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公开(公告)号：US11993570B2
公开(公告)日：2024-05-28
申请号：US17900412
申请日：2022-08-31
IPC分类号： C07C229/12 , A61K9/16 , C07C69/533 , C12N15/113
CPC分类号： C07C69/533 , A61K9/1617 , C12N15/113
摘要： The present invention provides a technique that enables introduction of active ingredients, in particular, nucleic acids, into cells with superior efficiency; and cationic lipids, etc., for use in the technique. The compound or a salt thereof according to the present invention is a compound represented by formula (I) or a salt thereof. In formula (I), n represents an integer of 2 to 5, R represents a linear C1-5 alkyl group, a linear C7-11 alkenyl group, or a linear C11 alkadienyl group, and wavy lines each independently represent a cis-bond or a trans-bond.
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公开(公告)号：US20200247747A1
公开(公告)日：2020-08-06
申请号：US16777273
申请日：2020-01-30
发明人： Yasushi Hattori , Yuhei Miyanohana , Yuichi Kajita , Tatsuki Koike , Yasutaka Hoashi , Norihito Tokunaga , Alexander Martin Pawliczek , Tsuneo Oda , Tohru Miyazaki , Yoshiteru Ito , Kohei Takeuchi , Keisuke Imamura , Takahiro Sugimoto
IPC分类号： C07D207/14 , C07D417/06 , C07D407/08
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.
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公开(公告)号：US10428023B2
公开(公告)日：2019-10-01
申请号：US16052967
申请日：2018-08-02
发明人： Yuichi Kajita , Yuhei Miyanohana , Tatsuki Koike , Kohei Takeuchi , Yoshiteru Ito , Norihito Tokunaga , Takahiro Sugimoto , Tohru Miyazaki , Tsuneo Oda , Yasutaka Hoashi , Yasushi Hattori , Keisuke Imamura
IPC分类号： C07D211/56 , A61P25/00 , C07D205/04 , C07D207/14 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D405/10 , C07D405/12 , C07D413/06 , C07D417/06 , C07D417/14 , C07D405/06 , C07D211/36
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof, is useful as an agent for the prophylaxis or treatment of narcolepsy.
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公开(公告)号：US08552037B2
公开(公告)日：2013-10-08
申请号：US13657956
申请日：2012-10-23
发明人： Osamu Uchikawa , Tatsuki Koike , Yasutaka Hoashi , Takafumi Takai
IPC分类号： A61K31/428 , A61K31/423 , C07D277/60 , C07D263/52
CPC分类号： A61K31/428 , A61K31/423 , C07D263/52 , C07D277/60 , C07D277/62 , C07D413/06
摘要： The present invention provides a compound represented by the formula which is useful as an agent for the prophylaxis or treatment of diseases related to the action of melatonin, or a salt thereof and the like.
摘要翻译： 本发明提供下式表示的化合物，其可用作预防或治疗与褪黑激素或其盐等有关的疾病的药剂。
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公开(公告)号：US11440883B2
公开(公告)日：2022-09-13
申请号：US16811426
申请日：2020-03-06
发明人： Yuichi Kajita , Yuhei Miyanohana , Tatsuki Koike , Kohei Takeuchi , Yoshiteru Ito , Norihito Tokunaga , Takahiro Sugimoto , Tohru Miyazaki , Tsuneo Oda , Yasutaka Hoashi , Yasushi Hattori , Keisuke Imamura
IPC分类号： C07D211/56 , C07D211/36 , C07D405/06 , A61P25/26 , C07D409/10 , A61P25/00 , C07D205/04 , C07D207/14 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D405/10 , C07D405/12 , C07D413/06 , C07D417/06 , C07D417/14
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof, is useful as an agent for the prophylaxis or treatment of narcolepsy.-
公开(公告)号：US11319286B2
公开(公告)日：2022-05-03
申请号：US16635408
申请日：2018-08-02
发明人： Tatsuhiko Fujimoto , Kentaro Rikimaru , Koichiro Fukuda , Hiromichi Sugimoto , Takahiro Matsumoto , Yuichi Kajita , Satoshi Mikami , Yuhei Miyanohana , Tatsuki Koike , Masaki Daini , Masaki Ogino , Kohei Takeuchi , Tohru Miyazaki , Yoshiteru Ito , Norihito Tokunaga , Takahiro Sugimoto , Tsuneo Oda , Yasutaka Hoashi , Yasushi Hattori , Keisuke Imamura
IPC分类号： C07D207/14 , C07D401/14 , C07D403/06 , A61P25/28
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof, has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.-
公开(公告)号：US08895591B2
公开(公告)日：2014-11-25
申请号：US14017819
申请日：2013-09-04
发明人： Osamu Uchikawa , Tatsuki Koike , Yasutaka Hoashi , Takafumi Takai
IPC分类号： C07D263/52 , C07D277/60 , A61K31/428 , A61K31/423 , C07D277/62 , C07D413/06
CPC分类号： A61K31/428 , A61K31/423 , C07D263/52 , C07D277/60 , C07D277/62 , C07D413/06
摘要： The present invention provides a compound represented by the formula which is useful as an agent for the prophylaxis or treatment of diseases related to the action of melatonin, or a salt thereof and the like.
摘要翻译： 本发明提供下式表示的化合物，其可用作预防或治疗与褪黑激素或其盐等有关的疾病的药剂。
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公开(公告)号：US12077522B2
公开(公告)日：2024-09-03
申请号：US17256330
申请日：2019-06-27
发明人： Tatsuhiko Fujimoto , Koichiro Fukuda , Hiromichi Sugimoto , Kentaro Rikimaru , Yoshihiro Banno , Takahiro Matsumoto , Norihito Tokunaga , Yoshihide Tomata , Yuji Ishichi , Shogo Marui , Tsuneo Oda , Tohru Miyazaki , Yasutaka Hoashi , Yasushi Hattori , Yuichi Kajita , Yuhei Miyanohana , Tatsuki Koike
IPC分类号： C07D401/14 , C07D211/56 , C07D405/14
CPC分类号： C07D401/14 , C07D211/56 , C07D405/14
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I):
wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.-
公开(公告)号：US20230257338A1
公开(公告)日：2023-08-17
申请号：US17900412
申请日：2022-08-31
IPC分类号： C07C69/533 , A61K9/16 , C12N15/113
CPC分类号： C07C69/533 , A61K9/1617 , C12N15/113
摘要： The present invention provides a technique that enables introduction of active ingredients, in particular, nucleic acids, into cells with superior efficiency; and cationic lipids, etc., for use in the technique. The compound or a salt thereof according to the present invention is a compound represented by formula (I) or a salt thereof. In formula (I), n represents an integer of 2 to 5, R represents a linear C1-5 alkyl group, a linear C7-11 alkenyl group, or a linear C11 alkadienyl group, and wavy lines each independently represent a cis-bond or a trans-bond.
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公开(公告)号：US11028048B2
公开(公告)日：2021-06-08
申请号：US16777273
申请日：2020-01-30
发明人： Yasushi Hattori , Yuhei Miyanohana , Yuichi Kajita , Tatsuki Koike , Yasutaka Hoashi , Norihito Tokunaga , Alexander Martin Pawliczek , Tsuneo Oda , Tohru Miyazaki , Marilena Pira , Javier Miguelez-Ramos
IPC分类号： C07D207/14 , C07D407/08 , C07D417/06
摘要： The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.
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