公开(公告)号：US20150152052A1

公开(公告)日：2015-06-04

申请号：US14389004

申请日：2013-03-28

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Minoru Sasaki ,  Hideki Furukawa ,  Kousuke Hidaka ,  Kyoko Toyofuku ,  Takatoshi Yogo ,  Toshiki Murata

IPC: C07D211/60 ,  C07D405/14 ,  C07D413/12 ,  C07D498/04 ,  C07D401/12 ,  C07D401/06

CPC classification number: C07D211/60 ,  C07D401/06 ,  C07D401/12 ,  C07D405/14 ,  C07D413/12 ,  C07D498/04

Abstract: Provided is an aromatic ring compound having a glucagon antagonistic action, which is useful for the prophylaxis or treatment of diabetes and the like. A compound represented by the formula (I): wherein each symbol is as defined in the DESCRIPTION, or a salt thereof has a superior glucagon antagonistic action, and is useful as a glucagon antagonist, a glucose production inhibitor or an agent for the prophylaxis or treatment of diabetes and the like.

Abstract translation: 提供具有胰高血糖素拮抗作用的芳香环化合物，其可用于预防或治疗糖尿病等。 由式（I）表示的化合物：其中各符号如说明书所定义，或其盐具有优良的胰高血糖素拮抗作用，可用作胰高血糖素拮抗剂，葡萄糖产生抑制剂或预防或 治疗糖尿病等。

公开(公告)号：US10308643B2

公开(公告)日：2019-06-04

申请号：US15210965

申请日：2016-07-15

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Akira Kaieda ,  Masashi Toyofuku ,  Masaki Daini ,  Hiroshi Nara ,  Masato Yoshikawa ,  Naoki Ishii ,  Kousuke Hidaka

IPC: C07D413/14 ,  C07D413/04 ,  C07D471/04 ,  C07D491/08 ,  C07D491/107 ,  C07D417/14 ,  C07D498/08

Abstract: The present invention provide a heterocyclic compound having a HDAC inhibitory action, and useful for the treatment of autoimmune diseases and/or inflammatory diseases, graft versus host disease, cancers, central nervous diseases including neurodegenerative diseases, Charcot-Marie-Tooth disease and the like, and a pharmaceutical composition comprising the compound.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US10968178B2

公开(公告)日：2021-04-06

申请号：US16496530

申请日：2018-03-29

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Yoshito Terao ,  Masashi Takahashi ,  Ryoma Hara ,  Kousuke Hidaka ,  Hideki Furukawa ,  Takeshi Yamasaki ,  Shizuo Kasai

IPC: C07D209/96 ,  C07D401/12 ,  C07D403/12 ,  C07D471/10 ,  C07D491/052 ,  A61P3/10 ,  A61P9/04

Abstract: The present invention aims to provide a heterocyclic compound having an IP6K inhibitory action and expected to be useful as a prophylactic or therapeutic agent for—diseases such as cardiac failure, diabetes and the like. A compound represented by the formula (I): wherein each symbol is as defined in the SPECIFICATION, or a salt thereof has an IP6K inhibitory action and is expected to be useful as a prophylactic or therapeutic agent for diseases such as cardiac failure, diabetes and the like.

公开(公告)号：US20180222896A1

公开(公告)日：2018-08-09

申请号：US15506380

申请日：2015-08-25

Applicant: Takeda Pharmaceutical Company, Limited

Inventor： Akira Kaieda ,  Noaki Ishii ,  Hiroshi Nara ,  Masato Yoshikawa ,  Masaki Daini ,  Mashashi Toyofuku ,  Kousuke Hidaka

IPC: C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D417/14 ,  C07D513/04 ,  C07D491/08

CPC classification number: C07D413/12 ,  A61K31/4245 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/55 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/08 ,  C07D491/107 ,  C07D513/04

Abstract: The present invention provides a heterocyclic compound having a HDAC inhibitory action, and useful for the treatment of autoimmune diseases and/or inflammatory diseases, graft versus host disease, cancers, central nervous diseases including neurodegenerative diseases and the like, and a medicament comprising the compound.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US10357484B2

公开(公告)日：2019-07-23

申请号：US15745290

申请日：2016-07-15

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Akira Kaieda ,  Masaki Daini ,  Hiroshi Nara ,  Masato Yoshikawa ,  Naoki Ishii ,  Masashi Toyofuku ,  Kousuke Hidaka

IPC: A61P25/28 ,  A61K31/427 ,  A61K31/437 ,  A61K31/444 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  A61K31/4035 ,  A61K31/4245 ,  A61K31/4439

Abstract: The present invention provide a heterocyclic compound having a HDAC inhibitory action, and useful for the treatment of autoimmune diseases and/or inflammatory diseases, graft versus host disease, cancers, central nervous diseases including neurodegenerative diseases, Charcot-Marie-Tooth disease and the like, and a medicament comprising the compound.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US10081624B2

公开(公告)日：2018-09-25

申请号：US15506380

申请日：2015-08-25

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Akira Kaieda ,  Naoki Ishii ,  Hiroshi Nara ,  Masato Yoshikawa ,  Masaki Daini ,  Masashi Toyofuku ,  Kousuke Hidaka

IPC: C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/08 ,  C07D513/04

CPC classification number: C07D413/12 ,  A61K31/4245 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/55 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/08 ,  C07D491/107 ,  C07D513/04

Abstract: The present invention provides a heterocyclic compound having a HDAC inhibitory action, and useful for the treatment of autoimmune diseases and/or inflammatory diseases, graft versus host disease, cancers, central nervous diseases including neurodegenerative diseases and the like, and a medicament comprising the compound.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US09073864B2

公开(公告)日：2015-07-07

申请号：US14389004

申请日：2013-03-28

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Minoru Sasaki ,  Hideki Furukawa ,  Kousuke Hidaka ,  Kyoko Toyofuku ,  Takatoshi Yogo ,  Toshiki Murata

IPC: C07D211/06 ,  A61K31/445 ,  C07D211/60 ,  C07D401/12 ,  C07D401/06 ,  C07D413/12 ,  C07D498/04 ,  C07D405/14

CPC classification number: C07D211/60 ,  C07D401/06 ,  C07D401/12 ,  C07D405/14 ,  C07D413/12 ,  C07D498/04

Abstract: Provided is an aromatic ring compound having a glucagon antagonistic action, which is useful for the prophylaxis or treatment of diabetes and the like. A compound represented by the formula (I): wherein each symbol is as defined in the DESCRIPTION, or a salt thereof has a superior glucagon antagonistic action, and is useful as a glucagon antagonist, a glucose production inhibitor or an agent for the prophylaxis or treatment of diabetes and the like.

Abstract translation: 提供具有胰高血糖素拮抗作用的芳香环化合物，其可用于预防或治疗糖尿病等。 由式（I）表示的化合物：其中各符号如说明书所定义，或其盐具有优良的胰高血糖素拮抗作用，可用作胰高血糖素拮抗剂，葡萄糖产生抑制剂或预防或 治疗糖尿病等。