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公开(公告)号：US12077522B2
公开(公告)日：2024-09-03
申请号：US17256330
申请日：2019-06-27
发明人： Tatsuhiko Fujimoto , Koichiro Fukuda , Hiromichi Sugimoto , Kentaro Rikimaru , Yoshihiro Banno , Takahiro Matsumoto , Norihito Tokunaga , Yoshihide Tomata , Yuji Ishichi , Shogo Marui , Tsuneo Oda , Tohru Miyazaki , Yasutaka Hoashi , Yasushi Hattori , Yuichi Kajita , Yuhei Miyanohana , Tatsuki Koike
IPC分类号： C07D401/14 , C07D211/56 , C07D405/14
CPC分类号： C07D401/14 , C07D211/56 , C07D405/14
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I):
wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.-
公开(公告)号：US10508083B2
公开(公告)日：2019-12-17
申请号：US16075240
申请日：2017-02-01
发明人： Tatsuhiko Fujimoto , Kentaro Rikimaru , Koichiro Fukuda , Hiromichi Sugimoto , Takahiro Matsumoto
IPC分类号： C07D211/36 , A61P25/00
摘要： Provided is a substituted piperidine compound having an orexin type 2 receptor agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as a prophylactic or therapeutic agent for narcolepsy.
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公开(公告)号：US11319286B2
公开(公告)日：2022-05-03
申请号：US16635408
申请日：2018-08-02
发明人： Tatsuhiko Fujimoto , Kentaro Rikimaru , Koichiro Fukuda , Hiromichi Sugimoto , Takahiro Matsumoto , Yuichi Kajita , Satoshi Mikami , Yuhei Miyanohana , Tatsuki Koike , Masaki Daini , Masaki Ogino , Kohei Takeuchi , Tohru Miyazaki , Yoshiteru Ito , Norihito Tokunaga , Takahiro Sugimoto , Tsuneo Oda , Yasutaka Hoashi , Yasushi Hattori , Keisuke Imamura
IPC分类号： C07D207/14 , C07D401/14 , C07D403/06 , A61P25/28
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof, has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.-
公开(公告)号：US20170226137A1
公开(公告)日：2017-08-10
申请号：US15421702
申请日：2017-02-01
发明人： Tatsuhiko Fujimoto , Kentaro Rikimaru , Koichiro Fukuda , Hiromichi Sugimoto , Takahiro Matsumoto , Norihito Tokunaga , Mariko Hirozane
IPC分类号： C07F7/18 , C07D211/24 , C07D401/14 , C07D405/06 , C07D413/06 , C07D405/14 , C07D401/06 , C07D409/12 , C07D401/12 , C07D405/12 , C07D417/06 , C07D417/14 , C07D211/56 , C07D409/06
CPC分类号： C07F7/1804 , C07D211/24 , C07D211/36 , C07D211/56 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/12 , C07D413/06 , C07D417/06 , C07D417/14
摘要： Provided is a substituted piperidine compound having an orexin type 2 receptor agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as a prophylactic or therapeutic agent for narcolepsy.
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公开(公告)号：US20150232460A1
公开(公告)日：2015-08-20
申请号：US14625812
申请日：2015-02-19
发明人： Charlotte Fieldhouse , Angela Glen , Stephanie Maine , Tatsuhiko Fujimoto , John Stephen Robinson
IPC分类号： C07D413/12 , A61K31/44 , C07D239/42 , A61K31/505 , C07D403/12 , A61K45/06 , C07D401/12 , A61K31/4439 , A61K31/497 , C07D241/20 , A61K31/4965 , C07D213/74 , A61K31/506
CPC分类号： C07D403/12 , A61K31/44 , A61K31/4439 , A61K31/4965 , A61K31/497 , A61K31/505 , A61K31/506 , A61K45/06 , C07D213/74 , C07D239/42 , C07D241/20 , C07D401/12 , C07D401/14 , C07D413/12
摘要： The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein L, X, Ra, Rb, R1, R2 and R3 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译： 本发明提供式（I）化合物及其药学上可接受的盐，其中L，X，Ra，Rb，R 1，R 2和R 3如本说明书中所定义，其制备方法，含有它们的药物组合物及其在 治疗。
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公开(公告)号：US11292766B2
公开(公告)日：2022-04-05
申请号：US16713667
申请日：2019-12-13
发明人： Tatsuhiko Fujimoto , Kentaro Rikimaru , Koichiro Fukuda , Hiromichi Sugimoto , Takahiro Matsumoto , Norihito Tokunaga , Mariko Hirozane
IPC分类号： C07D215/44 , C07D211/36 , C07D211/24 , C07D211/56 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/12 , C07D413/06 , C07D417/06 , C07D417/14 , A61P25/00
摘要： Provided is a substituted piperidine compound having an orexin type 2 receptor agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as a prophylactic or therapeutic agent for narcolepsy.
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7.发明授权公开(公告)号：US09790220B2
公开(公告)日：2017-10-17
申请号：US15120002
申请日：2015-02-19
IPC分类号： A61K31/015 , A61K31/16 , C07D417/14 , C07D401/12 , C07D413/12 , C07D417/12 , A61K31/4439 , A61K31/4545 , A61K31/4709 , A61K31/498
CPC分类号： C07D417/14 , A61K31/015 , A61K31/16 , A61K31/4439 , A61K31/4545 , A61K31/4709 , A61K31/498 , C07D401/12 , C07D413/12 , C07D417/12
摘要： The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, Formula (I) wherein L, X, Ra, Rb, R1, R2 and R3 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
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8.发明申请SUBSTITUTED CYCLOPENTANES, TETRAHYDROFURANES AND PYRROLIDINES AS OREXIN RECEPTOR ANTAGONISTS 有权取代环孢菌素，四氢呋喃和吡咯烷作为OREXIN受体拮抗剂公开(公告)号：US20170073340A1
公开(公告)日：2017-03-16
申请号：US15120002
申请日：2015-02-19
IPC分类号： C07D417/14 , A61K31/4439 , A61K31/4709 , A61K31/4545 , C07D401/12 , A61K31/498 , C07D417/12 , C07D413/12
CPC分类号： C07D417/14 , A61K31/015 , A61K31/16 , A61K31/4439 , A61K31/4545 , A61K31/4709 , A61K31/498 , C07D401/12 , C07D413/12 , C07D417/12
摘要： The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, Formula (I) wherein L, X, Ra, Rb, R1, R2 and R3 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译： 本发明提供式（I）化合物及其药学上可接受的盐，式（I）其中L，X，Ra，Rb，R 1，R 2和R 3如本说明书中所定义，其制备方法，含有 他们和他们在治疗中的用途。
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公开(公告)号：US20170066744A1
公开(公告)日：2017-03-09
申请号：US15120048
申请日：2015-02-19
发明人： Charlotte Fieldhouse , Angela Glen , Stephanie Maine , Tatsuhiko Fujimoto , John Stephen Robinson
IPC分类号： C07D403/12 , C07D239/42 , C07D401/14 , C07D413/12 , C07D241/20 , C07D213/74 , C07D401/12
CPC分类号： C07D403/12 , A61K31/44 , A61K31/4439 , A61K31/4965 , A61K31/497 , A61K31/505 , A61K31/506 , A61K45/06 , C07D213/74 , C07D239/42 , C07D241/20 , C07D401/12 , C07D401/14 , C07D413/12
摘要： The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, (I) wherein L, X, Ra, Rb, R1, R2 and R3 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译： 本发明提供式（I）化合物及其药学上可接受的盐，其中L，X，Ra，Rb，R 1，R 2和R 3如本说明书中所定义，其制备方法，含有它们的药物组合物及其在 治疗。
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公开(公告)号：US20190263843A1
公开(公告)日：2019-08-29
申请号：US16410463
申请日：2019-05-13
发明人： Tatsuhiko Fujimoto , Kentaro RIKIMARU , Koichiro FUKUDA , Hiromichi SUGIMOTO , Takahiro MATSUMOTO , Norihito TOKUNAGA , Mariko HIROZANE
IPC分类号： C07F7/18 , C07D405/06 , C07D417/06 , C07D413/06 , C07D409/12 , C07D409/06 , C07D405/14 , C07D211/24 , C07D417/14 , C07D401/14 , C07D401/12 , C07D401/06 , C07D211/56 , C07D405/12
摘要： Provided is a substituted piperidine compound having an orexin type 2 receptor agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as a prophylactic or therapeutic agent for narcolepsy.
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