公开(公告)号：US20160060273A1

公开(公告)日：2016-03-03

申请号：US14775265

申请日：2014-03-13

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Shizuo KASAI ,  Masaki OGINO ,  Ryo MIZOJIRI ,  Takeshi YAMASAKI ,  Hideki HIROSE ,  Nobuyuki TAKAKURA ,  Tohru YAMASHITA ,  Sachie MORIMOTO ,  Takashi NAKAHATA ,  Asato KINA

IPC: C07D498/10

CPC classification number: C07D498/10

Abstract: Provided is a compound represented by the following formula (1) or a salt thereof, which has an SSTR5 antagonistic action: wherein each symbol has the same definition as in the specification.

Abstract translation: 提供具有下式（1）表示的化合物或其盐，其具有SSTR5拮抗作用：其中每个符号具有与说明书中相同的定义。

公开(公告)号：US20140303378A1

公开(公告)日：2014-10-09

申请号：US14303238

申请日：2014-06-12

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Tomomi IKEMOTO ,  Hideya MIZUFUNE ,  Toshiaki NAGATA ,  Misayo SERA ,  Naohiro FUKUDA ,  Takeshi YAMASAKI

IPC: C07D207/337 ,  C07D207/36 ,  C07D207/30 ,  C07D207/48 ,  C07C225/14 ,  C07D207/333 ,  C07D401/12

CPC classification number: C07D207/337 ,  C07D207/30 ,  C07D207/333 ,  C07D207/34 ,  C07D207/36 ,  C07D207/48 ,  C07D401/12

Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.

Abstract translation: 本发明提供了可用作药物的磺酰基吡咯化合物的制备方法，用于该方法的中间体的制备方法和新的中间体。 本发明涉及一种制备磺酰基吡咯化合物（Ⅷ）的方法，其包括还原化合物（III）并水解还原产物得到化合物（Ⅳ），使化合物（Ⅳ）进行磺酰化反应得到化合物（Ⅵ）， 并使化合物（VI）进行胺化反应。

公开(公告)号：US20200377458A1

公开(公告)日：2020-12-03

申请号：US16496530

申请日：2017-03-29

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Yoshito TERAO ,  Masashi TAKAHASHI ,  Ryoma HARA ,  Kousuke HIDAKA ,  Hideki FURUKAWA ,  Takeshi YAMASAKI ,  Shizuo KASAl

IPC: C07D209/96 ,  C07D401/12 ,  A61P3/10 ,  A61P9/04 ,  C07D471/10 ,  C07D491/052 ,  C07D403/12

Abstract: The present invention aims to provide a heterocyclic compound having an IP6K inhibitory action and expected to be useful as a prophylactic or therapeutic agent for—diseases such as cardiac failure, diabetes and the like. A compound represented by the formula (I): wherein each symbol is as defined in the SPECIFICATION, or a salt thereof has an IP6K inhibitory action and is expected to be useful as a prophylactic or therapeutic agent for diseases such as cardiac failure, diabetes and the like.