公开(公告)号：US09133129B2

公开(公告)日：2015-09-15

申请号：US14353622

申请日：2012-10-23

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Tohru Yamashita ,  Takuya Fujimoto ,  Ryo Mizojiri ,  Kazuko Yonemori ,  Hideki Hirose ,  Zenichi Ikeda ,  Ikuo Fujimori ,  Kyoko Toyofuku ,  Tsuneo Yasuma ,  Nobuyuki Matsunaga

IPC: A61K31/437 ,  C07D471/04 ,  C07D231/56 ,  A61K31/343 ,  A61K31/416 ,  A61K31/4184 ,  A61K31/422 ,  A61K31/423 ,  A61K31/4439 ,  C07D413/04 ,  C07D498/04 ,  C07D307/80 ,  C07D235/18 ,  C07D263/57 ,  C07D513/04

CPC classification number: C07D231/56 ,  A61K31/343 ,  A61K31/416 ,  A61K31/4184 ,  A61K31/422 ,  A61K31/423 ,  A61K31/437 ,  A61K31/4439 ,  C07D235/18 ,  C07D263/57 ,  C07D307/80 ,  C07D413/04 ,  C07D498/04 ,  C07D513/04

Abstract: The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

Abstract translation: 本发明提供由式（I）表示的化合物：其中每个符号如说明书中所定义，或其盐。

公开(公告)号：US11952344B2

公开(公告)日：2024-04-09

申请号：US17754118

申请日：2020-09-25

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Yuya Oguro ,  Makoto Kamata ,  Shuhei Ikeda ,  Takeshi Wakabayashi ,  Norihito Tokunaga ,  Taku Kamei ,  Mitsuhiro Ito ,  Shigemitsu Matsumoto ,  Hirotaka Kamitani ,  Takaharu Hirayama ,  Toshio Tanaka ,  Hiroshi Banno ,  Nobuyuki Takakura ,  Jinichi Yonemori ,  Takuya Fujimoto

IPC: C07D213/61 ,  A61K31/444 ,  A61K31/495 ,  A61P25/00 ,  A61P29/00 ,  C07D211/04 ,  C07D213/65 ,  C07D213/68 ,  C07D221/04 ,  C07D237/08 ,  C07D239/26 ,  C07D239/34 ,  C07D333/38 ,  C07D401/12 ,  C07D405/02

CPC classification number: C07D211/04 ,  C07D237/08 ,  C07D239/26 ,  C07D405/02

Abstract: Provided is a heterocyclic compound that can have an antagonistic action on an NMD A receptor containing the NR2B subunit and that is expected to be useful as a prophylactic or therapeutic agent for depression, bipolar disorder, migraine, pain, peripheral symptoms of dementia and the like. A compound represented by the formula (I), wherein each symbol is as defined in the DESCRIPTION, or a salt thereof.

公开(公告)号：US20140243310A1

公开(公告)日：2014-08-28

申请号：US14353622

申请日：2012-10-23

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Tohru Yamashita ,  Takuya Fujimoto ,  Ryo Mizojiri ,  Kazuko Yonemori ,  Hideki Hirose ,  Zenichi Ikeda ,  Ikuo Fujimori ,  Kyoko Toyofuku ,  Tsuneo Yasuma ,  Nobuyuki Matsunaga

IPC: C07D231/56 ,  C07D498/04 ,  C07D307/80 ,  C07D413/04 ,  C07D263/57 ,  C07D235/18

CPC classification number: C07D231/56 ,  A61K31/343 ,  A61K31/416 ,  A61K31/4184 ,  A61K31/422 ,  A61K31/423 ,  A61K31/437 ,  A61K31/4439 ,  C07D235/18 ,  C07D263/57 ,  C07D307/80 ,  C07D413/04 ,  C07D498/04 ,  C07D513/04

Abstract: The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

Abstract translation: 本发明提供由式（I）表示的化合物：其中每个符号如说明书中所定义，或其盐。