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1.发明申请公开(公告)号：US20110217377A1
公开(公告)日：2011-09-08
申请号：US13108361
申请日：2011-05-16
申请人： Stephen E. Zale , Greg Troiano , Mir M. Ali , Jeff Hrkach , James Wright , Susan Low
发明人： Stephen E. Zale , Greg Troiano , Mir M. Ali , Jeff Hrkach , James Wright , Susan Low
IPC分类号： A61K9/14 , A61K31/337 , A61K31/436 , A61K31/519 , A61K31/437 , A61P35/00 , B82Y5/00
CPC分类号： A61K9/5153 , A61K9/0019 , A61K9/1641 , A61K31/337 , A61K31/436 , A61K31/475 , A61K31/519 , A61K47/542 , A61K47/593 , A61K47/60 , A61K47/6925 , A61K47/6937 , B82Y5/00
摘要： The present disclosure is directed in part to a biocompatible nanoparticle composition comprising a plurality of non-colloidal long circulating nanoparticles, each comprising a α-hydroxy polyester-co-polyether and a therapeutic agent, wherein such disclosed compositions provide a therapeutic effect for at least 12 hours.
摘要翻译： 本公开部分地涉及生物相容性纳米颗粒组合物，其包含多个非胶体长循环纳米颗粒，每个非胶体长循环纳米颗粒包含α-羟基聚酯 - 共聚醚和治疗剂，其中所述公开的组合物至少提供治疗效果 12小时。
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公开(公告)号：US09308179B2
公开(公告)日：2016-04-12
申请号：US13556647
申请日：2012-07-24
申请人： Stephen E. Zale , Greg Troiano , Mir M. Ali , Jeff Hrkach , James Wright
发明人： Stephen E. Zale , Greg Troiano , Mir M. Ali , Jeff Hrkach , James Wright
CPC分类号： A61K9/5153 , A61K9/0019 , A61K9/1641 , A61K31/337 , A61K31/436 , A61K31/475 , A61K31/519 , A61K47/542 , A61K47/593 , A61K47/60 , A61K47/6925 , A61K47/6937 , B82Y5/00
摘要： The present disclosure is directed in part to a biocompatible nanoparticle composition comprising a plurality of non-colloidal long circulating nanoparticles, each comprising a α-hydroxy polyester-co-polyether and a therapeutic agent, wherein such disclosed compositions provide a therapeutic effect for at least 12 hours.
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3.发明申请公开(公告)号：US20100216804A1
公开(公告)日：2010-08-26
申请号：US12638297
申请日：2009-12-15
申请人： Stephen E. Zale , Greg Troiano , Mir M. Ali , Jeff Hrkach , James Wright , Susan Low
发明人： Stephen E. Zale , Greg Troiano , Mir M. Ali , Jeff Hrkach , James Wright , Susan Low
IPC分类号： A61K9/14 , A61K31/337 , A61K31/4745 , A61K31/519 , A61K31/436 , A61P35/00
CPC分类号： A61K9/5153 , A61K9/0019 , A61K9/1641 , A61K31/337 , A61K31/436 , A61K31/475 , A61K31/519 , A61K47/542 , A61K47/593 , A61K47/60 , A61K47/6925 , A61K47/6937 , B82Y5/00
摘要： The present disclosure is directed in part to a biocompatible nanoparticle composition comprising a plurality of non-colloidal long circulating nanoparticles, each comprising a α-hydroxy polyester-co-polyether and a therapeutic agent, wherein such disclosed compositions provide a therapeutic effect for at least 12 hours.
摘要翻译： 本公开部分地涉及生物相容性纳米颗粒组合物，其包含多个非胶体长循环纳米颗粒，每个非胶体长循环纳米颗粒包含α-羟基聚酯 - 共聚醚和治疗剂，其中所述公开的组合物至少提供治疗效果 12小时。
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4.发明申请公开(公告)号：US20130034608A1
公开(公告)日：2013-02-07
申请号：US13556647
申请日：2012-07-24
申请人： Stephen E. Zale , Greg Troiano , Mir M. Ali , Jeff Hrkach , James Wright
发明人： Stephen E. Zale , Greg Troiano , Mir M. Ali , Jeff Hrkach , James Wright
IPC分类号： A61K9/14 , A61K31/337 , A61P35/00 , B82Y5/00
CPC分类号： A61K9/5153 , A61K9/0019 , A61K9/1641 , A61K31/337 , A61K31/436 , A61K31/475 , A61K31/519 , A61K47/542 , A61K47/593 , A61K47/60 , A61K47/6925 , A61K47/6937 , B82Y5/00
摘要： The present disclosure is directed in part to a biocompatible nanoparticle composition comprising a plurality of non-colloidal long circulating nanoparticles, each comprising a α-hydroxy polyester-co-polyether and a therapeutic agent, wherein such disclosed compositions provide a therapeutic effect for at least 12 hours.
摘要翻译： 本公开部分地涉及生物相容性纳米颗粒组合物，其包含多个非胶体长循环纳米颗粒，每个非胶体长循环纳米颗粒包含α-羟基聚酯 - 共聚醚和治疗剂，其中所述公开的组合物至少提供治疗效果 12小时。
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5.发明授权Therapeutic polymeric nanoparticles comprising vinca alkaloids and methods of making and using same 有权包括长春花生物碱的治疗性聚合物纳米颗粒及其制备和使用方法公开(公告)号：US08318211B2
公开(公告)日：2012-11-27
申请号：US12485467
申请日：2009-06-16
申请人： Stephen E. Zale , Greg Troiano , Mir Mukkaram Ali , Jeff Hrkach , James Wright
发明人： Stephen E. Zale , Greg Troiano , Mir Mukkaram Ali , Jeff Hrkach , James Wright
CPC分类号： A61K9/1647 , A61K9/14 , A61K9/1694 , A61K9/19 , A61K9/5153 , A61K31/4745 , A61K31/475 , A61K31/55 , A61K47/26
摘要： The present disclosure generally relates to therapeutic nanoparticles. Exemplary nanoparticles disclosed herein may include about 1 to about 20 weight percent of a vinca alkaloid; and about 50 to about 99 weight percent biocompatible polymer.
摘要翻译： 本公开一般涉及治疗性纳米颗粒。 本文公开的示例性纳米颗粒可包括约1至约20重量％的长春花生物碱; 和约50至约99重量％的生物相容性聚合物。
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6.发明申请公开(公告)号：US20120288541A1
公开(公告)日：2012-11-15
申请号：US13553210
申请日：2012-07-19
申请人： Stephen E. Zale , Greg Troiano , Mir Mukkaram Ali , Jeff Hrkach , James Wright
发明人： Stephen E. Zale , Greg Troiano , Mir Mukkaram Ali , Jeff Hrkach , James Wright
IPC分类号： A61K9/14 , A61P35/00 , A61K31/337 , B82Y5/00
CPC分类号： A61K47/34 , A61J3/00 , A61K9/10 , A61K9/107 , A61K9/1647 , A61K9/19 , A61K9/5146 , A61K9/5153 , A61K31/337 , A61K31/4355 , A61K31/436 , A61K31/437 , A61K31/439 , A61K31/475 , A61K31/704 , A61K31/7068 , A61K47/6915 , A61K47/6925 , A61K47/6937 , B82Y5/00 , C07C59/08 , Y10S977/773
摘要： The present disclosure generally relates to nanoparticles having about 0.2 to about 35 weight percent of a therapeutic agent; and about 10 to about 99 weight percent of biocompatible polymer such as a diblock poly(lactic) acid-poly(ethylene)glycol. Other aspects of the invention include methods of making such nanoparticles.
摘要翻译： 本公开内容通常涉及具有约0.2至约35重量％的治疗剂的纳米颗粒; 和约10至约99重量％的生物相容性聚合物，例如二嵌段聚（乳酸） - 聚（乙烯）二醇。 本发明的其它方面包括制备这种纳米颗粒的方法。
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7.发明申请Therapeutic polymeric nanoparticles with mTor inhibitors and methods of making and using same 有权具有mTor抑制剂的治疗性聚合物纳米颗粒及其制备和使用方法公开(公告)号：US20100069426A1
公开(公告)日：2010-03-18
申请号：US12485462
申请日：2009-06-16
申请人： Stephen E. Zale , Greg Troiano , Mir Mukkaram Ali , Jeff Hrkach , James Wright
发明人： Stephen E. Zale , Greg Troiano , Mir Mukkaram Ali , Jeff Hrkach , James Wright
IPC分类号： A61K31/436 , A61K47/32 , A61P35/00 , A61P37/06
CPC分类号： A61K9/14 , A61K9/19 , A61K9/5146 , A61K9/5153 , A61K31/00 , A61K31/435 , A61K31/436 , C07C59/08 , Y10S977/773
摘要： The present disclosure generally relates to therapeutic nanoparticles. Exemplary nanoparticles disclosed herein may include about 1 to about 20 weight percent of a mTOR inhibitor; and about 70 to about 99 weight percent biocompatible polymer.
摘要翻译： 本公开一般涉及治疗性纳米颗粒。 本文公开的示例性纳米颗粒可包括约1至约20重量％的mTOR抑制剂; 和约70至约99重量％的生物相容性聚合物。
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8.发明授权公开(公告)号：US08318208B1
公开(公告)日：2012-11-27
申请号：US13553210
申请日：2012-07-19
申请人： Stephen E. Zale , Greg Troiano , Mir Mukkaram Ali , Jeff Hrkach , James Wright
发明人： Stephen E. Zale , Greg Troiano , Mir Mukkaram Ali , Jeff Hrkach , James Wright
IPC分类号： A61K9/14 , C07C35/00 , C07C237/00 , C07C407/00
CPC分类号： A61K47/34 , A61J3/00 , A61K9/10 , A61K9/107 , A61K9/1647 , A61K9/19 , A61K9/5146 , A61K9/5153 , A61K31/337 , A61K31/4355 , A61K31/436 , A61K31/437 , A61K31/439 , A61K31/475 , A61K31/704 , A61K31/7068 , A61K47/6915 , A61K47/6925 , A61K47/6937 , B82Y5/00 , C07C59/08 , Y10S977/773
摘要： The present disclosure generally relates to nanoparticles having about 0.2 to about 35 weight percent of a therapeutic agent; and about 10 to about 99 weight percent of biocompatible polymer such as a diblock poly(lactic) acid-poly(ethylene)glycol. Other aspects of the invention include methods of making such nanoparticles.
摘要翻译： 本公开内容通常涉及具有约0.2至约35重量％的治疗剂的纳米颗粒; 和约10至约99重量％的生物相容性聚合物，例如二嵌段聚（乳酸） - 聚（乙烯）二醇。 本发明的其它方面包括制备这种纳米颗粒的方法。
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公开(公告)号：US08206747B2
公开(公告)日：2012-06-26
申请号：US12485399
申请日：2009-06-16
申请人： Stephen E. Zale , Greg Troiano , Mir Mukkaram Ali , Jeff Hrkach , James Wright
发明人： Stephen E. Zale , Greg Troiano , Mir Mukkaram Ali , Jeff Hrkach , James Wright
IPC分类号： A61K9/14 , C07C35/00 , C07C237/00 , C07D407/00
CPC分类号： A61K47/34 , A61J3/00 , A61K9/10 , A61K9/107 , A61K9/1647 , A61K9/19 , A61K9/5146 , A61K9/5153 , A61K31/337 , A61K31/4355 , A61K31/436 , A61K31/437 , A61K31/439 , A61K31/475 , A61K31/704 , A61K31/7068 , A61K47/6915 , A61K47/6925 , A61K47/6937 , B82Y5/00 , C07C59/08 , Y10S977/773
摘要： The present disclosure generally relates to nanoparticles having about 0.2 to about 35 weight percent of a therapeutic agent; and about 10 to about 99 weight percent of biocompatible polymer such as a diblock poly(lactic) acid-poly(ethylene)glycol. Other aspects of the invention include methods of making such nanoparticles.
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10.发明授权Therapeutic polymeric nanoparticles with mTor inhibitors and methods of making and using same 有权具有mTor抑制剂的治疗性聚合物纳米颗粒及其制备和使用方法公开(公告)号：US08613951B2
公开(公告)日：2013-12-24
申请号：US12485462
申请日：2009-06-16
申请人： Stephen E. Zale , Greg Troiano , Mir Mukkaram Ali , Jeff Hrkach , James Wright
发明人： Stephen E. Zale , Greg Troiano , Mir Mukkaram Ali , Jeff Hrkach , James Wright
IPC分类号： A61K9/14 , A61K9/51 , A61K31/436 , C07C59/08
CPC分类号： A61K9/14 , A61K9/19 , A61K9/5146 , A61K9/5153 , A61K31/00 , A61K31/435 , A61K31/436 , C07C59/08 , Y10S977/773
摘要： The present disclosure generally relates to therapeutic nanoparticles. Exemplary nanoparticles disclosed herein may include about 1 to about 20 weight percent of a mTOR inhibitor; and about 70 to about 99 weight percent biocompatible polymer.
摘要翻译： 本公开一般涉及治疗性纳米颗粒。 本文公开的示例性纳米颗粒可包括约1至约20重量％的mTOR抑制剂; 和约70至约99重量％的生物相容性聚合物。
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