA依赖性RNA聚合酶的抑制剂，以及使用其的组合物和治疗

公开(公告)号：US20050176701A1

公开(公告)日：2005-08-11

申请号：US10718337

申请日：2003-11-19

申请人： Allen Borchardt , Javier Gonzalez , Hui Li , Maria Linton , John Tatlock

发明人： Allen Borchardt , Javier Gonzalez , Hui Li , Maria Linton , John Tatlock

IPC分类号： A61K31/4025 , A61K31/452 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/541 , A61P31/14 , C07D263/58 , C07D285/06 , C07D309/32 , C07D405/06 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/06 , C07D407/10 , C07D407/12 , C07D409/06 , C07D409/10 , C07D413/02 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/02 , C07D417/06 , C07D417/10 , C07D417/12 , C07D471/04 , C07D473/30 , C07D473/36 , C07D487/04 , C07D495/04 , C07D513/04 , C07D45/02

CPC分类号： C07D285/06 , C07D263/58 , C07D309/32 , C07D405/06 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/06 , C07D407/10 , C07D407/12 , C07D409/06 , C07D409/10 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/10 , C07D417/12 , C07D471/04 , C07D473/30 , C07D473/36 , C07D487/04 , C07D495/04 , C07D513/04

摘要： The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, solvates, prodrugs and metabolites thereof, wherein W, Z, R1 and R2, are as defined herein. The invention also relates to methods of treating Hepatitis C virus in mammals by administering the compounds of formula 1, and to pharmaceutical compositions for treating such disorders, which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.

摘要翻译： 本发明涉及式1的化合物及其药学上可接受的盐，溶剂合物，前药和代谢物，其中W，Z，R 1和R 2定义同上这里。本发明还涉及通过给予式1化合物治疗哺乳动物中的丙型肝炎病毒的方法以及含有式1化合物的用于治疗这种病症的药物组合物。本发明还涉及制备式 1。