公开(公告)号：US20160159808A1

公开(公告)日：2016-06-09

申请号：US14907139

申请日：2014-07-23

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Masanori Kawasaki ,  Satoshi Mikami ,  Shinji Nakamura ,  Nobuyuki Negoro ,  Shuhei Ikeda ,  Izumi Nomura ,  Tomoko Ashizawa ,  Toshihiro Imaeda ,  Masaki Seto ,  Shigekazu Sasaki ,  Shogo Marui ,  Takahiko Taniguchi

IPC: C07D487/04 ,  C07D498/08 ,  C07D491/08 ,  C07D471/04 ,  C07D473/00

CPC classification number: C07D487/04 ,  C07D471/04 ,  C07D473/00 ,  C07D491/08 ,  C07D498/08

Abstract: A compound represented by the formula (I): wherein each symbol is as described in the SPECIFICATION, or a salt thereof has a PDE2A inhibitory action, and is useful as a prophylactic or therapeutic drug for schizophrenia, Alzheimer's disease and the like.

Abstract translation: 由式（I）表示的化合物：其中每个符号如说明书所述，或其盐具有PDE2A抑制作用，并且可用作精神分裂症，阿尔茨海默氏病等的预防或治疗药物。

公开(公告)号：US09085578B2

公开(公告)日：2015-07-21

申请号：US14379343

申请日：2013-02-19

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Hiroyuki Nagamiya ,  Masato Yoshida ,  Masaki Seto ,  Shogo Marui ,  Tsuneo Oda ,  Yuji Ishichi ,  Hideo Suzuki ,  Tomokazu Kusumoto ,  Takatoshi Yogo ,  Chul Yun Rhim ,  Cheolhwan Yoon ,  Gil Nam Lee ,  Hyun Bin Kang ,  Kwang Ok Kim ,  Hye Sun Jeon

IPC: C07D401/14 ,  A61K31/437 ,  C07D471/04 ,  C07D519/00

CPC classification number: C07D471/04 ,  C07D519/00

Abstract: The present invention provides an agent for the prophylaxis or treatment of autoimmune diseases (e.g., psoriasis, rheumatoid arthritis, inflammatory bowel disease, Sjogren's syndrome, Behcet's disease, multiple sclerosis, systemic lupus erythematosus etc.) and the like, which has a superior Tyk2 inhibitory action.The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.

Abstract translation: 本发明提供了一种用于预防或治疗自身免疫性疾病（例如牛皮癣，类风湿性关节炎，炎性肠病，干燥综合征，白塞病，多发性硬化，系统性红斑狼疮等）等，其具有优异的Tyk2 抑制作用。 本发明涉及由下式表示的化合物，其中每个符号如说明书中所定义，或其盐。

公开(公告)号：US12077522B2

公开(公告)日：2024-09-03

申请号：US17256330

申请日：2019-06-27

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Tatsuhiko Fujimoto ,  Koichiro Fukuda ,  Hiromichi Sugimoto ,  Kentaro Rikimaru ,  Yoshihiro Banno ,  Takahiro Matsumoto ,  Norihito Tokunaga ,  Yoshihide Tomata ,  Yuji Ishichi ,  Shogo Marui ,  Tsuneo Oda ,  Tohru Miyazaki ,  Yasutaka Hoashi ,  Yasushi Hattori ,  Yuichi Kajita ,  Yuhei Miyanohana ,  Tatsuki Koike

IPC: C07D401/14 ,  C07D211/56 ,  C07D405/14

CPC classification number: C07D401/14 ,  C07D211/56 ,  C07D405/14

Abstract: The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I):




wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.

公开(公告)号：US20150045349A1

公开(公告)日：2015-02-12

申请号：US14379343

申请日：2013-02-19

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Hiroyuki Nagamiya ,  Masato Yoshida ,  Masaki Seto ,  Shogo Marui ,  Tsuneo Oda ,  Yuji Ishichi ,  Hideo Suzuki ,  Tomokazu Kusumoto ,  Takatoshi Yogo ,  Chul Yun Rhim ,  Cheolhwan Yoon ,  Gil Nam Lee ,  Hyun Bin Kang ,  Kwang Ok Kim ,  Hye Sun Jeon

IPC: C07D471/04

CPC classification number: C07D471/04 ,  C07D519/00

Abstract: The present invention provides an agent for the prophylaxis or treatment of autoimmune diseases (e.g., psoriasis, rheumatoid arthritis, inflammatory bowel disease, Sjogren's syndrome, Behcet's disease, multiple sclerosis, systemic lupus erythematosus etc.) and the like, which has a superior Tyk2 inhibitory action.The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.