公开(公告)号：US20220185799A1

公开(公告)日：2022-06-16

申请号：US17452786

申请日：2021-10-29

申请人： Sunovion Pharmaceuticals Inc. ,  PGI Drug Discovery LLC

发明人： Linghong XIE ,  Philip Glyn JONES ,  Kerry L. SPEAR ,  Noel Aaron POWELL ,  Taleen G. HANANIA ,  Vadim ALEXANDROV

IPC分类号： C07D405/04 ,  C07D405/14 ,  C07D413/14 ,  C07D493/04 ,  C07D413/04

摘要： Disclosed are compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, Ra, R1, R2, R3, R4, R6, w and n1 are defined and described herein; compositions thereof; and methods of use thereof. These compounds are useful for treating a variety of neurological and psychiatric disorders, such as those described herein.

公开(公告)号：US20200024286A1

公开(公告)日：2020-01-23

申请号：US16403734

申请日：2019-05-06

申请人： Sunovion Pharmaceuticals Inc. ,  PGI Drug Discovery LLC

发明人： Milan CHYTIL ,  Sharon ENGEL ,  Taleen G. HANANIA ,  Vadim ALEXANDROV ,  Emer LEAHY

IPC分类号： C07D498/04 ,  C07D231/56 ,  C07D498/20 ,  C07D498/14 ,  C07D498/22

摘要： Disclosed are compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein Ring B, A1, A2, R6, w and n1 are defined and described herein; compositions thereof; and methods of use thereof. These compounds are useful for treating a variety of neurological and psychiatric disorders, such as those described herein.

公开(公告)号：US20180057506A1

公开(公告)日：2018-03-01

申请号：US15666719

申请日：2017-08-02

申请人： Sunovion Pharmaceuticals Inc. ,  PGI Drug Discovery LLC

发明人： Milan CHYTIL ,  Sharon Engel ,  Taleen G. HANANIA ,  Vadim ALEXANDROV ,  Emer LEAHY

IPC分类号： C07D498/04 ,  C07D498/22 ,  C07D498/14 ,  C07D498/20

CPC分类号： C07D498/04 ,  C07D231/56 ,  C07D498/14 ,  C07D498/20 ,  C07D498/22

摘要： Disclosed are compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein Ring B, A1, A2, R6, w and n1 are defined and described herein; compositions thereof; and methods of use thereof. These compounds are useful for treating a variety of neurological and psychiatric disorders, such as those described herein.

公开(公告)号：US20210300942A1

公开(公告)日：2021-09-30

申请号：US17179477

申请日：2021-02-19

申请人： Sunovion Pharmaceuticals Inc. ,  PGI Drug Discovery LLC

发明人： Milan CHYTIL ,  Sharon ENGEL ,  Taleen G. HANANIA ,  Vadim ALEXANDROV ,  Emer LEAHY

IPC分类号： C07D498/04 ,  C07D231/56 ,  C07D498/20 ,  C07D498/14 ,  C07D498/22

摘要： Disclosed are compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein Ring B, A1, A2, R6, w and n1 are defined and described herein; compositions thereof; and methods of use thereof. These compounds are useful for treating a variety of neurological and psychiatric disorders, such as those described herein.

公开(公告)号：US20190389845A1

公开(公告)日：2019-12-26

申请号：US16403698

申请日：2019-05-06

申请人： Sunovion Pharmaceuticals Inc. ,  PGI Drug Discovery LLC

发明人： Linghong Xie ,  Philip Glyn JONES ,  Kerry L. SPEAR ,  Noel Aaron POWELL ,  Taleen G. HANANIA ,  Vadim ALEXANDROV

IPC分类号： C07D405/04 ,  C07D405/14 ,  C07D413/14 ,  C07D493/04 ,  C07D413/04

摘要： Disclosed are compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, Ra, R1, R2, R3, R4, R6, w and n1 are defined and described herein; compositions thereof; and methods of use thereof. These compounds are useful for treating a variety of neurological and psychiatric disorders, such as those described herein.

公开(公告)号：US20180028492A1

公开(公告)日：2018-02-01

申请号：US15663672

申请日：2017-07-28

申请人： Sunovion Pharmaceuticals Inc.

发明人： Noel Aaron POWELL ,  Taleen G. HANANIA ,  Vadim ALEXANDROV ,  Carrie A. BOWEN

IPC分类号： A61K31/353 ,  A61K45/06 ,  C07D311/76 ,  C07D313/08 ,  A61K31/13 ,  C12P17/06

CPC分类号： A61K31/353 ,  A61K31/13 ,  A61K31/352 ,  A61K45/06 ,  C07D311/76 ,  C07D313/08 ,  C12P17/06

摘要： Compounds of formula I: are disclosed, as are pharmaceutical compositions containing such compounds. Methods of treating neurological or psychiatric diseases and disorders in a subject in need thereof are also disclosed.