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公开(公告)号：US11059780B2
公开(公告)日：2021-07-13
申请号：US16491811
申请日：2018-03-07
发明人： Masaki Daini , Yuhei Miyanohana , Satoshi Mikami , Yuichi Kajita , Masaki Ogino , Tatsuki Koike , Kohei Takeuchi
IPC分类号： C07D207/12 , C07D405/12 , C07D403/12 , C07D405/14 , C07D401/14 , C07D417/14 , C07D403/14 , C07D493/08 , C07D487/10 , C07D498/10 , C07D471/04 , C07D413/12 , C07D491/107 , C07D487/08
摘要： The present invention provides a substituted pyrrolidine compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof, has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.-
公开(公告)号：US09624184B2
公开(公告)日：2017-04-18
申请号：US14781665
申请日：2014-04-03
发明人： Tatsuki Koike , Masato Yoshikawa , Izumi Nomura , Yoshiteru Ito , Eiji Kimura , Haruhi Ando , Tomoaki Hasui , Toshiya Nishi
IPC分类号： C07D413/10 , C07D491/08 , C07D413/12 , C07D413/14 , C07D263/32 , C07D413/04
CPC分类号： C07D263/32 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14 , C07D491/08
摘要： The present invention relates to a compound represented by the formula (I), which is useful as an agent for the prophylaxis or treatment of epilepsy, neurodegenerative disease and the like. In the formula (I), each symbol is as defined in the specification.
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3.发明授权公开(公告)号：US09624170B2
公开(公告)日：2017-04-18
申请号：US15108000
申请日：2014-12-25
发明人： Tatsuki Koike , Makoto Fushimi , Jumpei Aida , Shuhei Ikeda , Tomokazu Kusumoto , Hideyuki Sugiyama , Hidekazu Tokuhara
IPC分类号： C07D207/273 , C07D401/12 , C07D403/12 , C07D403/14 , C07D409/12 , C07D471/04 , C07D405/12 , C07D417/14 , C07D417/12 , C07D413/12 , C07D403/04 , C07D401/14
CPC分类号： C07D207/273 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention aims to provide a compound having an MAGL inhibitory action, and useful as a prophylactic or therapeutic agent for neurodegenerative diseases (e.g., Alzheimer's disease, Huntington's disease, Parkinson's disease, amyotrophic lateral sclerosis, traumatic brain injury, glaucoma, multiple sclerosis and the like), anxiety disorder, pain (e.g., inflammatory pain, carcinomatous pain, nervous pain and the like), epilepsy and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.
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公开(公告)号：US09296746B2
公开(公告)日：2016-03-29
申请号：US14435899
申请日：2013-10-15
发明人： Tatsuki Koike , Masato Yoshikawa , Izumi Nomura , Yoshiteru Ito , Eiji Kimura , Tomoaki Hasui , Haruhi Ando , Hiromi Fukuda
IPC分类号： C07D413/02 , C07D403/02 , A61K31/4245 , A61K31/416 , C07D471/04 , C07D519/00 , C07D413/04
CPC分类号： C07D471/04 , C07D413/04 , C07D519/00
摘要： The present invention provides a compound or a salt thereof useful for an agent for the prophylaxis or treatment of neurodegenerative disease and the like. The present invention relates to a compound represented by the formula wherein each symbol is as defined in the present specification, or a salt thereof.
摘要翻译： 本发明提供可用于预防或治疗神经变性疾病等的药剂的化合物或其盐。 本发明涉及由下式表示的化合物，其中每个符号如本说明书中所定义，或其盐。
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公开(公告)号：US08871766B2
公开(公告)日：2014-10-28
申请号：US13944042
申请日：2013-07-17
IPC分类号： A61K31/50 , A61K31/501 , C07D405/14 , C07D413/14 , C07D413/10 , C07D401/10 , C07D498/08 , C07D401/14 , C07D417/14
CPC分类号： C07D498/08 , C07D401/10 , C07D401/14 , C07D405/10 , C07D405/14 , C07D413/10 , C07D413/14 , C07D417/14
摘要： The present invention provides a compound useful as an agent for the prophylaxis or treatment of neurodegenerative disease and the like, or a salt thereof.The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.
摘要翻译： 本发明提供可用作预防或治疗神经变性疾病等的药剂或其盐。 本发明涉及由下式表示的化合物，其中每个符号如说明书中所定义，或其盐。
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公开(公告)号：US08865717B2
公开(公告)日：2014-10-21
申请号：US13944000
申请日：2013-07-17
IPC分类号： A61K31/50 , A61K31/501 , C07D413/14 , C07D417/14 , C07D413/10 , C07D401/10 , C07D401/14 , C07D498/08 , C07D405/14
CPC分类号： C07D498/08 , C07D401/10 , C07D401/14 , C07D405/10 , C07D405/14 , C07D413/10 , C07D413/14 , C07D417/14
摘要： The present invention provides a compound useful as an agent for the prophylaxis or treatment of neurodegenerative disease and the like, or a salt thereof.The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.
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公开(公告)号：US08648079B2
公开(公告)日：2014-02-11
申请号：US13633995
申请日：2012-10-03
IPC分类号： A61K31/50 , A61K31/501
CPC分类号： C07D498/08 , C07D401/10 , C07D401/14 , C07D405/10 , C07D405/14 , C07D413/10 , C07D413/14 , C07D417/14
摘要： The present invention provides a compound useful as an agent for the prophylaxis or treatment of neurodegenerative disease and the like, or a salt thereof.The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.
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公开(公告)号：US12077522B2
公开(公告)日：2024-09-03
申请号：US17256330
申请日：2019-06-27
发明人： Tatsuhiko Fujimoto , Koichiro Fukuda , Hiromichi Sugimoto , Kentaro Rikimaru , Yoshihiro Banno , Takahiro Matsumoto , Norihito Tokunaga , Yoshihide Tomata , Yuji Ishichi , Shogo Marui , Tsuneo Oda , Tohru Miyazaki , Yasutaka Hoashi , Yasushi Hattori , Yuichi Kajita , Yuhei Miyanohana , Tatsuki Koike
IPC分类号： C07D401/14 , C07D211/56 , C07D405/14
CPC分类号： C07D401/14 , C07D211/56 , C07D405/14
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I):
wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.-
公开(公告)号：US11028048B2
公开(公告)日：2021-06-08
申请号：US16777273
申请日：2020-01-30
发明人： Yasushi Hattori , Yuhei Miyanohana , Yuichi Kajita , Tatsuki Koike , Yasutaka Hoashi , Norihito Tokunaga , Alexander Martin Pawliczek , Tsuneo Oda , Tohru Miyazaki , Marilena Pira , Javier Miguelez-Ramos
IPC分类号： C07D207/14 , C07D407/08 , C07D417/06
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.-
10.发明授权公开(公告)号：US10550129B2
公开(公告)日：2020-02-04
申请号：US16381163
申请日：2019-04-11
IPC分类号： C07D498/08 , C07D401/10 , C07D401/14 , C07D405/10 , C07D405/14 , C07D413/10 , C07D413/14 , C07D417/14
摘要： The present invention provides a compound useful as an agent for the prophylaxis or treatment of neurodegenerative disease and the like, or a salt thereof.The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.
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