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公开(公告)号：US20110039885A1
公开(公告)日：2011-02-17
申请号：US12734893
申请日：2008-12-08
IPC分类号： A61K31/47
CPC分类号： A61K31/472
摘要： The present invention relates to methods and compounds useful for increasing endothelial progenitor cell levels in blood and bone marrow. Methods and compounds for increasing endothelial progenitor cell mobilization are also provided.
摘要翻译： 本发明涉及可用于增加血液和骨髓中内皮祖细胞水平的方法和化合物。 还提供了用于增加内皮祖细胞动员的方法和化合物。
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公开(公告)号：US08609646B2
公开(公告)日：2013-12-17
申请号：US12804029
申请日：2010-07-12
申请人： Stephen J. Klaus , Christopher J. Molineaux , Thomas B. Neff , Volkmar Guenzler-Pukall , Ingrid Langsetmo Parobok , Todd W. Seeley , Robert C. Stephenson
发明人： Stephen J. Klaus , Christopher J. Molineaux , Thomas B. Neff , Volkmar Guenzler-Pukall , Ingrid Langsetmo Parobok , Todd W. Seeley , Robert C. Stephenson
CPC分类号： C07D217/24 , A61K31/00 , A61K31/165 , A61K31/17 , A61K31/395 , A61K31/472 , C07C275/40
摘要： The present invention relates to methods and compounds for decreasing the expression of hepcidin, a protein associated with regulation of iron metabolism.
摘要翻译： 本发明涉及用于降低与铁代谢调节相关的蛋白质铁调素的表达的方法和化合物。
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公开(公告)号：US20110039879A1
公开(公告)日：2011-02-17
申请号：US12734890
申请日：2008-12-08
IPC分类号： A61K31/437
CPC分类号： A61K31/472 , A61K31/4738 , A61K31/4743 , A61K31/4745
摘要： The present invention relates to methods and compounds useful for increasing white blood cell levels in blood and bone marrow. Methods and compounds for increasing hematopoietic progenitor cells are also provided.
摘要翻译： 本发明涉及可用于增加血液和骨髓中白细胞水平的方法和化合物。 还提供了用于增加造血祖细胞的方法和化合物。
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公开(公告)号：US08614204B2
公开(公告)日：2013-12-24
申请号：US10861590
申请日：2004-06-03
申请人： Stephen J. Klaus , Christopher J. Molineaux , Thomas B. Neff , Volkmar Guenzler-Pukall , Ingrid Langsetmo Parobok , Todd W. Seeley , Robert C. Stephenson
发明人： Stephen J. Klaus , Christopher J. Molineaux , Thomas B. Neff , Volkmar Guenzler-Pukall , Ingrid Langsetmo Parobok , Todd W. Seeley , Robert C. Stephenson
CPC分类号： C07D217/24 , A61K31/00 , A61K31/165 , A61K31/17 , A61K31/395 , A61K31/472 , C07C275/40
摘要： The present invention relates to methods and compounds for regulating or enhancing erythropoiesis and iron metabolism, and for treating or preventing iron deficiency and anemia of chronic disease.
摘要翻译： 本发明涉及用于调节或增强红细胞生成和铁代谢以及治疗或预防慢性疾病的铁缺乏和贫血的方法和化合物。
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公开(公告)号：US20110263644A1
公开(公告)日：2011-10-27
申请号：US13180262
申请日：2011-07-11
IPC分类号： A61K31/472 , A61P9/00 , A61K31/4725
CPC分类号： A61K45/06 , A61K31/121 , A61K31/194 , A61K38/49 , A61K2300/00
摘要： The present invention relates to methods and agents useful for the treatment of stroke, including ischemic stroke and hemorrhagic stroke. In particular, methods and agents for treating stroke in a subject are provided, wherein the agent is administered prior to diagnosis of the stroke as an ischemic stroke or a hemorrhagic stroke.
摘要翻译： 本发明涉及可用于治疗中风的方法和药剂，包括缺血性卒中和出血性中风。 特别地，提供了用于治疗受试者中风的方法和药剂，其中所述药物在诊断为中风之前作为缺血性中风或出血性中风进行施用。
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公开(公告)号：US20100144737A1
公开(公告)日：2010-06-10
申请号：US12316028
申请日：2008-12-08
CPC分类号： C12N5/0636 , A61K31/00 , A61K31/19 , A61K31/44 , A61K31/50 , C12N2501/999
摘要： The present invention relates to methods and compounds useful for inhibiting T helper cell differentiation. Methods and compounds for decreasing IL-12 signaling in T helper cells are also provided.
摘要翻译： 本发明涉及可用于抑制T辅助细胞分化的方法和化合物。 还提供了用于减少T辅助细胞中IL-12信号传导的方法和化合物。
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公开(公告)号：US09775902B2
公开(公告)日：2017-10-03
申请号：US13180262
申请日：2011-07-11
IPC分类号： A61K31/121 , A61K31/194 , A61K45/06 , A61K38/49
CPC分类号： A61K45/06 , A61K31/121 , A61K31/194 , A61K38/49 , A61K2300/00
摘要： The present invention relates to methods and agents useful for the treatment of stroke, including ischemic stroke and hemorrhagic stroke. In particular, methods and agents for treating stroke in a subject are provided, wherein the agent is administered prior to diagnosis of the stroke as an ischemic stroke or a hemorrhagic stroke.
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公开(公告)号：US08604013B2
公开(公告)日：2013-12-10
申请号：US12804042
申请日：2010-07-12
申请人： Stephen J. Klaus , Christopher J. Molineaux , Thomas B. Neff , Volkmar Guenzler-Pukall , Ingrid Langsetmo Parobok , Todd W. Seeley , Robert C. Stephenson
发明人： Stephen J. Klaus , Christopher J. Molineaux , Thomas B. Neff , Volkmar Guenzler-Pukall , Ingrid Langsetmo Parobok , Todd W. Seeley , Robert C. Stephenson
CPC分类号： C07D217/24 , A61K31/00 , A61K31/165 , A61K31/17 , A61K31/395 , A61K31/472 , C07C275/40
摘要： The present invention relates to methods for treating anemia in a subject having a low percent transferrin saturation by administering to the subject an effective amount of a compound that inhibits hypoxia-inducible factor prolyl hydroxylase activity.
摘要翻译： 本发明涉及通过向受试者施用有效量的抑制缺氧诱导因子脯氨酰羟化酶活性的化合物来治疗具有低转铁蛋白饱和度的受试者的贫血的方法。
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公开(公告)号：US20110038950A1
公开(公告)日：2011-02-17
申请号：US12804042
申请日：2010-07-12
申请人： Stephen J. Klaus , Christopher J. Molineaux , Thomas B. Neff , Volkmar Guenzler-Pukall , Ingrid Langsetmo Parobok , Todd W. Seeley , Robert C. Stephenson
发明人： Stephen J. Klaus , Christopher J. Molineaux , Thomas B. Neff , Volkmar Guenzler-Pukall , Ingrid Langsetmo Parobok , Todd W. Seeley , Robert C. Stephenson
IPC分类号： A61K31/33 , A61K33/26 , A61K31/51 , A61K31/525 , A61K31/714 , A61K31/4415 , A61P7/06
CPC分类号： C07D217/24 , A61K31/00 , A61K31/165 , A61K31/17 , A61K31/395 , A61K31/472 , C07C275/40
摘要： The present invention relates to methods and compounds for regulating or enhancing erythropoiesis and iron metabolism, and for treating or preventing iron deficiency and anemia of chronic disease.
摘要翻译： 本发明涉及用于调节或增强红细胞生成和铁代谢以及治疗或预防慢性疾病的铁缺乏和贫血的方法和化合物。
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公开(公告)号：US20100280044A1
公开(公告)日：2010-11-04
申请号：US12804029
申请日：2010-07-12
申请人： Stephen J. Klaus , Christopher J. Molineaux , Thomas B. Neff , Volkmar Guenzler-Pukall , Ingrid Langsetmo Parobok , Todd W. Seeley , Robert C. Stephenson
发明人： Stephen J. Klaus , Christopher J. Molineaux , Thomas B. Neff , Volkmar Guenzler-Pukall , Ingrid Langsetmo Parobok , Todd W. Seeley , Robert C. Stephenson
IPC分类号： A61K31/496 , A61K31/44 , A61K31/472 , A61P7/06 , A61P7/00
CPC分类号： C07D217/24 , A61K31/00 , A61K31/165 , A61K31/17 , A61K31/395 , A61K31/472 , C07C275/40
摘要： The present invention relates to methods and compounds for regulating or enhancing erthropoiesis and iron metabolism, and for treating or preventing iron deficiency and anemia of chronic disease.
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